{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T03:03:29Z","timestamp":1783479809812,"version":"3.55.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T00:00:00Z","timestamp":1634774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T00:00:00Z","timestamp":1634774400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004484","name":"Tehran University of Medical Sciences and Health Services","doi-asserted-by":"publisher","award":["99-1-209- 48299"],"award-info":[{"award-number":["99-1-209- 48299"]}],"id":[{"id":"10.13039\/501100004484","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1007\/s10620-021-07258-x","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T13:03:48Z","timestamp":1634821428000},"page":"3672-3682","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Anti-inflammatory Effects of Ivermectin in the Treatment of\u00a0Acetic Acid-Induced Colitis in Rats: Involvement of GABAB Receptors"],"prefix":"10.1007","volume":"67","author":[{"given":"Armin","family":"Aryannejad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammadreza","family":"Tabary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nafise","family":"Noroozi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baharnaz","family":"Mashinchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Setare","family":"Iranshahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Mohammad","family":"Tavangar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Razieh","family":"Mohammad Jafari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Rashidian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8001-5565","authenticated-orcid":false,"given":"Ahmad Reza","family":"Dehpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,21]]},"reference":[{"issue":"1","key":"7258_CR1","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1053\/j.gastro.2011.10.001","volume":"142","author":"NA Molodecky","year":"2012","unstructured":"Molodecky NA, Soon S, Rabi DM, Ghali WA, Ferris M, Chernoff G, Benchimol EI, Panaccione R, Ghosh S, Barkema HW. Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review. Gastroenterology 2012;142:46-54.e42.","journal-title":"Gastroenterology"},{"issue":"3","key":"7258_CR2","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1111\/j.1472-8206.2011.01016.x","volume":"27","author":"S Tasdemir","year":"2013","unstructured":"Tasdemir S, Parlakpinar H, Vardi N, Kaya E, Acet A. Effect of endogen-exogenous melatonin and erythropoietin on dinitrobenzene sulfonic acid\u2013induced colitis. Fundam Clin Pharmacol 2013;27:299\u2013307.","journal-title":"Fundam Clin Pharmacol"},{"issue":"7152","key":"7258_CR3","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1038\/nature06005","volume":"448","author":"R Xavier","year":"2007","unstructured":"Xavier R, Podolsky D. Unravelling the pathogenesis of inflammatory bowel disease. Nature 2007;448:427\u2013434.","journal-title":"Nature"},{"issue":"13","key":"7258_CR4","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1056\/NEJM199109263251306","volume":"325","author":"DK Podolsky","year":"1991","unstructured":"Podolsky DK. Inflammatory bowel disease. N Engl J Med 1991;325:928\u2013937.","journal-title":"N Engl J Med"},{"issue":"6","key":"7258_CR5","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1016\/j.coph.2011.09.013","volume":"11","author":"G Monteleone","year":"2011","unstructured":"Monteleone G, Pallone F, MacDonald TT. Emerging immunological targets in inflammatory bowel disease. Curr Opin Pharmacol 2011;11:640\u2013645.","journal-title":"Curr Opin Pharmacol"},{"issue":"1","key":"7258_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.clim.2009.02.006","volume":"132","author":"NA Braus","year":"2009","unstructured":"Braus NA, Elliott DE. Advances in the pathogenesis and treatment of IBD. Clin Immunol 2009;132:1\u20139.","journal-title":"Clin Immunol"},{"issue":"9573","key":"7258_CR7","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1016\/S0140-6736(07)60751-X","volume":"369","author":"DC Baumgart","year":"2007","unstructured":"Baumgart DC, Sandborn WJ. Inflammatory bowel disease: clinical aspects and established and evolving therapies. The Lancet 2007;369:1641\u20131657.","journal-title":"The Lancet"},{"key":"7258_CR8","doi-asserted-by":"crossref","unstructured":"Dejban P, Sahraei M, Chamanara M, Dehpour A, Rashidian A. Anti-inflammatory effect of amitriptyline in a rat model of acetic acid-induced colitis: the involvement of the TLR4\/NF-kB signaling pathway. Fundam Clin Pharmacol. 