{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T19:36:48Z","timestamp":1781206608471,"version":"3.54.1"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:00:00Z","timestamp":1744761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:00:00Z","timestamp":1744761600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"The Scientific and Technological Research Council of Turkiye","award":["118S260"],"award-info":[{"award-number":["118S260"]}]},{"name":"Ege University Scientific Research Projects Coordination","award":["TGA-2021-22732"],"award-info":[{"award-number":["TGA-2021-22732"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1007\/s10620-025-08951-x","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T05:28:31Z","timestamp":1744781311000},"page":"2665-2673","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Molecular and Functional Recovery of Esophageal Barrier Integrity After Laparoscopic Anti-reflux Surgery"],"prefix":"10.1007","volume":"70","author":[{"given":"Pelin","family":"Ergun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sezgi","family":"Kipcak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volkan","family":"Gorgulu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basak","family":"Doganavsargil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serhat","family":"Bor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,16]]},"reference":[{"key":"8951_CR1","doi-asserted-by":"publisher","first-page":"S4","DOI":"10.5152\/tjg.2017.03","volume":"28","author":"S Bor","year":"2017","unstructured":"Bor S, Sar\u0131ta\u015f Y\u00fcksel E. How is the gastroesophageal reflux disease prevalence, incidence, and frequency of complications (stricture\/esophagitis\/Barrett\u2019s esophagus\/carcinoma) in Turkey compared to other geographical regions globally? Turk J Gastroenterol 2017;28:S4-s9. https:\/\/doi.org\/10.5152\/tjg.2017.03.","journal-title":"Turk J Gastroenterol"},{"key":"8951_CR2","doi-asserted-by":"publisher","unstructured":"Gyawali CP, Yadlapati R, Fass R, et al. Updates to the modern diagnosis of GERD: Lyon consensus 2.0. Gut 2024, 73, 361\u2013371. https:\/\/doi.org\/10.1136\/gutjnl-2023-330616.","DOI":"10.1136\/gutjnl-2023-330616"},{"key":"8951_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2019.101649","volume":"40\u201341","author":"S Bor","year":"2019","unstructured":"Bor S. Reflux esophagitis, functional and non-functional. Best Pract Res Clin Gastroenterol 2019;40\u201341:101649. https:\/\/doi.org\/10.1016\/j.bpg.2019.101649.","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"8951_CR4","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1007\/s11894-009-0030-6","volume":"11","author":"LA Orlando","year":"2009","unstructured":"Orlando LA, Orlando RC. Dilated intercellular spaces as a marker of GERD. Curr Gastroenterol Rep 2009;11:190\u2013194. https:\/\/doi.org\/10.1007\/s11894-009-0030-6.","journal-title":"Curr Gastroenterol Rep"},{"key":"8951_CR5","doi-asserted-by":"publisher","first-page":"436","DOI":"10.5056\/jnm22142","volume":"29","author":"V Gorgulu","year":"2023","unstructured":"Gorgulu V, Ergun P, Kipcak S, et al. Revisiting the Role of Esophageal Mucosal Dilated Intercellular Spaces in the Diagnosis and Pathophysiology of Heartburn. J Neurogastroenterol Motil 2023;29:436\u2013445. https:\/\/doi.org\/10.5056\/jnm22142.","journal-title":"J Neurogastroenterol Motil"},{"key":"8951_CR6","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14022","volume":"32","author":"A Ustaoglu","year":"2020","unstructured":"Ustaoglu A, Nguyen A, Spechler S, et al. Mucosal pathogenesis in gastro-esophageal reflux disease. Neurogastroenterol Motil 2020;32:e14022. https:\/\/doi.org\/10.1111\/nmo.14022.","journal-title":"Neurogastroenterol Motil"},{"key":"8951_CR7","doi-asserted-by":"publisher","first-page":"1776","DOI":"10.1053\/j.gastro.2009.07.055","volume":"137","author":"RF Souza","year":"2009","unstructured":"Souza RF, Huo X, Mittal V, et al. Gastroesophageal