{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:07:13Z","timestamp":1787238433873,"version":"build-2736575974"},"reference-count":100,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T00:00:00Z","timestamp":1591315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T00:00:00Z","timestamp":1591315200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1007\/s10620-020-06352-w","type":"journal-article","created":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T02:03:06Z","timestamp":1591322586000},"page":"2187-2195","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Celiac Disease Screening for High-Risk Groups: Are We Doing It Right?"],"prefix":"10.1007","volume":"65","author":[{"given":"Dennis","family":"Kumral","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sana","family":"Syed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,6,5]]},"reference":[{"key":"6352_CR1","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.cgh.2017.06.037","volume":"16","author":"P Singh","year":"2018","unstructured":"Singh P, Arora A, Strand TA, et al. Global prevalence of celiac disease: systematic review and meta-analysis. Clin Gastroenterol Hepatol. 2018;16:823\u2013836.","journal-title":"Clin Gastroenterol Hepatol."},{"key":"6352_CR2","doi-asserted-by":"crossref","first-page":"S57","DOI":"10.1053\/j.gastro.2005.02.014","volume":"128","author":"C Dub\u00e9","year":"2005","unstructured":"Dub\u00e9 C, Rostom A, Sy R, et al. The prevalence of celiac disease in average-risk and at-risk Western European populations: a systematic review. Gastroenterology. 2005;128:S57\u2013S67.","journal-title":"Gastroenterology"},{"key":"6352_CR3","doi-asserted-by":"crossref","first-page":"530","DOI":"10.3109\/07853890.2010.514285","volume":"42","author":"C Catassi","year":"2010","unstructured":"Catassi C, Kryszak D, Bhatti B, et al. Natural history of celiac disease autoimmunity in a USA cohort followed since 1974. Ann Med. 2010;42:530\u2013538.","journal-title":"Ann Med."},{"key":"6352_CR4","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1053\/j.gastro.2009.03.059","volume":"137","author":"A Rubio-Tapia","year":"2009","unstructured":"Rubio-Tapia A, Kyle RA, Kaplan EL, et al. Increased prevalence and mortality in undiagnosed celiac disease. Gastroenterology. 2009;137:88\u201393.","journal-title":"Gastroenterology"},{"key":"6352_CR5","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/ajg.2015.8","volume":"110","author":"RS Choung","year":"2015","unstructured":"Choung RS, Ditah IC, Nadeau AM, et al. Trends and racial\/ethnic disparities in gluten-sensitive problems in the United States: findings from the National Health and Nutrition Examination Surveys from 1988 to 2012. Am J Gastroenterol. 2015;110:455\u2013461.","journal-title":"Am J Gastroenterol."},{"key":"6352_CR6","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1136\/bmj.318.7177.164","volume":"318","author":"H Hin","year":"1999","unstructured":"Hin H, Bird G, Fisher P, Mahy N, Jewell D. Coeliac disease in primary care: case finding study. Br Med J. 1999;318:164\u2013167.","journal-title":"Br Med J."},{"key":"6352_CR7","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1097\/00042737-200304000-00012","volume":"15","author":"DS Sanders","year":"2003","unstructured":"Sanders DS, Patel D, Stephenson TJ, et al. A primary care cross-sectional study of undiagnosed adult coeliac disease. Eur J Gastroenterol Hepatol. 2003;15:407\u2013413.","journal-title":"Eur J Gastroenterol Hepatol."},{"key":"6352_CR8","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.cgh.2006.10.020","volume":"5","author":"J West","year":"2007","unstructured":"West J, Logan RFA, Hill PG, Khaw K-T. The iceberg of celiac disease: what is below the waterline? Clin Gastroenterol Hepatol. 2007;5:59\u201362.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"6352_CR9","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1053\/j.gastro.2016.11.043","volume":"152","author":"RS Choung","year":"2017","unstructured":"Choung RS, Larson SA, Khaleghi S, et al. Prevalence and morbidity of undiagnosed celiac disease from a community-based study. Gastroenterology. 2017;152:830\u2013839.","journal-title":"Gastroenterology"},{"key":"6352_CR10","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1111\/apt.14625","volume":"47","author":"IA Hujoel","year":"2018","unstructured":"Hujoel IA, Van Dyke CT, Brantner T, et al. Natural history and clinical detection of undiagnosed coeliac disease in a North American community. Aliment Pharmacol Ther. 2018;47:1358\u20131366. https:\/\/doi.org\/10.1111\/apt.14625.","journal-title":"Aliment Pharmacol Ther"},{"key":"6352_CR11","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1471-230X-7-8","volume":"7","author":"M Silano","year":"2007","unstructured":"Silano M, Volta U, Mecchia A, et al. Delayed diagnosis of coeliac disease increases cancer risk. BMC Gastroenterol. 