2020.","DOI":"10.1111\/fcp.12642"},{"key":"7258_CR9","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-021-06357-2","author":"A Motavallian","year":"2021","unstructured":"Motavallian A, Bouzari S, Zamani E, Karimian P, Dabirian S, Molavi M, Torshkooh FA. An investigation of the anti-inflammatory effects of gabapentin on acetic acid-induced colitis in rats. Mol Biol Rep. 2021. https:\/\/doi.org\/10.1007\/s11033-021-06357-2.","journal-title":"Mol Biol Rep"},{"key":"7258_CR10","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/j.jss.2020.09.010","volume":"259","author":"M Tabary","year":"2021","unstructured":"Tabary M, Aryannejad A, Noroozi N, Tavangar SM, Jafari RM, Araghi F, Dadkhahfar S, Dehpour AR. Ivermectin increases random-pattern skin flap survival in rats: the novel role of GABAergic system. J Surg Res 2021;259:431\u2013441.","journal-title":"J Surg Res"},{"issue":"10","key":"7258_CR11","doi-asserted-by":"publisher","first-page":"2768","DOI":"10.1007\/s10620-017-4662-3","volume":"62","author":"S Aggarwal","year":"2017","unstructured":"Aggarwal S, Ahuja V, Paul J. Attenuated GABAergic signaling in intestinal epithelium contributes to pathogenesis of ulcerative colitis. Dig Dis Sci 2017;62:2768\u20132779. https:\/\/doi.org\/10.1007\/s10620-017-4662-3.","journal-title":"Dig Dis Sci"},{"issue":"6","key":"7258_CR12","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1007\/s00011-011-0307-8","volume":"60","author":"S Yan","year":"2011","unstructured":"Yan S, Ci X, Chen N, Chen C, Li X, Chu X, Li J, Deng X. Anti-inflammatory effects of ivermectin in mouse model of allergic asthma. Inflam Res 2011;60:589\u2013596.","journal-title":"Inflam Res"},{"key":"7258_CR13","unstructured":"Risks NIoHOfPfR, Association AREN. Institutional Animal Care and Use Committee Guidebook. vol 92. US Department of Health and Human Services, Public Health Service, National. 1992."},{"issue":"2","key":"7258_CR14","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s10787-016-0263-6","volume":"24","author":"A Rashidian","year":"2016","unstructured":"Rashidian A, Muhammadnejad A, Dehpour A-R, Mehr SE, Akhavan MM, Shirkoohi R, Chamanara M, Mousavi S-E, Rezayat S-M. Atorvastatin attenuates TNBS-induced rat colitis: the involvement of the TLR4\/NF-kB signaling pathway. Inflammopharmacology 2016;24:109\u2013118.","journal-title":"Inflammopharmacology"},{"issue":"30","key":"7258_CR15","first-page":"2020","volume":"2013","author":"W Underwood","year":"2020","unstructured":"Underwood W, Anthony R. AVMA guidelines for the euthanasia of animals. Retrieved March 2020;2013:2020\u20132021.","journal-title":"Retrieved March"},{"key":"7258_CR16","doi-asserted-by":"crossref","first-page":"351","DOI":"10.33549\/physiolres.930513","volume":"53","author":"M Franek","year":"2004","unstructured":"Franek M, Vaculin S, Rokyta R. GABA~ B receptor agonist baclofen has non-specific antinociceptive effect in the model of peripheral neuropathy in rat. Physiol Res 2004;53:351\u2013355.","journal-title":"Physiol Res"},{"issue":"1","key":"7258_CR17","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.cbi.2011.11.004","volume":"195","author":"a Witaicenis","year":"2012","unstructured":"Witaicenis A, Luchini AC, Hiruma-Lima CA, Felisbino SL, Garrido-Mesa N, Utrilla P, G\u00e1lvez J, di Stasi LC. Suppression of TNBS-induced colitis in rats by 4-methylesculetin, a natural coumarin: comparison with prednisolone and sulphasalazine. Chemico Biol Interact 