{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:16:43Z","timestamp":1740122203412,"version":"3.37.3"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2021,6,3]],"date-time":"2021-06-03T00:00:00Z","timestamp":1622678400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,6,3]],"date-time":"2021-06-03T00:00:00Z","timestamp":1622678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003806","name":"Hokuto Foundation for Bioscience","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003806","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1007\/s10620-021-07059-2","type":"journal-article","created":{"date-parts":[[2021,6,3]],"date-time":"2021-06-03T06:24:57Z","timestamp":1622701497000},"page":"2134-2142","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["LGR5-Expressing Cells in the Healing Process of Post-ESD Ulcers in Gastric Corpus"],"prefix":"10.1007","volume":"67","author":[{"given":"Yosuke","family":"Tobe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7694-9015","authenticated-orcid":false,"given":"Takeshi","family":"Uehara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mai","family":"Iwaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihiro","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Kinugawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Kuraishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyoshi","family":"Ota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,6,3]]},"reference":[{"key":"7059_CR1","doi-asserted-by":"publisher","first-page":"11452","DOI":"10.1073\/pnas.1106083108","volume":"108","author":"KS Carmon","year":"2011","unstructured":"Carmon KS, Gong X, Lin Q, Thomas A. Liu Q R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt\/beta-catenin signaling. Proc Natl Acad Sci USA. 2011;108:11452\u201311457.","journal-title":"Proc Natl Acad Sci USA."},{"key":"7059_CR2","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1038\/nature06196","volume":"449","author":"N Barker","year":"2007","unstructured":"Barker N, van Es JH, Kuipers J et al. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature. 2007;449:1003\u20131007.","journal-title":"Nature."},{"key":"7059_CR3","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1126\/science.1224676","volume":"337","author":"AG Schepers","year":"2012","unstructured":"Schepers AG, Snippert HJ, Stange DE et al. Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas. Science. 2012;337:730\u2013735.","journal-title":"Science."},{"key":"7059_CR4","doi-asserted-by":"publisher","first-page":"35486","DOI":"10.1371\/journal.pone.0035486","volume":"7","author":"E Simon","year":"2012","unstructured":"Simon E, Petke D, Boger C et al. The spatial distribution of LGR5+ cells correlates with gastric cancer progression. PLoS ONE. 2012;7:35486.","journal-title":"PLoS ONE."},{"key":"7059_CR5","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1038\/ncb3541","volume":"19","author":"M Leushacke","year":"2017","unstructured":"Leushacke M, Tan SH, Wong A et al. Lgr5-expressing chief cells drive epithelial regeneration and cancer in the oxyntic stomach. Nat Biol. 2017;19:774\u2013786.","journal-title":"Nat Biol."},{"key":"7059_CR6","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.jcmgh.2017.02.009","volume":"4","author":"Y Hayakawa","year":"2017","unstructured":"Hayakawa Y, Fox JG. Wang TC Isthmus Stem Cells Are the Origins of Metaplasia in the Gastric Corpus. Cell Mol Gastroenterol Hepatol. 2017;4:89\u201394.","journal-title":"Cell Mol Gastroenterol Hepatol."},{"key":"7059_CR7","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1111\/pin.12707","volume":"6","author":"T Nakajima","year":"2018","unstructured":"Nakajima T, Uehara T, Kobayashi Y et al. Leucine-rich repeat-containing G-protein-coupled receptor 5 expression and clinicopathological features of colorectal neuroendocrine neoplasms. Pathol Int. 2018;6:467\u2013472.","journal-title":"Pathol Int."