2007;7:8.","journal-title":"BMC Gastroenterol"},{"key":"6352_CR12","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1111\/j.1572-0241.2007.01173.x","volume":"102","author":"C Catassi","year":"2007","unstructured":"Catassi C, Kryszak D, Louis-Jacques O, et al. Detection of celiac disease in primary care: a multicenter case-finding study in North America. Am J Gastroenterol. 2007;102:1454\u20131460.","journal-title":"Am J Gastroenterol."},{"key":"6352_CR13","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/MPG.0000000000002497","volume":"70","author":"S Husby","year":"2020","unstructured":"Husby S, Koletzko S, Korponay-Szab\u00f3 I, et al. Hepatology and nutrition guidelines for diagnosing coeliac disease 2020. J Pediatr Gastroenterol Nutr. 2020;70:141\u2013156.","journal-title":"J Pediatr Gastroenterol Nutr."},{"key":"6352_CR14","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/ajg.2013.79","volume":"108","author":"A Rubio-Tapia","year":"2013","unstructured":"Rubio-Tapia A, Hill ID, Kelly CP, Calderwood AH, Murray JA. ACG clinical guidelines: diagnosis and management of celiac disease. Am J Gastroenterol. 2013;108:656\u2013676.","journal-title":"Am J Gastroenterol."},{"key":"6352_CR15","doi-asserted-by":"crossref","unstructured":"Herman C. Virtual mentor clinical pearl what makes a screening exam \u201cgood\u201d? Ethics J Am Med Assoc. 2006. 8. www.virtualmentor.org","DOI":"10.1001\/virtualmentor.2006.8.1.cprl1-0601"},{"key":"6352_CR16","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/j.1572-0241.2001.03462.x","volume":"96","author":"PHR Green","year":"2001","unstructured":"Green PHR, Stavropoulos SN, Panagi SG, et al. Characteristics of adult celiac disease in the USA: results of a national survey. Am J Gastroenterol. 2001;96:126\u2013131.","journal-title":"Am J Gastroenterol."},{"key":"6352_CR17","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1023\/A:1021956200382","volume":"48","author":"W Lo","year":"2003","unstructured":"Lo W, Sano K, Lebwohl B, Diamond B, Green PHR. Changing presentation of adult celiac disease. Dig Dis Sci. 2003;48:395\u2013398.","journal-title":"Dig Dis Sci."},{"key":"6352_CR18","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1001\/jama.2017.4413","volume":"317","author":"K Bibbins-Domingo","year":"2017","unstructured":"Bibbins-Domingo K, Grossman DC, Curry SJ, et al. Screening for celiac disease: US preventive services task force recommendation statement. JAMA J Am Med Assoc. 2017;317:1252\u20131257.","journal-title":"JAMA J Am Med Assoc"},{"key":"6352_CR19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00005176-200501000-00001","volume":"40","author":"ID Hill","year":"2005","unstructured":"Hill ID, Dirks MH, Liptak GS, et al. Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr. 2005;40:1\u201319.","journal-title":"J Pediatr Gastroenterol Nutr."},{"key":"6352_CR20","unstructured":"Coeliac disease: recognition, assessment and management NICE guideline. 2015. www.nice.org.uk\/guidance\/ng20"},{"key":"6352_CR21","doi-asserted-by":"crossref","unstructured":"Tovoli F, Negrini G, Sansone V, Faggiano C, Catenaro T, Bolondi L, et al. Celiac disease diagnosed through screening programs in at-risk adults is not associated with worse adherence to the gluten-free diet and might protect from osteopenia\/osteoporosis. 2018. www.mdpi.com\/journal\/nutrients.","DOI":"10.3390\/nu10121940"},{"issue":"4","key":"6352_CR22","volume":"22","author":"B Lebwohl","year":"2012","unstructured":"Lebwohl B, Rubio-Tapia A, Guandalini S, Newland C, Assiri A. Diagnosis of celiac disease. Gastrointest Endosc Clin N Am. 2012;22(4):661.","journal-title":"Gastrointest Endosc Clin N Am."},{"key":"6352_CR23","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1053\/j.gastro.2005.02.028","volume":"128","author":"A Rostom","year":"2005","unstructured":"Rostom A, Dub\u00e9 C, Cranney A, et al. The diagnostic accuracy of serologic tests for celiac disease: a systematic review. Gastroenterology. 2005;128:S38\u2013S46.","journal-title":"Gastroenterology"},{"key":"6352_CR24","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/nm0797-797","volume":"3","author":"W Dieterich","year":"1997","unstructured":"Dieterich W, Ehnis T, Bauer M, et al. Identification of tissue transglutaminase as the autoantigen of celiac disease. Nat Med. 1997;3:797\u2013801.","journal-title":"Nat Med."},{"key":"6352_CR25","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/S0022-3476(99)70410-5","volume":"134","author":"R Troncone","year":"1999","unstructured":"Troncone R, Maurano F, Rossi M, et al. IgA antibodies to tissue transglutaminase: an effective diagnostic test for celiac disease. J Pediatr. 1999;134:166\u2013171.","journal-title":"J Pediatr."