{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T19:15:44Z","timestamp":1793646944086,"version":"4.5.1"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T00:00:00Z","timestamp":1666137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T00:00:00Z","timestamp":1666137600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Medical Science and Technology Plan Projects of Zhejiang Province","award":["2017196257"],"award-info":[{"award-number":["2017196257"]}]},{"name":"Youth Foundation of Southwest Medical University","award":["0903-00031099"],"award-info":[{"award-number":["0903-00031099"]}]},{"name":"Doctoral Research Start-up Funding Project of Affiliated Hospital of Southwest Medical University","award":["16229"],"award-info":[{"award-number":["16229"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1007\/s10620-022-07720-4","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T10:02:46Z","timestamp":1666173766000},"page":"1386-1396","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Mid-Term and Long-Term Outcomes of Peroral Endoscopic Myotomy for the Treatment of Achalasia: A Systematic Review and Meta-Analysis"],"prefix":"10.1007","volume":"68","author":[{"given":"Han","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huifang","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wensen","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhan","family":"L\u00fc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6064-0526","authenticated-orcid":false,"given":"Xiaowei","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,10,19]]},"reference":[{"key":"7720_CR1","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/S0140-6736(13)60651-0","volume":"383","author":"GE Boeckxstaens","year":"2014","unstructured":"Boeckxstaens GE, Giovanni Z, Richter JE. Achalasia. Lancet 2014;383:83\u201393.","journal-title":"Lancet"},{"key":"7720_CR2","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/j.cgh.2016.05.036","volume":"15","author":"JA Duffield","year":"2017","unstructured":"Duffield JA, Hamer PW, Heddle R et al. Incidence of Achalasia in South Australia Based on Esophageal Manometry Findings. Clin Gastroenterol Hepatol 2017;15:360\u2013365.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"7720_CR3","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1038\/ajg.2013.196","volume":"108","author":"MF Vaezi","year":"2013","unstructured":"Vaezi MF, Pandolfino JE, Vela MF. ACG clinical guideline: diagnosis and management of achalasia. Am J Gastroenterol 2013;108:1238\u20131249.","journal-title":"Am J Gastroenterol"},{"key":"7720_CR4","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.1053\/j.gastro.2008.07.022","volume":"135","author":"JE Pandolfino","year":"2008","unstructured":"Pandolfino JE, Kwiatek MA, Nealis T et al. Achalasia: a new clinically relevant classification by high-resolution manometry. Gastroenterology 2008;135:1526\u20131533.","journal-title":"Gastroenterology"},{"key":"7720_CR5","doi-asserted-by":"publisher","DOI":"10.1093\/dote\/doy071","author":"G Zaninotto","year":"2018","unstructured":"Zaninotto G, Bennett C, Boeckxstaens G et al. The 2018 ISDE achalasia guidelines. Dis Esophagus. 2018. https:\/\/doi.org\/10.1093\/dote\/doy071.","journal-title":"Dis Esophagus"},{"key":"7720_CR6","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1055\/s-0029-1244080","volume":"42","author":"H Inoue","year":"2010","unstructured":"Inoue H, Minami H, Kobayashi Y et al. Peroral endoscopic myotomy (POEM) for esophageal achalasia. Endoscopy 2010;42:265\u2013271.","journal-title":"Endoscopy"},{"key":"7720_CR7","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1111\/dote.12387","volume":"29","author":"K Patel","year":"2015","unstructured":"Patel K, Abbassi-Ghadi N, Markar S et al. Peroral endoscopic myotomy for the treatment of esophageal achalasia: systematic review and pooled analysis. Dis Esophagus 2015;29:807\u2013819.","journal-title":"Dis Esophagus"},{"key":"7720_CR8","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71","volume":"372","author":"MJ Page","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 2021;372:n71.","journal-title":"BMJ"},{"key":"7720_CR9","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1007\/s10654-010-9491-z","volume":"25","author":"A