{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T16:25:01Z","timestamp":1782923101654,"version":"3.54.5"},"reference-count":66,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T00:00:00Z","timestamp":1739404800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T00:00:00Z","timestamp":1739404800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"crossref","award":["2023\/03973-1"],"award-info":[{"award-number":["2023\/03973-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"crossref","award":["2022\/14406-8"],"award-info":[{"award-number":["2022\/14406-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"crossref","award":["2022\/00086-2"],"award-info":[{"award-number":["2022\/00086-2"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"Coordination for the Improvement of Higher Education Personnel","doi-asserted-by":"crossref","award":["88887.841815\/2023-00"],"award-info":[{"award-number":["88887.841815\/2023-00"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1007\/s10620-025-08872-9","type":"journal-article","created":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T15:15:11Z","timestamp":1739459711000},"page":"1375-1394","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effect of Anti-TNF Monoclonal Antibody on Enteric Neurons and Enteric Glial Cells in Experimental Colitis"],"prefix":"10.1007","volume":"70","author":[{"given":"Roberta Figueiroa","family":"Souza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe Alexandre","family":"Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos Ant\u00f4nio Ferreira","family":"Caetano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline Bures","family":"De Paulo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Castelucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,13]]},"reference":[{"key":"8872_CR1","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1146\/annurev-physiol-021317-121515","volume":"81","author":"S Schneider","year":"2019","unstructured":"Schneider S, Wright CM, Heuckeroth RO. Unexpected Roles for the Second Brain: Enteric Nervous System as Master Regulator of Bowel Function. Annu Rev Physiol 2019;81:235\u2013259.","journal-title":"Annu Rev Physiol"},{"key":"8872_CR2","doi-asserted-by":"crossref","unstructured":"Pawolski V, Schmidt MHH. Neuron\u2013glia interaction in the developing and adult enteric nervous system. Cells, 2021.","DOI":"10.3390\/cells10010047"},{"key":"8872_CR3","doi-asserted-by":"publisher","first-page":"4713","DOI":"10.1007\/s00018-021-03812-y","volume":"78","author":"AM Holland","year":"2021","unstructured":"Holland AM, Bon-Frauches AC, Keszthelyi D et al. The enteric nervous system in gastrointestinal disease etiology. Cell. Mol. Life Sci. 2021;78:4713\u20134733.","journal-title":"Cell. Mol. Life Sci."},{"key":"8872_CR4","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1113\/JP271021","volume":"595","author":"V Grubi\u0161i\u0107","year":"2017","unstructured":"Grubi\u0161i\u0107 V, Gulbransen BD. Enteric glia: the most alimentary of all glia. J. Physiol. 2017;595:557\u2013570.","journal-title":"J. Physiol."},{"key":"8872_CR5","doi-asserted-by":"crossref","unstructured":"Furness JB. The enteric nervous system and neurogastroenterology. Nature Reviews Gastroenterology and Hepatology, 2012.","DOI":"10.1038\/nrgastro.2012.32"},{"key":"8872_CR6","doi-asserted-by":"publisher","first-page":"1803","DOI":"10.1007\/s10620-016-4183-5","volume":"61","author":"JD Wood","year":"2016","unstructured":"Wood JD. Enteric nervous system: neuropathic gastrointestinal motility. Dig Dis Sci 2016;61:1803\u20131816. https:\/\/doi.org\/10.1007\/s10620-016-4183-5.","journal-title":"Dig Dis Sci"},{"key":"8872_CR7","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.3390\/cells12131672","volume":"12","author":"MAF