{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T17:15:41Z","timestamp":1782494141193,"version":"3.54.5"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,5,29]],"date-time":"2020-05-29T00:00:00Z","timestamp":1590710400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,5,29]],"date-time":"2020-05-29T00:00:00Z","timestamp":1590710400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1007\/s10620-020-06343-x","type":"journal-article","created":{"date-parts":[[2020,5,29]],"date-time":"2020-05-29T08:03:59Z","timestamp":1590739439000},"page":"1153-1161","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Hot-Water Bathing Improves Symptoms in Patients with Cyclic Vomiting Syndrome and Is Modulated by Chronic Cannabis Use"],"prefix":"10.1007","volume":"66","author":[{"given":"Sheldon","family":"Rosen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Diaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuping","family":"Garacci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishnu Charan Suresh","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shashank R.","family":"Thyarala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia J.","family":"Hillard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thangam","family":"Venkatesan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,5,29]]},"reference":[{"key":"6343_CR1","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1053\/j.gastro.2016.02.011","volume":"150","author":"V Stanghellini","year":"2016","unstructured":"Stanghellini V, Chan FK, Hasler WL, et al. Gastroduodenal disorders. Gastroenterology. 2016;150:1380\u20131392.","journal-title":"Gastroenterology"},{"key":"6343_CR2","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/1741-7015-3-20","volume":"3","author":"DR Fleisher","year":"2005","unstructured":"Fleisher DR, Gornowicz B, Adams K, Burch R, Feldman EJ. Cyclic vomiting syndrome in 41 adults: the illness, the patients, and problems of management. BMC Med. 2005;3:20.","journal-title":"BMC Med"},{"key":"6343_CR3","doi-asserted-by":"crossref","first-page":"e13606","DOI":"10.1111\/nmo.13606","volume":"31","author":"T Venkatesan","year":"2019","unstructured":"Venkatesan T, Levinthal DJ, Li BUK, et al. Role of chronic cannabis use: cyclic vomiting syndrome vs cannabinoid hyperemesis syndrome. Neurogastroenterol Motil. 2019;31:e13606.","journal-title":"Neurogastroenterol Motil"},{"key":"6343_CR4","first-page":"876","volume":"17","author":"I Aziz","year":"2018","unstructured":"Aziz I, Palsson OS, Whitehead WE, Sperber AD, Simren M, Tornblom H. Epidemiology, clinical characteristics, and associations for Rome IV functional nausea and vomiting disorders in adults. Clin Gastroenterol Hepatol. 2018;17:876\u2013886.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"6343_CR5","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1111\/nmo.12843","volume":"28","author":"T Venkatesan","year":"2016","unstructured":"Venkatesan T, Zadvornova Y, Raff H, Hillard CJ. Endocannabinoid-related lipids are increased during an episode of cyclic vomiting syndrome. Neurogastroenterol Motil. 2016;28:1409\u20131418.","journal-title":"Neurogastroenterol Motil"},{"key":"6343_CR6","doi-asserted-by":"publisher","first-page":"e198","DOI":"10.1038\/ctg.2016.55","volume":"7","author":"DJ Levinthal","year":"2016","unstructured":"Levinthal DJ. The cyclic vomiting syndrome threshold: a framework for understanding pathogenesis and predicting successful treatments. Clin Transl Gastroenterol. 2016;7:e198.","journal-title":"Clin Transl Gastroenterol"},{"key":"6343_CR7","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1097\/MCG.0b013e3181ac6489","volume":"44","author":"RA Hejazi","year":"2010","unstructured":"Hejazi RA, Reddymasu SC, Namin F, Lavenbarg T, Foran P, McCallum RW. Efficacy of tricyclic antidepressant therapy in adults with cyclic vomiting syndrome: a two-year follow-up study. J Clin Gastroenterol. 2010;44:18\u201321.","journal-title":"J Clin Gastroenterol"},{"key":"6343_CR8","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/1471-230X-12-52","volume":"12","author":"N Kumar","year":"2012","unstructured":"Kumar N, Bashar Q, Reddy N, et al. Cyclic vomiting syndrome (CVS): is there a difference based on onset of symptoms\u2013pediatric versus adult? BMC Gastroenterol. 2012;12:52.","journal-title":"BMC Gastroenterol"},{"key":"6343_CR9","doi-asserted-by":"crossref","first-page":"e13604","DOI":"10.1111\/nmo.13604","volume":"31","author":"T Venkatesan","year":"2019","unstructured":"Venkatesan T, Levinthal DJ, Tarbell SE, et al. Guidelines on management of cyclic vomiting syndrome in adults by the American neurogastroenterology and motility society and the cyclic vomiting syndrome association. Neurogastroenterol Motil. 2019;31:e13604.","journal-title":"Neurogastroenterol Motil"},{"key":"6343_CR10","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1177\/0333102410390398","volume":"31","author":"T Hikita","year":"2011","unstructured":"Hikita T, Kodama H, Kaneko S, et al. Sumatriptan as a treatment for cyclic vomiting syndrome: a clinical trial. Cephalalgia. 