{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T07:34:10Z","timestamp":1770276850074,"version":"3.49.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T00:00:00Z","timestamp":1583971200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T00:00:00Z","timestamp":1583971200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1007\/s10620-020-06191-9","type":"journal-article","created":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T16:03:29Z","timestamp":1584029009000},"page":"521-525","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Effects of Low-Dose Amitriptyline on Epigastric Pain Syndrome in Functional Dyspepsia Patients"],"prefix":"10.1007","volume":"66","author":[{"given":"Jing","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-man","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-cong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,3,12]]},"reference":[{"key":"6191_CR1","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1053\/j.gastro.2005.11.059","volume":"130","author":"J Tack","year":"2006","unstructured":"Tack J, Talley NJ, Camilleri M, et al. Functional gastroduodenal disorders. Gastroenterology. 2006;130:1466\u20131479.","journal-title":"Gastroenterology"},{"key":"6191_CR2","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1136\/gutjnl-2014-307843","volume":"64","author":"AC Ford","year":"2015","unstructured":"Ford AC, Marwaha A, Sood R, et al. Global prevalence of, and risk factors for, uninvestigated dyspepsia: a meta-analysis. Gut.. 2015;64:1049\u20131057.","journal-title":"Gut."},{"key":"6191_CR3","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/j.cgh.2010.03.003","volume":"8","author":"RA Brook","year":"2010","unstructured":"Brook RA, Kleinman NL, Choung RS, et al. Functional dyspepsia impacts absenteeism and direct and indirect costs. Clin Gastroenterol Hepatol. 2010;8:498\u2013503.","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"Suppl 1","key":"6191_CR4","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1111\/j.1365-2982.2008.01097.x","volume":"20","author":"NJ Talley","year":"2008","unstructured":"Talley NJ. Functional gastrointestinal disorders as a public health problem. Neurogastroenterol Motil. 2008;20(Suppl 1):121\u2013129.","journal-title":"Neurogastroenterol Motil"},{"key":"6191_CR5","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1111\/j.1365-2036.2011.04640.x","volume":"33","author":"P Aro","year":"2011","unstructured":"Aro P, Talley NJ, Agr\u00e9us L, et al. Functional dyspepsia impairs quality of life in the adult population. Aliment Pharmacol Ther. 2011;33:1215\u20131224.","journal-title":"Aliment Pharmacol Ther"},{"key":"6191_CR6","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1053\/j.gastro.2016.02.032","volume":"150","author":"DA Drossman","year":"2016","unstructured":"Drossman DA. Functional gastrointestinal disorders: history, pathophysiology, clinical features and Rome IV. Gastroenterology. 2016;150:1262\u20131279.","journal-title":"Gastroenterology"},{"issue":"Suppl 2","key":"6191_CR7","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1111\/j.1365-2036.2005.02473.x","volume":"21","author":"M Otaka","year":"2005","unstructured":"Otaka M, Jin M, Odashima M, et al. New strategy of therapy for functional dyspepsia using famotidine, mosapride and amitriptyline. Aliment Pharmacol Ther. 2005;21(Suppl 2):42\u201346.","journal-title":"Aliment Pharmacol Ther"},{"key":"6191_CR8","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1111\/j.1572-0241.1998.00160.x","volume":"93","author":"H Mertz","year":"1998","unstructured":"Mertz H, Fass R, Kodner A, et al. Effect of amitriptyline on symptoms, sleep, and visceral perception in patients with functional dyspepsia. Am J Gastroenterol.. 1998;93:160\u2013165.","journal-title":"Am J Gastroenterol."},{"key":"6191_CR9","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1053\/j.gastro.2017.11.279","volume":"154","author":"DA Drossman","year":"2018","unstructured":"Drossman DA, Tack J, Ford AC, et al. Neuromodulators for functional gastrointestinal disorders (Disorders of Gut-Brain Interaction): a Rome foundation working team report. Gastroenterology. 2018;154:1140\u20131171.","journal-title":"Gastroenterology"},{"key":"6191_CR10","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1111\/j.1365-2982.2006.00867.x","volume":"19","author":"F Namin","year":"2007","unstructured":"Namin F, Patel J, Lin Z, et al. Clinical, psychiatric and manometric profile of cyclic vomiting syndrome in adults and response to tricyclic therapy. Neurogastroenterol Motil. 2007;19:196\u2013202.","journal-title":"Neurogastroenterol Motil"},{"key":"6191_CR11","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1038\/ajg.2014.148","volume":"109","author":"AC Ford","year":"2014","unstructured":"Ford AC, Quigley EM, Lacy BE, et al. Effect of antidepressants and psychological therapies, including hypnotherapy, in irritable bowel syndrome: systematic review and meta-analysis. Am J Gastroenterol. 