{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T03:06:19Z","timestamp":1792551979371,"version":"4.5.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T00:00:00Z","timestamp":1594771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T00:00:00Z","timestamp":1594771200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R01 AA24726"],"award-info":[{"award-number":["R01 AA24726"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R01 AA020703"],"award-info":[{"award-number":["R01 AA020703"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["U01 AA026939"],"award-info":[{"award-number":["U01 AA026939"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["P50 AA011999"],"award-info":[{"award-number":["P50 AA011999"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007496","name":"Biomedical Laboratory Research and Development, VA Office of Research and Development","doi-asserted-by":"publisher","award":["BX004594"],"award-info":[{"award-number":["BX004594"]}],"id":[{"id":"10.13039\/100007496","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30 DK120515"],"award-info":[{"award-number":["P30 DK120515"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1007\/s10620-020-06461-6","type":"journal-article","created":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T06:15:35Z","timestamp":1594793735000},"page":"3592-3604","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Transcriptomic Profiling Identifies Novel Hepatic and Intestinal Genes Following Chronic Plus Binge Ethanol Feeding in Mice"],"prefix":"10.1007","volume":"65","author":[{"given":"Lu","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huikuan","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6281-825X","authenticated-orcid":false,"given":"Bernd","family":"Schnabl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,7,15]]},"reference":[{"issue":"5","key":"6461_CR1","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.1053\/j.gastro.2011.09.002","volume":"141","author":"B Gao","year":"2011","unstructured":"Gao B, Bataller R. Alcoholic liver disease: pathogenesis and new therapeutic targets. Gastroenterology. 2011;141(5):1572\u20131585. https:\/\/doi.org\/10.1053\/j.gastro.2011.09.002.","journal-title":"Gastroenterology"},{"issue":"8","key":"6461_CR2","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1056\/NEJM199202203260802","volume":"326","author":"MJ Ramond","year":"1992","unstructured":"Ramond MJ, Poynard T, Rueff B, et al. A randomized trial of prednisolone in patients with severe alcoholic hepatitis. N Engl J Med. 1992;326(8):507\u2013512. https:\/\/doi.org\/10.1056\/NEJM199202203260802.","journal-title":"N Engl J Med"},{"issue":"2","key":"6461_CR3","doi-asserted-by":"publisher","first-page":"113","DOI":"10.14218\/JCTH.2016.00006","volume":"4","author":"B Saberi","year":"2016","unstructured":"Saberi B, Dadabhai AS, Jang YY, Gurakar A, Mezey E. Current management of alcoholic hepatitis and future therapies. J Clin Transl Hepatol. 2016;4(2):113\u2013122. https:\/\/doi.org\/10.14218\/JCTH.2016.00006.","journal-title":"J Clin Transl Hepatol"},{"issue":"1","key":"6461_CR4","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1002\/hep.24018","volume":"53","author":"AW Yan","year":"2011","unstructured":"Yan AW, Fouts DE, Brandl J, et al. Enteric dysbiosis associated with a mouse model of alcoholic liver disease. Hepatology. 2011;53(1):96\u2013105. https:\/\/doi.org\/10.1002\/hep.24018.","journal-title":"Hepatology"},{"issue":"9","key":"6461_CR5","doi-asserted-by":"publisher","first-page":"G966","DOI":"10.1152\/ajpgi.00380.2011","volume":"302","author":"EA Mutlu","year":"2012","unstructured":"Mutlu EA, Gillevet PM, Rangwala H, et al. Colonic microbiome is altered in alcoholism. Am J Physiol Gastrointest Liver Physiol. 