{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T14:33:51Z","timestamp":1769697231334,"version":"3.49.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T00:00:00Z","timestamp":1699488000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T00:00:00Z","timestamp":1699488000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1007\/s10620-023-08134-6","type":"journal-article","created":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T16:02:41Z","timestamp":1699545761000},"page":"275-288","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Features of Metabolite Changes in Disease Evolution in Cholecystolithiasis"],"prefix":"10.1007","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5404-7772","authenticated-orcid":false,"given":"Kun","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongzheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxuan","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuliang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,11,9]]},"reference":[{"key":"8134_CR1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0042471","volume":"7","author":"T Qiao","year":"2012","unstructured":"Qiao T et al. Cholecystolithiasis is associated with Clonorchis sinensis infection. PLoS One 2012;7:e42471.","journal-title":"PLoS One"},{"key":"8134_CR2","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1056\/NEJM198508013130501","volume":"313","author":"K Einarsson","year":"1985","unstructured":"Einarsson K et al. Influence of age on secretion of cholesterol and synthesis of bile acids by the liver. N Engl J Med 1985;313:277\u2013282.","journal-title":"N Engl J Med"},{"key":"8134_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/(SICI)1097-0096(199901)27:1<1::AID-JCU1>3.0.CO;2-H","volume":"27","author":"W Kratzer","year":"1999","unstructured":"Kratzer W, Mason RA, K\u00e4chele V. Prevalence of gallstones in sonographic surveys worldwide. J Clin Ultrasound 1999;27:1\u20137.","journal-title":"J Clin Ultrasound"},{"key":"8134_CR4","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1615\/JLongTermEffMedImplants.v15.i3.90","volume":"15","author":"BD Schirmer","year":"2005","unstructured":"Schirmer BD, Winters KL, Edlich RF. Cholelithiasis and cholecystitis. J Long Term Eff Med Implants 2005;15:329\u2013338.","journal-title":"J Long Term Eff Med Implants"},{"key":"8134_CR5","doi-asserted-by":"publisher","first-page":"593","DOI":"10.3748\/wjg.v7.i5.593","volume":"7","author":"JS Shi","year":"2001","unstructured":"Shi JS et al. Studies on gallstone in China. World J Gastroenterol 2001;7:593\u2013596.","journal-title":"World J Gastroenterol"},{"key":"8134_CR6","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1159\/000084525","volume":"71","author":"H V\u00f6lzke","year":"2005","unstructured":"V\u00f6lzke H et al. Independent risk factors for gallstone formation in a region with high cholelithiasis prevalence. Digestion 2005;71:97\u2013105.","journal-title":"Digestion"},{"key":"8134_CR7","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2021-053188","volume":"11","author":"FM Thunnissen","year":"2021","unstructured":"Thunnissen FM et al. Healthcare utilisation of patients with cholecystolithiasis in primary care: a multipractice comparative analysis. BMJ Open 2021;11:e053188.","journal-title":"BMJ Open"},{"key":"8134_CR8","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1097\/SGA.0000000000000235","volume":"39","author":"M Pak","year":"2016","unstructured":"Pak M, Lindseth G. Risk Factors for Cholelithiasis. Gastroenterol Nurs 2016;39:297\u2013309.","journal-title":"Gastroenterol Nurs"},{"key":"8134_CR9","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s00534-006-1152-y","volume":"14","author":"Y Kimura","year":"2007","unstructured":"Kimura Y et al. Definitions, pathophysiology, and epidemiology of acute cholangitis and cholecystitis: Tokyo Guidelines. J Hepatobiliary Pancreat Surg 2007;14:15\u201326.","journal-title":"J Hepatobiliary Pancreat Surg"},{"key":"8134_CR10","first-page":"148","volume":"117","author":"C Gutt","year":"2020","unstructured":"Gutt C, Schl\u00e4fer S, Lammert F. The Treatment of Gallstone Disease. Dtsch Arztebl Int 2020;117:148\u2013158.","journal-title":"Dtsch Arztebl Int"},{"key":"8134_CR11","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1111\/jgh.12241","volume":"28","author":"S Tazuma","year":"2013","unstructured":"Tazuma S et al. Nutritional factors (nutritional aspects) in biliary disorders: bile acid and lipid metabolism in gallstone diseases and pancreaticobiliary maljunction. J Gastroenterol Hepatol 