{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T23:55:37Z","timestamp":1790639737213,"version":"4.1.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T00:00:00Z","timestamp":1707436800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T00:00:00Z","timestamp":1707436800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021A1515010990"],"award-info":[{"award-number":["2021A1515010990"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1007\/s10620-024-08278-z","type":"journal-article","created":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T10:02:12Z","timestamp":1707472932000},"page":"798-810","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Restoration of the Mucosal IgA Response by Improving CD4+ T Pyroptosis Fails to Attenuate Gut Bacterial Translocation and Organ Damage After LPS Attack"],"prefix":"10.1007","volume":"69","author":[{"given":"Zi-Meng","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-nan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu-fei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-jun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0637-3049","authenticated-orcid":false,"given":"Xu-Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,9]]},"reference":[{"key":"8278_CR1","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1097\/CCM.0000000000002074","volume":"45","author":"JC Mira","year":"2017","unstructured":"Mira JC, Gentile LF, Mathias BJ et al. Sepsis pathophysiology, chronic critical illness, and persistent inflammation-immunosuppression and catabolism syndrome. Crit Care Med. 2017;45:253\u2013262.","journal-title":"Crit Care Med"},{"key":"8278_CR2","doi-asserted-by":"publisher","first-page":"2416","DOI":"10.1007\/s10620-019-05581-y","volume":"64","author":"P Amornphimoltham","year":"2019","unstructured":"Amornphimoltham P, Yuen PST, Star RA, Leelahavanichkul A. Gut leakage of fungal-derived inflammatory mediators: part of a gut-liver-kidney axis in bacterial sepsis. Dig Dis Sci. 2019;64:2416\u20132428.","journal-title":"Dig Dis Sci."},{"key":"8278_CR3","doi-asserted-by":"publisher","first-page":"289","DOI":"10.2174\/18761038MTA5BMDIr2","volume":"15","author":"Y Longhitano","year":"2020","unstructured":"Longhitano Y, Zanza C, Thangathurai D et al. Gut alterations in septic patients: a biochemical literature review. Rev Recent Clin Trials 2020;15:289\u2013297.","journal-title":"Rev Recent Clin Trials"},{"key":"8278_CR4","doi-asserted-by":"publisher","first-page":"1873","DOI":"10.3389\/fimmu.2019.01873","volume":"10","author":"C Wang","year":"2019","unstructured":"Wang C, Li Q, Ren J. Microbiota-immune interaction in the pathogenesis of gut-derived infection. Front Immunol. 2019;10:1873.","journal-title":"Front Immunol"},{"key":"8278_CR5","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1038\/nri3322","volume":"12","author":"O Pabst","year":"2012","unstructured":"Pabst O. New concepts in the generation and functions of IgA. Nat Rev Immunol. 2012;12:821\u2013832.","journal-title":"Nat Rev Immunol"},{"key":"8278_CR6","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1177\/1535370216669610","volume":"242","author":"J Cabrera-Perez","year":"2017","unstructured":"Cabrera-Perez J, Badovinac VP, Griffith TS. Enteric immunity, the gut microbiome, and sepsis: rethinking the germ theory of disease. Exp Biol Med (Maywood). 2017;242:127\u2013139.","journal-title":"Exp Biol Med (Maywood)."},{"key":"8278_CR7","doi-asserted-by":"publisher","first-page":"78","DOI":"10.3109\/13880209.2014.910535","volume":"53","author":"I Ates","year":"2015","unstructured":"Ates I, Dogan N, Aksoy M, Hal\u0131c\u0131 Z, G\u00fcndogdu C, Keles MS. The protective effects of IgM-enriched immunoglobulin and erythropoietin on the lung and small intestine tissues of rats with induced sepsis: biochemical and histopathological evaluation. Pharm Biol. 2015;53:78\u201384.","journal-title":"Pharm Biol"},{"key":"8278_CR8","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1111\/imr.12287","volume":"265","author":"I Jorgensen","year":"2015","unstructured":"Jorgensen I, Miao EA. Pyroptotic cell death defends against intracellular pathogens. Immunol Rev. 2015;265:130\u2013142.","journal-title":"Immunol Rev"},{"key":"8278_CR9","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1159\/000371388","volume":"7","author":"PT Santana","year":"2015","unstructured":"Santana PT, Benjamim CF, Martinez CG, Kurtenbach E, Takiya CM, Coutinho-Silva R. The P2X7 receptor contributes to the development of the exacerbated inflammatory response associated with sepsis. J Innate Immun. 