{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T03:54:00Z","timestamp":1782446040901,"version":"3.54.5"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T00:00:00Z","timestamp":1641427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T00:00:00Z","timestamp":1641427200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1007\/s10620-021-07318-2","type":"journal-article","created":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T21:11:51Z","timestamp":1641503511000},"page":"4492-4499","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Quantification of Interstitial Cells of Cajal in the Gastric Muscle of Patients with Gastroparesis at Per-Oral Endoscopic Pyloromyotomy: A Novel Approach for Future Research in Pathogenesis of Gastroparesis"],"prefix":"10.1007","volume":"67","author":[{"given":"Rushikesh","family":"Shah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie F.","family":"Calderon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenna E.","family":"Sanders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Mccurdy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aqsa","family":"Nasir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Massaad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengdan","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianyong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baiwen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Keilin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa","family":"Kransinskas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9931-5410","authenticated-orcid":false,"given":"Qiang","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,6]]},"reference":[{"key":"7318_CR1","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1111\/j.1365-2036.2008.03637.x","volume":"27","author":"A Patrick","year":"2008","unstructured":"Patrick A, Epstein O. Review article: gastroparesis. Aliment Pharmacol Ther 2008;27:724\u2013740.","journal-title":"Aliment Pharmacol Ther"},{"key":"7318_CR2","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1111\/j.1572-0241.2007.01658.x","volume":"103","author":"YR Wang","year":"2008","unstructured":"Wang YR, Fisher RS, Parkman HP. Gastroparesis-related hospitalizations in the United States: trends, characteristics, and outcomes, 1995\u20132004. Am J Gastroenterol 2008;103:313\u2013322.","journal-title":"Am J Gastroenterol"},{"key":"7318_CR3","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1053\/j.gastro.2008.12.047","volume":"136","author":"HK Jung","year":"2009","unstructured":"Jung HK, Choung RS, Locke GR 3rd et al. The incidence, prevalence, and outcomes of patients with gastroparesis in Olmsted County, Minnesota, from 1996 to 2006. Gastroenterology 2009;136:1225\u20131233.","journal-title":"Gastroenterology"},{"key":"7318_CR4","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.1053\/j.gastro.2004.09.055","volume":"127","author":"HP Parkman","year":"2004","unstructured":"Parkman HP, Hasler WL, Fisher RS et al. American Gastroenterological Association technical review on the diagnosis and treatment of gastroparesis. Gastroenterology 2004;127:1592\u20131622.","journal-title":"Gastroenterology"},{"key":"7318_CR5","doi-asserted-by":"crossref","unstructured":"Williams PA, Nikitina Y, Kedar A, et al. Long-term effects of gastric stimulation on gastric electrical physiology. J Gastrointest Surg 2013;17:50\u20135; discussion p 55\u20136.","DOI":"10.1007\/s11605-012-2020-5"},{"key":"7318_CR6","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1046\/j.1365-2982.1999.00164.x","volume":"11","author":"KM Sanders","year":"1999","unstructured":"Sanders KM, Ordog T, Koh SD et al. Development and plasticity of interstitial cells of Cajal. Neurogastroenterol Motil 1999;11:311\u2013338.","journal-title":"Neurogastroenterol Motil"},{"key":"7318_CR7","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1111\/j.1582-4934.2008.00352.x","volume":"12","author":"J Yin","year":"2008","unstructured":"Yin J, Chen JD. Roles of interstitial cells of Cajal in regulating gastrointestinal motility: in vitro versus in vivo studies. J Cell Mol Med 2008;12:1118\u20131129.","journal-title":"J Cell Mol Med"},{"key":"7318_CR8","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/s00441-003-0835-9","volume":"316","author":"B Mazet","year":"2004","unstructured":"Mazet B, Raynier C. Interstitial cells of Cajal in the guinea pig gastric antrum: distribution and regional density. Cell Tissue Res 2004;316:23\u201334.","journal-title":"Cell Tissue Res"},{"key":"7318_CR9","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1016\/0022-3468(95)90151-5","volume":"30","author":"JC Langer","year":"1995","unstructured":"Langer JC, Berezin I, Daniel EE. Hypertrophic pyloric stenosis: ultrastructural abnormalities of enteric nerves and the interstitial cells of Cajal. J Pediatr Surg 1995;30:1535\u20131543.","journal-title":"J Pediatr Surg"},{"key":"7318_CR10","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1136\/gut.52.7.966","volume":"52","author":"N Zarate","year":"2003","unstructured":"Zarate N, Mearin F, Wang XY et al. Severe idiopathic gastroparesis due to neuronal and interstitial cells of Cajal degeneration: pathological findings and management. Gut 2003;52:966\u2013970.","journal-title":"Gut"},{"key":"7318_CR11","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/S0022-3476(97)70106-9","volume":"131","author":"L Sigurdsson","year":"1997","unstructured":"Sigurdsson L, Flores A, Putnam PE et al. Postviral gastroparesis: presentation, treatment, and outcome. J Pediatr 1997;131:751\u2013754.","journal-title":"J Pediatr"},{"key":"7318_CR12","doi-asserted-by":"crossref","unstructured":"Rajan E, Gostout CJ, Wong Kee Song LM, et al. Innovative gastric endoscopic muscle biopsy to identify all cell types, including myenteric neurons and interstitial cells of Cajal in patients with idiopathic gastroparesis: a feasibility study (with video). Gastrointest Endosc 