Caetano","year":"2023","unstructured":"Caetano MAF, Magalh\u00e3es HIR, Duarte JRL et al. Butyrate Protects Myenteric Neurons Loss in Mice Following Experimental Ulcerative Colitis. Cells 2023;12:1672.","journal-title":"Cells"},{"key":"8872_CR8","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1038\/s41590-019-0415-0","volume":"20","author":"MF Neurath","year":"2019","unstructured":"Neurath MF. Targeting immune cell circuits and trafficking in inflammatory bowel disease. Nat Immunol 2019;20:970\u2013979.","journal-title":"Nat Immunol"},{"key":"8872_CR9","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/bs.apcsb.2019.08.009","volume":"119","author":"OR Griffiths","year":"2020","unstructured":"Griffiths OR, Landon J, Coxon RE et al. Inflammatory bowel disease and targeted oral anti-TNF\u03b1 therapy. Adv Protein Chem Struct Biol 2020;119:157\u2013198.","journal-title":"Adv Protein Chem Struct Biol"},{"key":"8872_CR10","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1038\/nprot.2007.41","volume":"2","author":"S Wirtz","year":"2007","unstructured":"Wirtz S, Neufert C, Weigmann B et al. Chemically induced mouse models of intestinal inflammation. Nat Protoc 2007;2:541\u2013546.","journal-title":"Nat Protoc"},{"key":"8872_CR11","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1038\/nprot.2017.044","volume":"12","author":"S Wirtz","year":"2017","unstructured":"Wirtz S, Popp V, Kindermann M et al. Chemically induced mouse models of acute and chronic intestinal inflammation. Nat Protoc 2017;12:1295\u20131309.","journal-title":"Nat Protoc"},{"key":"8872_CR12","doi-asserted-by":"publisher","first-page":"3440","DOI":"10.3748\/wjg.v29.i22.3440","volume":"9327","author":"HIR Magalh\u00e3es","year":"2023","unstructured":"Magalh\u00e3es HIR, Machado FA, Souza RF et al. Study of the roles of caspase-3 and nuclear factor kappa B in myenteric neurons in a P2X7 receptor knockout mouse model of ulcerative colitis. World J Gastroenterol 2023;9327:3440\u20133468.","journal-title":"World J Gastroenterol"},{"key":"8872_CR13","doi-asserted-by":"publisher","first-page":"7909","DOI":"10.3748\/wjg.v27.i46.7909","volume":"27","author":"HIR Magalh\u00e3es","year":"2021","unstructured":"Magalh\u00e3es HIR, Castelucci P. Enteric nervous system and inflammatory bowel diseases: Correlated impacts and therapeutic approaches through the P2X7 receptor. World J Gastroenterol 2021;27:7909\u20137924.","journal-title":"World J Gastroenterol"},{"key":"8872_CR14","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1007\/s00418-023-02208-2","volume":"160","author":"FA Machado","year":"2023","unstructured":"Machado FA, Souza RF, Figliuolo VR et al. Effects of experimental ulcerative colitis on myenteric neurons in P2X7-knockout mice. Histochem Cell Biol 2023;160:321\u2013339.","journal-title":"Histochem Cell Biol"},{"key":"8872_CR15","doi-asserted-by":"crossref","unstructured":"Chassaing B, Aitken JD, Malleshappa M, et al. Dextran sulfate sodium (DSS)-induced colitis in mice. Curr Protoc Immunol 2014:1\u201314.","DOI":"10.1002\/0471142735.im1525s104"},{"key":"8872_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1515\/jbcpp-2018-0036","volume":"30","author":"N Tatiya-Aphiradee","year":"2018","unstructured":"Tatiya-Aphiradee N, Chatuphonprasert W, Jarukamjorn K. Immune response and inflammatory pathway of ulcerative colitis. J Basic Clin Physiol Pharmacol 2018;30:1\u201310.","journal-title":"J Basic Clin Physiol Pharmacol"},{"key":"8872_CR17","doi-asserted-by":"publisher","first-page":"2733","DOI":"10.3748\/wjg.v29.i18.2733","volume":"29","author":"RF Souza","year":"2023","unstructured":"Souza RF, Caetano MAF, Magalh\u00e3es HIR et al. Study of tumor necrosis factor receptor in the inflammatory bowel disease. World J Gastroenterol 