2015;7:417\u2013427.","journal-title":"J Innate Immun"},{"key":"8278_CR10","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1016\/j.immuni.2015.10.009","volume":"43","author":"D Yang","year":"2015","unstructured":"Yang D, He Y, Mu\u00f1oz-Planillo R, Liu Q, N\u00fa\u00f1ez G. Caspase-11 requires the Pannexin-1 channel and the Purinergic P2X7 pore to mediate pyroptosis and endotoxic shock. Immunity 2015;43:923\u2013932.","journal-title":"Immunity"},{"key":"8278_CR11","doi-asserted-by":"publisher","first-page":"110964","DOI":"10.1016\/j.intimp.2023.110964","volume":"124","author":"R Guo","year":"2023","unstructured":"Guo R, Zhao G, Bai G et al. Depletion of mTOR ameliorates CD4+ T cell pyroptosis by promoting autophagy activity in septic mice. Int Immunopharmacol. 2023;124:110964.","journal-title":"Int Immunopharmacol"},{"key":"8278_CR12","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1146\/annurev-immunol-030409-101314","volume":"28","author":"S Fagarasan","year":"2010","unstructured":"Fagarasan S, Kawamoto S, Kanagawa O, Suzuki K. Adaptive immune regulation in the gut: T cell-dependent and T cell-independent IgA synthesis. Annu Rev Immunol. 2010;28:243\u2013273.","journal-title":"Annu Rev Immunol"},{"key":"8278_CR13","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/s10620-017-4801-x","volume":"63","author":"X-Y Zhang","year":"2018","unstructured":"Zhang X-Y, Chen Xi, Zhang H-F et al. Propofol does not reduce pyroptosis of enterocytes and intestinal epithelial injury after lipopolysaccharide challenge. Dig Dis Sci. 2018;63:81\u201391.","journal-title":"Dig Dis Sci"},{"key":"8278_CR14","doi-asserted-by":"publisher","first-page":"6573","DOI":"10.3390\/ijms22126573","volume":"22","author":"E Fuc","year":"2021","unstructured":"Fuc E, Z\u0142otkowska D, Wasilewska E, Wr\u00f3blewska B. OVA-experienced CD4+ T cell transfer and chicken protein challenge affect the immune response to OVA in a murine model. Int J Mol Sci. 2021;22:6573.","journal-title":"Int J Mol Sci"},{"key":"8278_CR15","doi-asserted-by":"publisher","first-page":"1019109","DOI":"10.3389\/fphar.2022.1019109","volume":"13","author":"Z Chang","year":"2022","unstructured":"Chang Z, Zhang Y, Lin M et al. Improvement of gut-vascular barrier by terlipressin reduces bacterial translocation and remote organ injuries in gut-derived sepsis. Front Pharmacol. 2022;13:1019109.","journal-title":"Front Pharmacol"},{"key":"8278_CR16","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1111\/jcmm.12789","volume":"20","author":"X-Y Zhang","year":"2016","unstructured":"Zhang X-Y, Liu Z-M, Zhang H-F et al. TGF-\u03b21 improves mucosal IgA dysfunction and dysbiosis following intestinal ischaemia-reperfusion in mice. J Cell Mol Med. 2016;20:1014\u20131023.","journal-title":"J Cell Mol Med"},{"key":"8278_CR17","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1097\/ALN.0b013e3182503964","volume":"116","author":"XY Zhang","year":"2012","unstructured":"Zhang XY, Liu ZM, Wen SH et al. Dexmedetomidine administration before, but not after, ischemia attenuates intestinal injury induced by intestinal ischemia-reperfusion in rats. Anesthesiology 2012;116:1035\u20131046.","journal-title":"Anesthesiology"},{"key":"8278_CR18","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1016\/j.jhep.2019.08.005","volume":"71","author":"J Mouries","year":"2019","unstructured":"Mouries J, Brescia P, Silvestri A et al. Microbiota-driven gut vascular barrier disruption is a prerequisite for non-alcoholic steatohepatitis development. J Hepatol. 2019;71:1216\u20131228.","journal-title":"J Hepatol"},{"key":"8278_CR19","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1016\/S0140-6736(12)61815-7","volume":"381","author":"J-L Vincent","year":"2013","unstructured":"Vincent J-L, Opal SM, Marshall JC, Tracey KJ. Sepsis definitions: time for change. Lancet 2013;381:774\u2013775.","journal-title":"Lancet"},{"key":"8278_CR20","doi-asserted-by":"publisher","first-page":"2594","DOI":"10.1001\/jama.2011.1829","volume":"306","author":"JS Boomer","year":"2011","unstructured":"Boomer JS, To K, Chang KC et al. Immunosuppression in patients who die of sepsis and multiple organ failure. JAMA 2011;306:2594\u20132605.","journal-title":"JAMA"},{"key":"8278_CR21","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1097\/00024382-199703000-00005","volume":"7","author":"J Osterberg","year":"1997","unstructured":"Osterberg J, Johnsson C, Gannedahl G, Westlund A, Haglund U. Alterations in mucosal immune cell distribution in septic rats. Shock 1997;7:182\u2013185.","journal-title":"Shock"},{"key":"8278_CR22","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1016\/j.immuni.2014.10.010","volume":"41","author":"M Proietti","year":"2014","unstructured":"Proietti M, Cornacchione V, Jost TR et al. ATP-gated ionotropic P2X7 receptor controls follicular T helper cell numbers in Peyer\u2019s patches to promote host-microbiota mutualism. Immunity 2014;41:789\u2013801.","journal-title":"Immunity"},{"key":"8278_CR23","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.molimm.2022.12.014","volume":"154","author":"Y Liu","year":"2023","unstructured":"Liu Y, Zhang Y, Liu Q et al. Inhibition of DDX3X ameliorated CD4+ T cells pyroptosis and improves survival in septic mice. Mol Immunol. 