},{"key":"7059_CR8","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1111\/pin.12451","volume":"66","author":"T Nakajima","year":"2016","unstructured":"Nakajima T, Uehara T, Maruyama Y, Iwaya M, Kobayashi Y, Ota H. Distribution of Lgr5-positive cancer cells in intramucosal gastric signet-ring cell carcinoma. Pathol Int. 2016;66:518\u2013523.","journal-title":"Pathol Int."},{"key":"7059_CR9","doi-asserted-by":"publisher","first-page":"12353","DOI":"10.1038\/s41598-019-48787-w","volume":"9","author":"S Jolly","year":"2019","unstructured":"Jolly S, Lang V, Koelzer VH et al. Single-cell quantification of mRNA expression in the human brain. Sci Rep. 2019;9:12353.","journal-title":"Sci Rep."},{"key":"7059_CR10","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1007\/BF00430818","volume":"392","author":"B Helpap","year":"1981","unstructured":"Helpap B, Hattori T, Gedigk P. Repair of gastric ulcer. A cell kinetic study. Virchows Arch A Pathol Anat Histol. 1981;392:159\u2013170.","journal-title":"Virchows Arch A Pathol Anat Histol."},{"key":"7059_CR11","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1111\/pin.12244","volume":"65","author":"H Ota","year":"2015","unstructured":"Ota H, Yamaguchi D, Iwaya M et al. Principal cells in gastric neoplasia of fundic gland (chief cell predominant) type show characteristics of immature chief cells. Pathol Int. 2015;65:202\u2013204.","journal-title":"Pathol Int."},{"key":"7059_CR12","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1136\/gutjnl-2020-320742","volume":"70","author":"H Nienhuser","year":"2020","unstructured":"Nienhuser H, Kim W, Malagola E et al. Mist1+ gastric isthmus stem cells are regulated by Wnt5a and expand in response to injury and inflammation in mice. Gut. 2020;70:654\u2013655.","journal-title":"Gut."},{"key":"7059_CR13","doi-asserted-by":"publisher","first-page":"2318","DOI":"10.15252\/embj.201797519","volume":"36","author":"MD Radyk","year":"2017","unstructured":"Radyk MD. Mills JC A chief source of cancer and repair in stomachs. EMBO J. 2017;36:2318\u20132320.","journal-title":"EMBO J."},{"key":"7059_CR14","doi-asserted-by":"publisher","first-page":"e12578","DOI":"10.1111\/hel.12578","volume":"24","author":"HY Kuo","year":"2019","unstructured":"Kuo HY, Chang WL, Yeh YC et al. Spasmolytic polypeptide-expressing metaplasia associated with higher expressions of miR-21, 155, and 223 can be regressed by Helicobacter pylori eradication in the gastric cancer familial relatives. Helicobacter. 2019;24:e12578.","journal-title":"Helicobacter."},{"key":"7059_CR15","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1136\/gutjnl-2012-302401","volume":"62","author":"VG Weis","year":"2013","unstructured":"Weis VG, Sousa JF, LaFleur BJ et al. Heterogeneity in mouse spasmolytic polypeptide-expressing metaplasia lineages identifies markers of metaplastic progression. Gut. 2013;62:1270\u20131279.","journal-title":"Gut."},{"key":"7059_CR16","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1007\/s00428-020-02805-9","volume":"477","author":"Y Wada","year":"2020","unstructured":"Wada Y, Kushima R, Kodama M et al. Histological changes associated with pyloric and pseudopyloric metaplasia after Helicobacter pylori eradication. Virchows Arch. 2020;477:489\u2013496.","journal-title":"Virchows Arch."},{"key":"7059_CR17","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1309\/AJCPQMAO3PW4OGOF","volume":"135","author":"H Ota","year":"2011","unstructured":"Ota H, Harada O, Uehara T, Hayama M. Ishii K Aberrant expression of TFF1, TFF2, and PDX1 and their diagnostic value in lobular endocervical glandular hyperplasia. Am J Clin Pathol. 2011;135:253\u2013261.","journal-title":"Am J Clin Pathol."},{"key":"7059_CR18","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/s00428-018-2469-z","volume":"474","author":"S Asaka","year":"2019","unstructured":"Asaka S, Nakajima T, Momose M, Miyamoto T, Uehara T. Ota H Trefoil factor family 2 protein: a potential immunohistochemical marker for aiding diagnosis of lobular endocervical glandular hyperplasia and gastric-type adenocarcinoma of the uterine cervix. Virchows Arch. 2019;474:79\u201386.","journal-title":"Virchows Arch."