{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T01:18:42Z","timestamp":1793409522304,"version":"4.5.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T00:00:00Z","timestamp":1739404800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T00:00:00Z","timestamp":1739404800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1007\/s10620-025-08861-y","type":"journal-article","created":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T08:10:22Z","timestamp":1739434222000},"page":"1511-1520","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A Score to Predict Advanced Colorectal Neoplasia in Adults Younger than Age 45"],"prefix":"10.1007","volume":"70","author":[{"given":"Sarah","family":"Wehbe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj Jessica","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacquelyn","family":"Bolwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Butler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol A.","family":"Burke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Liska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Macaron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,13]]},"reference":[{"key":"8861_CR1","doi-asserted-by":"publisher","first-page":"233","DOI":"10.3322\/caac.21772","volume":"73","author":"RL Siegel","year":"2023","unstructured":"Siegel RL, Wagle NS, Cercek A et al. Colorectal cancer statistics, 2023. CA Cancer J Clin 2023;73:233\u2013254. https:\/\/doi.org\/10.3322\/caac.21772.","journal-title":"CA Cancer J Clin"},{"key":"8861_CR2","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1053\/j.gastro.2019.07.055","volume":"158","author":"EM Stoffel","year":"2020","unstructured":"Stoffel EM, Murphy CC. Epidemiology and Mechanisms of the Increasing Incidence of Colon and Rectal Cancers in Young Adults. Gastroenterology 2020;158:341\u2013353. https:\/\/doi.org\/10.1053\/j.gastro.2019.07.055.","journal-title":"Gastroenterology"},{"key":"8861_CR3","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1001\/jamasurg.2014.1756]","volume":"150","author":"CE Bailey","year":"2015","unstructured":"Bailey CE, Hu CY, You YN et al. Increasing disparities in the age-related incidences of colon and rectal cancers in the United States, 1975\u20132010. JAMA Surg 2015;150:17\u201322. https:\/\/doi.org\/10.1001\/jamasurg.2014.1756].","journal-title":"JAMA Surg"},{"key":"8861_CR4","doi-asserted-by":"publisher","first-page":"1978","DOI":"10.1001\/jama.2021.4417","volume":"325","author":"JS Lin","year":"2021","unstructured":"Lin JS, Perdue LA, Henrikson NB et al. Screening for Colorectal Cancer: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force. Jama 2021;325:1978\u20131998. https:\/\/doi.org\/10.1001\/jama.2021.4417.","journal-title":"Jama"},{"key":"8861_CR5","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1016\/j.cgh.2016.08.037","volume":"15","author":"CC Murphy","year":"2017","unstructured":"Murphy CC, Sandler RS, Sanoff HK et al. Decrease in Incidence of Colorectal Cancer Among Individuals 50 Years or Older After Recommendations for Population-based Screening. Clin Gastroenterol Hepatol 2017;15:903\u201309.e6. https:\/\/doi.org\/10.1016\/j.cgh.2016.08.037.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"8861_CR6","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/s2468-1253(21)00426-x","volume":"7","author":"SG Patel","year":"2022","unstructured":"Patel SG, Karlitz JJ, Yen T et al. The rising tide of early-onset colorectal cancer: a comprehensive review of epidemiology, clinical features, biology, risk factors, prevention, and early detection. Lancet Gastroenterol Hepatol 2022;7:262\u2013274. https:\/\/doi.org\/10.1016\/s2468-1253(21)00426-x.","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"8861_CR7","doi-asserted-by":"publisher","unstructured":"Saad El Din K, Loree JM, Sayre EC, et al. Trends in the epidemiology of young-onset colorectal cancer: a worldwide systematic review. BMC Cancer 2020;20:288. https:\/\/doi.org\/10.1186\/s12885-020-06766-9","DOI":"10.1186\/s12885-020-06766-9"},{"key":"8861_CR8","doi-asserted-by":"publisher","first-page":"1820","DOI":"10.1136\/gutjnl-2018-317592","volume":"68","author":"FE