2023;29:2733\u20132746.","journal-title":"World J Gastroenterol"},{"key":"8872_CR18","doi-asserted-by":"publisher","first-page":"9300","DOI":"10.3748\/wjg.v22.i42.9300","volume":"22","author":"U Billmeier","year":"2016","unstructured":"Billmeier U, Dieterich W, Neurath MF et al. Molecular mechanism of action of anti-tumor necrosis factor antibodies in inflammatory bowel diseases. World J Gastroenterol 2016;22:9300\u20139313.","journal-title":"World J Gastroenterol"},{"key":"8872_CR19","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1016\/j.cellsig.2012.02.006","volume":"24","author":"L Cabal-Hierro","year":"2012","unstructured":"Cabal-Hierro L, Lazo PS. Signal transduction by tumor necrosis factor receptors. Cell Signal 2012;24:1297\u20131305.","journal-title":"Cell Signal"},{"key":"8872_CR20","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1016\/0092-8674(95)90192-2","volume":"83","author":"M Grell","year":"1995","unstructured":"Grell M, Douni E, Wajant H et al. The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor. Cell 1995;83:793\u2013802.","journal-title":"Cell"},{"key":"8872_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fped.2022.852580","volume":"10","author":"SY Choi","year":"2022","unstructured":"Choi SY, Kang B. Adalimumab in Pediatric Inflammatory Bowel Disease. Front Pediatr 2022;10:1\u20138.","journal-title":"Front Pediatr"},{"key":"8872_CR22","doi-asserted-by":"crossref","unstructured":"Hanauer SB, Sandborn WJ, Rutgeerts P, et al. Human Anti\u2013Tumor Necrosis Factor Monoclonal Antibody (Adalimumab) in Crohn\u2019s Disease: the CLASSIC-I Trial. 2006:323\u201333.","DOI":"10.1053\/j.gastro.2005.11.030"},{"key":"8872_CR23","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1053\/j.gastro.2006.11.041","volume":"132","author":"JF Colombel","year":"2007","unstructured":"Colombel JF, Sandborn WJ, Rutgeerts P et al. Adalimumab for Maintenance of Clinical Response and Remission in Patients With Crohn\u2019s Disease: The CHARM Trial. Gastroenterology 2007;132:52\u201365.","journal-title":"Gastroenterology"},{"key":"8872_CR24","doi-asserted-by":"publisher","first-page":"2200","DOI":"10.1016\/S0140-6736(22)00688-2","volume":"399","author":"BE Sands","year":"2022","unstructured":"Sands BE, Irving PM, Hoops T et al. Ustekinumab versus adalimumab for induction and maintenance therapy in biologic-naive patients with moderately to severely active Crohn\u2019s disease: a multicentre, randomised, double-blind, parallel-group, phase 3b trial. The Lancet 2022;399:2200\u20132211.","journal-title":"The Lancet"},{"key":"8872_CR25","doi-asserted-by":"publisher","first-page":"1996","DOI":"10.1007\/s10753-015-0180-7","volume":"38","author":"J B\u00e1b\u00ed\u010dkov\u00e1","year":"2015","unstructured":"B\u00e1b\u00ed\u010dkov\u00e1 J, T\u00f3thov\u00e1 \u013d, Lengyelov\u00e1 E et al. Sex Differences in Experimentally Induced Colitis in Mice: a Role for Estrogens. Inflammation 2015;38:1996\u20132006.","journal-title":"Inflammation"},{"key":"8872_CR26","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.bcp.2016.06.012","volume":"115","author":"M de Paula-Silva","year":"2016","unstructured":"de Paula-Silva M, Barrios BE, Macci\u00f3-Maretto L et al. Role of the protein annexin A1 on the efficacy of anti-TNF treatment in a murine model of acute colitis. Biochem Pharmacol 2016;115:104\u2013113.","journal-title":"Biochem Pharmacol"},{"key":"8872_CR27","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1016\/j.acthis.2016.06.006","volume":"118","author":"HZ Nooh","year":"2016","unstructured":"Nooh HZ, Nour-Eldien NM. The dual anti-inflammatory and antioxidant activities of natural honey promote cell proliferation and neural regeneration in a rat model of colitis. Acta Histochem 2016;118:588\u2013595.","journal-title":"Acta