{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T21:02:05Z","timestamp":1791061325099,"version":"4.1.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T00:00:00Z","timestamp":1616457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T00:00:00Z","timestamp":1616457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1007\/s10620-021-06938-y","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T06:03:29Z","timestamp":1616479409000},"page":"1222-1230","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Cost-Effectiveness of Empirical Bismuth-Based Quadruple Therapy and Tailored Therapy After Clarithromycin Resistance Tests for Helicobacter pylori Eradication"],"prefix":"10.1007","volume":"67","author":[{"given":"Young Woon","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga Young","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5383-7934","authenticated-orcid":false,"given":"Jung-Wook","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Chang","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Jee","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi Hyuk","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Young","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,23]]},"reference":[{"key":"6938_CR1","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1038\/ajg.2016.563","volume":"112","author":"WD Chey","year":"2017","unstructured":"Chey WD, Leontiadis GI, Howden CW, Moss SF. ACG clinical guideline: treatment of helicobacter pylori infection. Am J Gastroenterol. 2017;112:212\u2013239","journal-title":"Am J Gastroenterol."},{"key":"6938_CR2","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1056\/NEJMcp1001110","volume":"362","author":"KE McColl","year":"2010","unstructured":"McColl KE. Clinical practice Helicobacter pylori infection. N Engl J Med. 2010;362:1597\u20131604","journal-title":"N Engl J Med."},{"key":"6938_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.7704\/kjhugr.2011.11.1.1","volume":"11","author":"YS Kim","year":"2011","unstructured":"Kim YS, Baik GH. Epidemiology of Helicobacter pylori infection in Korea. Korean J Helicobacter Up Gastrointest Res. 2011;11:1\u20136","journal-title":"Korean J Helicobacter Up Gastrointest Res."},{"key":"6938_CR4","doi-asserted-by":"publisher","first-page":"11","DOI":"10.4143\/crt.2012.44.1.11","volume":"44","author":"KW Jung","year":"2012","unstructured":"Jung KW, Park S, Kong HJ et al. Cancer statistics in Korea: incidence, mortality, survival, and prevalence in 2009. Cancer Res Treat. 2012;44:11\u201324","journal-title":"Cancer Res Treat."},{"key":"6938_CR5","doi-asserted-by":"publisher","first-page":"368","DOI":"10.4166\/kjg.2010.55.6.368","volume":"55","author":"DK Cho","year":"2010","unstructured":"Cho DK, Park SY, Kee WJ et al. The trend of eradication rate of Helicobacter pylori infection and clinical factors that affect the eradication of first-line therapy. Korean J Gastroenterol. 2010;55:368\u2013375","journal-title":"Korean J Gastroenterol."},{"key":"6938_CR6","first-page":"156","volume":"48","author":"YS Choi","year":"2006","unstructured":"Choi YS, Cheon JH, Lee JY et al. The trend of eradication rates of first-line triple therapy for Helicobacter pylori infection: single center experience for recent eight years. Korean J Gastroenterol. 2006;48:156\u2013161","journal-title":"Korean J Gastroenterol."},{"key":"6938_CR7","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.3346\/jkms.2016.31.8.1246","volume":"31","author":"BJ Kim","year":"2016","unstructured":"Kim BJ, Kim HS, Song HJ et al. Online registry for nationwide database of current trend of helicobacter pylori eradication in Korea: interim analysis. J Korean Med Sci. 2016;31:1246\u20131253","journal-title":"J Korean Med Sci."},{"key":"6938_CR8","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1136\/gut.2009.192757","volume":"59","author":"DY Graham","year":"2010","unstructured":"Graham DY, Fischbach L. Helicobacter pylori treatment in the era of increasing antibiotic resistance. Gut. 2010;59:1143\u20131153","journal-title":"Gut."