},{"key":"6352_CR26","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/S0016-5085(98)70007-1","volume":"115","author":"W Dieterich","year":"1998","unstructured":"Dieterich W, Laag E, Schopper H, et al. Autoantibodies to tissue transglutaminase as predictors of celiac disease. Gastroenterology. 1998;115:1317\u20131321.","journal-title":"Gastroenterology"},{"key":"6352_CR27","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1111\/j.1398-9995.1994.tb00124.x","volume":"49","author":"E Grodzinsky","year":"1994","unstructured":"Grodzinsky E, Hed J, Skogh T. IgA antiendomysium antibodies have a high positive predictive value for celiac disease in asymptomatic patients. Allergy. 1994;49:593\u2013597.","journal-title":"Allergy"},{"key":"6352_CR28","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1258\/000456307780117993","volume":"44","author":"AHA Latiff","year":"2007","unstructured":"Latiff AHA, Kerr MA. The clinical significance of immunoglobulin A deficiency. Ann Clin Biochem. 2007;44:131\u2013139.","journal-title":"Ann Clin Biochem."},{"key":"6352_CR29","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1373\/clinchem.2008.103606","volume":"54","author":"KE McGowan","year":"2008","unstructured":"McGowan KE, Lyon ME, Butzner JD. Celiac disease and IgA deficiency: complications of serological testing approaches encountered in the clinic. Clin Chem. 2008;54:1203\u20131209.","journal-title":"Clin Chem."},{"key":"6352_CR30","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.dld.2004.06.017","volume":"36","author":"A Lenhardt","year":"2004","unstructured":"Lenhardt A, Plebani A, Marchetti F, et al. Role of human-tissue transglutaminase IgG and anti-gliadin IgG antibodies in the diagnosis of coeliac disease in patients with selective immunoglobulin A deficiency. Dig Liver Dis. 2004;36:730\u2013734.","journal-title":"Dig Liver Dis."},{"key":"6352_CR31","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1373\/clinchem.2009.128132","volume":"56","author":"D Villalta","year":"2010","unstructured":"Villalta D, Tonutti E, Prause C, et al. IgG antibodies against deamidated gliadin peptides for diagnosis of celiac disease in patients with IgA deficiency. Clin Chem. 2010;56:464\u2013468.","journal-title":"Clin Chem."},{"key":"6352_CR32","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1136\/gutjnl-2012-302196","volume":"62","author":"D Leffler","year":"2013","unstructured":"Leffler D, Schuppan D, Pallav K, et al. Kinetics of the histological, serological and symptomatic responses to gluten challenge in adults with coeliac disease. Gut. 2013;62:996\u20131004.","journal-title":"Gut"},{"key":"6352_CR33","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.14309\/ajg.0000000000000310","volume":"114","author":"NK Brown","year":"2019","unstructured":"Brown NK, Guandalini S, Semrad C, Kupfer SS. A clinician\u2019s guide to celiac disease HLA genetics. Am J Gastroenterol. 2019;114:1587\u20131592.","journal-title":"Am J Gastroenterol."},{"key":"6352_CR34","first-page":"5409653","volume":"2016","author":"LM Almeida","year":"2016","unstructured":"Almeida LM, Gandolfi L, Pratesi R, et al. Presence of DQ2.2 associated with DQ2.5 increases the risk for celiac disease. Autoimmune Dis. 2016;2016:5409653.","journal-title":"Autoimmune Dis."},{"key":"6352_CR35","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1001\/archinte.163.3.286","volume":"163","author":"A Fasano","year":"2003","unstructured":"Fasano A, Berti I, Gerarduzzi T, et al. Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: a large multicenter study. Arch Intern Med. 2003;163:286\u2013292.","journal-title":"Arch Intern Med."},{"key":"6352_CR36","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.cgh.2008.04.008","volume":"6","author":"A Rubio-Tapia","year":"2008","unstructured":"Rubio-Tapia A, Van Dyke CT, Lahr BD, et al. Predictors of family risk for celiac disease: a population-based study. Clin Gastroenterol Hepatol. 2008;6:983\u2013987.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"6352_CR37","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.1016\/j.mayocp.2019.03.027","volume":"94","author":"SS Nellikkal","year":"2019","unstructured":"Nellikkal SS, Hafed Y, Larson JJ, Murray JA, Absah I. High prevalence of celiac disease among screened first-degree relatives. Mayo Clin Proc. 2019;94:1807\u20131813. https:\/\/doi.org\/10.1016\/j.mayocp.2019.03.027.","journal-title":"Mayo Clin Proc."},{"key":"6352_CR38","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.cgh.2015.01.026","volume":"13","author":"L Emilsson","year":"2015","unstructured":"Emilsson L, Wijmenga C, Murray JA, Ludvigsson JF. Autoimmune disease in first-degree relatives and spouses of individuals with celiac disease. Clin Gastroenterol Hepatol. 2015;13(1271\u20131277):e2.","journal-title":"Clin Gastroenterol Hepatol."