{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T16:17:17Z","timestamp":1777825037751,"version":"3.51.4"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T00:00:00Z","timestamp":1702944000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T00:00:00Z","timestamp":1702944000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["311714\/2018-8"],"award-info":[{"award-number":["311714\/2018-8"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1007\/s10620-023-08214-7","type":"journal-article","created":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T16:02:46Z","timestamp":1703001766000},"page":"634-642","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Parental History of Type 2 Diabetes Mellitus and PNPLA3 Polymorphism Increase the Risk of Severe Stages of Nonalcoholic Fatty Liver Disease"],"prefix":"10.1007","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5780-4390","authenticated-orcid":false,"given":"Natalia Balassiano","family":"Wajsbrot","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie Carvalho","family":"Leite","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo Henrique Condeixa","family":"Franca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia Regina Lopes","family":"Cardoso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gil Fernando","family":"Salles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiane A.","family":"Villela-Nogueira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,12,19]]},"reference":[{"issue":"4","key":"8214_CR1","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1055\/s-0028-1091978","volume":"28","author":"M Lazo","year":"2008","unstructured":"Lazo M, Clark JM. The epidemiology of nonalcoholic fatty liver disease: a global perspective. Semin Liver Dis. 2008;28:339\u2013350. https:\/\/doi.org\/10.1055\/s-0028-1091978.","journal-title":"Semin Liver Dis."},{"issue":"2","key":"8214_CR2","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1002\/hep.30254","volume":"69","author":"ZM Younossi","year":"2019","unstructured":"Younossi ZM, Tampi R, Priyadarshini M, Nader F, Younossi IM, Racila A. Burden of illness and economic model for patients with nonalcoholic steatohepatitis in the United States. Hepatology. 2019;69:564\u2013572. https:\/\/doi.org\/10.1002\/hep.30254.","journal-title":"Hepatology."},{"issue":"6","key":"8214_CR3","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1016\/j.jhep.2016.07.033","volume":"65","author":"R Pais","year":"2016","unstructured":"Pais R, Barritt AS, Calmus Y et al. NAFLD and liver transplantation: current burden and expected challenges. J Hepatol. 2016;65:1245\u20131257. https:\/\/doi.org\/10.1016\/j.jhep.2016.07.033.","journal-title":"J Hepatol."},{"issue":"4","key":"8214_CR4","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1016\/j.jhep.2019.06.021","volume":"71","author":"ZM Younossi","year":"2019","unstructured":"Younossi ZM, Golabi P, de Avila L et al. The global epidemiology of NAFLD and NASH in patients with type 2 diabetes: a systematic review and meta-analysis. J Hepatol. 2019;71:793\u2013801. https:\/\/doi.org\/10.1016\/j.jhep.2019.06.021.","journal-title":"J Hepatol."},{"issue":"10","key":"8214_CR5","doi-asserted-by":"publisher","first-page":"2957","DOI":"10.1111\/j.1572-0241.2001.04667.x","volume":"96","author":"IR Willner","year":"2001","unstructured":"Willner IR, Waters B, Patil SR, Reuben A, Morelli J, Riely CA. Ninety patients with nonalcoholic steatohepatitis: insulin resistance, familial tendency, and severity of disease. Am J Gastroenterol. 2001;96:2957\u20132961. https:\/\/doi.org\/10.1111\/j.1572-0241.2001.04667.x.","journal-title":"Am J Gastroenterol."