2014;109:1350\u20131365.","journal-title":"Am J Gastroenterol"},{"key":"6191_CR12","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.clpt.2003.09.019","volume":"75","author":"WA Ray","year":"2004","unstructured":"Ray WA, Meredith S, Thapa PB, et al. Cyclic\u00a0antidepressants\u00a0and the\u00a0risk of\u00a0sudden cardiac death. Clin Pharmacol Ther. 2004;75:234\u2013241.","journal-title":"Clin Pharmacol Ther"},{"key":"6191_CR13","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1111\/nmo.12509","volume":"27","author":"H T\u00f6rnblom","year":"2015","unstructured":"T\u00f6rnblom H, Drossman DA. Centrally targeted pharmacotherapy for chronic abdominal pain. Neurogastroenterol Motil. 2015;27:455\u2013467.","journal-title":"Neurogastroenterol Motil"},{"key":"6191_CR14","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1097\/MPG.0b013e318217df7c","volume":"53","author":"JE Teitelbaum","year":"2011","unstructured":"Teitelbaum JE, Arora R. Long-term efficacy of low-dose tricyclic antidepressants for children with functional gastrointestinal disorders. J Pediatr Gastroenterol Nutr. 2011;53:260\u2013264.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"6191_CR15","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1111\/j.1365-2036.2008.03918.x","volume":"29","author":"NM Thoua","year":"2009","unstructured":"Thoua NM, Murray CD, Winchester WJ, et al. Amitriptyline modifies the visceral hypersensitivity response to acute stress in the irritable bowel syndrome. Aliment Pharmacol Ther. 2009;29:552\u2013560.","journal-title":"Aliment Pharmacol Ther"},{"key":"6191_CR16","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1046\/j.1365-2036.1999.00445.x","volume":"13","author":"NJ Talley","year":"1999","unstructured":"Talley NJ, Haque M, Wyeth JW, et al. Development of a new dyspepsia impact scale: the Nepean Dyspepsia Index. Aliment Pharmacol Ther. 1999;13:225\u2013235.","journal-title":"Aliment Pharmacol Ther"},{"key":"6191_CR17","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1002\/mpr.323","volume":"19","author":"LS Matza","year":"2010","unstructured":"Matza LS, Morlock R, Sexton C, et al. Identifying HAM-A cutoffs for mild, moderate, and severe generalized anxiety disorder. Int J Methods Psychiatr Res. 2010;19:223\u2013232.","journal-title":"Int J Methods Psychiatr Res"},{"key":"6191_CR18","first-page":"703","volume":"53","author":"DR Calot\u0103","year":"2012","unstructured":"Calot\u0103 DR, Ni\u0163escu C, Marinescu S, et al. Correlations between morphological appearance and psychosocial difficulties in patients with extensive burns who received allotransplant. Rom J Morphol Embryol. 2012;53:703\u2013711.","journal-title":"Rom J Morphol Embryol"},{"key":"6191_CR19","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/0165-1781(89)90047-4","volume":"28","author":"DJ Buysse","year":"1989","unstructured":"Buysse DJ, Reynolds CF, Monk TH, et al. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res. 1989;28:193\u2013213.","journal-title":"Psychiatry Res"},{"key":"6191_CR20","doi-asserted-by":"publisher","first-page":"5260","DOI":"10.3748\/wjg.v22.i22.5260","volume":"22","author":"SM Jiang","year":"2016","unstructured":"Jiang SM, Jia L, Liu J, et al. Beneficial effects of antidepressant mirtazapine in functional dyspepsia patients with weight loss. World J Gastroenterol.. 2016;22:5260\u20135266.","journal-title":"World J Gastroenterol."},{"key":"6191_CR21","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1111\/j.1572-0241.2007.01229.x","volume":"102","author":"WK Leung","year":"2007","unstructured":"Leung WK, Wu JC, Chan FK, et al. Initial treatment with lansoprazole in young dyspeptic patients with negative urea breath test result: a randomized controlled trial with 12-month follow-up. Am J Gastroenterol. 2007;102:1483\u20131488.","journal-title":"Am J Gastroenterol"},{"key":"6191_CR22","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.cgh.2006.09.012","volume":"5","author":"WH Wang","year":"2007","unstructured":"Wang WH, Huang JQ, Zheng GF, et al. Effects of proton-pump inhibitors on functional dyspepsia: a meta-analysis of randomized placebo-controlled trials. Clin Gastroenterol Hepatol. 2007;5:178\u2013185.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"6191_CR23","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1111\/j.1365-2982.2009.01261.x","volume":"21","author":"J Tack","year":"2009","unstructured":"Tack J, Masclee A, Heading R, et al. A dose-ranging, placebo-controlled, pilot trial of Acotiamide in patients with functional dyspepsia. Neurogastroenterol Motil. 2009;21:272\u2013280.","journal-title":"Neurogastroenterol Motil"},{"key":"6191_CR24","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1111\/j.1365-2982.2009.01449.x","volume":"22","author":"K Matsueda","year":"2010","unstructured":"Matsueda K, Hongo M, Tack J, et al. Clinical trial: dose-dependent therapeutic efficacy of acotiamide hydrochloride (Z-338) in patients with functional dyspepsia\u2014100\u00a0mg t.i.d is an optimal dosage. Neurogastroenterol Motil. 