{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:35:12Z","timestamp":1791477312408,"version":"4.3.4"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1007\/s10620-024-08661-w","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T17:03:59Z","timestamp":1729616639000},"page":"4268-4274","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Hepatocellular Carcinoma in Acute Hepatic Porphyria: A Meta-Analysis of Observational Studies"],"prefix":"10.1007","volume":"69","author":[{"given":"Ashwani K.","family":"Singal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rewanth K.","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohan C.","family":"Gudiwada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaswant J.","family":"Jasti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl E.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,22]]},"reference":[{"key":"8661_CR1","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1111\/j.1365-2796.1992.tb00949.x","volume":"231","author":"P Mustajoki","year":"1992","unstructured":"Mustajoki P, Kauppinen R, Lannfelt L, Lilius L, Koistinen J. Frequency of low erythrocyte porphobilinogen deaminase activity in Finland*. J Intern Med. 1992;231:389\u2013395.","journal-title":"J Intern Med."},{"key":"8661_CR2","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1080\/00365510902935979","volume":"69","author":"I Bylesj\u00f6","year":"2009","unstructured":"Bylesj\u00f6 I, Wikberg A, Andersson C. Clinical aspects of acute intermittent porphyria in northern Sweden: a population-based study. Scand J Clin Lab Investig. 2009;69:612\u2013618.","journal-title":"Scand J Clin Lab Investig."},{"key":"8661_CR3","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1056\/NEJMra1608634","volume":"377","author":"DM Bissell","year":"2017","unstructured":"Bissell DM, Anderson KE, Bonkovsky HL. Porphyria. N Engl J Med. 2017;377:862\u2013872.","journal-title":"N Engl J Med."},{"key":"8661_CR4","doi-asserted-by":"publisher","first-page":"2605","DOI":"10.1038\/s41436-019-0537-7","volume":"21","author":"B Chen","year":"2019","unstructured":"Chen B, Whatley S, Badminton M et al. International porphyria molecular diagnostic collaborative: an evidence-based database of verified pathogenic and benign variants for the porphyrias. Genetics Med. 2019;21:2605\u20132613.","journal-title":"Genetics Med."},{"key":"8661_CR5","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1053\/j.gastro.2019.04.050","volume":"157","author":"U St\u00f6lzel","year":"2019","unstructured":"St\u00f6lzel U, Doss MO, Schuppan D. Clinical guide and update on porphyrias. Gastroenterology. 2019;157:365-381.e364.","journal-title":"Gastroenterology."},{"key":"8661_CR6","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.1002\/hep.29313","volume":"66","author":"M Balwani","year":"2017","unstructured":"Balwani M, Wang B, Anderson KE et al. Acute hepatic porphyrias: recommendations for evaluation and long-term management. Hepatology. 2017;66:1314\u20131322.","journal-title":"Hepatology."},{"key":"8661_CR7","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1111\/j.1365-2796.1994.tb01279.x","volume":"236","author":"C Andersson","year":"1994","unstructured":"Andersson C, Lithner F. Hypertension and renal disease in patients with acute intermittent porphyria. J Intern Med. 1994;236:169\u2013175.","journal-title":"J Intern Med."},{"key":"8661_CR8","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1111\/joim.12646","volume":"282","author":"CM Baravelli","year":"2017","unstructured":"Baravelli CM, Sandberg S, Aarsand AK, Nilsen RM, Toll\u00e5nes MC. Acute hepatic porphyria and cancer risk: a nationwide cohort study. J Intern Med. 2017;282:229\u2013240.","journal-title":"J Intern Med."},{"key":"8661_CR9","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1038\/s41571-018-0073-4","volume":"15","author":"JM Llovet","year":"2018","unstructured":"Llovet JM, Montal R, Sia D, Finn RS. Molecular therapies and precision medicine for hepatocellular carcinoma. Nat Rev Clin Oncol. 2018;15:599\u2013616.","journal-title":"Nat Rev Clin Oncol."},{"key":"8661_CR10","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1038\/nrgastro.2016.176","volume":"14","author":"AP Thrift","year":"2017","unstructured":"Thrift AP, El-Serag HB, Kanwal F. Global epidemiology and burden of HCV infection and HCV-related disease. Nat Rev Gastroenterol Hepatol. 2017;14:122\u2013132.","journal-title":"Nat Rev Gastroenterol Hepatol."},{"key":"8661_CR11","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1053\/j.gastro.2016.11.020","volume":"152","author":"DL White","year":"2017","unstructured":"White DL, Thrift AP, Kanwal F, Davila J, El-Serag HB. Incidence of hepatocellular carcinoma in all 50 United States, from 2000 through 2012. Gastroenterology. 