{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T01:29:55Z","timestamp":1774574995432,"version":"3.50.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:00:00Z","timestamp":1601424000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:00:00Z","timestamp":1601424000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China Program","doi-asserted-by":"crossref","award":["81741057"],"award-info":[{"award-number":["81741057"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1007\/s10620-020-06629-0","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T21:03:01Z","timestamp":1601499781000},"page":"2992-3001","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Four Variants of SLCO2A1 Identified in Three Chinese Patients with Chronic Enteropathy Associated with the SLCO2A1 Gene"],"prefix":"10.1007","volume":"66","author":[{"given":"Hui","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuehong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dalian","family":"Ou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaowei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boda","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bai","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5876-1775","authenticated-orcid":false,"given":"Yongjun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoliu","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,9,30]]},"reference":[{"key":"6629_CR1","first-page":"297","volume":"85","author":"J Mazal","year":"2014","unstructured":"Mazal J. Crohn disease: pathophysiology, diagnosis, and treatment. Radiol. Technol.. 2014;85:297\u2013316.","journal-title":"Radiol Technol."},{"key":"6629_CR2","doi-asserted-by":"publisher","first-page":"612","DOI":"10.4253\/wjge.v6.i12.612","volume":"6","author":"P Tsibouris","year":"2014","unstructured":"Tsibouris P, Kalantzis C, Apostolopoulos P et al. Small bowel ulcerative lesions are common in elderly NSAIDs users with peptic ulcer bleeding. World J. Gastrointest. Endosc.. 2014;6:612\u2013619. https:\/\/doi.org\/10.4253\/wjge.v6.i12.612.","journal-title":"World J Gastroint Endosc."},{"key":"6629_CR3","first-page":"449","volume":"50","author":"IR Wilson","year":"1968","unstructured":"Wilson IR, Cooley NV, Luibel FJ. Nonspecific stenosing small bowel ulcers. Experience in one California county. Am. J. Gastroenterol.. 1968;50:449\u2013455.","journal-title":"Am J Gastroenterol."},{"key":"6629_CR4","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1007\/s10620-006-9080-x","volume":"51","author":"T Matsumoto","year":"2006","unstructured":"Matsumoto T, Nakamura S, Esaki M et al. Endoscopic features of chronic nonspecific multiple ulcers of the small intestine: comparison with nonsteroidal anti-inflammatory drug-induced enteropathy. Dig. Dis. Sci.. 2006;51:1357\u20131363. https:\/\/doi.org\/10.1007\/s10620-006-9080-x.","journal-title":"Dig Dis Sci."},{"key":"6629_CR5","doi-asserted-by":"publisher","first-page":"2121","DOI":"10.1172\/jci30473","volume":"118","author":"DH Adler","year":"2008","unstructured":"Adler DH, Cogan JD, Phillips JA et al. Inherited human cPLA(2alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction. J. Clin. Investig.. 2008;118:2121\u20132131. https:\/\/doi.org\/10.1172\/jci30473.","journal-title":"J Clin Investig."},{"key":"6629_CR6","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s12328-015-0559-x","volume":"8","author":"M Esaki","year":"2015","unstructured":"Esaki M, Umeno J, Kitazono T, Matsumoto T. Clinicopathologic features of chronic nonspecific multiple ulcers of the small intestine. Clin. J. Gastroenterol.. 2015;8:57\u201362. https:\/\/doi.org\/10.1007\/s12328-015-0559-x.","journal-title":"Clin J Gastroenterol."},{"key":"6629_CR7","doi-asserted-by":"publisher","first-page":"e1005581","DOI":"10.1371\/journal.pgen.1005581","volume":"11","author":"J Umeno","year":"2015","unstructured":"Umeno J, Hisamatsu T, Esaki M et al. A Hereditary Enteropathy Caused by Mutations in the SLCO2A1 Gene, Encoding a Prostaglandin Transporter. PLoS Genet. 2015;11:e1005581. https:\/\/doi.org\/10.1371\/journal.pgen.1005581.","journal-title":"PLoS Genet."},{"key":"6629_CR8","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1126\/science.7754369","volume":"268","author":"N Kanai","year":"1995","unstructured":"Kanai N, Lu R, Satriano JA, Bao Y, Wolkoff AW, Schuster VL. Identification and characterization of a prostaglandin transporter. Science. 1995;268:866\u2013869.","journal-title":"Science."},{"key":"6629_CR9","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1002\/humu.22042","volume":"33","author":"W Seifert","year":"2012","unstructured":"Seifert W, Kuhnisch J, Tuysuz B, Specker C, Brouwers A, Horn D. Mutations in the prostaglandin transporter encoding gene SLCO2A1 cause primary hypertrophic osteoarthropathy and isolated digital clubbing. Hum Mutat. 