2012;195:76\u201385.","journal-title":"Chemico Biol Interact"},{"issue":"7","key":"7258_CR18","doi-asserted-by":"publisher","first-page":"11078","DOI":"10.1002\/jcp.27944","volume":"234","author":"A Yousefi-Ahmadipour","year":"2019","unstructured":"Yousefi-Ahmadipour A, Rashidian A, Mirzaei MR, Farsinejad A, PourMohammadi-Nejad F, Ghazi-Khansari M, Ai J, Shirian S, Allahverdi A, Saremi J. Combination therapy of mesenchymal stromal cells and sulfasalazine attenuates trinitrobenzene sulfonic acid induced colitis in the rat: The S1P pathway. J Cell Physiol 2019;234:11078\u201311091.","journal-title":"J Cell Physiol"},{"issue":"6","key":"7258_CR19","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.3892\/ijmm.2016.2560","volume":"37","author":"M El-Salhy","year":"2016","unstructured":"El-Salhy M, Umezawa K. Anti-inflammatory effects of novel AP-1 and NF-\u03baB inhibitors in dextran-sulfate-sodium-induced colitis in rats. Int J Mol Med 2016;37:1457\u20131464.","journal-title":"Int J Mol Med"},{"issue":"2","key":"7258_CR20","first-page":"83","volume":"4","author":"C Deshmukh","year":"2010","unstructured":"Deshmukh C, Veeresh B, Pawar A. Protective effect of Emblica officinalis fruit extract on acetic acid induced colitis in rats. J Herbal Med Toxicol 2010;4:83\u201387.","journal-title":"J Herbal Med Toxicol"},{"issue":"2","key":"7258_CR21","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/S2095-4964(14)60011-X","volume":"12","author":"A Rashidian","year":"2014","unstructured":"Rashidian A, Mehrzadi S, Ghannadi AR, Mahzooni P, Sadr S, Minaiyan M. Protective effect of ginger volatile oil against acetic acid-induced colitis in rats: a light microscopic evaluation. J Integr Med 2014;12:115\u2013120.","journal-title":"J Integr Med"},{"issue":"3","key":"7258_CR22","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1007\/s10787-017-0409-1","volume":"26","author":"SM Rezayat","year":"2018","unstructured":"Rezayat SM, Dehpour A-R, Motamed SM, Yazdanparast M, Chamanara M, Sahebgharani M, Rashidian A. Foeniculum vulgare essential oil ameliorates acetic acid-induced colitis in rats through the inhibition of NF-kB pathway. Inflammopharmacology 2018;26:851\u2013859.","journal-title":"Inflammopharmacology"},{"issue":"2","key":"7258_CR23","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.vascn.2003.12.002","volume":"50","author":"AR Jurjus","year":"2004","unstructured":"Jurjus AR, Khoury NN, Reimund J-M. Animal models of inflammatory bowel disease. J Pharmacol Toxicol Methods 2004;50:81\u201392.","journal-title":"J Pharmacol Toxicol Methods"},{"issue":"2","key":"7258_CR24","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1080\/08923973.2019.1578973","volume":"41","author":"A Rashidian","year":"2019","unstructured":"Rashidian A, Keshavarz-Bahaghighat H, Abdollahi A, Chamanara M, Faghir-Ghanesefat H, Hoseini-Ahmadabadi M, Dehpour AR. Agmatine ameliorates acetic acid-induced colitis in rats: involvement of nitrergic system. Immunopharmacol Immunotoxicol 2019;41:242\u2013249.","journal-title":"Immunopharmacol Immunotoxicol"},{"issue":"6","key":"7258_CR25","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1080\/08923973.2019.1678635","volume":"41","author":"A Rashidian","year":"2019","unstructured":"Rashidian A, Rashki A, Abdollahi A, Haddadi N-S, Chamanara M, Mumtaz F, Dehpour AR. Dapsone reduced acetic acid-induced inflammatory response in rat colon tissue through inhibition of NF-kB signaling pathway. Immunopharmacol Immunotoxicol 2019;41:607\u2013613.","journal-title":"Immunopharmacol Immunotoxicol"},{"key":"7258_CR26","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/S0021-9258(19)50929-2","volume":"187","author":"E Roberts","year":"1950","unstructured":"Roberts E, Frankel S. \u03b3-Aminobutyric acid in brain: its formation from glutamic acid. J Biol Chem 1950;187:55\u201363.","journal-title":"J Biol Chem"},{"issue":"3","key":"7258_CR27","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1124\/pr.108.00505","volume":"60","author":"RW