2011;31:504\u2013507.","journal-title":"Cephalalgia"},{"key":"6343_CR11","doi-asserted-by":"publisher","first-page":"2563","DOI":"10.1007\/s00221-014-3967-0","volume":"232","author":"T Venkatesan","year":"2014","unstructured":"Venkatesan T, Sengupta J, Lodhi A, et al. An Internet survey of marijuana and hot shower use in adults with cyclic vomiting syndrome (CVS). Exp Brain Res. 2014;232:2563\u20132570.","journal-title":"Exp Brain Res"},{"key":"6343_CR12","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1136\/gut.2003.036350","volume":"53","author":"JH Allen","year":"2004","unstructured":"Allen JH, de Moore GM, Heddle R, Twartz JC. Cannabinoid hyperemesis: cyclical hyperemesis in association with chronic cannabis abuse. Gut. 2004;53:1566\u20131570.","journal-title":"Gut"},{"key":"6343_CR13","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.mayocp.2011.10.005","volume":"87","author":"DA Simonetto","year":"2012","unstructured":"Simonetto DA, Oxentenko AS, Herman ML, Szostek JH. Cannabinoid hyperemesis: a case series of 98 patients. Mayo Clin Proc. 2012;87:114\u2013119.","journal-title":"Mayo Clin Proc"},{"key":"6343_CR14","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1111\/j.1365-2982.2011.01791.x","volume":"24","author":"RS Choung","year":"2012","unstructured":"Choung RS, Locke GR 3rd, Lee RM, Schleck CD, Zinsmeister AR, Talley NJ. Cyclic vomiting syndrome and functional vomiting in adults: association with cannabinoid use in males. Neurogastroenterol Motil. 2012;24:20\u201326.","journal-title":"Neurogastroenterol Motil"},{"key":"6343_CR15","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1146\/annurev-psych-113011-143739","volume":"64","author":"R Mechoulam","year":"2013","unstructured":"Mechoulam R, Parker LA. The endocannabinoid system and the brain. Annu Rev Psychol. 2013;64:21\u201347.","journal-title":"Annu Rev Psychol"},{"key":"6343_CR16","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1111\/j.1476-5381.2010.01176.x","volume":"163","author":"LA Parker","year":"2011","unstructured":"Parker LA, Rock EM, Limebeer CL. Regulation of nausea and vomiting by cannabinoids. Br J Pharmacol. 2011;163:1411\u20131422.","journal-title":"Br J Pharmacol"},{"key":"6343_CR17","doi-asserted-by":"publisher","first-page":"2416","DOI":"10.1038\/npp.2012.100","volume":"37","author":"A Dlugos","year":"2012","unstructured":"Dlugos A, Childs E, Stuhr KL, Hillard CJ, de Wit H. Acute stress increases circulating anandamide and other N-acylethanolamines in healthy humans. Neuropsychopharmacology. 2012;37:2416\u20132427.","journal-title":"Neuropsychopharmacology"},{"key":"6343_CR18","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1016\/j.psyneuen.2009.03.013","volume":"34","author":"MN Hill","year":"2009","unstructured":"Hill MN, Miller GE, Carrier EJ, Gorzalka BB, Hillard CJ. Circulating endocannabinoids and N-acyl ethanolamines are differentially regulated in major depression and following exposure to social stress. Psychoneuroendocrinology. 2009;34:1257\u20131262.","journal-title":"Psychoneuroendocrinology"},{"key":"6343_CR19","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.neuroscience.2006.11.012","volume":"145","author":"J Villares","year":"2007","unstructured":"Villares J. Chronic use of marijuana decreases cannabinoid receptor binding and mRNA expression in the human brain. Neuroscience. 2007;145:323\u2013334.","journal-title":"Neuroscience"},{"key":"6343_CR20","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1124\/pr.109.001263","volume":"61","author":"AA Romanovsky","year":"2009","unstructured":"Romanovsky AA, Almeida MC, Garami A, et al. The transient receptor potential vanilloid-1 channel in thermoregulation: a thermosensor it is not. Pharmacol Rev. 2009;61:228\u2013261.","journal-title":"Pharmacol Rev"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-020-06343-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10620-020-06343-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-020-06343-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T17:22:26Z","timestamp":1696180946000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10620-020-06343-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,29]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["6343"],"URL":"https:\/\/doi.org\/10.1007\/s10620-020-06343-x","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,29]]},"assertion":[{"value":"16 November 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 May 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 May 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"Thangam Venkatesan is an ad hoc consultant for Takeda and Alnylam Pharmaceuticals. This does not have any bearing on the contents of this article. Cecilia Hillard serves on the scientific advisory boards for Beryl Therapeutics and Phytecs, Inc. and this does not pose any conflict of interest. The other authors have no relevant disclosures.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}