},{"key":"6938_CR9","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1007\/s00535-002-1079-2","volume":"38","author":"CS Eun","year":"2003","unstructured":"Eun CS, Han DS, Park JY et al. Changing pattern of antimicrobial resistance of Helicobacter pylori in Korean patients with peptic ulcer diseases. J Gastroenterol. 2003;38:436\u2013441","journal-title":"J Gastroenterol."},{"key":"6938_CR10","first-page":"356","volume":"50","author":"SY Bang","year":"2007","unstructured":"Bang SY, Han DS, Eun CS et al. Changing patterns of antibiotic resistance of Helicobacter pylori in patients with peptic ulcer disease. Korean J Gastroenterol. 2007;50:356\u2013362","journal-title":"Korean J Gastroenterol."},{"key":"6938_CR11","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1097\/MCG.0b013e3181d04592","volume":"44","author":"TJ Hwang","year":"2010","unstructured":"Hwang TJ, Kim N, Kim HB et al. Change in antibiotic resistance of Helicobacter pylori strains and the effect of A2143G point mutation of 23S rRNA on the eradication of H. pylori in a single center of Korea. J Clin Gastroenterol. 2010;44:536\u2013543","journal-title":"J Clin Gastroenterol."},{"key":"6938_CR12","doi-asserted-by":"publisher","first-page":"e12660","DOI":"10.1111\/hel.12660","volume":"24","author":"JY Lee","year":"2019","unstructured":"Lee JY, Kim N, Nam RH, In Choi S, Lee JW, Lee DH. Primary and secondary antibiotic resistance of Helicobacter pylori in Korea from 2003 to 2018. Helicobacter. 2019;24:e12660","journal-title":"Helicobacter."},{"key":"6938_CR13","doi-asserted-by":"publisher","first-page":"704","DOI":"10.3346\/jkms.2014.29.5.704","volume":"29","author":"EJ Gong","year":"2014","unstructured":"Gong EJ, Yun SC, Jung HY et al. Meta-analysis of first-line triple therapy for helicobacter pylori eradication in Korea: is it time to change? J Korean Med Sci. 2014;29:704\u2013713","journal-title":"J Korean Med Sci."},{"key":"6938_CR14","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1136\/gutjnl-2016-312288","volume":"66","author":"P Malfertheiner","year":"2017","unstructured":"Malfertheiner P, Megraud F, O\u2019Morain CA et al. Management of Helicobacter pylori infection-the Maastricht V\/Florence Consensus Report. Gut. 2017;66:6\u201330","journal-title":"Gut."},{"key":"6938_CR15","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1128\/CMR.00033-06","volume":"20","author":"F Megraud","year":"2007","unstructured":"Megraud F, Lehours P. Helicobacter pylori detection and antimicrobial susceptibility testing. Clin Microbiol Rev. 2007;20:280\u2013322","journal-title":"Clin Microbiol Rev."},{"key":"6938_CR16","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1136\/gut.50.3.285","volume":"50","author":"RJ Owen","year":"2002","unstructured":"Owen RJ. Molecular testing for antibiotic resistance in Helicobacter pylori. Gut. 2002;50:285\u2013289","journal-title":"Gut."},{"key":"6938_CR17","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1111\/j.1523-5378.2009.00654.x","volume":"14","author":"HY Woo","year":"2009","unstructured":"Woo HY, Park DI, Park H et al. Dual-priming oligonucleotide-based multiplex PCR for the detection of Helicobacter pylori and determination of clarithromycin resistance with gastric biopsy specimens. Helicobacter. 2009;14:22\u201328","journal-title":"Helicobacter."},{"key":"6938_CR18","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1186\/1471-230X-11-112","volume":"11","author":"P Lehours","year":"2011","unstructured":"Lehours P, Siffre E, Megraud F. DPO multiplex PCR as an alternative to culture and susceptibility testing to detect Helicobacter pylori and its resistance to clarithromycin. BMC Gastroenterol. 2011;11:112","journal-title":"BMC Gastroenterol."},{"key":"6938_CR19","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1093\/infdis\/jit287","volume":"208","author":"HJ Lee","year":"2013","unstructured":"Lee HJ, Kim JI, Cheung DY et al. Eradication of Helicobacter pylori according to 23S ribosomal RNA point mutations associated with clarithromycin resistance. J Infect Dis. 2013;208:1123\u20131130","journal-title":"J Infect Dis."