},{"key":"7059_CR19","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/j.jcmgh.2016.05.004","volume":"2","author":"AC Engevik","year":"2016","unstructured":"Engevik AC, Feng R, Choi E et al. The development of spasmolytic polypeptide\/TFF2-expressing metaplasia (SPEM) during gastric repair is absent in the aged stomach. Cell Mol Gastroenterol Hepatol. 2016;2:605\u2013624.","journal-title":"Cell Mol Gastroenterol Hepatol."},{"key":"7059_CR20","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1002\/path.5066","volume":"245","author":"JR Goldenring","year":"2018","unstructured":"Goldenring JR, Pyloric metaplasia, . pseudopyloric metaplasia, ulcer-associated cell lineage and spasmolytic polypeptide-expressing metaplasia: reparative lineages in the gastrointestinal mucosa. J Pathol. 2018;245:132\u2013137.","journal-title":"J Pathol."},{"key":"7059_CR21","doi-asserted-by":"publisher","first-page":"G583","DOI":"10.1152\/ajpgi.00351.2017","volume":"314","author":"H Kinoshita","year":"2018","unstructured":"Kinoshita H, Hayakawa Y, Niu Z et al. Mature gastric chief cells are not required for the development of metaplasia. Am J Physiol Gastrointest Liver Physiol. 2018;314:G583\u2013G596.","journal-title":"Am J Physiol Gastrointest Liver Physiol."},{"key":"7059_CR22","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.1053\/j.gastro.2020.01.046","volume":"158","author":"M Hata","year":"2020","unstructured":"Hata M, Kinoshita H, Hayakawa Y et al. GPR30-expressing gastric chief cells do not dedifferentiate but are eliminated via PDK-dependent cell competition during development of metaplasia. Gastroenterology. 2020;158:1650-1666 e1615.","journal-title":"Gastroenterology."},{"key":"7059_CR23","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.stem.2019.07.008","volume":"25","author":"S Han","year":"2019","unstructured":"Han S, Fink J, Jorg DJ et al. Defining the identity and dynamics of adult gastric isthmus stem cells. Cell stem cell. 2019;25:342-356 e347.","journal-title":"Cell stem cell."},{"key":"7059_CR24","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1038\/s41556-019-0339-9","volume":"21","author":"M Sigal","year":"2019","unstructured":"Sigal M, Reines MDM, Mullerke S et al. R-spondin-3 induces secretory, antimicrobial Lgr5(+) cells in the stomach. Nat Cell Biol. 2019;21:812\u2013823.","journal-title":"Nat Cell Biol."},{"key":"7059_CR25","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1097\/PAS.0b013e3181d94d53","volume":"34","author":"H Ueyama","year":"2010","unstructured":"Ueyama H, Yao T, Nakashima Y et al. Gastric adenocarcinoma of fundic gland type (chief cell predominant type): proposal for a new entity of gastric adenocarcinoma. Am J Surg Pathol. 2010;34:609\u2013619.","journal-title":"Am J Surg Pathol."}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-021-07059-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10620-021-07059-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-021-07059-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,4]],"date-time":"2022-06-04T16:11:30Z","timestamp":1654359090000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10620-021-07059-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,3]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["7059"],"URL":"https:\/\/doi.org\/10.1007\/s10620-021-07059-2","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"type":"print","value":"0163-2116"},{"type":"electronic","value":"1573-2568"}],"subject":[],"published":{"date-parts":[[2021,6,3]]},"assertion":[{"value":"17 August 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 May 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors state there are no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}