{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:32:58Z","timestamp":1790875978440,"version":"4.1.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T00:00:00Z","timestamp":1597363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T00:00:00Z","timestamp":1597363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1007\/s10620-020-06508-8","type":"journal-article","created":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T12:55:52Z","timestamp":1597409752000},"page":"2336-2344","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Endoscopic Closure Utilizing Endoloop and Endoclips After Gastric Endoscopic Submucosal Dissection for Patients on Antithrombotic Therapy"],"prefix":"10.1007","volume":"66","author":[{"given":"Mai","family":"Ego","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2736-6921","authenticated-orcid":false,"given":"Seiichiro","family":"Abe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Nonaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhisa","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigetaka","family":"Yoshinaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Oda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,8,14]]},"reference":[{"key":"6508_CR1","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1111\/den.13246","volume":"31","author":"H Suzuki","year":"2019","unstructured":"Suzuki H, Takizawa K, Hirasawa T, et al. Short-term outcomes of multicenter prospective cohort study of gastric endoscopic resection: \u2018Real-world evidence\u2019 in Japan. Dig Endosc. 2019;31:30\u201339.","journal-title":"Dig Endosc"},{"key":"6508_CR2","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1007\/s10120-017-0704-y","volume":"21","author":"N Hasuike","year":"2018","unstructured":"Hasuike N, Ono H, Boku N, et al. A non-randomized confirmatory trial of an expanded indication for endoscopic submucosal dissection for intestinal-type gastric cancer (cT1a): the Japan Clinical Oncology Group study (JCOG0607). Gastric Cancer. 2018;21:114\u2013123.","journal-title":"Gastric Cancer"},{"key":"6508_CR3","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/den.12518","volume":"28","author":"H Ono","year":"2016","unstructured":"Ono H, Yao K, Fujishiro M, et al. Guidelines for endoscopic submucosal dissection and endoscopic mucosal resection for early gastric cancer. Dig Endosc. 2016;28:3\u201315.","journal-title":"Dig Endosc"},{"key":"6508_CR4","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1186\/1471-230X-14-172","volume":"14","author":"T Matsumura","year":"2014","unstructured":"Matsumura T, Arai M, Maruoka D, et al. Risk factors for early and delayed post-operative bleeding after endoscopic submucosal dissection of gastric neoplasms, including patients with continued use of antithrombotic agents. BMC Gastroenterol. 2014;14:172.","journal-title":"BMC Gastroenterol"},{"key":"6508_CR5","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1016\/j.gie.2016.06.033","volume":"84","author":"D Libanio","year":"2016","unstructured":"Libanio D, Costa MN, Pimentel-Nunes P, et al. Risk factors for bleeding after gastric endoscopic submucosal dissection: a systematic review and meta-analysis. Gastrointest Endosc. 2016;84:572\u2013586.","journal-title":"Gastrointest Endosc"},{"key":"6508_CR6","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1186\/1471-230X-13-136","volume":"13","author":"T Takeuchi","year":"2013","unstructured":"Takeuchi T, Ota K, Harada S, et al. The postoperative bleeding rate and its risk factors in patients on antithrombotic therapy who undergo gastric endoscopic submucosal dissection. BMC Gastroenterol. 2013;13:136.","journal-title":"BMC Gastroenterol"},{"key":"6508_CR7","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1055\/s-2007-995530","volume":"40","author":"K Takizawa","year":"2008","unstructured":"Takizawa K, Oda I, Gotoda T, et al. Routine coagulation of visible vessels may prevent delayed bleeding after endoscopic submucosal dissection\u2014an analysis of risk factors. Endoscopy. 