reflux might cause esophagitis through a cytokine-mediated mechanism rather than caustic acid injury. Gastroenterology 2009;137:1776\u20131784. https:\/\/doi.org\/10.1053\/j.gastro.2009.07.055.","journal-title":"Gastroenterology"},{"key":"8951_CR8","doi-asserted-by":"publisher","first-page":"871","DOI":"10.4240\/wjgs.v16.i3.871","volume":"16","author":"P Ergun","year":"2024","unstructured":"Ergun P, Kipcak S, Selvi Gunel N, et al. Inflammatory responses in esophageal mucosa before and after laparoscopic antireflux surgery. World J Gastrointest Surg 2024;16:871\u2013881. https:\/\/doi.org\/10.4240\/wjgs.v16.i3.871.","journal-title":"World J Gastrointest Surg"},{"key":"8951_CR9","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1097\/MCG.0000000000001560","volume":"56","author":"P Ergun","year":"2022","unstructured":"Ergun P, Kipcak S, Dettmar PW, et al. Pepsin and pH of Gastric Juice in Patients With Gastrointestinal Reflux Disease and Subgroups. J Clin Gastroenterol 2022;56:512\u2013517. https:\/\/doi.org\/10.1097\/MCG.0000000000001560.","journal-title":"J Clin Gastroenterol"},{"key":"8951_CR10","doi-asserted-by":"publisher","unstructured":"Samuels TL, Blaine-Sauer S, Yan K, et al. Topical Alginate Protection against Pepsin-Mediated Esophageal Damage: E-Cadherin Proteolysis and Matrix Metalloproteinase Induction. Int J Mol Sci 2023, 24, https:\/\/doi.org\/10.3390\/ijms24097932.","DOI":"10.3390\/ijms24097932"},{"key":"8951_CR11","doi-asserted-by":"publisher","first-page":"290","DOI":"10.5056\/jnm22186","volume":"30","author":"P Ergun","year":"2024","unstructured":"Ergun P, Kipcak S, Gunel NS, et al. Roles of Cytokines in Pathological and Physiological Gastroesophageal Reflux Exposure. J Neurogastroenterol Motil 2024;30:290\u2013302. https:\/\/doi.org\/10.5056\/jnm22186.","journal-title":"J Neurogastroenterol Motil"},{"key":"8951_CR12","doi-asserted-by":"publisher","unstructured":"Ergun P, Samuels TL, Mathison AJ, et al. Global Transcriptomic Analysis of Topical Sodium Alginate Protection against Peptic Damage in an In Vitro Model of Treatment-Resistant Gastroesophageal Reflux Disease. Int J Mol Sci 2024, 25, https:\/\/doi.org\/10.3390\/ijms251910714.","DOI":"10.3390\/ijms251910714"},{"key":"8951_CR13","doi-asserted-by":"publisher","first-page":"1928","DOI":"10.1136\/gutjnl-2019-318260","volume":"68","author":"A Pauwels","year":"2019","unstructured":"Pauwels A, Boecxstaens V, Andrews CN, et al. How to select patients for antireflux surgery? The ICARUS guidelines (international consensus regarding preoperative examinations and clinical characteristics assessment to select adult patients for antireflux surgery). Gut 2019;68:1928\u20131941. https:\/\/doi.org\/10.1136\/gutjnl-2019-318260.","journal-title":"Gut"},{"key":"8951_CR14","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.1016\/j.cgh.2020.03.057","volume":"19","author":"D Patel","year":"2021","unstructured":"Patel D, Fass R, Vaezi M. Untangling Nonerosive Reflux Disease From Functional Heartburn. Clin Gastroenterol Hepatol 2021;19:1314\u20131326. https:\/\/doi.org\/10.1016\/j.cgh.2020.03.057.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"8951_CR15","doi-asserted-by":"publisher","unstructured":"Delshad SD, Almario, CV, Chey WD, Spiegel BMR. Prevalence of Gastroesophageal Reflux Disease and Proton Pump Inhibitor-Refractory Symptoms. Gastroenterology 2020, 158, 1250\u20131261 e1252, https:\/\/doi.org\/10.1053\/j.gastro.2019.12.014.","DOI":"10.1053\/j.gastro.2019.12.014"},{"key":"8951_CR16","doi-asserted-by":"publisher","first-page":"17","DOI":"10.5056\/jnm23145","volume":"30","author":"TA Davis","year":"2024","unstructured":"Davis TA, Gyawali CP. Refractory Gastroesophageal Reflux Disease: Diagnosis and Management. J Neurogastroenterol Motil 2024;30:17\u201328. https:\/\/doi.org\/10.5056\/jnm23145.","journal-title":"J Neurogastroenterol Motil"},{"key":"8951_CR17","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1590\/S0004-2803.202202000-40","volume":"59","author":"D