2012;33:660\u2013664. https:\/\/doi.org\/10.1002\/humu.22042.","journal-title":"Hum Mutat."},{"key":"6629_CR10","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.ajhg.2011.11.019","volume":"90","author":"Z Zhang","year":"2012","unstructured":"Zhang Z, Xia W, He J et al. Exome sequencing identifies SLCO2A1 mutations as a cause of primary hypertrophic osteoarthropathy. Am. J. Hum. Genet.. 2012;90:125\u2013132. https:\/\/doi.org\/10.1016\/j.ajhg.2011.11.019.","journal-title":"Am J Hum Genet."},{"key":"6629_CR11","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1002\/humu.22111","volume":"33","author":"CP Diggle","year":"2012","unstructured":"Diggle CP, Parry DA, Logan CV et al. Prostaglandin transporter mutations cause pachydermoperiostosis with myelofibrosis. Hum Mutat. 2012;33:1175\u20131181. https:\/\/doi.org\/10.1002\/humu.22111.","journal-title":"Hum Mutat."},{"key":"6629_CR12","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-017-1426-y","author":"J Umeno","year":"2018","unstructured":"Umeno J, Esaki M, Hirano A et al. Clinical features of chronic enteropathy associated with SLCO2A1 gene: a new entity clinically distinct from Crohn's disease. J. Gastroenterol.. 2018. https:\/\/doi.org\/10.1007\/s00535-017-1426-y.","journal-title":"J Gastroenterol."},{"key":"6629_CR13","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1136\/gutjnl-2012-303581","volume":"63","author":"MA Brooke","year":"2014","unstructured":"13. Brooke MA, Longhurst HJ, Plagnol V et al. Cryptogenic multifocal ulcerating stenosing enteritis associated with homozygous deletion mutations in cytosolic phospholipase A2-alpha. Gut. 2014;63:96-104. doi:10.1136\/gutjnl-2012-303581.","journal-title":"Gut."},{"key":"6629_CR14","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/0888-7543(95)80093-2","volume":"26","author":"A Tay","year":"1995","unstructured":"Tay A, Simon JS, Squire J, Hamel K, Jacob HJ, Skorecki K. Cytosolic phospholipase A2 gene in human and rat: chromosomal localization and polymorphic markers. Genomics. 1995;26:138\u2013141.","journal-title":"Genomics."},{"key":"6629_CR15","doi-asserted-by":"publisher","first-page":"e000223","DOI":"10.1136\/bmjgast-2018-000223","volume":"5","author":"X Sun","year":"2018","unstructured":"Sun X, Hosoe N, Miyanaga R et al. A male Korean who was diagnosed with chronic enteropathy associated with SLCO2A1 (CEAS): case report with literature review. BMJ Open Gastroenterol. 2018;5:e000223. https:\/\/doi.org\/10.1136\/bmjgast-2018-000223.","journal-title":"BMJ Open Gastroenterol."},{"key":"6629_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2019.05.003","author":"P Hu","year":"2019","unstructured":"Hu P, He H, Dai N, Zhang S, Deng L. Chronic enteropathy associated with SLCO2A1 gene: A case report and literature review. Clin. Res. Hepatol. Gastroenterol.. 2019. https:\/\/doi.org\/10.1016\/j.clinre.2019.05.003","journal-title":"Clin Res Hepatol Gastroenterol."},{"key":"6629_CR17","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1186\/s13023-019-1264-5","volume":"14","author":"Q Wang","year":"2019","unstructured":"Wang Q, Li YH, Lin GL et al. Primary hypertrophic osteoarthropathy related gastrointestinal complication has distinctive clinical and pathological characteristics: two cases report and review of the literature. Orphanet J Rare Dis. 2019;14:297. https:\/\/doi.org\/10.1186\/s13023-019-1264-5.","journal-title":"Orphanet J Rare Dis."},{"key":"6629_CR18","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/s11894-019-0721-6","volume":"21","author":"A Singh","year":"2019","unstructured":"Singh A. Cryptogenic Multifocal Ulcerating Stenosing Enteropathy(CMUSE) and\/or Chronic Non-specific Multiple Ulcers of the Small Intestine(CNSU) and Non-granulomatous Ulcerating Jejunoileitis (NGUJI). Curr Gastroenterol Rep. 2019;21:53. https:\/\/doi.org\/10.1007\/s11894-019-0721-6.","journal-title":"Curr Gastroenterol Rep."},{"key":"6629_CR19","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/gim.2015.30","volume":"17","author":"S Richards","year":"2015","unstructured":"Richards S, Aziz N, Bale S et al. Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. Genet Med. 2015;17:405\u2013424. https:\/\/doi.org\/10.1038\/gim.2015.30.","journal-title":"Genet Med."},{"key":"6629_CR20","doi-asserted-by":"publisher","first-page":"9686","DOI":"10.1038\/s41598-017-09671-7","volume":"7","author":"H Huang","year":"2017","unstructured":"Huang H, Wang Y, Cao Y et al. Interleukin-6, tumor necrosis factor-alpha and receptor activator of nuclear factor kappa ligand are elevated in hypertrophic gastric mucosa of pachydermoperiostosis. Sci Rep. 2017;7:9686. https:\/\/doi.org\/10.1038\/s41598-017-09671-7.","journal-title":"Sci Rep."