{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T02:46:24Z","timestamp":1780109184543,"version":"3.54.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T00:00:00Z","timestamp":1718755200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T00:00:00Z","timestamp":1718755200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1007\/s10620-024-08449-y","type":"journal-article","created":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T14:02:17Z","timestamp":1718805737000},"page":"3079-3084","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Validation of a Machine Learning Algorithm, EVendo, for Predicting Esophageal Varices in Hepatocellular Carcinoma"],"prefix":"10.1007","volume":"69","author":[{"given":"Jamie O.","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Punya","family":"Chittajallu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihane N.","family":"Benhammou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arpan","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph R.","family":"Pisegna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Tabibian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tien S.","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,19]]},"reference":[{"key":"8449_CR1","doi-asserted-by":"publisher","first-page":"1894","DOI":"10.1056\/NEJMoa1915745","volume":"382","author":"RS Finn","year":"2020","unstructured":"Finn RS, Qin S, Ikeda M et al. Atezolizumab plus bevacizumab in unresectable hepatocellular carcinoma. N Engl J Med. 2020;382:1894\u20131905.","journal-title":"N Engl J Med"},{"key":"8449_CR2","doi-asserted-by":"publisher","first-page":"2480","DOI":"10.3390\/cancers15092480","volume":"15","author":"CW Wu","year":"2023","unstructured":"Wu CW, Lui RN, Wong VW et al. Baveno VII criteria is an accurate risk stratification tool to predict high-risk varices requiring intervention and hepatic events in patients with advanced hepatocellular carcinoma. Cancers. 2023;15:2480.","journal-title":"Cancers"},{"key":"8449_CR3","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1177\/2050640615615041","volume":"4","author":"M Iavarone","year":"2016","unstructured":"Iavarone M, Primignani M, Vavassori S et al. Determinants of esophageal varices bleeding in patients with advanced hepatocellular carcinoma treated with sorafenib. United Eur Gastroenterol J. 2016;4:363\u2013370.","journal-title":"United European Gastroenterol J"},{"key":"8449_CR4","doi-asserted-by":"publisher","first-page":"4317","DOI":"10.1200\/JCO.20.02672","volume":"38","author":"JD Gordan","year":"2020","unstructured":"Gordan JD, Kennedy EB, Abou-Alfa GK et al. Systemic therapy for advanced hepatocellular carcinoma: ASCO guideline. J Clin Oncol. 2020;38:4317\u20134345.","journal-title":"Journal of Clinical Oncology"},{"key":"8449_CR5","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1016\/j.jhep.2021.07.004","volume":"75","author":"J Bruix","year":"2021","unstructured":"Bruix J, Chan SL, Galle PR, Rimassa L, Sangro B. Systemic treatment of hepatocellular carcinoma: An EASL position paper. J Hepatol. 2021;75:960\u2013974.","journal-title":"J Hepatol"},{"key":"8449_CR6","doi-asserted-by":"publisher","first-page":"4105","DOI":"10.1200\/JCO.2023.41.16_suppl.4105","volume":"41","author":"CL LEE","year":"2023","unstructured":"LEE CL, Freeman M, O'Donnell C et al. Real-world multicentre analysis of patients with hepatocellular carcinoma (HCC) treated with atezolizumab and bevacizumab (A+B): Efficacy, esophagogastroduodenoscopy (EGD) uptake and bleeding complications. J Clin Oncol. 2023;41:4105\u20134105.","journal-title":"J Clin Oncol"},{"key":"8449_CR7","first-page":"e48954","volume":"15","author":"C Guinazu","year":"2023","unstructured":"Guinazu C, Fernandez Munoz A, Maldonado MD et al. Assessing the predictive factors for bleeding in esophageal variceal disease: A systematic review. Cureus. 2023;15:e48954.","journal-title":"Cureus"},{"key":"8449_CR8","doi-asserted-by":"publisher","first-page":"4806","DOI":"10.3748\/wjg.v23.i26.4806","volume":"23","author":"B Kraja","year":"2017","unstructured":"Kraja B, Mone I, Akshija I, Kocollari A, Prifti S, Burazeri G. Predictors of esophageal varices and first variceal bleeding in liver cirrhosis patients. World J Gastroenterol. 2017;23:4806\u20134814.","journal-title":"World J Gastroenterol"},{"key":"8449_CR9","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.21037\/atm-20-2444","volume":"8","author":"SF Wang","year":"2020","unstructured":"Wang SF, Huang YT, Huang CH, Chang SH, Lin CY. Fibrosis index predicts variceal bleeding and reduces need for nonselective beta-blocker in compensated cirrhosis with initial small esophageal varices without red-color sign. Ann Transl Med. 2020;8:1223.","journal-title":"Ann Transl Med"},{"key":"8449_CR10","doi-asserted-by":"publisher","first-page":"4616","DOI":"10.1007\/s00330-022-08601-0","volume":"32","author":"Y Liu","year":"2022","unstructured":"Liu Y, Tan HY, Zhang XG, Zhen YH, Gao F, Lu XF. Prediction of high-risk esophageal varices in patients with chronic liver disease with point and 2D shear wave elastography: a systematic review and meta-analysis. Eur Radiol. 