Vuik","year":"2019","unstructured":"Vuik FE, Nieuwenburg SA, Bardou M et al. Increasing incidence of colorectal cancer in young adults in Europe over the last 25 years. Gut 2019;68:1820\u20131826. https:\/\/doi.org\/10.1136\/gutjnl-2018-317592.","journal-title":"Gut"},{"key":"8861_CR9","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1053\/j.gastro.2021.06.006","volume":"161","author":"JM Kolb","year":"2021","unstructured":"Kolb JM, Hu J, DeSanto K et al. Early-age onset colorectal neoplasia in average-risk individuals undergoing screening colonoscopy: a systematic review and meta-analysis. Gastroenterology 2021;161:1145\u201355.e12. https:\/\/doi.org\/10.1053\/j.gastro.2021.06.006.","journal-title":"Gastroenterology"},{"key":"8861_CR10","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1001\/jama.2021.6238","volume":"325","author":"UPST Force","year":"2021","unstructured":"Force UPST. Screening for Colorectal Cancer: US Preventive Services Task Force Recommendation Statement. JAMA 2021;325:1965\u20131977. https:\/\/doi.org\/10.1001\/jama.2021.6238.","journal-title":"JAMA"},{"key":"8861_CR11","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.1001\/jama.2019.3076","volume":"321","author":"RGS Meester","year":"2019","unstructured":"Meester RGS, Mannalithara A, Lansdorp-Vogelaar I et al. Trends in incidence and stage at diagnosis of colorectal cancer in adults aged 40 through 49 years, 1975\u20132015. Jama 2019;321:1933\u20131934. https:\/\/doi.org\/10.1001\/jama.2019.3076.","journal-title":"Jama"},{"key":"8861_CR12","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1002\/1878-0261.12417","volume":"13","author":"G Mauri","year":"2019","unstructured":"Mauri G, Sartore-Bianchi A, Russo AG et al. Early-onset colorectal cancer in young individuals. Mol Oncol 2019;13:109\u2013131. https:\/\/doi.org\/10.1002\/1878-0261.12417.","journal-title":"Mol Oncol"},{"key":"8861_CR13","doi-asserted-by":"publisher","first-page":"2752","DOI":"10.1016\/j.cgh.2019.10.009","volume":"18","author":"V Gausman","year":"2020","unstructured":"Gausman V, Dornblaser D, Anand S et al. Risk factors associated with early-onset colorectal cancer. Clin Gastroenterol Hepatol 2020;18:2752\u201359.e2. https:\/\/doi.org\/10.1016\/j.cgh.2019.10.009.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"8861_CR14","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1016\/j.cgh.2021.01.037","volume":"20","author":"DE O'Sullivan","year":"2022","unstructured":"O\u2019Sullivan DE, Sutherland RL, Town S et al. Risk factors for early-onset colorectal cancer: a systematic review and meta-analysis. Clin Gastroenterol Hepatol 2022;20:1229\u201340.e5. https:\/\/doi.org\/10.1016\/j.cgh.2021.01.037.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"8861_CR15","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s12876-016-0562-9","volume":"17","author":"YM Park","year":"2017","unstructured":"Park YM, Kim HS, Park JJ et al. A simple scoring model for advanced colorectal neoplasm in asymptomatic subjects aged 40\u201349 years. BMC Gastroenterology 2017;17:7. https:\/\/doi.org\/10.1186\/s12876-016-0562-9.","journal-title":"BMC Gastroenterology"},{"key":"8861_CR16","doi-asserted-by":"publisher","first-page":"2981","DOI":"10.3748\/wjg.v22.i10.2981","volume":"22","author":"SE Lee","year":"2016","unstructured":"Lee SE, Jo HB, Kwack WG et al. Characteristics of and risk factors for colorectal neoplasms in young adults in a screening population. World J Gastroenterol 2016;22:2981\u20132992. https:\/\/doi.org\/10.3748\/wjg.v22.i10.2981.","journal-title":"World J Gastroenterol"},{"key":"8861_CR17","doi-asserted-by":"publisher","first-page":"3611","DOI":"10.3748\/wjg.v22.i13.3611","volume":"22","author":"JY Kim","year":"2016","unstructured":"Kim JY, Jung YS, Park JH et al. Different risk factors for advanced colorectal neoplasm in young adults. World J Gastroenterol 2016;22:3611\u20133620. https:\/\/doi.org\/10.3748\/wjg.v22.i13.3611.","journal-title":"World J Gastroenterol"},{"key":"8861_CR18","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1097\/mcg.0000000000001967","volume":"58","author":"J