Olsen","year":"2008","unstructured":"Olsen RW, Sieghart W. International Union of Pharmacology. LXX. Subtypes of \u03b3-aminobutyric acidA receptors: classification on the basis of subunit composition, pharmacology, and function. Pharmacol Rev 2008;60:243\u2013260.","journal-title":"Pharmacol Rev"},{"key":"7258_CR28","doi-asserted-by":"publisher","first-page":"987","DOI":"10.3389\/fimmu.2018.00987","volume":"9","author":"X Ma","year":"2018","unstructured":"Ma X, Sun Q, Sun X, Chen D, Wei C, Yu X, Liu C, Li Y, Li J. Activation of GABAA receptors in colon epithelium exacerbates acute colitis. Front Immunol 2018;9:987.","journal-title":"Front Immunol"},{"issue":"2","key":"7258_CR29","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1254\/jphs.94.211","volume":"94","author":"Y Uezono","year":"2004","unstructured":"Uezono Y, Kaibara M, Hayashi H, Kawakami S, Enjoji A, Kanematsu T, Taniyama K. Characterization of GABAB receptor in the human colon. J Pharmacol Sci 2004;94:211\u2013213.","journal-title":"J Pharmacol Sci"},{"issue":"1","key":"7258_CR30","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/s00726-011-1193-7","volume":"45","author":"Z Jin","year":"2013","unstructured":"Jin Z, Mendu SK, Birnir B. GABA is an effective immunomodulatory molecule. Amino Acids 2013;45:87\u201394.","journal-title":"Amino Acids"},{"issue":"7","key":"7258_CR31","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1007\/s00210-014-0985-1","volume":"387","author":"A Piechota-Polanczyk","year":"2014","unstructured":"Piechota-Polanczyk A, Fichna J. The role of oxidative stress in pathogenesis and treatment of inflammatory bowel diseases. Naunyn-Schmiedeberg\u2019s Archiv Pharmacol 2014;387:605\u2013620.","journal-title":"Naunyn-Schmiedeberg's Archiv Pharmacol"},{"issue":"7","key":"7258_CR32","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1111\/j.1600-0625.2010.01076.x","volume":"19","author":"B Duthey","year":"2010","unstructured":"Duthey B, H\u00fcbner A, Diehl S, Boehncke S, Pfeffer J, Boehncke WH. Anti-inflammatory effects of the GABAB receptor agonist baclofen in allergic contact dermatitis. Exp Dermatol 2010;19:661\u2013666.","journal-title":"Exp Dermatol"},{"issue":"7","key":"7258_CR33","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1038\/nri1132","volume":"3","author":"G Bouma","year":"2003","unstructured":"Bouma G, Strober W. The immunological and genetic basis of inflammatory bowel disease. Nat Rev Immunol 2003;3:521\u2013533.","journal-title":"Nat Rev Immunol"},{"issue":"7","key":"7258_CR34","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.1023\/A:1018895500721","volume":"42","author":"S Dionne","year":"1997","unstructured":"Dionne S, Hiscott J, D\u2019agata I, Duhaime A, Seidman E. Quantitative PCR analysis of TNF-\u03b1 and IL-1\u03b2 mRNA levels in pediatric IBD mucosal biopsies. Dig Dis Sci 1997;42:1557\u20131566. https:\/\/doi.org\/10.1023\/A:1018895500721.","journal-title":"Dig Dis Sci"},{"issue":"4","key":"7258_CR35","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1038\/clpt.2011.328","volume":"91","author":"I Ord\u00e1s","year":"2012","unstructured":"Ord\u00e1s I, Mould DR, Feagan BG, Sandborn WJ. Anti-TNF monoclonal antibodies in inflammatory bowel disease: pharmacokinetics-based dosing paradigms. Clin Pharmacol Ther 2012;91:635\u2013646.","journal-title":"Clin Pharmacol Ther"},{"issue":"9","key":"7258_CR36","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1038\/nm0996-998","volume":"2","author":"MF Neurath","year":"1996","unstructured":"Neurath MF, Pettersson S, Zum B\u00fcschenfelde K-HM, Strober W. Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF\u2013\u03baB abrogates established experimental colitis in mice. Nat Med 1996;2:998\u20131004.","journal-title":"Nat Med"},{"key":"7258_CR37","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.brainresbull.2019.04.018","volume":"149","author":"F Liu","year":"2019","unstructured":"Liu F, Zhang Y-Y, Song N, Lin J, Liu M-k, Huang C-L, Zhou C, Wang H, Wang M, Shen J-F. GABAB receptor activation attenuates inflammatory orofacial pain by modulating interleukin-1\u03b2 in satellite glial cells: Role of NF-\u03baB and MAPK signaling pathways. Brain Res Bull 2019;149:240\u2013250.","journal-title":"Brain Res Bull"},{"issue":"3","key":"7258_CR38","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1038\/sj.bjp.0701887","volume":"124","author":"E Ardite","year":"1998","unstructured":"Ardite E, Panes J, Miranda M, Salas A, Elizalde J, Sans M, Arce Y, Bordas J, Fern\u00e1ndez-Checa J, Pique J. Effects of steroid treatment on activation of nuclear factor \u03baB in patients with inflammatory bowel disease. Br J Pharmacol 1998;124:431\u2013433.","journal-title":"Br J Pharmacol"},{"issue":"6","key":"7258_CR39","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1038\/onc.2009.421","volume":"29","author":"D Wang","year":"2010","unstructured":"Wang D, Dubois RN. The role of COX-2 in intestinal inflammation and colorectal cancer. Oncogene 2010;29:781\u2013788. https:\/\/doi.org\/10.1038\/onc.2009.421.","journal-title":"Oncogene"},{"issue":"4","key":"7258_CR40","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1111\/j.1365-2567.2004.01984.x","volume":"113","author":"G Kolios","year":"2004","unstructured":"Kolios G, Valatas V, Ward SG. Nitric oxide in inflammatory bowel disease: a universal messenger in an unsolved puzzle. Immunology 2004;113:427\u2013437. https:\/\/doi.org\/10.1111\/j.1365-2567.2004.01984.x.","journal-title":"Immunology"},{"issue":"5","key":"7258_CR41","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1007\/s10787-007-1603-3","volume":"15","author":"SP Dudhgaonkar","year":"2007","unstructured":"Dudhgaonkar SP, Tandan SK, Kumar D, Raviprakash V, Kataria M. Influence of simultaneous inhibition of cyclooxygenase-2 and inducible nitric oxide synthase in experimental colitis in rats. Inflammopharmacology 2007;15:188\u2013195. https:\/\/doi.org\/10.1007\/s10787-007-1603-3.","journal-title":"Inflammopharmacology"},{"key":"7258_CR42","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.amsu.2016.07.019","volume":"11","author":"E Antoniou","year":"2016","unstructured":"Antoniou E, Margonis GA, Angelou A, Pikouli A, Argiri P, Karavokyros I, Papalois A, Pikoulis E. The TNBS-induced colitis animal model: an overview. Ann Med Surg 2016;11:9\u201315.","journal-title":"Ann Med Surg"},{"issue":"5","key":"7258_CR43","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1016\/0016-5085(92)91710-L","volume":"102","author":"T Yamada","year":"1992","unstructured":"Yamada T, Marshall S, Specian RD, Grisham MB. A comparative analysis of two models of colitis in rats. Gastroenterology 1992;102:1524\u20131534.","journal-title":"Gastroenterology"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-021-07258-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10620-021-07258-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-021-07258-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T04:30:14Z","timestamp":1673584214000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10620-021-07258-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,21]]},"references-count":43,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["7258"],"URL":"https:\/\/doi.org\/10.1007\/s10620-021-07258-x","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,21]]},"assertion":[{"value":"22 June 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 September 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 October 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All experiments were carried out according to the National Institutes of Health Guide for the Care and Use of Laboratory Animals (NIH Publications No. 8523, revised in 2011). All the study protocols were also approved by the Ethics in Medical Research Committee of Tehran University of Medical Sciences (No. IR.TUMS.MEDICINE.REC.1399.135) and were therefore performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}