2008;40:179\u2013183.","journal-title":"Endoscopy"},{"key":"6508_CR8","doi-asserted-by":"publisher","first-page":"1610","DOI":"10.1111\/j.1572-0241.2007.01197.x","volume":"102","author":"N Uedo","year":"2007","unstructured":"Uedo N, Takeuchi Y, Yamada T, et al. Effect of a proton pump inhibitor or an H2-receptor antagonist on prevention of bleeding from ulcer after endoscopic submucosal dissection of early gastric cancer: a prospective randomized controlled trial. Am J Gastroenterol. 2007;102:1610\u20131616.","journal-title":"Am J Gastroenterol"},{"key":"6508_CR9","doi-asserted-by":"publisher","first-page":"1746","DOI":"10.1007\/s00464-016-5167-4","volume":"31","author":"K Igarashi","year":"2017","unstructured":"Igarashi K, Takizawa K, Kakushima N, et al. Should antithrombotic therapy be stopped in patients undergoing gastric endoscopic submucosal dissection? Surg Endosc. 2017;31:1746\u20131753.","journal-title":"Surg Endosc"},{"key":"6508_CR10","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1111\/den.13388","volume":"31","author":"Y Yamamoto","year":"2019","unstructured":"Yamamoto Y, Kikuchi D, Nagami Y, et al. Management of adverse events related to endoscopic resection of upper gastrointestinal\nneoplasms: review of the literature and recommendations from experts. Dig Endosc. 2019;31:4\u201320.","journal-title":"Dig Endosc"},{"key":"6508_CR11","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1007\/s10620-019-05776-3","volume":"65","author":"Y Toya","year":"2020","unstructured":"Toya Y, Endo M, Oizumi T, et al. Risk factors for post-gastric endoscopic submucosal dissection bleeding with a special emphasis on anticoagulant therapy. Dig Dis Sci. 2020;65:557\u2013564. https:\/\/doi.org\/10.1007\/s10620-019-05776-3.","journal-title":"Dig Dis Sci"},{"key":"6508_CR12","doi-asserted-by":"publisher","first-page":"E374","DOI":"10.1055\/s-0034-1392594","volume":"47","author":"S Abe","year":"2015","unstructured":"Abe S, Oda I, Mori G, et al. Complete endoscopic closure of a large gastric defect with endoloop and endoclips after complex endoscopic submucosal dissection. Endoscopy. 2015;47:E374\u2013E375.","journal-title":"Endoscopy"},{"key":"6508_CR13","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1016\/S0016-5107(04)02033-4","volume":"60","author":"T Matsuda","year":"2004","unstructured":"Matsuda T, Fujii T, Emura F, et al. Complete closure of a large defect after EMR of a lateral spreading colorectal tumor when using a two-channel colonoscope. Gastrointest Endosc. 2004;60:836\u2013838.","journal-title":"Gastrointest Endosc"},{"key":"6508_CR14","first-page":"2691","volume":"47","author":"K Ogoshi","year":"2005","unstructured":"Ogoshi K, Kaneko E, Tada M, et al. The management of anticoagulation and antiplatelet therapy for endoscopic procedures. Gastroenterol Endosc. 2005;47:2691\u20132695.","journal-title":"Gastroenterol Endosc"},{"key":"6508_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/den.12183","volume":"26","author":"K Fujimoto","year":"2014","unstructured":"Fujimoto K, Fujishiro M, Kato M, et al. Guidelines for gastroenterological endoscopy in patients undergoing antithrombotic treatment. Dig Endosc. 2014;26:1\u201314.","journal-title":"Dig Endosc"},{"key":"6508_CR16","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1111\/j.1443-1661.2012.01376.x","volume":"25","author":"I Oda","year":"2013","unstructured":"Oda I, Suzuki H, Nonaka S, et al. Complications of gastric endoscopic submucosal dissection. Dig Endosc. 2013;25:71\u201378.","journal-title":"Dig Endosc"},{"key":"6508_CR17","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1007\/s00464-010-1137-4","volume":"25","author":"K Okada","year":"2011","unstructured":"Okada K, Yamamoto Y, Kasuga A, et al. Risk factors for delayed bleeding after endoscopic submucosal dissection for gastric neoplasm. Surg Endosc. 2011;25:98\u2013107.","journal-title":"Surg Endosc"},{"key":"6508_CR18","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1111\/jgh.13872","volume":"33","author":"Y Kono","year":"2018","unstructured":"Kono Y, Obayashi Y, Baba Y, et al. Postoperative bleeding risk after gastric endoscopic submucosal dissection during antithrombotic drug therapy. J Gastroenterol Hepatol. 