2013;28:103\u2013107.","journal-title":"J Gastroenterol Hepatol"},{"key":"8134_CR12","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/S0140-6736(06)69044-2","volume":"368","author":"P Portincasa","year":"2006","unstructured":"Portincasa P, Moschetta A, Palasciano G. Cholesterol gallstone disease. Lancet 2006;368:230\u2013239.","journal-title":"Lancet"},{"key":"8134_CR13","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1194\/jlr.M700295-JLR200","volume":"49","author":"ZY Jiang","year":"2008","unstructured":"Jiang ZY et al. Increased expression of LXR alpha, ABCG5, ABCG8, and SR-BI in the liver from normolipidemic, nonobese Chinese gallstone patients. J Lipid Res 2008;49:464\u2013472.","journal-title":"J Lipid Res"},{"key":"8134_CR14","doi-asserted-by":"crossref","unstructured":"Wang, D.Q., D.E. Cohen, and M.C. Carey, Biliary lipids and cholesterol gallstone disease. J Lipid Res, 2009. 50 Suppl: p. S406\u201311.","DOI":"10.1194\/jlr.R800075-JLR200"},{"key":"8134_CR15","doi-asserted-by":"publisher","first-page":"2101","DOI":"10.1053\/j.gastro.2008.03.011","volume":"134","author":"HH Wang","year":"2008","unstructured":"Wang HH et al. Effect of ezetimibe on the prevention and dissolution of cholesterol gallstones. Gastroenterology 2008;134:2101\u20132110.","journal-title":"Gastroenterology"},{"key":"8134_CR16","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1007\/s00535-005-1702-0","volume":"40","author":"S Tazuma","year":"2005","unstructured":"Tazuma S. Homocysteine and gallstone diseases: is hyperhomocysteinemia a prerequisite for or secondary to gallstone formation? J Gastroenterol 2005;40:1085\u20131087.","journal-title":"J Gastroenterol"},{"key":"8134_CR17","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1016\/S0016-5085(79)80224-3","volume":"76","author":"JM Been","year":"1979","unstructured":"Been JM, Bills PM, Lewis D. Microstructure of gallstones. Gastroenterology 1979;76:548\u2013555.","journal-title":"Gastroenterology"},{"key":"8134_CR18","first-page":"733","volume":"77","author":"AK Srivastava","year":"1983","unstructured":"Srivastava AK, Lal K, Tandon RK. A layerwise quantitation of human cholesterol gallstone constituents. Indian J Med Res 1983;77:733\u2013738.","journal-title":"Indian J Med Res"},{"key":"8134_CR19","doi-asserted-by":"crossref","unstructured":"Maki, T., Pathogenesis of calcium bilirubinate gallstone: role of E. coli, beta-glucuronidase and coagulation by inorganic ions, polyelectrolytes and agitation. Ann Surg, 1966. 164: p. 90\u2013100.","DOI":"10.1097\/00000658-196607000-00010"},{"key":"8134_CR20","doi-asserted-by":"publisher","first-page":"413","DOI":"10.3748\/wjg.v8.i3.413","volume":"8","author":"XT Liu","year":"2002","unstructured":"Liu XT, Hu J. Relationship between bilirubin free radical and formation of pigment gallstone. World J Gastroenterol 2002;8:413\u2013417.","journal-title":"World J Gastroenterol"},{"key":"8134_CR21","first-page":"883","volume":"129","author":"J Bugajska","year":"2019","unstructured":"Bugajska J et al. Characteristics of amino acid profiles and incretin hormones in patients with gallstone disease: a pilot study. Pol Arch Intern Med 2019;129:883\u2013888.","journal-title":"Pol Arch Intern Med"},{"key":"8134_CR22","doi-asserted-by":"crossref","unstructured":"Pang, Z., et al., MetaboAnalyst 5.0: narrowing the gap between raw spectra and functional insights. Nucleic Acids Res, 2021. 49: p. W388-w396.","DOI":"10.1093\/nar\/gkab382"},{"key":"8134_CR23","unstructured":"Adler, J. and I. Parmryd, Quantifying colocalization by correlation: the Pearson correlation coefficient is superior to the Mander's overlap coefficient. (1552\u20134930 (Electronic))."},{"key":"8134_CR24","doi-asserted-by":"publisher","first-page":"2844","DOI":"10.3748\/wjg.v24.i26.2844","volume":"24","author":"RS McCain","year":"2018","unstructured":"McCain RS et al. Current practices and future prospects for the management of gallbladder polyps: A topical review. World J Gastroenterol 2018;24:2844\u20132852.","journal-title":"World J Gastroenterol"},{"key":"8134_CR25","doi-asserted-by":"publisher","first-page":"4903","DOI":"10.1007\/s00464-021-08843-x","volume":"36","author":"T Guo","year":"2022","unstructured":"Guo T et al. Surgical methods of treatment for cholecystolithiasis combined with choledocholithiasis: six years\u2019 experience of a single institution. Surg Endosc 2022;36:4903\u20134911.","journal-title":"Surg Endosc"},{"key":"8134_CR26","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1001\/archsurg.1994.01420320055010","volume":"129","author":"SM