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Yuji Naito received scholarship funds from Taiyo Kagaku Co., Ltd. and from EA Pharma Co. Ltd.; a collaboration research fund from Taiyo Kagaku Co., Ltd.; and received lecture fees by Mylan EPD Co., Takeda Pharma Co. Ltd., Mochida Pharma Co. Ltd., EA Pharma Co. Ltd., Otsuka Pharma Co. Ltd., and Miyarisan Pharma Co. Ltd. The present research was partly supported by these funds. Neither the funding agency nor any outside organization has participated in the study design or has any competing interests. These companies have approved the final version of the manuscript. Osamu Dohi, Shinya Yamada, Tsugitaka Ishida, Akifumi Fukui, Ryusuke Horie, Takeshi Yasuda, Nobuhisa Yamada, Yusuke Horii, Atsushi Majima, Keika Zen, Nobuaki Yagi, and Yoshito Itoh declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was performed in accordance with the Declaration of Helsinki, and this protocol was approved by the ethics committee at each participating institution.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}