Stang","year":"2010","unstructured":"Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol 2010;25:603\u2013605.","journal-title":"Eur J Epidemiol"},{"key":"7720_CR10","doi-asserted-by":"publisher","first-page":"d5928","DOI":"10.1136\/bmj.d5928","volume":"343","author":"JP Higgins","year":"2011","unstructured":"Higgins JP, Altman DG, G\u00f8tzsche PC, Cochrane Statistical Methods Group et al. The Cochrane Collaboration\u2019s tool for assessing risk of bias in randomised trials. BMJ 2011;343:d5928.","journal-title":"BMJ"},{"key":"7720_CR11","doi-asserted-by":"publisher","first-page":"1856","DOI":"10.1007\/s00464-019-06952-2","volume":"34","author":"E Shemmeri","year":"2020","unstructured":"Shemmeri E, Aye RW, Farivar AS et al. Use of a report card to evaluate outcomes of achalasia surgery: beyond the Eckardt score. Surg Endosc 2020;34:1856\u20131862.","journal-title":"Surg Endosc"},{"key":"7720_CR12","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1136\/gutjnl-2017-314722","volume":"67","author":"CP Gyawali","year":"2018","unstructured":"Gyawali CP, Kahrilas PJ, Savarino E et al. Modern diagnosis of GERD: the Lyon Consensus. Gut 2018;67:1351\u20131362.","journal-title":"Gut"},{"key":"7720_CR13","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.gie.2014.06.035","volume":"81","author":"WF Chen","year":"2015","unstructured":"Chen WF, Li QL, Zhou PH et al. Long-term outcomes of peroral endoscopic myotomy for achalasia in pediatric patients: a prospective, single-center study. Gastrointest Endosc 2015;81:91\u2013100.","journal-title":"Gastrointest Endosc"},{"key":"7720_CR14","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1093\/ejcts\/ezu320","volume":"47","author":"X Chen","year":"2015","unstructured":"Chen X, Li QP, Ji GZ et al. Two-year follow-up for 45 patients with achalasia who underwent peroral endoscopic myotomy. Eur J Cardiothorac Surg 2015;47:890\u2013896.","journal-title":"Eur J Cardiothorac Surg"},{"key":"7720_CR15","doi-asserted-by":"publisher","first-page":"2841","DOI":"10.1007\/s00464-014-4013-9","volume":"29","author":"JW Hu","year":"2015","unstructured":"Hu JW, Li QL, Zhou PH et al. Peroral endoscopic myotomy for advanced achalasia with sigmoid-shaped esophagus: long-term outcomes from a prospective, single-center study. Surg Endosc 2015;29:2841\u20132850.","journal-title":"Surg Endosc"},{"key":"7720_CR16","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1097\/SLA.0000000000001870","volume":"264","author":"ES Hungness","year":"2016","unstructured":"Hungness ES, Sternbach JM, Teitelbaum EN et al. Per-oral Endoscopic Myotomy (POEM) After the Learning Curve: Durable Long-term Results With a Low Complication Rate. Ann Surg 2016;264:508\u2013517.","journal-title":"Ann Surg"},{"key":"7720_CR17","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1136\/gutjnl-2014-308649","volume":"65","author":"YB Werner","year":"2016","unstructured":"Werner YB, Costamagna G, Swanstr\u00f6m LL et al. Clinical response to peroral endoscopic myotomy in patients with idiopathic achalasia at a minimum follow-up of 2 years. Gut 2016;65:899\u2013906.","journal-title":"Gut"},{"key":"7720_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/dote\/dow011","volume":"30","author":"H Guo","year":"2017","unstructured":"Guo H, Yang H, Zhang X et al. Long-term outcomes of peroral endoscopic myotomy for patients with achalasia: a retrospective single-center study. Dis Esophagus 2017;30:1\u20136.","journal-title":"Dis Esophagus"},{"key":"7720_CR19","doi-asserted-by":"publisher","first-page":"E331","DOI":"10.1055\/s-0043-105517","volume":"5","author":"Z Nabi","year":"2017","unstructured":"Nabi Z, Ramchandani M, Chavan R et al. Per-oral endoscopic myotomy for achalasia cardia: outcomes in over 400 consecutive patients. Endosc Int Open 2017;5:E331\u2013E339.","journal-title":"Endosc Int Open"},{"key":"7720_CR20","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1016\/j.gie.2016.09.017","volume":"85","author":"S Ngamruengphong","year":"2017","unstructured":"Ngamruengphong S, Inoue H, Chiu PW et al. Long-term outcomes of per-oral endoscopic myotomy in patients with achalasia with a minimum follow-up of 2 years: an international multicenter study. Gastrointest Endosc 2017;85:927\u2013933.","journal-title":"Gastrointest