{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T16:10:20Z","timestamp":1785168620494,"version":"3.55.0"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T00:00:00Z","timestamp":1605225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T00:00:00Z","timestamp":1605225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100016387","name":"Grifols","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100016387","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1007\/s10620-020-06677-6","type":"journal-article","created":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T10:02:57Z","timestamp":1605261777000},"page":"3612-3618","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Increased Risk of ACLF and Inpatient Mortality in Hospitalized Patients with Cirrhosis and Hepatic Hydrothorax"],"prefix":"10.1007","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3640-4851","authenticated-orcid":false,"given":"Jacqueline G.","family":"O\u2019Leary","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Rajender Reddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puneeta","family":"Tandon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott W.","family":"Biggins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick S.","family":"Kamath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guadalupe","family":"Garcia-Tsao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedict","family":"Maliakkal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer C.","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Fallon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo E.","family":"Vargas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Thuluvath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram","family":"Subramanian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leroy R.","family":"Thacker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmohan S.","family":"Bajaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,11,13]]},"reference":[{"key":"6677_CR1","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1016\/j.cld.2019.06.003","volume":"23","author":"R Cartin-Ceba","year":"2019","unstructured":"Cartin-Ceba R, Krowka MJ. Pulmonary complications of portal hypertension. Clin Liver Dis. 2019;23:683\u2013711.","journal-title":"Clin Liver Dis"},{"key":"6677_CR2","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1056\/NEJM194204232261702","volume":"226","author":"J Frothingham","year":"1937","unstructured":"Frothingham J. Cirrhosis of the liver complicated by persistent right hydrothorax and ascites. New Engl J Med. 1937;226:679\u2013682.","journal-title":"New Engl J Med"},{"key":"6677_CR3","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1378\/chest.126.1.142","volume":"126","author":"LU Liu","year":"2004","unstructured":"Liu LU, Haddadin HA, Bodian CA, et al. Outcome analysis of cirrhotic patients undergoing chest tube placement. Chest. 2004;126:142\u2013148.","journal-title":"Chest"},{"key":"6677_CR4","first-page":"566","volume":"81","author":"BA Runyon","year":"1986","unstructured":"Runyon BA, Greenblatt M, Ming RH. Hepatic hydrothorax is a relative contraindication to chest tube insertion. Am J Gastroenterol. 1986;81:566\u2013567.","journal-title":"Am J Gastroenterol"},{"key":"6677_CR5","doi-asserted-by":"publisher","first-page":"3321","DOI":"10.1007\/s10620-016-4260-9","volume":"61","author":"F Hou","year":"2016","unstructured":"Hou F, Qi X, Guo X. Effectiveness and safety of pleurodesis for hepatic hydrothorax: a systematic review and meta-analysis. Dig Dis Sci. 2016;61:3321\u20133334. https:\/\/doi.org\/10.1007\/s10620-016-4260-9.","journal-title":"Dig Dis Sci"},{"key":"6677_CR6","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1002\/hep.510250611","volume":"25","author":"FD Gordon","year":"1997","unstructured":"Gordon FD, Anastopoulos HT, Crenshaw W, et al. The successful treatment of symptomatic, refractory hepatic hydrothorax with transjugular intrahepatic portosystemic shunt. Hepatology. 1997;25:1366\u20131369.","journal-title":"Hepatology"},{"key":"6677_CR7","doi-asserted-by":"publisher","first-page":"2164","DOI":"10.1111\/liv.14200","volume":"39","author":"A Jindal","year":"2019","unstructured":"Jindal A, Mukund A, Kumar G, et al. Efficacy and safety of transjugular intrahepatic portosystemic shunt in difficult-to-manage hydrothorax in cirrhosis. Liver Int. 2019;39:2164\u20132173.","journal-title":"Liver Int"},{"key":"6677_CR8","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1111\/jgh.14842","volume":"35","author":"LA Sobotka","year":"2020","unstructured":"Sobotka LA, Spitzer C, Hinton A, et al. Management of hepatic hydrothorax and effect on length of stay, mortality, cost, and 30-day hospital readmission. J Gastroenterol Hepatol. 2020;35:641\u2013647.","journal-title":"J Gastroenterol Hepatol"},{"key":"6677_CR9","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1002\/hep.28414","volume":"64","author":"JS Bajaj","year":"2016","unstructured":"Bajaj JS, Reddy KR, Tandon P, et al. The 3-month readmission rate remains unacceptably high in a large North American cohort of patients with cirrhosis. Hepatology. 2016;64:200\u2013208.","journal-title":"Hepatology"},{"key":"6677_CR10","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.1002\/hep.22853","volume":"49","author":"BA Runyon","year":"2009","unstructured":"Runyon BA, Committee APG. Management of adult patients with ascites due to cirrhosis: an update. Hepatology. 2009;49:2087\u20132107.","journal-title":"Hepatology"},{"key":"6677_CR11","doi-asserted-by":"publisher","first-page":"2367","DOI":"10.1002\/hep.29773","volume":"67","author":"JG O\u2019Leary","year":"2018","unstructured":"O\u2019Leary JG, Reddy KR, Garcia-Tsao G, et al. NACSELD acute-on-chronic liver failure (NACSELD-ACLF) score predicts 30-day survival in hospitalized patients with cirrhosis. Hepatology. 2018;67:2367\u20132374.","journal-title":"Hepatology"},{"key":"6677_CR12","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1002\/hep.27077","volume":"60","author":"JS Bajaj","year":"2014","unstructured":"Bajaj JS, O\u2019Leary JG, Reddy KR, et al. Survival in infection-related acute-on-chronic liver failure is defined by extrahepatic organ failures. Hepatology. 2014;60:250\u2013256.","journal-title":"Hepatology"},{"key":"6677_CR13","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1097\/MEG.0000000000001628","volume":"32","author":"CJ Steib","year":"2020","unstructured":"Steib CJ, Li H, Zhang J, et al. Transjugular intrahepatic portosystemic shunt for patients with liver cirrhosis: survey evaluating indications, standardization of procedures and anticoagulation in 43 German hospitals. Eur J Gastroenterol Hepatol. 2020;32:1179\u20131185.","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"6677_CR14","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/S0002-9343(01)00744-6","volume":"111","author":"X Xiol","year":"2001","unstructured":"Xiol X, Castellote J, Cortes-Beut R, et al. Usefulness and complications of thoracentesis in cirrhotic patients. Am J Med. 2001;111:67\u201369.","journal-title":"Am J Med"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-020-06677-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10620-020-06677-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-020-06677-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,18]],"date-time":"2021-09-18T14:15:15Z","timestamp":1631974515000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10620-020-06677-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,13]]},"references-count":14,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["6677"],"URL":"https:\/\/doi.org\/10.1007\/s10620-020-06677-6","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,13]]},"assertion":[{"value":"11 June 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 October 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 November 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}