2023;154:54\u201360.","journal-title":"Mol Immunol"},{"key":"8278_CR24","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.nut.2003.11.015","volume":"20","author":"Y-N Lai","year":"2004","unstructured":"Lai Y-N, Yeh S-L, Lin M-T, Shang H-F, Yeh C-L, Chen W-J. Glutamine supplementation enhances mucosal immunity in rats with Gut-Derived sepsis. Nutrition 2004;20:286\u2013291.","journal-title":"Nutrition"},{"key":"8278_CR25","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1016\/j.nut.2014.11.021","volume":"31","author":"J Fan","year":"2015","unstructured":"Fan J, Li G, Lidong Wu et al. Parenteral glutamine supplementation in combination with enteral nutrition improves intestinal immunity in septic rats. Nutrition 2015;31:766\u2013774.","journal-title":"Nutrition"},{"key":"8278_CR26","doi-asserted-by":"publisher","first-page":"1798","DOI":"10.3389\/fmicb.2017.01798","volume":"8","author":"Q Zeng","year":"2017","unstructured":"Zeng Q, He X, Puthiyakunnon S et al. Probiotic mixture golden Bifido prevents neonatal Escherichia coli K1 translocation via enhancing intestinal defense. Front Microbiol. 2017;8:1798.","journal-title":"Front Microbiol"},{"key":"8278_CR27","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1097\/SHK.0000000000002174","volume":"60","author":"X Dong","year":"2023","unstructured":"Dong X, Hao Tu, Bai X, Qin S, Li Z. Intrinsic\/extrinsic apoptosis and pyroptosis contribute to the selective depletion of B cell subsets in septic shock patients. Shock 2023;60:345\u2013353.","journal-title":"Shock"},{"key":"8278_CR28","doi-asserted-by":"publisher","first-page":"13622","DOI":"10.14814\/phy2.13622","volume":"6","author":"N Arulkumaran","year":"2018","unstructured":"Arulkumaran N, Sixma ML, Pollen S et al. P2X7 receptor antagonism ameliorates renal dysfunction in a rat model of sepsis. Physiol Rep. 2018;6:13622.","journal-title":"Physiol Rep."},{"key":"8278_CR29","doi-asserted-by":"publisher","first-page":"e3261","DOI":"10.1002\/jgm.3261","volume":"22","author":"Z Zou","year":"2020","unstructured":"Zou Z, Wang Q, Zhou M et al. Protective effects of P2X7R antagonist in sepsis-induced acute lung injury in mice via regulation of circ_0001679 and circ_0001212 and downstream Pln, Cdh2, and Nprl3 expression. J Gene Med. 2020;22:e3261.","journal-title":"J Gene Med"},{"key":"8278_CR30","doi-asserted-by":"publisher","first-page":"1881","DOI":"10.1021\/acs.jproteome.2c00851","volume":"22","author":"J Huang","year":"2023","unstructured":"Huang J, Wang Z, Zhang X et al. Lipidomics study of sepsis-induced liver and lung injury under anti-HMGB1 intervention. J Proteome Res. 2023;22:1881\u20131895.","journal-title":"J Proteome Res"},{"key":"8278_CR31","doi-asserted-by":"publisher","first-page":"3307","DOI":"10.1007\/s10620-018-5282-2","volume":"63","author":"Su Xu-Yu Zhang","year":"2018","unstructured":"Xu-Yu Zhang Su, Guan H-F, Li R-Y, Liu Z-M. Activation of PD-1 protects intestinal immune defense through IL-10\/miR-155 pathway after intestinal ischemia reperfusion. Dig Dis Sci. 2018;63:3307\u20133316.","journal-title":"Dig Dis Sci"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-024-08278-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10620-024-08278-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-024-08278-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,23]],"date-time":"2024-03-23T18:07:14Z","timestamp":1711217234000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10620-024-08278-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,9]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["8278"],"URL":"https:\/\/doi.org\/10.1007\/s10620-024-08278-z","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,9]]},"assertion":[{"value":"20 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 January 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 February 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}