},{"issue":"1","key":"8214_CR6","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/s0002-9343(99)00315-0","volume":"108","author":"VM Struben","year":"2000","unstructured":"Struben VM, Hespenheide EE, Caldwell SH. Nonalcoholic steatohepatitis and cryptogenic cirrhosis within kindreds. Am J Med. 2000;108:9\u201313. https:\/\/doi.org\/10.1016\/s0002-9343(99)00315-0.","journal-title":"Am J Med."},{"issue":"5","key":"8214_CR7","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1053\/j.gastro.2009.01.050","volume":"136","author":"JB Schwimmer","year":"2009","unstructured":"Schwimmer JB, Celedon MA, Lavine JE et al. Heritability of nonalcoholic fatty liver disease. Gastroenterology. 2009;136:1585\u20131592. https:\/\/doi.org\/10.1053\/j.gastro.2009.01.050.","journal-title":"Gastroenterology."},{"issue":"7","key":"8214_CR8","doi-asserted-by":"publisher","first-page":"1784","DOI":"10.1053\/j.gastro.2015.08.011","volume":"149","author":"R Loomba","year":"2015","unstructured":"Loomba R, Schork N, Chen CH et al. Heritability of hepatic fibrosis and steatosis based on a prospective twin study. Gastroenterology. 2015;149:1784\u20131793. https:\/\/doi.org\/10.1053\/j.gastro.2015.08.011.","journal-title":"Gastroenterology."},{"issue":"5","key":"8214_CR9","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1002\/hep.28674","volume":"64","author":"J Cui","year":"2016","unstructured":"Cui J, Chen CH, Lo MT et al. Shared genetic effects between hepatic steatosis and fibrosis: a prospective twin study. Hepatology. 2016;64:1547\u20131558. https:\/\/doi.org\/10.1002\/hep.28674.","journal-title":"Hepatology."},{"issue":"9","key":"8214_CR10","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1111\/j.1478-3231.2011.02566.x","volume":"31","author":"JM Petit","year":"2011","unstructured":"Petit JM, Guiu B, Masson D et al. PNPLA3 polymorphism influences liver fibrosis in unselected patients with type 2 diabetes. Liver Int. 2011;31:1332\u20131336. https:\/\/doi.org\/10.1111\/j.1478-3231.2011.02566.x.","journal-title":"Liver Int."},{"issue":"9","key":"8214_CR11","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1016\/j.numecd.2019.06.002","volume":"29","author":"CM Machado","year":"2019","unstructured":"Machado CM, Leite NC, Fran\u00e7a PH, Cardoso CR, Salles GF, Villela-Nogueira CA. PNPLA3 gene polymorphism in Brazilian patients with type 2 diabetes: a prognostic marker beyond liver disease? Nutr Metab Cardiovasc Dis. 2019;29:965\u2013971. https:\/\/doi.org\/10.1016\/j.numecd.2019.06.002.","journal-title":"Nutr Metab Cardiovasc Dis."},{"issue":"12","key":"8214_CR12","doi-asserted-by":"publisher","first-page":"E430","DOI":"10.1210\/jc.2010-0814","volume":"95","author":"JM Petit","year":"2010","unstructured":"Petit JM, Guiu B, Masson D et al. Specifically PNPLA3-mediated accumulation of liver fat in obese patients with type 2 diabetes. J Clin Endocrinol Metab. 2010;95:E430\u2013E436. https:\/\/doi.org\/10.1210\/jc.2010-0814.","journal-title":"J Clin Endocrinol Metab."},{"issue":"4","key":"8214_CR13","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1038\/ng.2901","volume":"46","author":"J Kozlitina","year":"2014","unstructured":"Kozlitina J, Smagris E, Stender S et al. Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease. Nat Genet. 2014;46:352\u2013356. https:\/\/doi.org\/10.1038\/ng.2901.","journal-title":"Nat Genet."},{"issue":"2","key":"8214_CR14","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1002\/hep.27490","volume":"61","author":"P Dongiovanni","year":"2015","unstructured":"Dongiovanni P, Petta S, Maglio C et al. Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease. Hepatology. 2015;61:506\u2013514. https:\/\/doi.org\/10.1002\/hep.27490.","journal-title":"Hepatology."