2012;302(9):G966\u2013G978. https:\/\/doi.org\/10.1152\/ajpgi.00380.2011.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"7783","key":"6461_CR6","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1038\/s41586-019-1742-x","volume":"575","author":"Y Duan","year":"2019","unstructured":"Duan Y, Llorente C, Lang S, et al. Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease. Nature. 2019;575(7783):505\u2013511. https:\/\/doi.org\/10.1038\/s41586-019-1742-x.","journal-title":"Nature"},{"issue":"2","key":"6461_CR7","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/j.jhep.2018.03.031","volume":"69","author":"K Brandl","year":"2018","unstructured":"Brandl K, Hartmann P, Jih LJ, et al. Dysregulation of serum bile acids and FGF19 in alcoholic hepatitis. J Hepatol. 2018;69(2):396\u2013405. https:\/\/doi.org\/10.1016\/j.jhep.2018.03.031.","journal-title":"J Hepatol"},{"key":"6461_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2020.06.006","author":"H Chu","year":"2020","unstructured":"Chu H, Jiang L, Gao B, et al. The selective PPAR-delta agonist seladelpar reduces ethanol-induced liver disease by restoring gut barrier function and bile acid homeostasis in mice. Transl Res. 2020;. https:\/\/doi.org\/10.1016\/j.trsl.2020.06.006.","journal-title":"Transl Res"},{"issue":"7","key":"6461_CR9","doi-asserted-by":"publisher","first-page":"2829","DOI":"10.1172\/JCI90562","volume":"127","author":"AM Yang","year":"2017","unstructured":"Yang AM, Inamine T, Hochrath K, et al. Intestinal fungi contribute to development of alcoholic liver disease. J Clin Investig. 2017;127(7):2829\u20132841. https:\/\/doi.org\/10.1172\/JCI90562.","journal-title":"J Clin Investig"},{"issue":"4","key":"6461_CR10","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1038\/nmeth.4197","volume":"14","author":"R Patro","year":"2017","unstructured":"Patro R, Duggal G, Love MI, Irizarry RA, Kingsford C. Salmon provides fast and bias-aware quantification of transcript expression. Nat Methods. 2017;14(4):417\u2013419. https:\/\/doi.org\/10.1038\/nmeth.4197.","journal-title":"Nat Methods"},{"issue":"12","key":"6461_CR11","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","volume":"15","author":"MI Love","year":"2014","unstructured":"Love MI, Huber W, Anders S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 2014;15(12):550. https:\/\/doi.org\/10.1186\/s13059-014-0550-8.","journal-title":"Genome Biol"},{"issue":"5","key":"6461_CR12","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","volume":"16","author":"G Yu","year":"2012","unstructured":"Yu G, Wang LG, Han Y, He QY. ClusterProfiler: an R package for comparing biological themes among gene clusters. Omics. 2012;16(5):284\u2013287. https:\/\/doi.org\/10.1089\/omi.2011.0118.","journal-title":"Omics"},{"issue":"6","key":"6461_CR13","doi-asserted-by":"publisher","first-page":"2150","DOI":"10.1002\/hep.29676","volume":"67","author":"P Hartmann","year":"2018","unstructured":"Hartmann P, Hochrath K, Horvath A, et al. Modulation of the intestinal bile acid\/farnesoid X receptor\/fibroblast growth factor 15 axis improves alcoholic liver disease in mice. Hepatology. 2018;67(6):2150\u20132166. https:\/\/doi.org\/10.1002\/hep.29676.","journal-title":"Hepatology"},{"issue":"5","key":"6461_CR14","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/nmeth.f.303","volume":"7","author":"JG Caporaso","year":"2010","unstructured":"Caporaso JG, Kuczynski J, Stombaugh J, et al. QIIME allows analysis of high-throughput community sequencing data. Nat Methods. 2010;7(5):335\u2013336. https:\/\/doi.org\/10.1038\/nmeth.f.303.","journal-title":"Nat Methods"},{"issue":"7","key":"6461_CR15","doi-asserted-by":"publisher","first-page":"5069","DOI":"10.1128\/AEM.03006-05","volume":"72","author":"TZ DeSantis","year":"2006","unstructured":"DeSantis TZ, Hugenholtz P, Larsen N, et al. Greengenes, a chimera-checked 16S rRNA gene database and workbench compatible with ARB. Appl Environ Microbiol. 