2017;152:812-820.e815.","journal-title":"Gastroenterology."},{"key":"8661_CR12","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1006\/abbi.1995.1080","volume":"316","author":"PI Oteiza","year":"1995","unstructured":"Oteiza PI, Kleinman CG, Demasi M, Bechara EJ. 5-Aminolevulinic acid induces iron release from ferritin. Arch Biochem Biophys. 1995;316:607\u2013611.","journal-title":"Arch Biochem Biophys."},{"key":"8661_CR13","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/S0306-4522(97)00262-5","volume":"82","author":"RC Carneiro","year":"1998","unstructured":"Carneiro RC, Reiter RJ. Melatonin protects against lipid peroxidation induced by delta-aminolevulinic acid in rat cerebellum, cortex and hippocampus. Neuroscience. 1998;82:293\u2013299.","journal-title":"Neuroscience."},{"key":"8661_CR14","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1056\/NEJM199701163360306","volume":"336","author":"A Brzezinski","year":"1997","unstructured":"Brzezinski A. Melatonin in humans. N Engl J Med. 1997;336:186\u2013195.","journal-title":"N Engl J Med."},{"key":"8661_CR15","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/0024-3205(93)90271-4","volume":"53","author":"H Puy","year":"1993","unstructured":"Puy H, Deybach J-C, Baudry P, Callebert J, Touitou Y, Nordmann Y. Decreased nocturnal plasma melatonin levels in patients with recurrent acute intermittent porphyria attacks. Life Sci. 1993;53:621\u2013627.","journal-title":"Life Sci."},{"key":"8661_CR16","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1172\/JCI118376","volume":"97","author":"H Puy","year":"1996","unstructured":"Puy H, Deybach JC, Bogdan A et al. Increased delta aminolevulinic acid and decreased pineal melatonin production: a common event in acute porphyria studies in the rat. J Clin Investig. 1996;97:104\u2013110.","journal-title":"J Clin Investig."},{"key":"8661_CR17","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1111\/j.0954-6820.1984.tb05005.x","volume":"215","author":"F Lithner","year":"1984","unstructured":"Lithner F, Wetterberg L. Hepatocellular carcinoma in patients with acute intermittent porphyria. Acta Med Scand. 1984;215:271\u2013274.","journal-title":"Acta Med Scand."},{"key":"8661_CR18","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/caac.21492","volume":"68","author":"F Bray","year":"2018","unstructured":"Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: Cancer J Clin. 2018;68:394\u2013424.","journal-title":"CA Cancer J Clin."},{"key":"8661_CR19","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1111\/j.1365-2796.2010.02335.x","volume":"269","author":"E Innala","year":"2011","unstructured":"Innala E, Andersson C. Screening for hepatocellular carcinoma in acute intermittent porphyria: a 15-year follow-up in northern Sweden. J Intern Med. 2011;269:538\u2013545.","journal-title":"J Intern Med."},{"key":"8661_CR20","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1007\/s10545-012-9576-9","volume":"36","author":"E Sardh","year":"2013","unstructured":"Sardh E, Wahlin S, Bjornstedt M, Harper P, Andersson DE. High risk of primary liver cancer in a cohort of 179 patients with Acute Hepatic Porphyria. J Inherit Metab Dis. 2013;36:1063\u20131071.","journal-title":"J Inherit Metab Dis."},{"key":"8661_CR21","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1093\/oxfordjournals.aje.a009745","volume":"149","author":"MS Linet","year":"1999","unstructured":"Linet MS, Gridley G, Nyr\u00e9n O et al. Primary liver cancer, other malignancies, and mortality risks following porphyria: a cohort study in Denmark and Sweden. Am J Epidemiol. 1999;149:1010\u20131015.","journal-title":"Am J Epidemiol."},{"key":"8661_CR22","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1046\/j.1365-2796.1996.21847000.x","volume":"240","author":"C Andersson","year":"1996","unstructured":"Andersson C, Bjersing L, Lithner F. The epidemiology of hepatocellular carcinoma in patients with acute intermittent porphyria. J Intern Med. 1996;240:195\u2013201.","journal-title":"J Intern Med."},{"key":"8661_CR23","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1007\/s10545-012-9544-4","volume":"36","author":"G Elder","year":"2013","unstructured":"Elder G, Harper P, Badminton M, Sandberg S, Deybach JC. The incidence of inherited porphyrias in Europe. J Inherit Metab Dis. 2013;36:849\u2013857.","journal-title":"J Inherit Metab Dis."},{"key":"8661_CR24","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1016\/S0168-8278(00)80097-5","volume":"32","author":"C Andant","year":"2000","unstructured":"Andant C, Puy H, Bogard C et al. Hepatocellular carcinoma in patients with acute hepatic porphyria: frequency of occurrence and related factors. J Hepatol. 