},{"key":"6352_CR39","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1007\/s00431-018-3199-6","volume":"177","author":"MMS Wessels","year":"2018","unstructured":"Wessels MMS, de Rooij N, Roovers L, Verhage J, de Vries W, Mearin ML. Towards an individual screening strategy for first-degree relatives of celiac patients. Eur J Pediatr. 2018;177:1585\u20131592.","journal-title":"Eur J Pediatr."},{"key":"6352_CR40","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.ecl.2010.05.011","volume":"39","author":"DM Maahs","year":"2010","unstructured":"Maahs DM, West NA, Lawrence JM, Mayer-Davis EJ, Davis B. Chapter 1: epidemiology of type 1 diabetes. Endocrinol Metab Clin. 2010;39:481\u2013497.","journal-title":"Endocrinol Metab Clin"},{"key":"6352_CR41","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1186\/s12876-016-0488-2","volume":"16","author":"A Kyl\u00f6k\u00e4s","year":"2016","unstructured":"Kyl\u00f6k\u00e4s A, Kaukinen K, Huhtala H, Collin P, M\u00e4ki M, Kurppa K. Type 1 and type 2 diabetes in celiac disease: prevalence and effect on clinical and histological presentation. BMC Gastroenterol. 2016;16:76. https:\/\/doi.org\/10.1186\/s12876-016-0488-2.","journal-title":"BMC Gastroenterol."},{"key":"6352_CR42","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.2337\/dc16-2508","volume":"40","author":"ME Craig","year":"2017","unstructured":"Craig ME, Prinz N, Boyle CT, et al. Prevalence of celiac disease in 52,721 youth with type 1 diabetes: international comparison across three continents. Diabetes Care. 2017;40:1034\u20131040.","journal-title":"Diabetes Care"},{"key":"6352_CR43","doi-asserted-by":"crossref","first-page":"240","DOI":"10.3109\/08916934.2016.1164144","volume":"49","author":"D Smigoc Schweiger","year":"2016","unstructured":"Smigoc Schweiger D, Mendez A, Kunilo Jamnik S, et al. High-risk genotypes HLA-DR3-DQ2\/DR3-DQ2 and DR3-DQ2\/DR4-DQ8 in co-occurrence of type 1 diabetes and celiac disease. Autoimmunity. 2016;49:240\u2013247.","journal-title":"Autoimmunity"},{"key":"6352_CR44","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1111\/j.1399-5448.2008.00367.x","volume":"9","author":"K Larsson","year":"2008","unstructured":"Larsson K, Carlsson A, Cederwall E, et al. Annual screening detects celiac disease in children with type 1 diabetes. Pediatr Diabetes. 2008;9:354\u2013359. https:\/\/doi.org\/10.1111\/j.1399-5448.2008.00367.x.","journal-title":"Pediatr Diabetes"},{"key":"6352_CR45","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0168-8227(98)00012-6","volume":"40","author":"H Lunt","year":"1998","unstructured":"Lunt H, Florkowski CM, Cundy T, et al. A population-based study of bone mineral density in women with longstanding Type 1 (insulin dependent) diabetes. Diabetes Res Clin Pract. 1998;40:31\u201338.","journal-title":"Diabetes Res Clin Pract"},{"issue":"4","key":"6352_CR46","doi-asserted-by":"crossref","first-page":"785","DOI":"10.2337\/diacare.24.4.785","volume":"24","author":"A Neu","year":"2001","unstructured":"Neu A, Ehehalt S, Willasch A, Kehrer M, Hub R, Ranke MB. Rising incidence of type 1 diabetes in Germany: 12-year trend analysis in children 0\u201314 years of age. Diabetes Care. 2001;24(4):785\u2013786.","journal-title":"Diabetes Care"},{"key":"6352_CR47","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1007\/s10620-007-9988-9","volume":"53","author":"DR Diniz-Santos","year":"2008","unstructured":"Diniz-Santos DR, Brand\u00e3o F, Adan L, Moreira A, Vicente EJ, Silva LR. Bone mineralization in young patients with type 1 diabetes mellitus and screening-identified evidence of celiac disease. Dig Dis Sci. 2008;53:1240\u20131245.","journal-title":"Dig Dis Sci."},{"key":"6352_CR48","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.2337\/dc11-0149","volume":"34","author":"JS Leeds","year":"2011","unstructured":"Leeds JS, Hopper AD, Hadjivassiliou M, Tesfaye S, Sanders DS. High prevalence of microvascular complications in adults with type 1 diabetes and newly diagnosed celiac disease. Diabetes Care. 2011;34:2158\u20132163.","journal-title":"Diabetes Care"},{"key":"6352_CR49","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1097\/MPG.0000000000000789","volume":"61","author":"A Tsouka","year":"2015","unstructured":"Tsouka A, Mahmud FH, Marcon MA. Celiac disease alone and associated with type 1 diabetes mellitus. J Pediatr Gastroenterol Nutr. 2015;61:297\u2013302.","journal-title":"J Pediatr Gastroenterol Nutr."},{"key":"6352_CR50","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-2883","author":"A Pham-Short","year":"2015","unstructured":"Pham-Short A, Gcdem H-I, Donaghue KC, et al. Screening for celiac disease in type 1 diabetes: a systematic review. Rev Artic Pediatr. 2015;. https:\/\/doi.org\/10.1542\/peds.2014-2883.","journal-title":"Rev Artic Pediatr."},{"key":"6352_CR51","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1001\/jamapediatrics.2016.0486","volume":"170","author":"P Hanley","year":"2016","unstructured":"Hanley P, Lord K, Bauer AJ. Thyroid disorders in children and adolescents: a review. JAMA Pediatr. 