Endosc"},{"key":"7720_CR21","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1016\/j.gie.2017.10.039","volume":"87","author":"X Zhang","year":"2018","unstructured":"Zhang X, Modayil RJ, Friedel D et al. Per-oral endoscopic myotomy in patients with or without prior Heller\u2019s myotomy: comparing long-term outcomes in a large U.S. single-center cohort (with videos). Gastrointest Endosc 2018;87:972\u2013985.","journal-title":"Gastrointest Endosc"},{"key":"7720_CR22","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1007\/s11605-017-3398-x","volume":"21","author":"W Zhang","year":"2017","unstructured":"Zhang W, Linghu EQ. Peroral Endoscopic Myotomy for Type III Achalasia of Chicago Classification: Outcomes with a Minimum Follow-Up of 24 Months. J Gastrointest Surg 2017;21:785\u2013791.","journal-title":"J Gastrointest Surg"},{"key":"7720_CR23","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1016\/j.gie.2017.10.031","volume":"87","author":"QL Li","year":"2018","unstructured":"Li QL, Wu QN, Zhang XC et al. Outcomes of per-oral endoscopic myotomy for treatment of esophageal achalasia with a median follow-up of 49 months. Gastrointest Endosc 2018;87:1405\u20131412.","journal-title":"Gastrointest Endosc"},{"key":"7720_CR24","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1007\/s00464-017-5699-2","volume":"32","author":"EN Teitelbaum","year":"2018","unstructured":"Teitelbaum EN, Dunst CM, Reavis KM et al. Clinical outcomes five years after POEM for treatment of primary esophageal motility disorders. Surg Endosc 2018;32:421\u2013427.","journal-title":"Surg Endosc"},{"key":"7720_CR25","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1007\/s10620-018-5373-0","volume":"64","author":"C He","year":"2019","unstructured":"He C, Li M, Lu B et al. Long-Term Efficacy of Peroral Endoscopic Myotomy for Patients with Achalasia: Outcomes with a Median Follow-Up of 36 Months. Dig Dis Sci 2019;64:803\u2013810.","journal-title":"Dig Dis Sci"},{"key":"7720_CR26","first-page":"1","volume":"84","author":"OV Hern\u00e1ndez-Mondrag\u00f3n","year":"2019","unstructured":"Hern\u00e1ndez-Mondrag\u00f3n OV, Sol\u00f3rzano-Pineda OM, Gonz\u00e1lez-Mart\u00ednez MA et al. Peroral endoscopic myotomy for the treatment of achalasia and other esophageal motor disorders: Short-term and medium-term results at a Mexican tertiary care center. Rev Gastroenterol Mex 2019;84:1\u201310.","journal-title":"Rev Gastroenterol Mex"},{"key":"7720_CR27","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1001\/jama.2019.8859","volume":"322","author":"FA Ponds","year":"2019","unstructured":"Ponds FA, Fockens P, Lei A et al. Effect of Peroral Endoscopic Myotomy vs Pneumatic Dilation on Symptom Severity and Treatment Outcomes Among Treatment-Naive Patients With Achalasia: A Randomized Clinical Trial. JAMA 2019;322:134\u2013144.","journal-title":"JAMA"},{"key":"7720_CR28","doi-asserted-by":"publisher","first-page":"2219","DOI":"10.1056\/NEJMoa1905380","volume":"381","author":"YB Werner","year":"2019","unstructured":"Werner YB, Hakanson B, Martinek J et al. Endoscopic or Surgical Myotomy in Patients with Idiopathic Achalasia. N Engl J Med 2019;381:2219\u20132229.","journal-title":"N Engl J Med"},{"key":"7720_CR29","doi-asserted-by":"publisher","first-page":"E650","DOI":"10.1055\/a-1120-8125","volume":"8","author":"OI Brewer Gutierrez","year":"2020","unstructured":"Brewer Gutierrez OI, Moran RA et al. Long-term outcomes of per-oral endoscopic myotomy in achalasia patients with a minimum follow-up of 4 years: a multicenter study. Endosc Int Open 2020;8:E650\u2013E655.","journal-title":"Endosc Int Open"},{"key":"7720_CR30","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1016\/j.jpedsurg.2019.07.010","volume":"55","author":"Z Nabi","year":"2020","unstructured":"Nabi Z, Ramchandani M, Darisetty S et al. Impact of prior treatment on long-term outcome of peroral endoscopic myotomy in pediatric achalasia. J Pediatr Surg 2020;55:1552\u20131555.","journal-title":"J Pediatr Surg"},{"key":"7720_CR31","doi-asserted-by":"publisher","first-page":"323","DOI":"10.15403\/jgld-2676","volume":"29","author":"C Tefas","year":"2020","unstructured":"Tefas C, Boro\u0219 C, Ciobanu L et al. POEM: Five Years of Experience in a Single East European Center. J Gastrointestin Liver Dis 2020;29:323\u2013328.","journal-title":"J Gastrointestin Liver