Histochem"},{"key":"8872_CR28","doi-asserted-by":"crossref","unstructured":"Katsandegwaza B, Horsnell W, Smith K. Inflammatory Bowel Disease: A Review of Pre-Clinical Murine Models of Human Disease. Int J Mol Sci 2022;23.","DOI":"10.3390\/ijms23169344"},{"key":"8872_CR29","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1093\/ibd\/izad312","volume":"30","author":"C Yang","year":"2024","unstructured":"Yang C, Merlin D. Unveiling colitis: a journey through the dextran sodium sulfate-induced model. Inflamm Bowel Dis 2024;30:844\u2013853.","journal-title":"Inflamm Bowel Dis"},{"key":"8872_CR30","doi-asserted-by":"crossref","unstructured":"Jamwal S, Kumar P. Animal Models of Inflammatory Bowel Disease. Animal Models for the Study of Human Disease: Second Edition 2017:467\u201377.","DOI":"10.1016\/B978-0-12-809468-6.00019-X"},{"key":"8872_CR31","doi-asserted-by":"crossref","unstructured":"Bell CJ, Gall DG, Wallace JL. Disruption of colonic electrolyte transport in experimental colitis. Am J Physiol Gastrointest Liver Physiol 1995;268.","DOI":"10.1152\/ajpgi.1995.268.4.G622"},{"key":"8872_CR32","first-page":"238","volume":"69","author":"HS Cooper","year":"1993","unstructured":"Cooper HS, Murthy SNS, Shah RS et al. Clinicopathologic study of dextran sulfate sodium experimental murine colitis. Laboratory Investigation 1993;69:238\u2013250.","journal-title":"Laboratory Investigation"},{"key":"8872_CR33","volume-title":"The Enteric Nervous System","author":"JB Furness","year":"2006","unstructured":"Furness JB. The Enteric Nervous System, 1st edn. Malden, Massachusetts, USA: Blackwell Publishing Ltd; 2006.","edition":"1"},{"key":"8872_CR34","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/S0165-1838(00)00127-2","volume":"81","author":"JB Furness","year":"2000","unstructured":"Furness JB. Types of neurons in the enteric nervous system. J Auton Nerv Syst 2000;81:87\u201396.","journal-title":"J Auton Nerv Syst"},{"key":"8872_CR35","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1136\/gut.37.2.260","volume":"75","author":"F Hadziselimovic","year":"1995","unstructured":"Hadziselimovic F, Emmons LR, Gallati H. Soluble tumour necrosis factor receptors p55 and p75 in the urine monitor disease activity and the efficacy of treatment of inflammatory bowel disease. Gut 1995;75:260\u2013263.","journal-title":"Gut"},{"key":"8872_CR36","doi-asserted-by":"publisher","first-page":"20131","DOI":"10.1016\/S0021-9258(17)30479-9","volume":"265","author":"H Loetscher","year":"1990","unstructured":"Loetscher H, Schlaeger EJ, Lahm HW et al. Purification and partial amino acid sequence analysis of two distinct tumor necrosis factor receptors from HL60 cells. Journal of Biological Chemistry 1990;265:20131\u201320138.","journal-title":"Journal of Biological Chemistry"},{"key":"8872_CR37","doi-asserted-by":"publisher","first-page":"48","DOI":"10.4239\/wjd.v14.i1.48","volume":"14","author":"BP Barta","year":"2023","unstructured":"Barta BP, Onhausz B, Doghmi AAL et al. Gut region-specific TNFR expression: TNFR2 is more affected than TNFR1 in duodenal myenteric ganglia of diabetic rats. World J Diabetes 2023;14:48\u201361.","journal-title":"World J Diabetes"},{"key":"8872_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fimmu.2013.00478","volume":"4","author":"DL Faustman","year":"2013","unstructured":"Faustman DL, Davis M. TNF receptor 2 and disease: Autoimmunity and regenerative medicine. Front Immunol 2013;4:1\u20138.","journal-title":"Front Immunol"},{"key":"8872_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fimmu.2020.585880","volume":"11","author":"P Gough","year":"2020","unstructured":"Gough P, Myles IA. Tumor Necrosis Factor Receptors: Pleiotropic Signaling Complexes and Their Differential Effects. Front Immunol 2020;11:1\u201314.","journal-title":"Front