2016;170:1008\u20131019.","journal-title":"JAMA Pediatr."},{"key":"6352_CR52","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/j.autrev.2018.05.013","volume":"17","author":"GJ Kahaly","year":"2018","unstructured":"Kahaly GJ, Frommer L, Schuppan D. Celiac disease and endocrine autoimmunity\u2014the genetic link. Autoimmun Rev. 2018;17:1169\u20131175.","journal-title":"Autoimmun Rev."},{"key":"6352_CR53","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1111\/j.1572-0241.2001.03617.x","volume":"96","author":"C Sategna-Guidetti","year":"2001","unstructured":"Sategna-Guidetti C, Volta U, Ciacci C, et al. Prevalence of thyroid disorders in untreated adult celiac disease patients and effect of gluten withdrawal: an Italian multicenter study. Am J Gastroenterol. 2001;96:751\u2013757. https:\/\/doi.org\/10.1111\/j.1572-0241.2001.03617.x.","journal-title":"Am J Gastroenterol."},{"key":"6352_CR54","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1007\/BF03343864","volume":"24","author":"GF Meloni","year":"2001","unstructured":"Meloni GF, Tomasi PA, Bertoncelli A, Fanciulli G, Delitala G, Meloni T. Prevalence of silent celiac disease in patients with autoimmune thyroiditis from Northern Sardinia. J Endocrinol Invest. 2001;24:298\u2013302.","journal-title":"J Endocrinol Invest."},{"key":"6352_CR55","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1067\/mpd.2001.118189","volume":"139","author":"D Larizza","year":"2001","unstructured":"Larizza D, Calcaterra V, De Giacomo C, et al. Celiac disease in children with autoimmune thyroid disease. J Pediatr. 2001;139:738\u2013740.","journal-title":"J Pediatr."},{"key":"6352_CR56","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jpeds.2016.02.058","volume":"174","author":"C Canova","year":"2016","unstructured":"Canova C, Pitter G, Ludvigsson JF, et al. Celiac disease and risk of autoimmune disorders: a population-based matched birth cohort study. J Pediatr. 2016;174:146\u2013152.","journal-title":"J Pediatr."},{"key":"6352_CR57","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jpeds.2016.04.019","volume":"174","author":"NR Reilly","year":"2016","unstructured":"Reilly NR, Verma R. Time to screen children with celiac disease for thyroid disease? J Pediatr. 2016;174:7\u20139.","journal-title":"J Pediatr."},{"key":"6352_CR58","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1111\/j.1365-2265.2005.02214.x","volume":"62","author":"CL Ch\u2019ng","year":"2005","unstructured":"Ch\u2019ng CL, Biswas M, Benton A, Jones MK, Kingham JGC. Prospective screening for coeliac disease in patients with Graves\u2019 hyperthyroidism using anti-gliadin and tissue transglutaminase antibodies. Clin Endocrinol (Oxf). 2005;62:303\u2013306. https:\/\/doi.org\/10.1111\/j.1365-2265.2005.02214.x.","journal-title":"Clin Endocrinol (Oxf)."},{"key":"6352_CR59","doi-asserted-by":"crossref","first-page":"E419","DOI":"10.1210\/jc.2011-1851","volume":"97","author":"C Virili","year":"2012","unstructured":"Virili C, Bassotti G, Santaguida MG, et al. Atypical celiac disease as cause of increased need for thyroxine: a systematic study. J Clin Endocrinol Metab. 2012;97:E419\u2013E422.","journal-title":"J Clin Endocrinol Metab."},{"key":"6352_CR60","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1182\/blood-2013-06-508325","volume":"123","author":"NJ Kassebaum","year":"2014","unstructured":"Kassebaum NJ, Jasrasaria R, Naghavi M, et al. A systematic analysis of global anemia burden from 1990 to 2010. Blood. 2014;123:615\u2013624.","journal-title":"Blood."},{"key":"6352_CR61","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1056\/NEJMra1401038","volume":"372","author":"C Camaschella","year":"2015","unstructured":"Camaschella C. Iron-deficiency anemia. N Engl J Med. 2015;372:1832\u20131843.","journal-title":"N Engl J Med."},{"key":"6352_CR62","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.freeradbiomed.2018.07.020","volume":"133","author":"I Yanatori","year":"2019","unstructured":"Yanatori I, Kishi F. DMT1 and iron transport. Free Radic Biol Med. 2019;133:55\u201363.","journal-title":"Free Radic Biol Med."},{"key":"6352_CR63","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1182\/blood-2013-10-512624","volume":"123","author":"C Hershko","year":"2014","unstructured":"Hershko C, Camaschella C. How I treat unexplained refractory iron deficiency anemia. Blood. 2014;123:326\u2013333.","journal-title":"Blood."},{"key":"6352_CR64","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1053\/j.gastro.2018.04.016","volume":"155","author":"S Mahadev","year":"2018","unstructured":"Mahadev S, Laszkowska M, Sundstr\u00f6m J, et al. Prevalence of celiac disease in patients with iron deficiency anemia\u2014a systematic review with meta-analysis. Gastroenterology. 