2022;32:4616\u20134627.","journal-title":"Eur Radiol"},{"key":"8449_CR11","doi-asserted-by":"publisher","first-page":"1894","DOI":"10.1016\/j.cgh.2019.01.025","volume":"17","author":"TS Dong","year":"2019","unstructured":"Dong TS, Kalani A, Aby ES et al. Machine learning-based development and validation of a scoring system for screening high-risk esophageal varices. Clin Gastroenterol Hepatol. 2019;17:1894\u20131901.e1.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"8449_CR12","doi-asserted-by":"publisher","first-page":"378","DOI":"10.4103\/sjg.sjg_624_21","volume":"28","author":"K Alswat","year":"2022","unstructured":"Alswat K, Alanazi M, Bashmail A et al. Validation of the EVendo score for the prediction of varices in cirrhotic patients. Saudi J Gastroenterol. 2022;28:378\u2013384.","journal-title":"Saudi J Gastroenterol"},{"key":"8449_CR13","doi-asserted-by":"crossref","unstructured":"North Italian Endoscopic Club for the S, Treatment of Esophageal V. Prediction of the first variceal hemorrhage in patients with cirrhosis of the liver and esophageal varices. A prospective multicenter study. N Engl J Med. 1988;319:983\u2013989.","DOI":"10.1056\/NEJM198810133191505"},{"key":"8449_CR14","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/s00508-017-1262-3","volume":"129","author":"T Reiberger","year":"2017","unstructured":"Reiberger T, Puspok A, Schoder M et al. Austrian consensus guidelines on the management and treatment of portal hypertension (Billroth III). Wien Klin Wochenschr. 2017;129:135\u2013158.","journal-title":"Wien Klin Wochenschr"},{"key":"8449_CR15","doi-asserted-by":"publisher","first-page":"321","DOI":"10.51821\/88.2.9553","volume":"85","author":"M Pizzamiglio","year":"2022","unstructured":"Pizzamiglio M, Weicker A, de Terwangne C, Henrion J, Descamps OS, De Vos M. Validation of Baveno VI and expanded-Baveno VI criteria for predicting gastroesophageal varices in patients with alcoholic and non-alcoholic fatty liver disease. Acta Gastroenterol Belg. 2022;85:321\u2013329.","journal-title":"Acta Gastroenterol Belg"},{"key":"8449_CR16","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1016\/j.jhep.2020.09.034","volume":"74","author":"H Wang","year":"2021","unstructured":"Wang H, Wen B, Chang X et al. Baveno VI criteria and spleen stiffness measurement rule out high-risk varices in virally suppressed HBV-related cirrhosis. J Hepatol. 2021;74:584\u2013592.","journal-title":"J Hepatol"},{"key":"8449_CR17","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1016\/j.jhep.2018.05.019","volume":"69","author":"S Petta","year":"2018","unstructured":"Petta S, Sebastiani G, Bugianesi E et al. Non-invasive prediction of esophageal varices by stiffness and platelet in non-alcoholic fatty liver disease cirrhosis. J Hepatol. 2018;69:878\u2013885.","journal-title":"J Hepatol"},{"key":"8449_CR18","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1016\/j.jhep.2021.12.022","volume":"76","author":"R de Franchis","year":"2022","unstructured":"de Franchis R, Bosch J, Garcia-Tsao G, Reiberger T, Ripoll C, Baveno VIIF. Baveno VII\u2014Renewing consensus in portal hypertension. J Hepatol. 2022;76:959\u2013974.","journal-title":"J Hepatol"},{"key":"8449_CR19","doi-asserted-by":"publisher","first-page":"1442","DOI":"10.1111\/liv.13732","volume":"38","author":"J Bae","year":"2018","unstructured":"Bae J, Sinn DH, Kang W et al. Validation of the Baveno VI and the expanded Baveno VI criteria to identify patients who could avoid screening endoscopy. Liver Int. 2018;38:1442\u20131448.","journal-title":"Liver Int"},{"key":"8449_CR20","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.aohep.2019.08.005","volume":"19","author":"S Nawalerspanya","year":"2020","unstructured":"Nawalerspanya S, Sripongpun P, Chamroonkul N, Kongkamol C, Piratvisuth T. Validation of original, expanded Baveno VI, and stepwise & platelet-MELD criteria to rule out varices needing treatment in compensated cirrhosis from various etiologies. Ann Hepatol. 2020;19:209\u2013213.","journal-title":"Ann Hepatol"},{"key":"8449_CR21","doi-asserted-by":"publisher","first-page":"2511","DOI":"10.1111\/j.1572-0241.2006.00874.x","volume":"101","author":"EG Giannini","year":"2006","unstructured":"Giannini EG, Zaman A, Kreil A, et al. Platelet count\/spleen diameter ratio for the noninvasive diagnosis of esophageal varices: results of a multicenter, prospective, validation study. Am J Gastroenterol. 2006;101:2511\u20132519.","journal-title":"Am J Gastroenterol"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-024-08449-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10620-024-08449-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-024-08449-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T17:02:17Z","timestamp":1724432537000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10620-024-08449-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,19]]},"references-count":21,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["8449"],"URL":"https:\/\/doi.org\/10.1007\/s10620-024-08449-y","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,19]]},"assertion":[{"value":"8 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 April 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 June 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"There are no disclosures, financial, professional, or personal to report.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}