},{"key":"6938_CR20","doi-asserted-by":"publisher","first-page":"648","DOI":"10.5009\/gnl18079","volume":"12","author":"TG Gweon","year":"2018","unstructured":"Gweon TG, Kim JS, Kim BW. An Economic Modeling Study of Helicobacter pylori Eradication: Comparison of Dual Priming Oligonucleotide-Based Multiplex Polymerase Chain Reaction and Empirical Treatment. Gut Liver. 2018;12:648\u2013654","journal-title":"Gut Liver."},{"key":"6938_CR21","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1111\/jgh.14383","volume":"34","author":"JH Cho","year":"2019","unstructured":"Cho JH, Jeon SR, Kim HG, Jin SY, Park S. Cost-effectiveness of a tailored Helicobacter pylori eradication strategy based on the presence of a 23S ribosomal RNA point mutation that causes clarithromycin resistance in Korean patients. J Gastroenterol Hepatol. 2019;34:700\u2013706","journal-title":"J Gastroenterol Hepatol."},{"key":"6938_CR22","doi-asserted-by":"publisher","first-page":"6547","DOI":"10.3748\/wjg.v20.i21.6547","volume":"20","author":"WC Chung","year":"2014","unstructured":"Chung WC, Jung SH, Oh JH et al. Dual-priming oligonucleotide-based multiplex PCR using tissue samples in rapid urease test in the detection of Helicobacter pylori infection. World J Gastroenterol. 2014;20:6547\u20136553","journal-title":"World J Gastroenterol."},{"key":"6938_CR23","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1111\/j.1523-5378.2009.00718.x","volume":"14","author":"W Cai","year":"2009","unstructured":"Cai W, Zhou L, Ren W, Deng L, Yu M. Variables influencing outcome of Helicobacter pylori eradication therapy in South China. Helicobacter. 2009;14:91\u201396","journal-title":"Helicobacter."},{"key":"6938_CR24","doi-asserted-by":"publisher","first-page":"232","DOI":"10.4166\/kjg.2017.70.5.232","volume":"70","author":"JS Park","year":"2017","unstructured":"Park JS, Park JE, Oh BS et al. Trend in the Eradication Rates of Helicobacter pylori Infection Over the Last 10 Years in West Gyeonggi-do, Korea: A Single Center Experience. Korean J Gastroenterol. 2017;70:232\u2013238","journal-title":"Korean J Gastroenterol."},{"key":"6938_CR25","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.3904\/kjim.2018.054","volume":"34","author":"YW Chang","year":"2019","unstructured":"Chang YW, Ko WJ, Oh CH et al. Clarithromycin resistance and female gender affect Helicobacter pylori eradication failure in chronic gastritis. Korean J Intern Med. 2019;34:1022\u20131029","journal-title":"Korean J Intern Med."},{"key":"6938_CR26","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1007\/BF01213292","volume":"32","author":"P Moayyedi","year":"1997","unstructured":"Moayyedi P, Chalmers DM, Axon AT. Patient factors that predict failure of omeprazole, clarithromycin, and tinidazole to eradicate Helicobacter pylori. J Gastroenterol. 1997;32:24\u201327","journal-title":"J Gastroenterol."},{"key":"6938_CR27","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1136\/gut.2003.022111","volume":"53","author":"F Megraud","year":"2004","unstructured":"Megraud F. H pylori antibiotic resistance: prevalence, importance, and advances in testing. Gut. 2004;53:1374\u20131384","journal-title":"Gut."},{"key":"6938_CR28","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1111\/j.1440-1746.2009.05982.x","volume":"24","author":"KM Fock","year":"2009","unstructured":"Fock KM, Katelaris P, Sugano K et al. Second Asia-Pacific Consensus Guidelines for Helicobacter pylori infection. J Gastroenterol Hepatol. 2009;24:1587\u20131600","journal-title":"J Gastroenterol Hepatol."},{"key":"6938_CR29","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.clinre.2015.12.012","volume":"40","author":"N Muller","year":"2016","unstructured":"Muller N, Amiot A, Le Thuaut A, Bastuji-Garin S, Deforges L, Delchier JC. Rescue therapy with bismuth-containing quadruple therapy in patients infected with metronidazole-resistant Helicobacter pylori strains. Clin Res Hepatol Gastroenterol. 2016;40:517\u2013524","journal-title":"Clin Res Hepatol Gastroenterol."