2018;155:374\u2013382.","journal-title":"Gastroenterology"},{"key":"6352_CR65","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1002\/ajh.20996","volume":"82","author":"JW Harper","year":"2007","unstructured":"Harper JW, Holleran SF, Ramakrishnan R, Bhagat G, Green PHR. Anemia in celiac disease is multifactorial in etiology. Am J Hematol. 2007;82:996\u20131000. https:\/\/doi.org\/10.1002\/ajh.20996.","journal-title":"Am J Hematol."},{"key":"6352_CR66","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1097\/MPG.0000000000001234","volume":"64","author":"M Repo","year":"2017","unstructured":"Repo M, Lindfors K, M\u00e4ki M, et al. Anemia and iron deficiency in children with potential celiac disease. J Pediatr Gastroenterol Nutr. 2017;64:56\u201362.","journal-title":"J Pediatr Gastroenterol Nutr."},{"key":"6352_CR67","first-page":"585","volume":"90","author":"C Hershko","year":"2005","unstructured":"Hershko C, Hoffbrand AV, Keret D, et al. Role of autoimmune gastritis, Helicobacter pylori and celiac disease in refractory or unexplained iron deficiency anemia. Haematologica. 2005;90:585\u2013595.","journal-title":"Haematologica"},{"key":"6352_CR68","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1097\/00004836-200209000-00006","volume":"35","author":"RAJ Ransford","year":"2002","unstructured":"Ransford RAJ, Hayes M, Palmer M, Hall MJ. A controlled, prospective screening study of celiac disease presenting as iron deficiency anemia. J Clin Gastroenterol. 2002;35:228\u2013233.","journal-title":"J Clin Gastroenterol."},{"key":"6352_CR69","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1053\/j.gastro.2016.02.031","volume":"150","author":"BE Lacy","year":"2016","unstructured":"Lacy BE, Mearin F, Chang L, et al. Bowel disorders. Gastroenterology. 2016;150:1393\u20131407.","journal-title":"Gastroenterology"},{"key":"6352_CR70","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.cgh.2012.02.029","volume":"10","author":"RM Lovell","year":"2012","unstructured":"Lovell RM, Ford AC. Global prevalence of and risk factors for irritable Bowel syndrome: a meta-analysis. Clin Gastroenterol Hepatol. 2012;10:712\u2013721.","journal-title":"Clin Gastroenterol Hepatol."},{"key":"6352_CR71","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1053\/j.gastro.2013.09.046","volume":"146","author":"EP Halmos","year":"2014","unstructured":"Halmos EP, Power VA, Shepherd SJ, Gibson PR, Muir JG. A diet low in FODMAPs reduces symptoms of irritable Bowel syndrome. Gastroenterology. 2014;146:67\u201375.","journal-title":"Gastroenterology"},{"key":"6352_CR72","doi-asserted-by":"crossref","first-page":"4542","DOI":"10.3390\/nu7064542","volume":"7","author":"B Shahbazkhani","year":"2015","unstructured":"Shahbazkhani B, Sadeghi A, Malekzadeh R, et al. Non-celiac gluten sensitivity has narrowed the spectrum of irritable Bowel syndrome: a double-blind randomized placebo-controlled trial. Nutrients. 2015;7:4542\u20134554.","journal-title":"Nutrients."},{"key":"6352_CR73","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1053\/j.gastro.2017.10.040","volume":"154","author":"GI Skodje","year":"2018","unstructured":"Skodje GI, Sarna VK, Minelle IH, et al. Fructan, rather than gluten, induces symptoms in patients with self-reported non-celiac gluten sensitivity. Gastroenterology. 2018;154:529\u2013539.","journal-title":"Gastroenterology"},{"key":"6352_CR74","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1001\/archinternmed.2009.22","volume":"169","author":"AC Ford","year":"2009","unstructured":"Ford AC, Chey WD, Talley NJ, Malhotra A, Spiegel BMR, Moayyedi P. Yield of diagnostic tests for celiac disease in individuals with symptoms suggestive of irritable bowel syndrome systematic review and meta-analysis. Arch Intern Med. 2009;169:651\u2013658.","journal-title":"Arch Intern Med."},{"key":"6352_CR75","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/ajg.2016.466","volume":"112","author":"AJ Irvine","year":"2017","unstructured":"Irvine AJ, Chey WD, Ford AC. Screening for celiac disease in irritable Bowel syndrome: an updated systematic review and meta-analysis. Am J Gastroenterol. 2017;112:65\u201376.","journal-title":"Am J Gastroenterol"},{"key":"6352_CR76","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.07.004","author":"W Smalley","year":"2019","unstructured":"Smalley W, Falck-Ytter C, Carrasco-Labra A, Wani S, Lytvyn L, Falck-Ytter Y. AGA clinical practice guidelines on the laboratory evaluation of functional diarrhea and diarrhea-predominant irritable bowel syndrome in adults (IBS-D). Gastroenterology. 2019;. https:\/\/doi.org\/10.1053\/j.gastro.2019.07.004.","journal-title":"Gastroenterology"},{"key":"6352_CR77","doi-asserted-by":"crossref","unstructured":"Spiegel BMR, Derosa VP, Gralnek IM, Wang V, Dulai GS. Testing for Celiac Sprue in Irritable Bowel Syndrome With Predominant Diarrhea: A Cost-Effectiveness Analysis. 