2018;33:453\u2013460.","journal-title":"J Gastroenterol Hepatol"},{"key":"6508_CR19","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-319926","author":"W Hatta","year":"2020","unstructured":"Hatta W, Tsuji Y, Yoshio T, et al. Prediction model of bleeding after endoscopic submucosal dissection for early gastric cancer: BEST-J score. Gut. 2020. https:\/\/doi.org\/10.1136\/gutjnl-2019-319926.","journal-title":"Gut"},{"key":"6508_CR20","doi-asserted-by":"publisher","first-page":"1882","DOI":"10.1007\/s00464-008-9743-0","volume":"22","author":"KD Choi","year":"2008","unstructured":"Choi KD, Jung HY, Lee GH, et al. Application of metal hemoclips for closure of endoscopic mucosal resection-induced ulcers of the stomach to prevent delayed bleeding. Surg Endosc. 2008;22:1882\u20131886.","journal-title":"Surg Endosc"},{"key":"6508_CR21","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1007\/s00464-014-3725-1","volume":"29","author":"S Maekawa","year":"2015","unstructured":"Maekawa S, Nomura R, Murase T, et al. Complete closure of artificial gastric ulcer after endoscopic submucosal dissection by combined use of a single over-the-scope clip and through-the-scope clips (with videos). Surg Endosc. 2015;29:500\u2013504.","journal-title":"Surg Endosc"},{"key":"6508_CR22","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1016\/j.gie.2019.12.046","volume":"91","author":"O Goto","year":"2020","unstructured":"Goto O, Oyama T, Ono H, et al. Endoscopic hand-suturing is feasible, safe, and may reduce bleeding risk after gastric endoscopic submucosal dissection: a multicenter pilot study (with video). Gastrointest Endosc. 2020;91:1195\u20131202.","journal-title":"Gastrointest Endosc"},{"key":"6508_CR23","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/j.gie.2013.10.051","volume":"79","author":"SV Kantsevoy","year":"2014","unstructured":"Kantsevoy SV, Bitner M, Mitrakov AA, et al. Endoscopic suturing closure of large mucosal defects after endoscopic submucosal dissection is technically feasible, fast, and eliminates the need for hospitalization (with videos). Gastrointest Endosc. 2014;79:503\u2013507.","journal-title":"Gastrointest Endosc"},{"key":"6508_CR24","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1055\/a-0860-5280","volume":"51","author":"Y Kataoka","year":"2019","unstructured":"Kataoka Y, Tsuji Y, Hirasawa K, et al. Endoscopic tissue shielding to prevent bleeding after endoscopic submucosal dissection: a prospective multicenter randomized controlled trial. Endoscopy. 2019;51:619\u2013627.","journal-title":"Endoscopy"},{"key":"6508_CR25","doi-asserted-by":"publisher","first-page":"E111","DOI":"10.1055\/s-0034-1377180","volume":"2","author":"O Goto","year":"2014","unstructured":"Goto O, Sasaki M, Ishii H, et al. A new endoscopic closure method for gastric mucosal defects: feasibility of endoscopic hand suturing in an ex vivo porcine model (with video). Endosc Int Open. 2014;2:E111\u2013E116.","journal-title":"Endosc Int Open"},{"key":"6508_CR26","first-page":"E39","volume":"3","author":"T Yoshioka","year":"2015","unstructured":"Yoshioka T, Nishida T, Tsujii M, et al. Renal dysfunction is an independent risk factor for bleeding after gastric ESD. Endosc Int Open. 2015;3:E39\u2013E45.","journal-title":"Endosc Int Open"},{"key":"6508_CR27","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1055\/s-0034-1364938","volume":"46","author":"M Sekiguchi","year":"2014","unstructured":"Sekiguchi M, Suzuki H, Oda I, et al. Risk of recurrent gastric cancer after endoscopic resection with a positive lateral margin. Endoscopy. 2014;46:273\u2013278.","journal-title":"Endoscopy"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-020-06508-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10620-020-06508-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-020-06508-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T23:38:40Z","timestamp":1628897920000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10620-020-06508-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,14]]},"references-count":27,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["6508"],"URL":"https:\/\/doi.org\/10.1007\/s10620-020-06508-8","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,14]]},"assertion":[{"value":"3 June 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 July 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 August 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"Authors declare no conflict of interests for this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}