{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T21:03:59Z","timestamp":1749157439188,"version":"3.37.3"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T00:00:00Z","timestamp":1600387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T00:00:00Z","timestamp":1600387200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"the Clinical Characteristic Applied Research Projects","award":["Z181100001718084"],"award-info":[{"award-number":["Z181100001718084"]}]},{"DOI":"10.13039\/501100015850","name":"The Digestive Medical Coordinated Development Center of Beijing Hospitals Authority","doi-asserted-by":"crossref","award":["XXZ0404"],"award-info":[{"award-number":["XXZ0404"]}],"id":[{"id":"10.13039\/501100015850","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81271901"],"award-info":[{"award-number":["81271901"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Beijing Natural Science Foundation","award":["7152073"],"award-info":[{"award-number":["7152073"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1007\/s10620-020-06601-y","type":"journal-article","created":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T04:11:44Z","timestamp":1600402304000},"page":"3054-3061","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["FAM172A Deletion May Enhance Hepatic Steatosis by Promoting ER Stress"],"prefix":"10.1007","volume":"66","author":[{"given":"Fan","family":"Xiao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meixin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junru","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingling","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8893-653X","authenticated-orcid":false,"given":"Hongshan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,9,18]]},"reference":[{"key":"6601_CR1","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1038\/nrneph.2017.129","volume":"13","author":"AV Cybulsky","year":"2017","unstructured":"Cybulsky AV. Endoplasmic reticulum stress, the unfolded protein response and autophagy in kidney diseases. Nat Rev Nephrol. 2017;13:681\u2013696.","journal-title":"Nat Rev Nephrol."},{"key":"6601_CR2","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1055\/s-0033-1358522","volume":"33","author":"R Green","year":"2013","unstructured":"Green R, Henkel A. The unfolded protein response in fatty liver disease. Semin Liver Dis 2013;33:321\u2013329.","journal-title":"Semin Liver Dis"},{"key":"6601_CR3","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1038\/nrendo.2016.124","volume":"12","author":"ABPMM Lagouge","year":"2016","unstructured":"Lagouge ABPMM. Endoplasmic reticulum proteostasis in hepatic steatosis. Nat Rev Endocrinol. 2016;12:710\u2013722.","journal-title":"Nat Rev Endocrinol."},{"key":"6601_CR4","doi-asserted-by":"publisher","first-page":"1969","DOI":"10.1007\/s00018-016-2161-x","volume":"73","author":"W Liu","year":"2016","unstructured":"Liu W, Baker RD, Bhatia T, et al. Pathogenesis of nonalcoholic steatohepatitis. Cell Mol Sci 2016;73:1969\u20131987.","journal-title":"Cell Mol Sci"},{"key":"6601_CR5","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1146\/annurev-pathol-020117-043617","volume":"13","author":"MA Juan Pablo Arab","year":"2018","unstructured":"Juan Pablo Arab MA, Trauner M. Recent insights into the pathogenesis of nonalcoholic fatty liver disease. Ann Rev Pathol. 2018;13:321\u2013350.","journal-title":"Ann Rev Pathol"},{"key":"6601_CR6","doi-asserted-by":"publisher","first-page":"E620","DOI":"10.1073\/pnas.1715378115","volume":"115","author":"C B\u00e9langer","year":"2018","unstructured":"B\u00e9langer C, B\u00e9rub\u00e9-Simard F-A, Leduc E, et al. Dysregulation of cotranscriptional alternative splicing underlies CHARGE syndrome. Proc Natl Acad Sci. 2018;115:E620\u2013E629.","journal-title":"Proc Natl Acad Sci."},{"key":"6601_CR7","doi-asserted-by":"publisher","first-page":"3554","DOI":"10.3892\/or.2017.5592","volume":"37","author":"W Liu","year":"2017","unstructured":"Liu W, Qian K, Wei X, et al. miR-27a promotes proliferation, migration, and invasion of colorectal cancer by targeting FAM172A and acts as a diagnostic and prognostic biomarker. Oncol Rep. 2017;37:3554\u20133564.","journal-title":"Oncol Rep."},{"key":"6601_CR8","doi-asserted-by":"publisher","first-page":"353","DOI":"10.3892\/mmr.2015.4548","volume":"13","author":"MF Li","year":"2016","unstructured":"Li MF, Zhang R, Guo MG, et al. FAM172A protein promotes the proliferation of human papillary thyroid carcinoma cells via the p38 mitogen-activated protein kinase pathway. Mol Med Rep. 2016;13:353\u2013358.","journal-title":"Mol Med Rep."},{"key":"6601_CR9","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1038\/labinvest.2016.139","volume":"97","author":"F Xiao","year":"2016","unstructured":"Xiao F, Zhang J, Zhang C, et al. Hepatic stimulator substance inhibits calcium overflow through the mitochondria-associated membrane compartment during nonalcoholic steatohepatitis. Lab Investig. 2016;97:289\u2013301.","journal-title":"Lab Investig"},{"key":"6601_CR10","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.mad.2016.07.001","volume":"157","author":"P Bozaykut","year":"2016","unstructured":"Bozaykut P, Sahin A, Karademir B, et al. Endoplasmic reticulum stress related molecular mechanisms in nonalcoholic steatohepatitis. Mech Ageing Dev. 2016;157:17\u201329.","journal-title":"Mech Ageing Dev."},{"key":"6601_CR11","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.3748\/wjg.v20.i7.1768","volume":"20","author":"X-Q Zhang","year":"2014","unstructured":"Zhang X-Q. Role of endoplasmic reticulum stress in the pathogenesis of nonalcoholic fatty liver disease. World J Gastroenterol. 2014;20:1768.","journal-title":"World J Gastroenterol"},{"key":"6601_CR12","doi-asserted-by":"publisher","first-page":"7352","DOI":"10.3390\/ijms15057352","volume":"15","author":"A Takaki","year":"2014","unstructured":"Takaki A, Kawai D, Yamamoto K. Molecular mechanisms and new treatment strategies for non-alcoholic steatohepatitis (NASH). Int J Mol Sci. 2014;15:7352\u20137379.","journal-title":"Int J Mol Sci."},{"key":"6601_CR13","doi-asserted-by":"publisher","first-page":"51870","DOI":"10.1039\/C7RA09918E","volume":"7","author":"WF Shen","year":"2017","unstructured":"Shen WF, Feng ZQ, Wang P, et al. FAM172A controls endoplasmic reticulum (ER) stress related to NF-\u03baB signaling pathway in hepatocellular carcinoma. RSC Adv. 2017;7:51870\u201351878.","journal-title":"RSC Adv."},{"key":"6601_CR14","doi-asserted-by":"publisher","first-page":"6501","DOI":"10.1007\/s13277-015-4166-8","volume":"37","author":"C Cui","year":"2015","unstructured":"Cui C, Ye L, Huang Z, et al. FAM172A is a tumor suppressor in colorectal carcinoma. Tumor Biol. 2015;37:6501\u20136510.","journal-title":"Tumor Biol."}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-020-06601-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10620-020-06601-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-020-06601-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T23:05:07Z","timestamp":1631919907000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10620-020-06601-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,18]]},"references-count":14,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["6601"],"URL":"https:\/\/doi.org\/10.1007\/s10620-020-06601-y","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"type":"print","value":"0163-2116"},{"type":"electronic","value":"1573-2568"}],"subject":[],"published":{"date-parts":[[2020,9,18]]},"assertion":[{"value":"10 October 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 September 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 September 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}