2004;","DOI":"10.1053\/j.gastro.2004.03.012"},{"key":"6352_CR78","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1111\/j.1365-2036.2004.01958.x","volume":"19","author":"SM Mein","year":"2004","unstructured":"Mein SM, Ladabaum U. Serological testing for coeliac disease in patients with symptoms of irritable bowel syndrome: a cost-effectiveness analysis. Aliment Pharmacol Ther. 2004;19:1199\u20131210. https:\/\/doi.org\/10.1111\/j.1365-2036.2004.01958.x.","journal-title":"Aliment Pharmacol Ther."},{"key":"6352_CR79","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1007\/s10198-012-0441-4","volume":"14","author":"L Mohseninejad","year":"2013","unstructured":"Mohseninejad L, Feenstra T, Van Der Horst HE, Woutersen-Koch L, et al. Targeted screening for coeliac disease among irritable bowel syndrome patients: analysis of cost-effectiveness and value of information. Eur J Health Econ. 2013;14:947\u2013957.","journal-title":"Eur J Health Econ"},{"key":"6352_CR80","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.10.029","author":"A Bharucha","year":"2013","unstructured":"Bharucha A, Dorn S, Lembo A, Pressman A. AGA American Gastroenterological Association Medical Position Statement on Constipation. Gastroenterological Association A. Gastroenterology. 2013;. https:\/\/doi.org\/10.1053\/j.gastro.2012.10.029.","journal-title":"Gastroenterology"},{"key":"6352_CR81","doi-asserted-by":"crossref","first-page":"S87","DOI":"10.1053\/j.gastro.2005.02.026","volume":"128","author":"JJ Zone","year":"2005","unstructured":"Zone JJ. Skin manifestations of celiac disease. Gastroenterology. 2005;128:S87\u2013S91.","journal-title":"Gastroenterology"},{"key":"6352_CR82","doi-asserted-by":"crossref","unstructured":"Kelly CP. Celiac Disease and Refractory Celiac Disease. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran\u2019s Gastrointestinal and Liver Disease. United Kingdom: Elsevier Health Science; 2010. p. 1797\u20131820.","DOI":"10.1016\/B978-1-4160-6189-2.00104-9"},{"key":"6352_CR83","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.jaad.2010.09.777","volume":"64","author":"D Bolotin","year":"2011","unstructured":"Bolotin D, Petronic-Rosic V. Dermatitis herpetiformis: part I. Epidemiology, pathogenesis, and clinical presentation. J Am Acad Dermatol. 2011;64:1017\u20131024.","journal-title":"J Am Acad Dermatol"},{"key":"6352_CR84","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1111\/j.1399-0039.1997.tb02706.x","volume":"49","author":"A Spurkland","year":"1997","unstructured":"Spurkland A, Ingvarsson G, Falk ES, Knutsen I, Sollid LM, Thorsby E. Dermatitis herpetiformis and celiac disease are both primarily associated with the HLA-DQ (\u03b11*0501, (\u03b21*02) or the HLA-DQ (\u03b11*03, (\u03b21*0302) heterodimers. Tissue Antigens. 1997;49:29\u201334. https:\/\/doi.org\/10.1111\/j.1399-0039.1997.tb02706.x.","journal-title":"Tissue Antigens"},{"key":"6352_CR85","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1001\/archderm.1996.03890320060010","volume":"132","author":"JJ Zone","year":"1996","unstructured":"Zone JJ, Meyer LJ, Petersen MJ. Deposition of granular IgA relative to clinical lesions in dermatitis herpetiformis. Arch Dermatol. 1996;132:912\u2013918.","journal-title":"Arch Dermatol."},{"key":"6352_CR86","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1016\/S0140-6736(66)91692-8","volume":"288","author":"J Marks","year":"1966","unstructured":"Marks J. Small-bowel changes in dermatitis herpetiformis. Lancet. 1966;288:1280\u20131282.","journal-title":"Lancet."},{"key":"6352_CR87","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1067\/mjd.2001.114733","volume":"45","author":"YI Zhu","year":"2001","unstructured":"Zhu YI, Stiller MJ. Dapsone and sulfones in dermatology: overview and update. J Am Acad Dermatol. 2001;45:420\u2013434.","journal-title":"J Am Acad Dermatol."},{"key":"6352_CR88","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/j.1365-2133.1994.tb08557.x","volume":"131","author":"JJ Garioch","year":"1994","unstructured":"Garioch JJ, Lewis HM, Sargent SA, Leonard JN, Fry L. 25 years\u2019 experience of a gluten-free diet in the treatment of dermatitis herpetiformis. Br J Dermatol. 1994;131:541\u2013545.","journal-title":"Br J Dermatol."},{"key":"6352_CR89","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/S0140-6736(18)31503-4","volume":"392","author":"F Rodrigues","year":"2018","unstructured":"Rodrigues F, Bachmeyer C. Coeliac disease and dermatitis herpetiformis. The Lancet. 2018;392:916.","journal-title":"The Lancet"},{"key":"6352_CR90","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1111\/j.1468-3083.2009.03188.x","volume":"23","author":"M Caproni","year":"2009","unstructured":"Caproni M, Antiga E, Melani L, Fabbri P. Guidelines for the diagnosis and treatment of dermatitis herpetiformis. J Eur Acad Dermatol Venereol. 2009;23:633\u2013638. https:\/\/doi.org\/10.1111\/j.1468-3083.2009.03188.x.","journal-title":"J Eur Acad Dermatol Venereol."