2016;84:512\u20137.","DOI":"10.1016\/j.gie.2016.04.029"},{"key":"7318_CR13","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.gie.2015.06.056","volume":"83","author":"MO Othman","year":"2016","unstructured":"Othman MO, Davis B, Saroseik I et al. EUS-guided FNA biopsy of the muscularis propria of the antrum in patients with gastroparesis is feasible and safe. Gastrointest Endosc 2016;83:327\u2013333.","journal-title":"Gastrointest Endosc"},{"key":"7318_CR14","doi-asserted-by":"publisher","first-page":"909","DOI":"10.3748\/wjg.v25.i8.909","volume":"25","author":"P Mekaroonkamol","year":"2019","unstructured":"Mekaroonkamol P, Shah R, Cai Q. Outcomes of per oral endoscopic pyloromyotomy in gastroparesis worldwide. World J Gastroenterol 2019;25:909\u2013922.","journal-title":"World J Gastroenterol"},{"issue":"8","key":"7318_CR15","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1111\/nmo.12854","volume":"28","author":"P Mekaroonkamol","year":"2016","unstructured":"Mekaroonkamol P, Li LY, Xu Y et al. Gastric peroral endoscopic pyloromyotomy (GPOEM) as a salvage therapy for refractory gastroparesis: a case series of different subtypes. Neurogastroenterol Motil 2016;28:1272\u20131277.","journal-title":"Neurogastroenterol Motil"},{"key":"7318_CR16","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/j.gie.2017.01.031","volume":"86","author":"S Dacha","year":"2017","unstructured":"Dacha S, Mekaroonkamol P, Li L et al. Outcomes and quality-of-life assessment after gastric per-oral endoscopic pyloromyotomy (with video). Gastrointestinal Endoscopy. 2017;86:282\u2013289.","journal-title":"Gastrointestinal Endoscopy."},{"key":"7318_CR17","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1111\/nmo.12806","volume":"28","author":"S Moraveji","year":"2016","unstructured":"Moraveji S, Bashashati M, Elhanafi S, Sunny J, Sarosiek I, Davis B, Torabi A, McCallum RW. Depleted interstitial cells of Cajal and fibrosis in the pylorus: novel features of gastroparesis. Neurogastroenterol Motil. 2016;28:1048\u20131054.","journal-title":"Neurogastroenterol Motil."},{"key":"7318_CR18","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1111\/j.1365-2982.2007.00936.x","volume":"19","author":"KM Choi","year":"2007","unstructured":"Choi KM, Gibbons SJ, Roeder JL et al. Regulation of interstitial cells of Cajal in the mouse gastric body by neuronal nitric oxide. Neurogastroenterol Motil 2007;19:585\u2013595.","journal-title":"Neurogastroenterol Motil"},{"key":"7318_CR19","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1007\/s00535-006-1909-8","volume":"41","author":"H Iwasaki","year":"2006","unstructured":"Iwasaki H, Kajimura M, Osawa S et al. A deficiency of gastric interstitial cells of Cajal accompanied by decreased expression of neuronal nitric oxide synthase and substance P in patients with type 2 diabetes mellitus. J Gastroenterol 2006;41:1076\u20131087.","journal-title":"J Gastroenterol"},{"key":"7318_CR20","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/j.1365-2982.2009.01365.x","volume":"22","author":"Z Lin","year":"2010","unstructured":"Lin Z, Sarosiek I, Forster J, Damjanov I, Hou Q et al. Association of the status of interstitial cells of Cajal and electrogastrogram parameters, gastric emptying and symptoms in patients with gastroparesis. Neurogastroenterol Motil. 2010;22:56\u201361.","journal-title":"Neurogastroenterol Motil."},{"key":"7318_CR21","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1007\/s10620-009-1071-2","volume":"55","author":"J Harberson","year":"2010","unstructured":"Harberson J, Thomas RM, Harbison SP, Parkman HP. Gastric neuromuscular pathology in gastroparesis: analysis of full-thickness antral biopsies. Dig Dis Sci. 2010;55:359\u2013370.","journal-title":"Dig Dis Sci."},{"key":"7318_CR22","doi-asserted-by":"publisher","first-page":"236","DOI":"10.3390\/gidisord2030023","volume":"2","author":"Z Gonzalez","year":"2020","unstructured":"Gonzalez Z, Sarosiek I, Bashashati M et al. Comparison of the Status of Interstitial Cells of Cajal in the Smooth Muscle of the Antrum and Pylorus in Diabetic Male and Female Patients with Severe Gastroparesis. Gastrointestinal Disorders. 2020;2:236\u201324522.","journal-title":"Gastrointestinal Disorders."},{"key":"7318_CR23","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1111\/j.1365-2982.2012.01894.x","volume":"24","author":"M Grover","year":"2012","unstructured":"Grover M, Bernard CE, Pasricha PJ et al. Clinical-histological associations in gastroparesis: results from the Gastroparesis Clinical Research Consortium. Neurogastroenterol Motil 2012;24:531\u2013539.","journal-title":"Neurogastroenterol Motil"},{"key":"7318_CR24","doi-asserted-by":"publisher","unstructured":"Chen HM, Calderon LF, Shah R, et al. Simultaneous Examination of Eosinophil Infiltration in Esophageal Mucosa and Muscle in Patients with Achalasia: Direct Biopsy of the Esophageal Muscle at Per-oral Endoscopic Myotomy. Dig Dis Sci. 2021 Jan 27 :1\u20137. doi:\u00a0https:\/\/doi.org\/10.1007\/s10620-021-06827-4 [Epub ahead of print]","DOI":"10.1007\/s10620-021-06827-4"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-021-07318-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10620-021-07318-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-021-07318-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T12:58:10Z","timestamp":1700053090000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10620-021-07318-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,6]]},"references-count":24,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["7318"],"URL":"https:\/\/doi.org\/10.1007\/s10620-021-07318-2","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,6]]},"assertion":[{"value":"7 May 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 October 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 January 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors have nothing to disclosure","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}