},{"key":"6938_CR30","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1046\/j.1523-5378.2000.00027.x","volume":"5","author":"MW Whitehead","year":"2000","unstructured":"Whitehead MW, Phillips RH, Sieniawska CE et al. Double-blind comparison of absorbable colloidal bismuth subcitrate and nonabsorbable bismuth subnitrate in the eradication of Helicobacter pylori and the relief of nonulcer dyspepsia. Helicobacter. 2000;5:169\u2013175","journal-title":"Helicobacter."},{"key":"6938_CR31","doi-asserted-by":"publisher","first-page":"7361","DOI":"10.3748\/wjg.14.7361","volume":"14","author":"AC Ford","year":"2008","unstructured":"Ford AC, Malfertheiner P, Giguere M, Santana J, Khan M, Moayyedi P. Adverse events with bismuth salts for Helicobacter pylori eradication: systematic review and meta-analysis. World J Gastroenterol. 2008;14:7361\u20137370","journal-title":"World J Gastroenterol."},{"issue":"802\u2013807","key":"6938_CR32","first-page":"e801","volume":"11","author":"X Liang","year":"2013","unstructured":"Liang X, Xu X, Zheng Q et al. Efficacy of bismuth-containing quadruple therapies for clarithromycin-, metronidazole-, and fluoroquinolone-resistant Helicobacter pylori infections in a prospective study. Clin Gastroenterol Hepatol. 2013;11:e801","journal-title":"Clin Gastroenterol Hepatol."},{"key":"6938_CR33","doi-asserted-by":"publisher","first-page":"e12565","DOI":"10.1111\/hel.12565","volume":"24","author":"SW Ko","year":"2019","unstructured":"Ko SW, Kim YJ, Chung WC, Lee SJ. Bismuth supplements as the first-line regimen for Helicobacter pylori eradication therapy: Systemic review and meta-analysis. Helicobacter. 2019;24:e12565","journal-title":"Helicobacter."},{"key":"6938_CR34","doi-asserted-by":"publisher","first-page":"323","DOI":"10.23736\/S1121-421X.18.02465-0","volume":"64","author":"R Pellicano","year":"2018","unstructured":"Pellicano R, Ribaldone DG, Astegiano M et al. Gastroenterology today: between certainties and news. Minerva Gastroenterol Dietol. 2018;64:323\u2013332","journal-title":"Minerva Gastroenterol Dietol."},{"key":"6938_CR35","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1111\/j.1523-5378.2011.00844.x","volume":"16","author":"JW Chung","year":"2011","unstructured":"Chung JW, Lee JH, Jung HY et al. Second-line Helicobacter pylori eradication: a randomized comparison of 1-week or 2-week bismuth-containing quadruple therapy. Helicobacter. 2011;16:289\u2013294","journal-title":"Helicobacter."},{"key":"6938_CR36","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1111\/j.1523-5378.2009.00735.x","volume":"15","author":"BH Lee","year":"2010","unstructured":"Lee BH, Kim N, Hwang TJ et al. Bismuth-containing quadruple therapy as second-line treatment for Helicobacter pylori infection: effect of treatment duration and antibiotic resistance on the eradication rate in Korea. Helicobacter. 2010;15:38\u201345","journal-title":"Helicobacter."},{"key":"6938_CR37","doi-asserted-by":"publisher","first-page":"e33","DOI":"10.3346\/jkms.2020.35.e33","volume":"35","author":"TH Kim","year":"2020","unstructured":"Kim TH, Park JM, Cheung DY, Oh JH. Comparison of 7- and 14-day eradication therapy for helicobacter pylori with first- and second-line regimen: randomized clinical trial. J Korean Med Sci. 2020;35:e33","journal-title":"J Korean Med Sci."},{"key":"6938_CR38","doi-asserted-by":"publisher","first-page":"163960","DOI":"10.1155\/2015\/163960","volume":"2015","author":"GH Jheng","year":"2015","unstructured":"Jheng GH, Wu IC, Shih HY et al. Comparison of second-line quadruple therapies with or without bismuth for helicobacter pylori infection. Biomed Res Int. 2015;2015:163960","journal-title":"Biomed Res Int."},{"key":"6938_CR39","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1111\/j.1523-5378.2011.00857.x","volume":"16","author":"MP Dore","year":"2011","unstructured":"Dore MP, Farina V, Cuccu M, Mameli L, Massarelli G, Graham DY. Twice-a-day bismuth-containing quadruple therapy for Helicobacter pylori eradication: a randomized trial of 10 and 14 days. Helicobacter. 