Dis"},{"key":"7720_CR32","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1097\/CM9.0000000000000735","volume":"133","author":"WG Zhang","year":"2020","unstructured":"Zhang WG, Chai NL, Zhai YQ et al. Long-term outcomes of peroral endoscopic myotomy in achalasia patients with a minimum follow-up of 7 years. Chin Med J (Engl) 2020;133:996\u2013998.","journal-title":"Chin Med J (Engl)"},{"key":"7720_CR33","doi-asserted-by":"publisher","first-page":"5709","DOI":"10.1007\/s00464-020-08031-3","volume":"35","author":"SC McKay","year":"2021","unstructured":"McKay SC, Dunst CM, Sharata AM et al. POEM: clinical outcomes beyond 5 years. Surg Endosc 2021;35:5709\u20135716.","journal-title":"Surg Endosc"},{"key":"7720_CR34","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1055\/s-0042-114426","volume":"48","author":"E Akintoye","year":"2016","unstructured":"Akintoye E, Kumar N, Obaitan I et al. Peroral endoscopic myotomy: a meta-analysis. Endoscopy 2016;48:1059\u20131068.","journal-title":"Endoscopy"},{"key":"7720_CR35","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1097\/SLE.0b013e31825a2478","volume":"22","author":"CE Weber","year":"2012","unstructured":"Weber CE, Davis CS, Kramer HJ et al. Medium and long-term outcomes after pneumatic dilation or laparoscopic Heller myotomy for achalasia: a meta-analysis. Surg Laparosc Endosc Percutan Tech 2012;22:289\u2013296.","journal-title":"Surg Laparosc Endosc Percutan Tech"},{"key":"7720_CR36","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1136\/gutjnl-2015-310602","volume":"65","author":"A Moonen","year":"2016","unstructured":"Moonen A, Annese V, Belmans A et al. Long-term results of the European achalasia trial: a multicentre randomised controlled trial comparing pneumatic dilation versus laparoscopic Heller myotomy. Gut 2016;65:732\u2013739.","journal-title":"Gut"},{"key":"7720_CR37","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1002\/bjs.11049","volume":"106","author":"C Andolfi","year":"2019","unstructured":"Andolfi C, Fisichella PM. Meta-analysis of clinical outcome after treatment for achalasia based on manometric subtypes. Br J Surg 2019;106:332\u2013341.","journal-title":"Br J Surg"},{"key":"7720_CR38","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1016\/j.gie.2017.10.022","volume":"87","author":"A Repici","year":"2018","unstructured":"Repici A, Fuccio L, Maselli R et al. GERD after per-oral endoscopic myotomy as compared with Heller\u2019s myotomy with fundoplication: a systematic review with meta-analysis. Gastrointest Endosc 2018;87:934\u2013943.","journal-title":"Gastrointest Endosc"},{"key":"7720_CR39","doi-asserted-by":"publisher","first-page":"E843","DOI":"10.1055\/a-1401-9853","volume":"9","author":"YB Perbtani","year":"2021","unstructured":"Perbtani YB, Westerveld DR, Yang DJ et al. CYP2C19 genotype variability in patients with refractory gastroesophageal reflux after per-oral endoscopic myotomy (POEM). Endosc Int Open 2021;9:E843\u2013E847.","journal-title":"Endosc Int Open"},{"key":"7720_CR40","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1016\/j.cgh.2017.11.048","volume":"16","author":"Z Liu","year":"2018","unstructured":"Liu Z, Zhang X, Zhang W et al. Comprehensive Evaluation of the Learning Curve for Peroral Endoscopic Myotomy. Clin Gastroenterol Hepatol 2018;16:1420\u20131426.","journal-title":"Clin Gastroenterol Hepatol"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-022-07720-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10620-022-07720-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-022-07720-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T07:34:57Z","timestamp":1681371297000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10620-022-07720-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,19]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["7720"],"URL":"https:\/\/doi.org\/10.1007\/s10620-022-07720-4","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,19]]},"assertion":[{"value":"18 May 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 October 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 October 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors declare that no conflict of interest relevant to this article was reported.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}