},{"issue":"9365","key":"6352_CR91","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/S0140-6736(03)12987-X","volume":"361","author":"NJ Roizen","year":"2003","unstructured":"Roizen NJ, Patterson D. Down\u2019s syndrome. Lancet. 2003;361(9365):1281\u20131289.","journal-title":"Lancet."},{"key":"6352_CR92","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jpeds.2012.12.087","volume":"163","author":"K M\u00e5rild","year":"2013","unstructured":"M\u00e5rild K, Stephansson O, Grahnquist L, Cnattingius S, S\u00f6derman G, Ludvigsson JF. Down syndrome is associated with elevated risk of celiac disease: a nationwide case\u2013control study. J Pediatr. 2013;163:237\u2013242.","journal-title":"J Pediatr."},{"key":"6352_CR93","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-2123","author":"NL Swigonski","year":"2006","unstructured":"Swigonski NL, Kuhlenschmidt HL, Bull MJ, Corkins MR, Downs SM. Screening for celiac disease in asymptomatic children with down syndrome: cost-effectiveness of preventing lymphoma. Pediatrics. 2006;. https:\/\/doi.org\/10.1542\/peds.2005-2123.","journal-title":"Pediatrics"},{"key":"6352_CR94","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1542\/peds.2011-1605","volume":"128","author":"MJ Bull","year":"2011","unstructured":"Bull MJ, Saal HM, Braddock SR, et al. Clinical report\u2014health supervision for children with Down syndrome. Pediatrics. 2011;128:393\u2013406.","journal-title":"Pediatrics"},{"key":"6352_CR95","doi-asserted-by":"publisher","first-page":"3098","DOI":"10.1002\/ajmg.a.37879","volume":"170","author":"C Sharr","year":"2016","unstructured":"Sharr C, Lavigne J, Elsharkawi IMA, et al. Detecting celiac disease in patients with Down syndrome. Am J Med Genet A. 2016;170:3098\u20133105. https:\/\/doi.org\/10.1002\/ajmg.a.37879.","journal-title":"Am J Med Genet A"},{"key":"6352_CR96","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1210\/jc.2006-1374","volume":"92","author":"CA Bondy","year":"2007","unstructured":"Bondy CA. Clinical practice guideline: care of girls and women with Turner syndrome: a guideline of the Turner Syndrome Study Group. J Clin Endocrinol Metab. 2007;92:10\u201325.","journal-title":"J Clin Endocrinol Metab."},{"key":"6352_CR97","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1136\/archdischild-2013-304617","volume":"99","author":"MJ Goldacre","year":"2014","unstructured":"Goldacre MJ, Seminog OO. Turner syndrome and autoimmune diseases: record-linkage study. Arch Dis Child. 2014;99:71\u201373.","journal-title":"Arch Dis Child."},{"key":"6352_CR98","doi-asserted-by":"crossref","first-page":"20152232","DOI":"10.1542\/peds.2015-2232","volume":"137","author":"K M\u00e5rild","year":"2016","unstructured":"M\u00e5rild K, St\u00f8rdal K, Hagman A, Ludvigsson JF. Turner syndrome and celiac disease: a case\u2013control study. Pediatrics. 2016;137:20152232.","journal-title":"Pediatrics"},{"key":"6352_CR99","doi-asserted-by":"crossref","unstructured":"Rajani S, Huynh HQ, Turner J. The changing frequency of celiac disease diagnosed at the Stollery Children\u2019s Hospital. Can J Gastroenterol. 2010;24. www.cdc.gov\/epi.","DOI":"10.1155\/2010\/968062"},{"key":"6352_CR100","doi-asserted-by":"publisher","DOI":"10.2147\/JMDH.S95323","author":"D Migliarese Isaac","year":"2016","unstructured":"Migliarese Isaac D, Wu J, Mager DR, Turner JM. Managing the pediatric patient with celiac disease: a multidisciplinary approach. J Multidiscipl Healthc. 2016;. https:\/\/doi.org\/10.2147\/JMDH.S95323.","journal-title":"J Multidiscipl Healthc"}],"updated-by":[{"DOI":"10.1007\/s10620-020-06453-6","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2020,7,4]],"date-time":"2020-07-04T00:00:00Z","timestamp":1593820800000}}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-020-06352-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10620-020-06352-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-020-06352-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T20:19:48Z","timestamp":1622837988000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10620-020-06352-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,5]]},"references-count":100,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["6352"],"URL":"https:\/\/doi.org\/10.1007\/s10620-020-06352-w","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,5]]},"assertion":[{"value":"5 June 2020","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2020","order":2,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":3,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The original version of the article is unfortunately missing the funding information. Funding note is given below.","order":4,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"No authors have any conflicts of interest to report.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}