Kurzweil","year":"1994","unstructured":"Kurzweil SM et al. Hyperbilirubinemia without common bile duct abnormalities and hyperamylasemia without pancreatitis in patients with gallbladder disease. Arch Surg 1994;129:829\u2013833.","journal-title":"Arch Surg"},{"key":"8134_CR27","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1038\/nrendo.2016.98","volume":"12","author":"X Han","year":"2016","unstructured":"Han X. Lipidomics for studying metabolism. Nat Rev Endocrinol 2016;12:668\u2013679.","journal-title":"Nat Rev Endocrinol"},{"key":"8134_CR28","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1002\/jhbp.684","volume":"26","author":"T Ohigashi","year":"2019","unstructured":"Ohigashi T et al. Protective effect of phosphatidylcholine on lysophosphatidylcholine-induced cellular senescence in cholangiocyte. J Hepatobiliary Pancreat Sci 2019;26:568\u2013577.","journal-title":"J Hepatobiliary Pancreat Sci"},{"key":"8134_CR29","doi-asserted-by":"crossref","unstructured":"Sugiyama, Y., et al., Altered bile composition in the gallbladder and common bile duct of patients with anomalous pancreaticobiliary ductal junction. World J Surg, 2000. 24: p. 17\u201320; discussion 21.","DOI":"10.1007\/s002689910004"},{"key":"8134_CR30","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1002\/jhbp.20","volume":"21","author":"K Fujita","year":"2014","unstructured":"Fujita K et al. Partial characterization of proapoptotic action of biliary deteriorated lipids on biliary epithelial cells in pancreaticobiliary diseases. J Hepatobiliary Pancreat Sci 2014;21:212\u2013218.","journal-title":"J Hepatobiliary Pancreat Sci"},{"key":"8134_CR31","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1002\/jhbp.256","volume":"22","author":"R Shimizu","year":"2015","unstructured":"Shimizu R et al. Cholangiocyte senescence caused by lysophosphatidylcholine as a potential implication in carcinogenesis. J Hepatobiliary Pancreat Sci 2015;22:675\u2013682.","journal-title":"J Hepatobiliary Pancreat Sci"},{"key":"8134_CR32","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1111\/cas.12118","volume":"104","author":"N Ohtani","year":"2013","unstructured":"Ohtani N, Hara E. Roles and mechanisms of cellular senescence in regulation of tissue homeostasis. Cancer Sci 2013;104:525\u2013530.","journal-title":"Cancer Sci"},{"key":"8134_CR33","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1071\/BI9731009","volume":"26","author":"RH Holloway","year":"1973","unstructured":"Holloway RH, Heath T. Effect of oestradiol benzoate on biliary phospholipids in the rat. Aust J Biol Sci 1973;26:1009\u20131013.","journal-title":"Aust J Biol Sci"},{"key":"8134_CR34","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/0005-2760(83)90167-4","volume":"751","author":"G Mingrone","year":"1983","unstructured":"Mingrone G, Greco AV, Passi S. The possible role of free fatty acids in the pathogenesis of cholesterol gallstones in man. Biochim Biophys Acta 1983;751:138\u2013144.","journal-title":"Biochim Biophys Acta"},{"key":"8134_CR35","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1186\/s12944-021-01527-4","volume":"20","author":"Y Xiang","year":"2021","unstructured":"Xiang Y et al. Free fatty acids and triglyceride change in the gallbladder bile of gallstone patients with pancreaticobiliary reflux. Lipids Health Dis 2021;20:97.","journal-title":"Lipids Health Dis"},{"key":"8134_CR36","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/s11906-001-0021-y","volume":"3","author":"BM Egan","year":"2001","unstructured":"Egan BM, Greene EL, Goodfriend TL. Nonesterified fatty acids in blood pressure control and cardiovascular complications. Curr Hypertens Rep 2001;3:107\u2013116.","journal-title":"Curr Hypertens Rep"},{"key":"8134_CR37","doi-asserted-by":"crossref","unstructured":"Boden, G., Obesity and free fatty acids. Endocrinol Metab Clin North Am, 2008. 37: p. 635\u201346, viii-ix.","DOI":"10.1016\/j.ecl.2008.06.007"},{"key":"8134_CR38","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1172\/JCI119636","volume":"100","author":"HO Steinberg","year":"1997","unstructured":"Steinberg HO et al. Elevated circulating free fatty acid levels impair endothelium-dependent vasodilation. J Clin Invest 1997;100:1230\u20131239.","journal-title":"J Clin Invest"},{"key":"8134_CR39","doi-asserted-by":"publisher","first-page":"3098","DOI":"10.1002\/hep4.2088","volume":"6","author":"A Behrendt","year":"2022","unstructured":"Behrendt A et al. Vasor: Accurate prediction of variant effects for amino acid substitutions in multidrug resistance protein 3. Hepatol Commun 2022;6:3098\u20133111.","journal-title":"Hepatol Commun"},{"key":"8134_CR40","doi-asserted-by":"publisher","first-page":"H1160","DOI":"10.1152\/ajpheart.00114.2016","volume":"311","author":"W Wang","year":"2016","unstructured":"Wang W et al. Defective branched chain amino acid catabolism contributes to cardiac dysfunction and remodeling following myocardial infarction. Am J Physiol Heart Circ Physiol 2016;311:H1160-h1169.