},{"issue":"1","key":"8214_CR15","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1002\/hep.23623","volume":"52","author":"G Musso","year":"2010","unstructured":"Musso G, Gambino R, Cassader M, Pagano G. A meta-analysis of randomized trials for the treatment of nonalcoholic fatty liver disease. Hepatology. 2010;52:79\u2013104. https:\/\/doi.org\/10.1002\/hep.23623.","journal-title":"Hepatology."},{"key":"8214_CR16","doi-asserted-by":"publisher","unstructured":"Karlas T, Petroff D, Sasso M, et al. Individual patient data meta-analysis of controlled attenuation parameter (CAP) technology for assessing steatosis. J Hepatol. 05 2017;66:1022\u20131030. https:\/\/doi.org\/10.1016\/j.jhep.2016.12.022","DOI":"10.1016\/j.jhep.2016.12.022"},{"issue":"2","key":"8214_CR17","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1002\/hep.23312","volume":"51","author":"VW Wong","year":"2010","unstructured":"Wong VW, Vergniol J, Wong GL et al. Diagnosis of fibrosis and cirrhosis using liver stiffness measurement in nonalcoholic fatty liver disease. Hepatology. 2010;51:454\u2013462. https:\/\/doi.org\/10.1002\/hep.23312.","journal-title":"Hepatology."},{"issue":"3","key":"8214_CR18","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.aohep.2018.10.004","volume":"18","author":"DF Mazo","year":"2019","unstructured":"Mazo DF, Malta FM, Stefano JT et al. Validation of PNPLA3 polymorphisms as risk factor for NAFLD and liver fibrosis in an admixed population. Ann Hepatol. 2019;18:466\u2013471. https:\/\/doi.org\/10.1016\/j.aohep.2018.10.004.","journal-title":"Ann Hepatol."},{"issue":"3","key":"8214_CR19","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1002\/hep.25772","volume":"56","author":"R Loomba","year":"2012","unstructured":"Loomba R, Abraham M, Unalp A et al. Association between diabetes, family history of diabetes, and risk of nonalcoholic steatohepatitis and fibrosis. Hepatology. 2012;56:943\u2013951. https:\/\/doi.org\/10.1002\/hep.25772.","journal-title":"Hepatology."},{"issue":"4","key":"8214_CR20","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1900\/RDS.2007.4.236","volume":"4","author":"A Adibi","year":"2007","unstructured":"Adibi A, Janghorbani M, Shayganfar S, Amini M. First-degree relatives of patients with type 2 diabetes mellitus and risk of non-alcoholic fatty liver disease. Rev Diabet Stud. 2007;4:236\u2013241. https:\/\/doi.org\/10.1900\/RDS.2007.4.236.","journal-title":"Rev Diabet Stud."},{"key":"8214_CR21","doi-asserted-by":"publisher","unstructured":"De Pergola G, Castellana F, Zupo R, et al. A family history of type 2 diabetes as a predictor of fatty liver disease in diabetes-free individuals with excessive body weight. Sci Rep. 16 2021;11:24084. https:\/\/doi.org\/10.1038\/s41598-021-03583-3","DOI":"10.1038\/s41598-021-03583-3"},{"issue":"4","key":"8214_CR22","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1111\/liv.13956","volume":"39","author":"MT Long","year":"2019","unstructured":"Long MT, Gurary EB, Massaro JM et al. Parental non-alcoholic fatty liver disease increases risk of non-alcoholic fatty liver disease in offspring. Liver Int. 2019;39:740\u2013747. https:\/\/doi.org\/10.1111\/liv.13956.","journal-title":"Liver Int."},{"issue":"25","key":"8214_CR23","doi-asserted-by":"publisher","first-page":"2890","DOI":"10.3748\/wjg.v28.i25.2890","volume":"28","author":"NB Wajsbrot","year":"2022","unstructured":"Wajsbrot NB, Leite NC, Salles GF, Villela-Nogueira CA. Non-alcoholic fatty liver disease and the impact of genetic, epigenetic and environmental factors in the offspring. World J Gastroenterol. 2022;28:2890\u20132899. https:\/\/doi.org\/10.3748\/wjg.v28.i25.2890.","journal-title":"World J Gastroenterol."