Immunol"},{"key":"8872_CR40","doi-asserted-by":"publisher","first-page":"3339","DOI":"10.1523\/JNEUROSCI.3564-12.2013","volume":"33","author":"PY Gougeon","year":"2013","unstructured":"Gougeon PY, Lourenssen S, Han TY et al. The pro-inflammatory cytokines IL-1\u03b2 and TNF\u03b1 are neurotrophic for enteric neurons. Journal of Neuroscience 2013;33:3339\u20133351.","journal-title":"Journal of Neuroscience"},{"key":"8872_CR41","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1016\/j.ajpath.2021.02.021","volume":"191","author":"M Sanchez-Ruiz","year":"2021","unstructured":"Sanchez-Ruiz M, Iorgu AM, K\u00fcster F et al. CD8 T cell-derived perforin and TNF-\u03b1 are crucial mediators of neuronal destruction in experimental autoimmune enteric ganglionitis. American Journal of Pathology 2021;191:1064\u20131076.","journal-title":"American Journal of Pathology"},{"key":"8872_CR42","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.cytogfr.2004.03.011","volume":"15","author":"G Eissner","year":"2004","unstructured":"Eissner G, Kolch W, Scheurich P. Ligands working as receptors: Reverse signaling by members of the TNF superfamily enhance the plasticity of the immune system. Cytokine Growth Factor Rev 2004;15:353\u2013366.","journal-title":"Cytokine Growth Factor Rev"},{"key":"8872_CR43","doi-asserted-by":"crossref","unstructured":"da Silva Watanabe P, Cavichioli AM, D\u2019Arc de Lima Mendes J, et al. Colonic motility adjustments in acute and chronic DSS-induced colitis. Life Sci 2023;321.","DOI":"10.1016\/j.lfs.2023.121642"},{"key":"8872_CR44","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2022.120562","volume":"301","author":"S Cerantola","year":"2022","unstructured":"Cerantola S, Faggin S, Caputi V et al. Small intestine neuromuscular dysfunction in a mouse model of dextran sulfate sodium-induced ileitis: Involvement of dopaminergic neurotransmission. Life Sci 2022;301:120562.","journal-title":"Life Sci"},{"key":"8872_CR45","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/s00418-014-1270-6","volume":"143","author":"MV da Silva","year":"2015","unstructured":"da Silva MV, Marosti AR, Mendes CE et al. Differential effects of experimental ulcerative colitis on P2X7 receptor expression in enteric neurons. Histochem Cell Biol 2015;143:171\u2013184.","journal-title":"Histochem Cell Biol"},{"key":"8872_CR46","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/s00418-021-02039-z","volume":"157","author":"MM Evangelinellis","year":"2022","unstructured":"Evangelinellis MM, Souza RF, Mendes CE et al. Effects of a P2X7 receptor antagonist on myenteric neurons in the distal colon of an experimental rat model of ulcerative colitis. Histochem Cell Biol 2022;157:65\u201381.","journal-title":"Histochem Cell Biol"},{"key":"8872_CR47","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1111\/j.1365-2982.2005.00703.x","volume":"17","author":"DR Linden","year":"2005","unstructured":"Linden DR, Couvrette JM, Ciolino A et al. Indiscriminate loss of myenteric neurones in the TNBS-inflamed guinea-pig distal colon. Neurogastroenterology and Motility 2005;17:751\u2013760.","journal-title":"Neurogastroenterology and Motility"},{"key":"8872_CR48","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1111\/j.1365-2982.2011.01748.x","volume":"23","author":"C Cirillo","year":"2011","unstructured":"Cirillo C, Sarnelli G, Turco F et al. Proinflammatory stimuli activates human-derived enteroglial cells and induces autocrine nitric oxide production. Neurogastroenterology and Motility 2011;23:10\u201312.","journal-title":"Neurogastroenterology and Motility"},{"key":"8872_CR49","doi-asserted-by":"publisher","first-page":"4035","DOI":"10.3748\/wjg.v13.i30.4035","volume":"13","author":"G Bassotti","year":"2007","unstructured":"Bassotti