},{"key":"6629_CR21","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1002\/jbmr.3157","volume":"32","author":"SS Li","year":"2017","unstructured":"Li SS, He JW, Fu WZ, Liu YJ, Hu YQ, Zhang ZL. Clinical, biochemical, and genetic features of 41 Han Chinese families with primary hypertrophic osteoarthropathy, and their therapeutic response to etoricoxib: results from a six-month prospective clinical intervention. J Bone Miner Res. 2017;32:1659\u20131666. https:\/\/doi.org\/10.1002\/jbmr.3157.","journal-title":"J Bone Miner Res."},{"key":"6629_CR22","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20190349","author":"MS Oba","year":"2017","unstructured":"Oba MS, Murakami Y, Nishiwaki Y et al. Estimated prevalence of Cronkhite-Canada Syndrome, Chronic Enteropathy Associated with SLCO2A1 Gene, and Intestinal Beh\u00e7et's Disease in Japan in 2017: a nationwide survey. J Epidemiol. 2020. https:\/\/doi.org\/10.2188\/jea.JE20190349.","journal-title":"J Epidemiol."},{"issue":"3","key":"6629_CR23","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1136\/gut.48.3.333","volume":"48","author":"G Perlemuter","year":"2001","unstructured":"Perlemuter G, Guillevin L, Legman P, Weiss L, Couturier D, Chaussade S. Cryptogenetic multifocal ulcerous\nstenosing enteritis: an atypical type of vasculitis or a disease mimicking vasculitis. Gastroenterology. 2001;48(3):333\u2013338. https:\/\/doi.org\/10.1136\/gut.48.3.333.","journal-title":"Gastroenterology"},{"key":"6629_CR24","doi-asserted-by":"publisher","first-page":"e7527","DOI":"10.1097\/md.0000000000007527","volume":"96","author":"Y Zhang","year":"2017","unstructured":"Zhang Y, Huang L, Liu R et al. Case report of a pair of siblings with cryptogenic multifocal ulcerating stenosing enteritis: A rare disease easily to be misdiagnosed as Crohn disease. Medicine. 2017;96:e7527. https:\/\/doi.org\/10.1097\/md.0000000000007527.","journal-title":"Medicine."},{"key":"6629_CR25","first-page":"S63","volume":"23","author":"S Yanai","year":"2017","unstructured":"Yanai S, Yamaguchi S, Nakamura S et al. Immunohistochemical distinction of chronic enteropathy associated with SLCO2A1 from Crohn's disease. Inflamm Bowel Dis. 2017;23:S63.","journal-title":"Inflamm Bowel Dis."},{"key":"6629_CR26","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1111\/jgh.13061","volume":"31","author":"S Yamaguchi","year":"2016","unstructured":"Yamaguchi S, Yanai S, Nakamura S et al. Immunohistochemistry differentiation between chronic enteropathy associated with SLCO2A1 and other inflammatory bowel diseases. J Gastroenterol hepatol. 2016;31:123.","journal-title":"J Gastroenterol Hepatol."},{"key":"6629_CR27","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.3748\/wjg.v25.i14.1753","volume":"25","author":"Y Matsuno","year":"2019","unstructured":"Matsuno Y, Umeno J, Esaki M et al. Measurement of prostaglandin metabolites is useful in diagnosis of small bowel ulcerations. World journal of gastroenterology. 2019;25:1753\u20131763. https:\/\/doi.org\/10.3748\/wjg.v25.i14.1753.","journal-title":"World J Gastroenterol."},{"key":"6629_CR28","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.plefa.2013.04.004","volume":"89","author":"I Gomez","year":"2013","unstructured":"Gomez I, Foudi N, Longrois D, Norel X. The role of prostaglandin E2 in human vascular inflammation. Prostaglandins Leukot Essent Fatty Acids. 2013;89:55\u201363. https:\/\/doi.org\/10.1016\/j.plefa.2013.04.004.","journal-title":"Prostagl Leukot Essent Fatty Acids."},{"key":"6629_CR29","doi-asserted-by":"publisher","first-page":"4879","DOI":"10.1111\/bph.12815","volume":"171","author":"K Omori","year":"2014","unstructured":"Omori K, Kida T, Hori M, Ozaki H, Murata T. Multiple roles of the PGE2 -EP receptor signal in vascular permeability. Br J Pharmacol. 2014;171:4879\u20134889. https:\/\/doi.org\/10.1111\/bph.12815.","journal-title":"Br J Pharmacol."}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-020-06629-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10620-020-06629-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-020-06629-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T02:36:07Z","timestamp":1632969367000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10620-020-06629-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,30]]},"references-count":29,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["6629"],"URL":"https:\/\/doi.org\/10.1007\/s10620-020-06629-0","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,30]]},"assertion":[{"value":"16 January 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 September 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the Ethics Committee of The Second Xiangya Hospital of Central South University and all methods were in accordance with the Declaration of Helsinki. All participants provided written informed consent forms to genetic and biochemical analysis and to publication of all identifying images.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}