{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:55:27Z","timestamp":1792043727332,"version":"4.4.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T00:00:00Z","timestamp":1668556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T00:00:00Z","timestamp":1668556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the Training Fund of Chongqing Medical University","award":["PYJJ2019-04"],"award-info":[{"award-number":["PYJJ2019-04"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1007\/s10620-022-07717-z","type":"journal-article","created":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T08:33:52Z","timestamp":1668587632000},"page":"521-528","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Clinical Efficacy of Tandospirone on Functional Dyspepsia Patients with Anxiety: A Randomized, Placebo-Controlled Study"],"prefix":"10.1007","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5460-6943","authenticated-orcid":false,"given":"Lulu","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenguang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3196-5257","authenticated-orcid":false,"given":"Sai","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,16]]},"reference":[{"key":"7717_CR1","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1016\/S0140-6736(20)30469-4","volume":"396","author":"AC Ford","year":"2020","unstructured":"Ford AC, Mahadeva S, Carbone MF, Lacy BE, Talley NJ. Functional dyspepsia. Lancet 2020;396:1689\u20131702.","journal-title":"Lancet"},{"key":"7717_CR2","first-page":"84","volume":"101","author":"A Mounsey","year":"2020","unstructured":"Mounsey A, Barzin A, Rietz A. Functional Dyspepsia: Evaluation and Management. Am Fam Physician 2020;101:84\u201388.","journal-title":"Am Fam Physician"},{"key":"7717_CR3","doi-asserted-by":"publisher","first-page":"320","DOI":"10.5056\/jnm14165","volume":"21","author":"T Oshima","year":"2015","unstructured":"Oshima T, Miwa H. Epidemiology of Functional Gastrointestinal Disorders in Japan and in the World. J Neurogastroenterol Motil 2015;21:320\u2013329.","journal-title":"J Neurogastroenterol Motil"},{"key":"7717_CR4","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.1016\/j.cgh.2015.03.032","volume":"13","author":"HG Ly","year":"2015","unstructured":"Ly HG, Weltens N, Tack J, Van Oudenhove L. Acute Anxiety and Anxiety Disorders Are Associated With Impaired Gastric Accommodation in Patients With Functional Dyspepsia. Clin Gastroenterol Hepatol 2015;13:1584-1591.e3.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"7717_CR5","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1038\/nrgastro.2013.10","volume":"10","author":"L Van Oudenhove","year":"2013","unstructured":"Van Oudenhove L, Aziz Q. The role of psychosocial factors and psychiatric disorders in functional dyspepsia. Nat Rev Gastroenterol Hepatol 2013;10:158\u2013167.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"7717_CR6","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1053\/j.gastro.2015.01.039","volume":"148","author":"P Aro","year":"2015","unstructured":"Aro P, Talley NJ, Johansson SE, Agr\u00e9us L, Ronkainen J. Anxiety Is Linked to New-Onset Dyspepsia in the Swedish Population: A 10-Year Follow-up Study. Gastroenterology 2015;148:928\u2013937.","journal-title":"Gastroenterology"},{"key":"7717_CR7","doi-asserted-by":"publisher","first-page":"2779","DOI":"10.1038\/ajg.2009.427","volume":"104","author":"H Miwa","year":"2009","unstructured":"Miwa H, Nagahara A, Tominaga K et al. Efficacy of the 5-HT1A agonist tandospirone citrate in improving symptoms of patients with functional dyspepsia: a randomized controlled trial. Am J Gastroenterol 2009;104:2779\u20132787.","journal-title":"Am J Gastroenterol"},{"key":"7717_CR8","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1111\/j.1365-2036.2005.02472.x","volume":"21","author":"Y Kinoshita","year":"2005","unstructured":"Kinoshita Y, Hashimoto T, Kawamura A et al. Effects of famotidine, mosapride and tandospirone for treatment of functional dyspepsia. Aliment Pharmacol Ther 2005;21:37\u201341.","journal-title":"Aliment Pharmacol Ther"},{"key":"7717_CR9","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1111\/j.1365-2982.2008.01220.x","volume":"21","author":"S