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"8134_CR41","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1111\/1753-0407.12645","volume":"10","author":"Z Bloomgarden","year":"2018","unstructured":"Bloomgarden Z. Diabetes and branched-chain amino acids: What is the link? J Diabetes 2018;10:350\u2013352.","journal-title":"J Diabetes"},{"key":"8134_CR42","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1097\/HCO.0000000000000552","volume":"33","author":"DK Tobias","year":"2018","unstructured":"Tobias DK et al. Altered branched chain amino acid metabolism: toward a unifying cardiometabolic hypothesis. Curr Opin Cardiol 2018;33:558\u2013564.","journal-title":"Curr Opin Cardiol"},{"key":"8134_CR43","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1152\/physrev.00041.2018","volume":"100","author":"I Kimura","year":"2020","unstructured":"Kimura I et al. Free Fatty Acid Receptors in Health and Disease. Physiol Rev 2020;100:171\u2013210.","journal-title":"Physiol Rev"},{"key":"8134_CR44","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1136\/gut.47.3.397","volume":"47","author":"JP Segain","year":"2000","unstructured":"Segain JP et al. Butyrate inhibits inflammatory responses through NFkappaB inhibition: implications for Crohn\u2019s disease. Gut 2000;47:397\u2013403.","journal-title":"Gut"},{"key":"8134_CR45","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/j.jnutbio.2011.01.007","volume":"23","author":"EL Vieira","year":"2012","unstructured":"Vieira EL et al. Oral administration of sodium butyrate attenuates inflammation and mucosal lesion in experimental acute ulcerative colitis. J Nutr Biochem 2012;23:430\u2013436.","journal-title":"J Nutr Biochem"},{"key":"8134_CR46","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111661","volume":"139","author":"R Mirzaei","year":"2021","unstructured":"Mirzaei R et al. Role of microbiota-derived short-chain fatty acids in nervous system disorders. Biomed Pharmacother 2021;139:111661.","journal-title":"Biomed Pharmacother"},{"key":"8134_CR47","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111619","volume":"139","author":"R Mirzaei","year":"2021","unstructured":"Mirzaei R et al. Role of microbiota-derived short-chain fatty acids in cancer development and prevention. Biomed Pharmacother 2021;139:111619.","journal-title":"Biomed Pharmacother"},{"key":"8134_CR48","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/cmi.2017.57","volume":"15","author":"CH Kim","year":"2018","unstructured":"Kim CH. Microbiota or short-chain fatty acids: which regulates diabetes? Cell Mol Immunol 2018;15:88\u201391.","journal-title":"Cell Mol Immunol"},{"key":"8134_CR49","doi-asserted-by":"publisher","first-page":"660","DOI":"10.5551\/jat.RV17006","volume":"24","author":"H Ohira","year":"2017","unstructured":"Ohira H, Tsutsui W, Fujioka Y. Are Short Chain Fatty Acids in Gut Microbiota Defensive Players for Inflammation and Atherosclerosis? J Atheroscler Thromb 2017;24:660\u2013672.","journal-title":"J Atheroscler Thromb"},{"key":"8134_CR50","doi-asserted-by":"publisher","first-page":"277","DOI":"10.3389\/fimmu.2019.00277","volume":"10","author":"D Parada Venegas","year":"2019","unstructured":"Parada Venegas D et al. Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases. Front Immunol 2019;10:277.","journal-title":"Front Immunol"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-023-08134-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10620-023-08134-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-023-08134-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,13]],"date-time":"2024-01-13T11:11:56Z","timestamp":1705144316000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10620-023-08134-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,9]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["8134"],"URL":"https:\/\/doi.org\/10.1007\/s10620-023-08134-6","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,9]]},"assertion":[{"value":"26 July 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 September 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 November 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}