G, Villanacci V, Fisogni S et al. Enteric glial cells and their role in gastrointestinal motor abnormalities: Introducing the neuro-gliopathies. World J Gastroenterol 2007;13:4035\u20134041.","journal-title":"World J Gastroenterol"},{"key":"8872_CR50","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1471-230X-11-2","volume":"11","author":"GBT Von Boyen","year":"2011","unstructured":"Von Boyen GBT, Schulte N, Pfl\u00fcger C et al. Distribution of enteric glia and GDNF during gut inflammation. BMC Gastroenterol 2011;11:2\u20138.","journal-title":"BMC Gastroenterol"},{"key":"8872_CR51","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1136\/gut.2003.012625","volume":"53","author":"GBT Von Boyen","year":"2004","unstructured":"Von Boyen GBT, Steinkamp M, Reinshagen M et al. Proinflammatory cytokines increase glial fibrillary acidic protein expression in enteric glia. Gut 2004;53:222\u2013228.","journal-title":"Gut"},{"key":"8872_CR52","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2023.137315","volume":"809","author":"C Le Berre","year":"2023","unstructured":"Le Berre C, Naveilhan P, Rolli-Derkinderen M. Enteric glia at center stage of inflammatory bowel disease. Neurosci Lett 2023;809:137315.","journal-title":"Neurosci Lett"},{"key":"8872_CR53","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1002\/glia.22746","volume":"63","author":"W Boesmans","year":"2015","unstructured":"Boesmans W, Lasrado R, Vanden Berghe P et al. Heterogeneity and phenotypic plasticity of glial cells in the mammalian enteric nervous system. Glia 2015;63:229\u2013241.","journal-title":"Glia"},{"key":"8872_CR54","doi-asserted-by":"publisher","first-page":"2040","DOI":"10.1002\/glia.22876","volume":"63","author":"M Rao","year":"2015","unstructured":"Rao M, Nelms BD, Dong L et al. Enteric glia express proteolipid protein 1 and are a transcriptionally unique population of glia in the mammalian nervous system. Glia 2015;63:2040\u20132057.","journal-title":"Glia"},{"key":"8872_CR55","first-page":"1","volume":"23","author":"A Koz\u0142owska","year":"2023","unstructured":"Koz\u0142owska A, Kozera P, Majewski M et al. Co-expression of caspase-3 or caspase-8 with galanin in the human stomach section affected by carcinoma. Histochem Cell Biol 2023;23:1\u201365.","journal-title":"Histochem Cell Biol"},{"key":"8872_CR56","first-page":"1","volume":"3","author":"Y Otsuki","year":"2003","unstructured":"Otsuki Y, Li Z, Shibata M. Apoptotic Detection Methods - from Morphology to Gene Yoshinori Otsuki Zhonglian Li Masa-Aki Shibata. Progr. Histochem. Cytochem. 2003;3:1\u201365.","journal-title":"Progr. Histochem. Cytochem."},{"key":"8872_CR57","doi-asserted-by":"crossref","unstructured":"Jodeleit H, Winkelmann P, Caesar J, et al. Head-to-head study of oxelumab and adalimumab in a mouse model of ulcerative colitis based on NOD\/Scid IL2R\u03b3null mice reconstituted with human peripheral blood mononuclear cells. DMM Disease Models and Mechanisms 2021;14.","DOI":"10.1242\/dmm.046995"},{"key":"8872_CR58","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1093\/ibd\/izz284","volume":"26","author":"H Jodeleit","year":"2020","unstructured":"Jodeleit H, Caesar J, Villarroel Aguilera C et al. The Combination of Patient Profiling and Preclinical Studies in a Mouse Model Based on NOD\/Scid IL2R\u03b3 null Mice Reconstituted with Peripheral Blood Mononuclear Cells from Patients with Ulcerative Colitis May Lead to Stratification of Patients for Treatmen. Inflamm Bowel Dis 2020;26:557\u2013569.","journal-title":"Inflamm Bowel Dis"},{"key":"8872_CR59","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1002\/mds.28890","volume":"37","author":"CH Lin","year":"2022","unstructured":"Lin CH, Lin HY, Ho EP et al. Mild Chronic Colitis Triggers Parkinsonism in LRRK2 Mutant Mice