2011;16:295\u2013300","journal-title":"Helicobacter."},{"key":"6938_CR40","doi-asserted-by":"publisher","first-page":"667","DOI":"10.5152\/tjg.2019.18793","volume":"30","author":"D Ozer Etik","year":"2019","unstructured":"Ozer Etik D, Sezer S, Suna N, Oztas E, Kilic ZMY. Can the treatment duration be shortened in bismuth-containing therapies for Helicobacter pylori eradication? Turk J Gastroenterol. 2019;30:667\u2013672","journal-title":"Turk J Gastroenterol."},{"key":"6938_CR41","doi-asserted-by":"crossref","unstructured":"Graham DY. Transitioning of helicobacter pylori therapy from trial and error to antimicrobial stewardship. Antibiotics (Basel). 2020;9.","DOI":"10.3390\/antibiotics9100671"},{"key":"6938_CR42","doi-asserted-by":"publisher","first-page":"2355","DOI":"10.1016\/S0140-6736(16)31409-X","volume":"388","author":"JM Liou","year":"2016","unstructured":"Liou JM, Fang YJ, Chen CC et al. Concomitant, bismuth quadruple, and 14-day triple therapy in the first-line treatment of Helicobacter pylori: a multicentre, open-label, randomised trial. Lancet. 2016;388:2355\u20132365","journal-title":"Lancet."},{"key":"6938_CR43","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1038\/ajg.2009.508","volume":"105","author":"J Luther","year":"2010","unstructured":"Luther J, Higgins PD, Schoenfeld PS, Moayyedi P, Vakil N, Chey WD. Empiric quadruple vs. triple therapy for primary treatment of Helicobacter pylori infection: systematic review and meta-analysis of efficacy and tolerability. Am J Gastroenterol 2010;105:65\u201373","journal-title":"Am J Gastroenterol"},{"key":"6938_CR44","doi-asserted-by":"publisher","first-page":"5669","DOI":"10.3748\/wjg.v18.i40.5669","volume":"18","author":"S Di Caro","year":"2012","unstructured":"Di Caro S, Fini L, Daoud Y et al. Levofloxacin\/amoxicillin-based schemes vs quadruple therapy for Helicobacter pylori eradication in second-line. World J Gastroenterol. 2012;18:5669\u20135678","journal-title":"World J Gastroenterol."},{"key":"6938_CR45","doi-asserted-by":"crossref","unstructured":"Park JY, Shin TS, Kim JH, Yoon HJ, Kim BJ, Kim JG. The Prevalence of Multidrug Resistance of Helicobacter pylori and Its Impact on Eradication in Korea from 2017 to 2019: A Single-Center Study. Antibiotics (Basel). 2020;9","DOI":"10.3390\/antibiotics9100646"},{"key":"6938_CR46","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.3346\/jkms.2015.30.8.1001","volume":"30","author":"SW Lee","year":"2015","unstructured":"Lee SW, Kim HJ, Kim JG. Treatment of helicobacter pylori infection in korea: a systematic review and meta-analysis. J Korean Med Sci. 2015;30:1001\u20131009","journal-title":"J Korean Med Sci."}],"updated-by":[{"DOI":"10.1007\/s10620-021-07061-8","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T00:00:00Z","timestamp":1621468800000}}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-021-06938-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10620-021-06938-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-021-06938-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:04:36Z","timestamp":1666742676000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10620-021-06938-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,23]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["6938"],"URL":"https:\/\/doi.org\/10.1007\/s10620-021-06938-y","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,23]]},"assertion":[{"value":"6 September 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 March 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 March 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 May 2021","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s10620-021-07061-8","URL":"https:\/\/doi.org\/10.1007\/s10620-021-07061-8","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declaration"}},{"value":"All authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The data that support the findings of this study are available from the corresponding author, JW Kim, upon reasonable request.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of data"}}]}}