Kindt","year":"2009","unstructured":"Kindt S, Van Oudenhove L, Broekaert D et al. Immune dysfunction in patients with functional gastrointestinal disorders. Neurogastroenterol Motil 2009;21:389\u2013398.","journal-title":"Neurogastroenterol Motil"},{"key":"7717_CR10","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1038\/nrgastro.2016.191","volume":"14","author":"N Powell","year":"2017","unstructured":"Powell N, Walker MM, Talley NJ. The mucosal immune system: master regulator of bidirectional gut-brain communications. Nat Rev Gastroenterol Hepatol 2017;14:143\u2013159.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"7717_CR11","doi-asserted-by":"publisher","first-page":"7260130","DOI":"10.1155\/2017\/7260130","volume":"2017","author":"C Phillips","year":"2017","unstructured":"Phillips C. Brain-Derived Neurotrophic Factor, Depression, and Physical Activity: Making the Neuroplastic Connection. Neural Plast 2017;2017:7260130.","journal-title":"Neural Plast"},{"key":"7717_CR12","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.psyneuen.2010.07.013","volume":"36","author":"BA Bus","year":"2011","unstructured":"Bus BA, Molendijk ML, Penninx BJ et al. Determinants of serum brain-derived neurotrophic factor. Psychoneuroendocrinology 2011;36:228\u2013239.","journal-title":"Psychoneuroendocrinology"},{"key":"7717_CR13","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.jad.2011.06.041","volume":"135","author":"E Satomura","year":"2011","unstructured":"Satomura E, Baba H, Nakano Y, Maeshima H, Suzuki T, Arai H. Correlations between brain-derived neurotrophic factor and clinical symptoms in medicated patients with major depression. J Affect Disord 2011;135:332\u2013335.","journal-title":"J Affect Disord"},{"key":"7717_CR14","doi-asserted-by":"publisher","first-page":"e13176","DOI":"10.1111\/nmo.13176","volume":"30","author":"C Cheung","year":"2018","unstructured":"Cheung C, Lan LL, Kyaw M et al. Up-regulation of transient receptor potential vanilloid (TRPV) and down-regulation of brain-derived neurotrophic factor (BDNF) expression in patients with functional dyspepsia (FD). Neurogastroenterol Motil 2018;30:e13176.","journal-title":"Neurogastroenterol Motil"},{"key":"7717_CR15","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1038\/nrgastro.2013.14","volume":"10","author":"J Tack","year":"2013","unstructured":"Tack J, Talley NJ. Functional dyspepsia\u2013symptoms, definitions and validity of the Rome III criteria. Nat Rev Gastroenterol Hepatol 2013;10:134\u2013141.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"7717_CR16","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1111\/j.1365-2036.2005.02572.x","volume":"22","author":"B Adam","year":"2005","unstructured":"Adam B, Liebregts T, Saadat-Gilani K, Vinson B, Holtmann G. Validation of the gastrointestinal symptom score for the assessment of symptoms in patients with functional dyspepsia. Aliment Pharmacol Ther 2005;22:357\u2013363.","journal-title":"Aliment Pharmacol Ther"},{"key":"7717_CR17","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1111\/j.1572-0241.2006.01183.x","volume":"102","author":"U von Arnim","year":"2007","unstructured":"von Arnim U, Peitz U, Vinson B, Gundermann KJ, Malfertheiner P. STW 5, a phytopharmacon for patients with functional dyspepsia: results of a multicenter, placebo-controlled double-blind study. Am J Gastroenterol 2007;102:1268\u20131275.","journal-title":"Am J Gastroenterol"},{"key":"7717_CR18","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1186\/s12876-017-0675-9","volume":"17","author":"K Forssmann","year":"2017","unstructured":"Forssmann K, Meier L, Uehleke B, Breuer C, Stange R. A non-interventional, observational study of a fixed combination of pepsin and amino acid hydrochloride in patients with functional dyspepsia. BMC Gastroenterol 2017;17:123.","journal-title":"BMC Gastroenterol"},{"key":"7717_CR19","doi-asserted-by":"publisher","first-page":"e12638","DOI":"10.1097\/MD.0000000000012638","volume":"97","author":"P Hu","year":"2018","unstructured":"Hu P, Yang Q, Kong L, Hu L, Zeng L. Relationship between the anxiety\/depression and care