Bolwell","year":"2024","unstructured":"Bolwell J, Butler R, Burke CA et al. Risk factors associated with advanced colorectal neoplasia in adults younger than age 45. J Clin Gastroenterol 2024;58:882\u2013888. https:\/\/doi.org\/10.1097\/mcg.0000000000001967.","journal-title":"J Clin Gastroenterol"},{"key":"8861_CR19","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1016\/j.gie.2020.08.038","volume":"93","author":"SN Laique","year":"2021","unstructured":"Laique SN, Hayat U, Sarvepalli S et al. Application of optical character recognition with natural language processing for large-scale quality metric data extraction in colonoscopy reports. Gastrointest Endosc 2021;93:750\u2013757. https:\/\/doi.org\/10.1016\/j.gie.2020.08.038.","journal-title":"Gastrointest Endosc"},{"key":"8861_CR20","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1136\/gutjnl-2013-304965","volume":"63","author":"MF Kaminski","year":"2014","unstructured":"Kaminski MF, Polkowski M, Kraszewska E et al. A score to estimate the likelihood of detecting advanced colorectal neoplasia at colonoscopy. Gut 2014;63:1112\u20131119. https:\/\/doi.org\/10.1136\/gutjnl-2013-304965.","journal-title":"Gut"},{"key":"8861_CR21","doi-asserted-by":"publisher","unstructured":"Liang PS, Williams JL, Dominitz JA, et al. Age-Stratified Prevalence and Predictors of Neoplasia Among U.S. Adults Undergoing Screening Colonoscopy in a National Endoscopy Registry. Gastroenterology 2022;163:742\u201353.e4. https:\/\/doi.org\/10.1053\/j.gastro.2022.05.036","DOI":"10.1053\/j.gastro.2022.05.036"},{"key":"8861_CR22","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1016\/j.cgh.2013.08.042","volume":"12","author":"S Tao","year":"2014","unstructured":"Tao S, Hoffmeister M, Brenner H. Development and validation of a scoring system to identify individuals at high risk for advanced colorectal neoplasms who should undergo colonoscopy screening. Clin Gastroenterol Hepatol 2014;12:478\u2013485. https:\/\/doi.org\/10.1016\/j.cgh.2013.08.042.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"8861_CR23","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1053\/j.gastro.2006.08.015","volume":"131","author":"OS Lin","year":"2006","unstructured":"Lin OS, Kozarek RA, Schembre DB et al. Risk stratification for colon neoplasia: screening strategies using colonoscopy and computerized tomographic colonography. Gastroenterology 2006;131:1011\u20131019. https:\/\/doi.org\/10.1053\/j.gastro.2006.08.015.","journal-title":"Gastroenterology"},{"key":"8861_CR24","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1111\/jgh.13835","volume":"33","author":"JJY Sung","year":"2018","unstructured":"Sung JJY, Wong MCS, Lam TYT et al. A modified colorectal screening score for prediction of advanced neoplasia: A prospective study of 5744 subjects. J Gastroenterol Hepatol 2018;33:187\u2013194. https:\/\/doi.org\/10.1111\/jgh.13835.","journal-title":"J Gastroenterol Hepatol"},{"key":"8861_CR25","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1200\/jco.2008.17.4813","volume":"27","author":"Y Park","year":"2009","unstructured":"Park Y, Freedman AN, Gail MH et al. Validation of a colorectal cancer risk prediction model among white patients age 50 years and older. J Clin Oncol 2009;27:694\u2013698. https:\/\/doi.org\/10.1200\/jco.2008.17.4813.","journal-title":"J Clin Oncol"},{"key":"8861_CR26","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1200\/jco.2008.17.4797","volume":"27","author":"AN Freedman","year":"2009","unstructured":"Freedman AN, Slattery ML, Ballard-Barbash R et al. Colorectal cancer risk prediction tool for white men and women without known susceptibility. J Clin Oncol 2009;27:686\u2013693. https:\/\/doi.org\/10.1200\/jco.2008.17.4797.","journal-title":"J Clin Oncol"},{"key":"8861_CR27","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1136\/gut.2010.221168","volume":"60","author":"KG Yeoh","year":"2011","unstructured":"Yeoh KG, Ho KY, Chiu HM et al. The Asia-Pacific Colorectal Screening score: a validated tool that stratifies risk for colorectal advanced neoplasia in asymptomatic Asian subjects. Gut 