2000;32:933\u2013939.","journal-title":"J Hepatol."},{"key":"8661_CR25","first-page":"393","volume":"5","author":"L Bjersing","year":"1996","unstructured":"Bjersing L, Andersson C, Lithner F. Hepatocellular carcinoma in patients from northern Sweden with acute intermittent porphyria: morphology and mutations. Cancer Epidemiol Biomarkers Prev. 1996;5:393\u2013397.","journal-title":"Cancer Epidemiol Biomarkers Prev."},{"key":"8661_CR26","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/bjc.1988.23","volume":"57","author":"R Kauppinen","year":"1988","unstructured":"Kauppinen R, Mustajoki P. Acute hepatic porphyria and hepatocellular carcinoma. Br J Cancer. 1988;57:117\u2013120.","journal-title":"Br J Cancer."},{"key":"8661_CR27","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/bjc.1984.188","volume":"50","author":"L Hardell","year":"1984","unstructured":"Hardell L, Bengtsson NO, Jonsson U, Eriksson S, Larsson LG. Aetiological aspects on primary liver cancer with special regard to alcohol, organic solvents and acute intermittent porphyria\u2013an epidemiological investigation. Br J Cancer. 1984;50:389\u2013397.","journal-title":"Br J Cancer."},{"key":"8661_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/00005792-199201000-00001","volume":"71","author":"R Kauppinen","year":"1992","unstructured":"Kauppinen R, Mustajoki P. Prognosis of acute porphyria: occurrence of acute attacks, precipitating factors, and associated diseases. Medicine. 1992;71:1\u201313.","journal-title":"Medicine."},{"key":"8661_CR29","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1046\/j.1365-2796.1999.0448e.x","volume":"245","author":"C Andersson","year":"1999","unstructured":"Andersson C, Bylesj\u00f6 I, Lithner F. Effects of diabetes mellitus on patients with acute intermittent porphyria. J Intern Med. 1999;245:193\u2013197.","journal-title":"J Intern Med."},{"key":"8661_CR30","doi-asserted-by":"publisher","first-page":"d5928","DOI":"10.1136\/bmj.d5928","volume":"343","author":"JP Higgins","year":"2011","unstructured":"Higgins JP, Altman DG, Gotzsche PC et al. The Cochrane Collaboration\u2019s tool for assessing risk of bias in randomised trials. BMJ. 2011;343:d5928.","journal-title":"BMJ."},{"key":"8661_CR31","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1016\/j.jhep.2022.06.023","volume":"77","author":"A Fontanellas","year":"2022","unstructured":"Fontanellas A, Avila MA. Hydroxymethylbilane synthase (aka porphobilinogen deaminase): a novel metabolic tumor suppressor gene in hepatocellular carcinoma. J Hepatol. 2022;77:912\u2013914.","journal-title":"J Hepatol."},{"key":"8661_CR32","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1016\/j.jhep.2022.05.018","volume":"77","author":"L Molina","year":"2022","unstructured":"Molina L, Zhu J, Trepo E et al. Bi-allelic hydroxymethylbilane synthase inactivation defines a homogenous clinico-molecular subtype of hepatocellular carcinoma. J Hepatol. 2022;77:1038\u20131046.","journal-title":"J Hepatol."},{"key":"8661_CR33","doi-asserted-by":"publisher","first-page":"2647","DOI":"10.1007\/s00432-022-04384-5","volume":"149","author":"T Haverkamp","year":"2023","unstructured":"Haverkamp T, Bronisch O, Knosel T et al. Heterogeneous molecular behavior in liver tumors (HCC and CCA) of two patients with acute intermittent porphyria. J Cancer Res Clin Oncol. 2023;149:2647\u20132655.","journal-title":"J Cancer Res Clin Oncol."},{"key":"8661_CR34","doi-asserted-by":"publisher","first-page":"2947","DOI":"10.3390\/cancers14122947","volume":"14","author":"D Ramai","year":"2022","unstructured":"Ramai D, Deliwala SS, Chandan S et al. Risk of hepatocellular carcinoma in patients with porphyria: a systematic review. Cancers. 2022;14:2947.","journal-title":"Cancers."}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-024-08661-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10620-024-08661-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-024-08661-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T13:04:40Z","timestamp":1731675880000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10620-024-08661-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,22]]},"references-count":34,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["8661"],"URL":"https:\/\/doi.org\/10.1007\/s10620-024-08661-w","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,22]]},"assertion":[{"value":"29 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None of the authors have any financial or any other conflicts to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}