2010;22:618.","journal-title":"Neurogastroenterol Motil"},{"key":"6191_CR25","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1046\/j.1365-2036.2001.01090.x","volume":"15","author":"TG Dinan","year":"2001","unstructured":"Dinan TG, Mahmud N, Rathore O, et al. A double-blind placebo-controlled study of buspirone-stimulated prolactin release in non-ulcer dyspepsia: are central serotoninergic responses enhanced? Aliment Pharmacol Ther. 2001;15:1613\u20131618.","journal-title":"Aliment Pharmacol Ther"},{"key":"6191_CR26","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1016\/j.cgh.2008.02.051","volume":"6","author":"LA Van Kerkhoven","year":"2008","unstructured":"Van Kerkhoven LA, Laheij RJ, Aparicio N, et al. Effect of the antidepressant venlafaxine in functional dyspepsia: a randomized, double-blind, placebo-controlled trial. Clin Gastroenterol Hepatol. 2008;6:746\u2013752.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"6191_CR27","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1159\/000121346","volume":"26","author":"K Mimidis","year":"2008","unstructured":"Mimidis K, Tack J. Pathogenesis of dyspepsia. Dig Dis. 2008;26:194\u2013202.","journal-title":"Dig Dis"},{"key":"6191_CR28","doi-asserted-by":"publisher","first-page":"2229","DOI":"10.1023\/B:DDAS.0000007856.71462.6c","volume":"48","author":"G Sarnelli","year":"2003","unstructured":"Sarnelli G, Cuomo R, Janssens J, et al. Symptom patterns and pathophysiological mechanisms in dyspeptic patients with and without Helicobacter pylori. Dig Dis Sci. 2003;48:2229\u20132236.","journal-title":"Dig Dis Sci"},{"issue":"13","key":"6191_CR29","first-page":"222","volume":"115","author":"A Madisch","year":"2018","unstructured":"Madisch A, Andresen V, Enck P, et al. The diagnosis and treatment of functional dyspepsia. Dtsch Arztebl Int. 2018;115(13):222\u2013232.","journal-title":"Dtsch Arztebl Int"},{"key":"6191_CR30","first-page":"1","volume":"3","author":"A Vandenberghe","year":"2020","unstructured":"Vandenberghe A, Schol J, Van den Houte K, et al. Current and emerging therapeutic options for the management of functional dyspepsia. Expert Opin Pharmacother. 2020;3:1\u201312.","journal-title":"Expert Opin Pharmacother"},{"key":"6191_CR31","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1111\/j.1365-2036.2008.03633.x","volume":"27","author":"H Vahedi","year":"2008","unstructured":"Vahedi H, Merat S, Momtahen S, et al. Clinical trial: the effect of amitriptyline in patients with diarrhoea-predominant irritable bowel syndrome. Aliment Pharmacol Ther. 2008;27:678\u2013684.","journal-title":"Aliment Pharmacol Ther"},{"key":"6191_CR32","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1111\/j.1365-2036.2011.04775.x","volume":"34","author":"B Braak","year":"2011","unstructured":"Braak B, Klooker TK, Wouters MM, et al. Randomised clinical trial: the effects of amitriptyline on drinking capacity and symptoms in patients with functional dyspepsia, a double-blind placebo-controlled study. Aliment Pharmacol Ther. 2011;34:638\u2013648.","journal-title":"Aliment Pharmacol Ther"},{"key":"6191_CR33","doi-asserted-by":"publisher","first-page":"7455","DOI":"10.3748\/wjg.v19.i42.7455","volume":"19","author":"LQ You","year":"2013","unstructured":"You LQ, Liu J, Jia L, et al. Effect of low-dose amitriptyline on globus pharyngeus and its side effects. World J Gastroenterol. 2013;19:7455\u20137460.","journal-title":"World J Gastroenterol"},{"key":"6191_CR34","doi-asserted-by":"publisher","first-page":"4214","DOI":"10.3748\/wjg.v19.i26.4214","volume":"19","author":"W Huang","year":"2013","unstructured":"Huang W, Jiang SM, Jia L, et al. Effect of amitriptyline on gastrointestinal function and brain-gut peptides: a double-blind trial. World J Gastroenterol. 2013;19:4214\u20134220.","journal-title":"World J Gastroenterol"},{"issue":"2","key":"6191_CR35","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1053\/j.gastro.2015.04.020","volume":"149","author":"Nicholas J Talley","year":"2015","unstructured":"Talley Nicholas J, Richard Locke G, et al. Effect of\u2002amitriptyline\u2002and escitalopram on\u2002Functional\u2002Dyspepsia: a multi-center, randomized, controlled study. Gastroenterology. 2015;149(2):340\u2013349.","journal-title":"Gastroenterology"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-020-06191-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10620-020-06191-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-020-06191-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T00:25:39Z","timestamp":1615508739000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10620-020-06191-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,12]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["6191"],"URL":"https:\/\/doi.org\/10.1007\/s10620-020-06191-9","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,12]]},"assertion":[{"value":"23 April 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 March 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 March 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"All authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}