2011;60:1236\u20131241. https:\/\/doi.org\/10.1136\/gut.2010.221168.","journal-title":"Gut"},{"key":"8861_CR28","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1093\/aje\/kwr337","volume":"175","author":"QC Cai","year":"2012","unstructured":"Cai QC, Yu ED, Xiao Y et al. Derivation and validation of a prediction rule for estimating advanced colorectal neoplasm risk in average-risk Chinese. Am J Epidemiol 2012;175:584\u2013593. https:\/\/doi.org\/10.1093\/aje\/kwr337.","journal-title":"Am J Epidemiol"},{"key":"8861_CR29","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.amjmed.2006.05.055","volume":"120","author":"JA Driver","year":"2007","unstructured":"Driver JA, Gaziano JM, Gelber RP et al. Development of a risk score for colorectal cancer in men. Am J Med 2007;120:257\u2013263. https:\/\/doi.org\/10.1016\/j.amjmed.2006.05.055.","journal-title":"Am J Med"},{"key":"8861_CR30","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1097\/mcg.0000000000000102","volume":"49","author":"DH Kim","year":"2015","unstructured":"Kim DH, Cha JM, Shin HP et al. Development and validation of a risk stratification-based screening model for predicting colorectal advanced neoplasia in Korea. J Clin Gastroenterol 2015;49:41\u201349. https:\/\/doi.org\/10.1097\/mcg.0000000000000102.","journal-title":"J Clin Gastroenterol"},{"key":"8861_CR31","doi-asserted-by":"publisher","first-page":"2648","DOI":"10.1111\/j.1572-0241.2003.08771.x","volume":"98","author":"M Bet\u00e9s","year":"2003","unstructured":"Bet\u00e9s M, Mu\u00f1oz-Navas MA, Duque JM et al. Use of colonoscopy as a primary screening test for colorectal cancer in average risk people. Am J Gastroenterol 2003;98:2648\u20132654. https:\/\/doi.org\/10.1111\/j.1572-0241.2003.08771.x.","journal-title":"Am J Gastroenterol"},{"key":"8861_CR32","doi-asserted-by":"publisher","first-page":"450","DOI":"10.3748\/wjg.v30.i5.450","volume":"30","author":"LL Xu","year":"2024","unstructured":"Xu LL, Lin Y, Han LY et al. Development and validation of a prediction model for early screening of people at high risk for colorectal cancer. World J Gastroenterol 2024;30:450\u2013461. https:\/\/doi.org\/10.3748\/wjg.v30.i5.450.","journal-title":"World J Gastroenterol"},{"key":"8861_CR33","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1016\/j.canep.2010.04.021","volume":"34","author":"E Ma","year":"2010","unstructured":"Ma E, Sasazuki S, Iwasaki M et al. 10-Year risk of colorectal cancer: development and validation of a prediction model in middle-aged Japanese men. Cancer Epidemiol 2010;34:534\u2013541. https:\/\/doi.org\/10.1016\/j.canep.2010.04.021.","journal-title":"Cancer Epidemiol"},{"key":"8861_CR34","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.1111\/jgh.16243","volume":"38","author":"JW Deng","year":"2023","unstructured":"Deng JW, Zhou YL, Dai WX et al. Noninvasive predictive models based on lifestyle analysis and risk factors for early-onset colorectal cancer. J Gastroenterol Hepatol 2023;38:1768\u20131777. https:\/\/doi.org\/10.1111\/jgh.16243.","journal-title":"J Gastroenterol Hepatol"},{"key":"8861_CR35","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1056\/NEJMoa1100370","volume":"366","author":"AG Zauber","year":"2012","unstructured":"Zauber AG, Winawer SJ, O\u2019Brien MJ et al. Colonoscopic polypectomy and long-term prevention of colorectal-cancer deaths. N Engl J Med 2012;366:687\u2013696. https:\/\/doi.org\/10.1056\/NEJMoa1100370.","journal-title":"N Engl J Med"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-025-08861-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10620-025-08861-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-025-08861-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T21:49:01Z","timestamp":1743889741000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10620-025-08861-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,13]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["8861"],"URL":"https:\/\/doi.org\/10.1007\/s10620-025-08861-y","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,13]]},"assertion":[{"value":"3 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}