},{"issue":"5","key":"8214_CR24","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1111\/j.1478-3231.2011.02482.x","volume":"31","author":"NC Leite","year":"2011","unstructured":"Leite NC, Villela-Nogueira CA, Pannain VL et al. Histopathological stages of nonalcoholic fatty liver disease in type 2 diabetes: prevalences and correlated factors. Liver Int. 2011;31:700\u2013706. https:\/\/doi.org\/10.1111\/j.1478-3231.2011.02482.x.","journal-title":"Liver Int."},{"issue":"2","key":"8214_CR25","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1017\/thg.2019.11","volume":"22","author":"AR Avery","year":"2019","unstructured":"Avery AR, Duncan GE. Heritability of Type 2 Diabetes in the Washington State Twin Registry. Twin Res Hum Genet. 2019;22:95\u201398. https:\/\/doi.org\/10.1017\/thg.2019.11.","journal-title":"Twin Res Hum Genet."},{"issue":"6","key":"8214_CR26","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1017\/thg.2015.83","volume":"18","author":"G Willemsen","year":"2015","unstructured":"Willemsen G, Ward KJ, Bell CG et al. The concordance and heritability of type 2 diabetes in 34,166 twin pairs from international twin registers: the Discordant Twin (DISCOTWIN) Consortium. Twin Res Hum Genet. 2015;18:762\u2013771. https:\/\/doi.org\/10.1017\/thg.2015.83.","journal-title":"Twin Res Hum Genet."},{"issue":"12","key":"8214_CR27","doi-asserted-by":"publisher","first-page":"2201","DOI":"10.2337\/diabetes.49.12.2201","volume":"49","author":"JB Meigs","year":"2000","unstructured":"Meigs JB, Cupples LA, Wilson PW. Parental transmission of type 2 diabetes: the Framingham Offspring Study. Diabetes. 2000;49:2201\u20132207. https:\/\/doi.org\/10.2337\/diabetes.49.12.2201.","journal-title":"Diabetes."},{"issue":"10","key":"8214_CR28","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.1007\/s00125-019-4914-1","volume":"62","author":"W Perng","year":"2019","unstructured":"Perng W, Oken E, Dabelea D. Developmental overnutrition and obesity and type 2 diabetes in offspring. Diabetologia. 2019;62:1779\u20131788. https:\/\/doi.org\/10.1007\/s00125-019-4914-1.","journal-title":"Diabetologia."},{"issue":"3","key":"8214_CR29","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.metabol.2006.10.026","volume":"56","author":"M Tesauro","year":"2007","unstructured":"Tesauro M, Rizza S, Iantorno M et al. Vascular, metabolic, and inflammatory abnormalities in normoglycemic offspring of patients with type 2 diabetes mellitus. Metabolism. 2007;56:413\u2013419. https:\/\/doi.org\/10.1016\/j.metabol.2006.10.026.","journal-title":"Metabolism."},{"issue":"3","key":"8214_CR30","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/S2468-1253(20)30357-5","volume":"6","author":"D Petroff","year":"2021","unstructured":"Petroff D, Blank V, Newsome PN et al. Assessment of hepatic steatosis by controlled attenuation parameter using the M and XL probes: an individual patient data meta-analysis. Lancet Gastroenterol Hepatol. 2021;6:185\u2013198. https:\/\/doi.org\/10.1016\/S2468-1253(20)30357-5.","journal-title":"Lancet Gastroenterol Hepatol."}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-023-08214-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10620-023-08214-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-023-08214-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T18:21:14Z","timestamp":1707762074000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10620-023-08214-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,19]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["8214"],"URL":"https:\/\/doi.org\/10.1007\/s10620-023-08214-7","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,19]]},"assertion":[{"value":"21 June 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 November 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 December 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have nothing to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}