2006;72(7):5069\u20135072. https:\/\/doi.org\/10.1128\/AEM.03006-05.","journal-title":"Appl Environ Microbiol"},{"issue":"5","key":"6461_CR16","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1002\/hep.29251","volume":"66","author":"D Slijepcevic","year":"2017","unstructured":"Slijepcevic D, Abbing RLPR, Katafuchi T, et al. Hepatic uptake of conjugated bile acids is mediated by both sodium taurocholate cotransporting polypeptide and organic anion transporting polypeptides and modulated by intestinal sensing of plasma bile acid levels in mice. Hepatology. 2017;66(5):1631\u20131643. https:\/\/doi.org\/10.1002\/hep.29251.","journal-title":"Hepatology"},{"issue":"37","key":"6461_CR17","doi-asserted-by":"publisher","first-page":"5630","DOI":"10.3748\/wjg.14.5630","volume":"14","author":"O Martinez-Augustin","year":"2008","unstructured":"Martinez-Augustin O, Sanchez de Medina F. Intestinal bile acid physiology and pathophysiology. World J Gastroenterol. 2008;14(37):5630\u20135640. https:\/\/doi.org\/10.3748\/wjg.14.5630.","journal-title":"World J Gastroenterol"},{"key":"6461_CR18","doi-asserted-by":"publisher","unstructured":"Watson RP, Lilley E, Panesar M, et al. Increased prokineticin 2 expression in gut inflammation: role in visceral pain and intestinal ion transport. Neurogastroenterol Motil. 2012;24(1):65\u201375, e12. https:\/\/doi.org\/10.1111\/j.1365-2982.2011.01804.x.","DOI":"10.1111\/j.1365-2982.2011.01804.x"},{"key":"6461_CR19","doi-asserted-by":"publisher","unstructured":"Pradhan-Sundd T, Vats R, Russell JO, et al. Dysregulated bile transporters and impaired tight junctions during chronic liver injury in mice. Gastroenterology. 2018;155(4):1218\u20131232.e24. https:\/\/doi.org\/10.1053\/j.gastro.2018.06.048.","DOI":"10.1053\/j.gastro.2018.06.048"},{"issue":"4","key":"6461_CR20","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1038\/s41385-019-0170-4","volume":"12","author":"B Gyongyosi","year":"2019","unstructured":"Gyongyosi B, Cho Y, Lowe P, et al. Alcohol-induced IL-17A production in Paneth cells amplifies endoplasmic reticulum stress, apoptosis, and inflammasome-IL-18 activation in the proximal small intestine in mice. Mucosal Immunol. 2019;12(4):930\u2013944. https:\/\/doi.org\/10.1038\/s41385-019-0170-4.","journal-title":"Mucosal Immunol"},{"issue":"40","key":"6461_CR21","doi-asserted-by":"publisher","first-page":"42491","DOI":"10.18632\/oncotarget.6382","volume":"6","author":"H Liu","year":"2015","unstructured":"Liu H, Gong M, French BA, et al. Aberrant modulation of the BRCA1 and G1\/S cell cycle pathways in alcoholic hepatitis patients with Mallory Denk Bodies revealed by RNA sequencing. Oncotarget. 2015;6(40):42491\u201342503. https:\/\/doi.org\/10.18632\/oncotarget.6382.","journal-title":"Oncotarget"},{"issue":"5","key":"6461_CR22","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1002\/hep.29645","volume":"67","author":"E Khanova","year":"2018","unstructured":"Khanova E, Wu R, Wang W, et al. Pyroptosis by caspase11\/4-gasdermin-D pathway in alcoholic hepatitis in mice and patients. Hepatology. 2018;67(5):1737\u20131753. https:\/\/doi.org\/10.1002\/hep.29645.","journal-title":"Hepatology"},{"issue":"3","key":"6461_CR23","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1016\/j.yexmp.2015.09.005","volume":"99","author":"H Liu","year":"2015","unstructured":"Liu H, French BA, Li J, Tillman B, French SW. Altered regulation of miR-34a and miR-483-3p in alcoholic hepatitis and DDC fed mice. Exp Mol Pathol. 