burden of the major caregiver of stroke patients. Medicine (Baltimore) 2018;97:e12638.","journal-title":"Medicine (Baltimore)"},{"key":"7717_CR20","doi-asserted-by":"publisher","first-page":"52","DOI":"10.5056\/jnm.2010.16.1.52","volume":"16","author":"AW Tse","year":"2010","unstructured":"Tse AW, Lai LH, Lee CC et al. Validation of Self-administrated Questionnaire for Psychiatric Disorders in Patients with Functional Dyspepsia. J Neurogastroenterol Motil 2010;16:52\u201360.","journal-title":"J Neurogastroenterol Motil"},{"key":"7717_CR21","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1080\/17474124.2020.1801414","volume":"14","author":"N Koloski","year":"2020","unstructured":"Koloski N, Holtmann G, Talley NJ. Is there a causal link between psychological disorders and functional gastrointestinal disorders. Expert Rev Gastroenterol Hepatol 2020;14:1047\u20131059.","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"7717_CR22","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1016\/j.cgh.2016.12.032","volume":"15","author":"MP Jones","year":"2017","unstructured":"Jones MP, Tack J, Van Oudenhove L et al. Mood and Anxiety Disorders Precede Development of Functional Gastrointestinal Disorders in Patients but Not in the Population. Clin Gastroenterol Hepatol 2017;15:1014-1020.e4.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"7717_CR23","doi-asserted-by":"publisher","first-page":"175628481880559","DOI":"10.1177\/1756284818805597","volume":"11","author":"CJ Black","year":"2018","unstructured":"Black CJ, Houghton LA, Ford AC. Insights into the evaluation and management of dyspepsia: recent developments and new guidelines. Therap Adv Gastroenterol 2018;11:1756284818805597.","journal-title":"Therap Adv Gastroenterol"},{"key":"7717_CR24","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1007\/s00535-005-1687-8","volume":"40","author":"M Hojo","year":"2005","unstructured":"Hojo M, Miwa H, Yokoyama T et al. Treatment of functional dyspepsia with antianxiety or antidepressive agents: systematic review. J Gastroenterol 2005;40:1036\u20131042.","journal-title":"J Gastroenterol"},{"key":"7717_CR25","doi-asserted-by":"publisher","first-page":"659","DOI":"10.3389\/fpsyt.2018.00659","volume":"9","author":"N Xiong","year":"2018","unstructured":"Xiong N, Duan Y, Wei J, Mewes R, Leonhart R. Antidepressants vs. Placebo for the Treatment of Functional Gastrointestinal Disorders in Adults: A Systematic Review and Meta-Analysis. Front Psychiatry. 2018;9:659.","journal-title":"Front Psychiatry."},{"key":"7717_CR26","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/j.psyneuen.2010.08.006","volume":"36","author":"A Cubeddu","year":"2011","unstructured":"Cubeddu A, Bucci F, Giannini A et al. Brain-derived neurotrophic factor plasma variation during the different phases of the menstrual cycle in women with premenstrual syndrome. Psychoneuroendocrinology 2011;36:523\u2013530.","journal-title":"Psychoneuroendocrinology"},{"key":"7717_CR27","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1038\/mp.2010.98","volume":"16","author":"ML Molendijk","year":"2011","unstructured":"Molendijk ML, Bus BA, Spinhoven P et al. Serum levels of brain-derived neurotrophic factor in major depressive disorder: state-trait issues, clinical features and pharmacological treatment. Mol Psychiatry 2011;16:1088\u20131095.","journal-title":"Mol Psychiatry"},{"key":"7717_CR28","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/j.biopsych.2012.03.032","volume":"72","author":"KG Bath","year":"2012","unstructured":"Bath KG, Chuang J, Spencer-Segal JL et al. Variant brain-derived neurotrophic factor (Valine66Methionine) polymorphism contributes to developmental and estrous stage-specific expression of anxiety-like behavior in female mice. Biol Psychiatry 2012;72:499\u2013504.","journal-title":"Biol Psychiatry"},{"key":"7717_CR29","doi-asserted-by":"publisher","first-page":"15570","DOI":"10.1073\/pnas.0803702105","volume":"105","author":"M Bergami","year":"2008","unstructured":"Bergami M, Rimondini R, Santi S, Blum R, G\u00f6tz M, Canossa M. Deletion of TrkB in adult progenitors alters newborn neuron integration into hippocampal circuits and increases