Through Activating TNF-\u03b1 Pathway. Mov Disord 2022;37:745\u2013757.","journal-title":"Mov Disord"},{"key":"8872_CR60","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1002\/ana.24176","volume":"76","author":"F Richter","year":"2014","unstructured":"Richter F, L\u00fctz W, Eitner A et al. Tumor necrosis factor reduces the amplitude of rat cortical spreading depression in vivo. Ann Neurol 2014;76:43\u201353.","journal-title":"Ann Neurol"},{"key":"8872_CR61","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/j.acthis.2017.05.001","volume":"119","author":"MV da Silva","year":"2017","unstructured":"da Silva MV, Marosti AR, Mendes CE et al. Submucosal neurons and enteric glial cells expressing the P2X7 receptor in rat experimental colitis. Acta Histochem 2017;119:481\u2013494.","journal-title":"Acta Histochem"},{"key":"8872_CR62","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1007\/s00441-013-1620-z","volume":"353","author":"PA Girotti","year":"2013","unstructured":"Girotti PA, Misawa R, Palombit K et al. Differential effects of undernourishment on the differentiation and maturation of rat enteric neurons. Cell Tissue Res 2013;353:367\u2013380.","journal-title":"Cell Tissue Res"},{"key":"8872_CR63","doi-asserted-by":"publisher","first-page":"4693","DOI":"10.3748\/wjg.v18.i34.4693","volume":"18","author":"MS Mizuno","year":"2012","unstructured":"Mizuno MS, Crisma AR, Borelli P et al. Expression of the P2X2 receptor in different classes of ileum myenteric neurons in the female obese ob\/ob mouse. World J Gastroenterol 2012;18:4693\u20134703.","journal-title":"World J Gastroenterol"},{"key":"8872_CR64","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1007\/s10620-019-05496-8","volume":"64","author":"K Palombit","year":"2019","unstructured":"Palombit K, Mendes CE, Tavares-de-Lima W et al. Blockage of the P2X7 Receptor Attenuates Harmful Changes Produced by Ischemia and Reperfusion in the Myenteric Plexus. Dig Dis Sci 2019;64:1815\u20131829. https:\/\/doi.org\/10.1007\/s10620-019-05496-8.","journal-title":"Dig Dis Sci"},{"key":"8872_CR65","doi-asserted-by":"publisher","first-page":"2262","DOI":"10.1007\/s10620-011-1588-z","volume":"56","author":"AS Paulino","year":"2011","unstructured":"Paulino AS, Palombit K, Cavriani G et al. Effects of ischemia and reperfusion on P2X2 receptor expressing neurons of the rat ileum enteric nervous system. Dig Dis Sci 2011;56:2262\u20132275. https:\/\/doi.org\/10.1007\/s10620-011-1588-z.","journal-title":"Dig Dis Sci"},{"key":"8872_CR66","doi-asserted-by":"publisher","first-page":"2645","DOI":"10.1038\/onc.2015.327","volume":"35","author":"S Das","year":"2016","unstructured":"Das S, Rachagani S, Sheinin Y et al. Mice deficient in Muc4 are resistant to experimental colitis and colitis-associated colorectal cancer. Oncogene 2016;35:2645\u20132654.","journal-title":"Oncogene"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-025-08872-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10620-025-08872-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-025-08872-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T20:54:14Z","timestamp":1743972854000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10620-025-08872-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,13]]},"references-count":66,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["8872"],"URL":"https:\/\/doi.org\/10.1007\/s10620-025-08872-9","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,13]]},"assertion":[{"value":"11 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All experimental protocols were approved by Ethics Committee on Animal Use of the Biomedical Science Institute of the University of S\u00e3o Paulo under protocol No. 7335180618.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}