2015;99(3):552\u2013557. https:\/\/doi.org\/10.1016\/j.yexmp.2015.09.005.","journal-title":"Exp Mol Pathol"},{"issue":"12","key":"6461_CR24","doi-asserted-by":"publisher","first-page":"e1002429","DOI":"10.1371\/journal.pgen.1002429","volume":"7","author":"W Zhang","year":"2011","unstructured":"Zhang W, Thompson BJ, Hietakangas V, Cohen SM. MAPK\/ERK signaling regulates insulin sensitivity to control glucose metabolism in Drosophila. PLoS Genet. 2011;7(12):e1002429. https:\/\/doi.org\/10.1371\/journal.pgen.1002429.","journal-title":"PLoS Genet"},{"issue":"1","key":"6461_CR25","doi-asserted-by":"publisher","first-page":"G6","DOI":"10.1152\/ajpgi.00328.2001","volume":"282","author":"R Kishore","year":"2002","unstructured":"Kishore R, Hill JR, McMullen MR, Frenkel J, Nagy LE. ERK1\/2 and Egr-1 contribute to increased TNF-alpha production in rat Kupffer cells after chronic ethanol feeding. Am J Physiol Gastrointest Liver Physiol. 2002;282(1):G6\u2013G15. https:\/\/doi.org\/10.1152\/ajpgi.00328.2001.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"8","key":"6461_CR26","doi-asserted-by":"publisher","first-page":"2942","DOI":"10.1172\/jci42168","volume":"120","author":"E van de Steeg","year":"2010","unstructured":"van de Steeg E, Wagenaar E, van der Kruijssen CM, et al. Organic anion transporting polypeptide 1a\/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs. J Clin Investig. 2010;120(8):2942\u20132952. https:\/\/doi.org\/10.1172\/jci42168.","journal-title":"J Clin Investig"},{"issue":"1","key":"6461_CR27","doi-asserted-by":"publisher","first-page":"e53028","DOI":"10.1371\/journal.pone.0053028","volume":"8","author":"L Bull-Otterson","year":"2013","unstructured":"Bull-Otterson L, Feng W, Kirpich I, et al. Metagenomic analyses of alcohol induced pathogenic alterations in the intestinal microbiome and the effect of Lactobacillus rhamnosus GG treatment. PloS One. 2013;8(1):e53028. https:\/\/doi.org\/10.1371\/journal.pone.0053028.","journal-title":"PloS One"},{"issue":"12","key":"6461_CR28","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1136\/gutjnl-2012-303816","volume":"62","author":"T Le Roy","year":"2013","unstructured":"Le Roy T, Llopis M, Lepage P, et al. Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice. Gut. 2013;62(12):1787\u20131794. https:\/\/doi.org\/10.1136\/gutjnl-2012-303816.","journal-title":"Gut"},{"issue":"1","key":"6461_CR29","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1038\/s41572-018-0014-7","volume":"4","author":"HK Seitz","year":"2018","unstructured":"Seitz HK, Bataller R, Cortez-Pinto H, et al. Alcoholic liver disease. Nat Rev Dis Primers. 2018;4(1):16. https:\/\/doi.org\/10.1038\/s41572-018-0014-7.","journal-title":"Nat Rev Dis Primers"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-020-06461-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10620-020-06461-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-020-06461-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T00:35:03Z","timestamp":1626309303000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10620-020-06461-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,15]]},"references-count":29,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["6461"],"URL":"https:\/\/doi.org\/10.1007\/s10620-020-06461-6","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,15]]},"assertion":[{"value":"26 May 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 June 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"B.S. has been consulting for Ferring Research Institute, Intercept Pharmaceuticals, HOST Therabiomics and Patara Pharmaceuticals. B.S.\u2019s institution UC San Diego has received Grant support from BiomX, NGM Biopharmaceuticals, CymaBay Therapeutics, Synlogic Operating Company and Axial Biotherapeutics.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}