anxiety-like behavior. Proc Natl Acad Sci USA 2008;105:15570\u201315575.","journal-title":"Proc Natl Acad Sci USA"},{"key":"7717_CR30","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1080\/13651501.2020.1723642","volume":"24","author":"R Dutt","year":"2020","unstructured":"Dutt R, Shankar N, Srivastava S, Yadav A, Ahmed RS. Cardiac autonomic tone, plasma BDNF levels and paroxetine response in newly diagnosed patients of generalised anxiety disorder. Int J Psychiatry Clin Pract 2020;24:135\u2013142.","journal-title":"Int J Psychiatry Clin Pract"},{"key":"7717_CR31","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.jad.2015.07.023","volume":"186","author":"Y Wang","year":"2015","unstructured":"Wang Y, Zhang H, Li Y et al. BDNF Val66Met polymorphism and plasma levels in Chinese Han population with obsessive-compulsive disorder and generalized anxiety disorder. J Affect Disord 2015;186:7\u201312.","journal-title":"J Affect Disord"},{"key":"7717_CR32","doi-asserted-by":"publisher","first-page":"535","DOI":"10.3109\/15622975.2011.587892","volume":"13","author":"ML Molendijk","year":"2012","unstructured":"Molendijk ML, Bus BA, Spinhoven P et al. Gender specific associations of serum levels of brain-derived neurotrophic factor in anxiety. World J Biol Psychiatry 2012;13:535\u2013543.","journal-title":"World J Biol Psychiatry"},{"key":"7717_CR33","doi-asserted-by":"publisher","first-page":"e1252","DOI":"10.7717\/peerj.1252","volume":"3","author":"D Carlino","year":"2015","unstructured":"Carlino D, Francavilla R, Baj G et al. Brain-derived neurotrophic factor serum levels in genetically isolated populations: gender-specific association with anxiety disorder subtypes but not with anxiety levels or Val66Met polymorphism. PeerJ 2015;3:e1252.","journal-title":"PeerJ"},{"key":"7717_CR34","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1111\/eci.12548","volume":"45","author":"S Keely","year":"2015","unstructured":"Keely S, Walker MM, Marks E, Talley NJ. Immune dysregulation in the functional gastrointestinal disorders. Eur J Clin Invest. 2015;45:1350\u20131359.","journal-title":"Eur J Clin Invest."},{"key":"7717_CR35","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1053\/j.gastro.2009.03.039","volume":"137","author":"P Aro","year":"2009","unstructured":"Aro P, Talley NJ, Ronkainen J et al. Anxiety is associated with uninvestigated and functional dyspepsia (Rome III criteria) in a Swedish population-based study. Gastroenterology 2009;137:94\u2013100.","journal-title":"Gastroenterology"},{"key":"7717_CR36","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1136\/gutjnl-2011-300474","volume":"61","author":"NA Koloski","year":"2012","unstructured":"Koloski NA, Jones M, Kalantar J, Weltman M, Zaguirre J, Talley NJ. The brain\u2013gut pathway in functional gastrointestinal disorders is bidirectional: a 12-year prospective population-based study. Gut 2012;61:1284\u20131290.","journal-title":"Gut"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-022-07717-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10620-022-07717-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-022-07717-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T07:55:18Z","timestamp":1675842918000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10620-022-07717-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,16]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["7717"],"URL":"https:\/\/doi.org\/10.1007\/s10620-022-07717-z","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,16]]},"assertion":[{"value":"10 October 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 October 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 November 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors declare that they have no potential conflicts, including financial interests, activities, relationships, and affiliations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study protocol was approved by the local Ethical Committee of First Affiliated Hospital of Chongqing Medical University (No.20163101).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from each participant.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}