Chinzon","year":"2022","unstructured":"Chinzon D, Domingues G, Tosetto N, Perrotti M. Safety of Long-Term Proton Pump Inhibitors: Facts and Myths. Arq Gastroenterol 2022;59:219\u2013225. https:\/\/doi.org\/10.1590\/S0004-2803.202202000-40.","journal-title":"Arq Gastroenterol"},{"key":"8951_CR18","doi-asserted-by":"publisher","unstructured":"Fossmark R, Martinsen TC, Waldum HL. Adverse Effects of Proton Pump Inhibitors-Evidence and Plausibility. Int J Mol Sci 2019, 20, https:\/\/doi.org\/10.3390\/ijms20205203.","DOI":"10.3390\/ijms20205203"},{"key":"8951_CR19","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1001\/archsurg.140.10.946","volume":"140","author":"P Pessaux","year":"2005","unstructured":"Pessaux P, Arnaud JP, Delattre JF, et al. Laparoscopic antireflux surgery: five-year results and beyond in 1340 patients. Arch Surg 2005;140:946\u2013951. https:\/\/doi.org\/10.1001\/archsurg.140.10.946.","journal-title":"Arch Surg"},{"key":"8951_CR20","doi-asserted-by":"publisher","first-page":"394","DOI":"10.5056\/jnm19059","volume":"25","author":"S Park","year":"2019","unstructured":"Park S, Park JM, Kim JJ, et al. Multicenter Prospective Study of Laparoscopic Nissen Fundoplication for Gastroesophageal Reflux Disease in Korea. J Neurogastroenterol Motil 2019;25:394\u2013402. https:\/\/doi.org\/10.5056\/jnm19059.","journal-title":"J Neurogastroenterol Motil"},{"key":"8951_CR21","doi-asserted-by":"publisher","unstructured":"Sanberg Ljungdalh J, Rubin KH, Durup J, et al. Long-term patient satisfaction and durability of laparoscopic anti-reflux surgery in a large Danish cohort: study protocol for a retrospective cohort study with development of a novel scoring system for patient selection. BMJ Open 2020, 10, e034257, https:\/\/doi.org\/10.1136\/bmjopen-2019-034257.","DOI":"10.1136\/bmjopen-2019-034257"},{"key":"8951_CR22","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1007\/s00464-003-9267-6","volume":"19","author":"T Kamolz","year":"2005","unstructured":"Kamolz T, Granderath FA, Schweiger UM, Pointner R. Laparoscopic Nissen fundoplication in patients with nonerosive reflux disease. Surgical Endoscopy And Other Interventional Techniques 2005;19:494\u2013500. https:\/\/doi.org\/10.1007\/s00464-003-9267-6.","journal-title":"Surgical Endoscopy And Other Interventional Techniques"},{"key":"8951_CR23","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1002\/bjs.5493","volume":"93","author":"I Mainie","year":"2006","unstructured":"Mainie I, Tutuian R, Agrawal A, et al. Combined multichannel intraluminal impedance-pH monitoring to select patients with persistent gastro-oesophageal reflux for laparoscopic Nissen fundoplication. Br J Surg 2006;93:1483\u20131487. https:\/\/doi.org\/10.1002\/bjs.5493.","journal-title":"Br J Surg"},{"key":"8951_CR24","doi-asserted-by":"publisher","first-page":"215013272110467","DOI":"10.1177\/21501327211046736","volume":"12","author":"PT Kroner","year":"2021","unstructured":"Kroner PT, Cortes P, Lukens FJ. The Medical Management of Gastroesophageal Reflux Disease: A Narrative Review. J Prim Care Community Health 2021;12:21501327211046736. https:\/\/doi.org\/10.1177\/21501327211046736.","journal-title":"J Prim Care Community Health"},{"key":"8951_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.disamonth.2019.02.002","volume":"66","author":"R Roark","year":"2020","unstructured":"Roark R, Sydor M, Chatila AT, et al. Management of gastroesophageal reflux disease. Dis Mon 2020;66:100849. https:\/\/doi.org\/10.1016\/j.disamonth.2019.02.002.","journal-title":"Dis Mon"},{"key":"8951_CR26","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1136\/gut.2010.224824","volume":"60","author":"JA Broeders","year":"2011","unstructured":"Broeders JA, Bredenoord AJ, Hazebroek EJ, et al. Effects of anti-reflux surgery on weakly acidic reflux and belching. Gut 2011;60:435\u2013441. https:\/\/doi.org\/10.1136\/gut.2010.224824.","journal-title":"Gut"},{"key":"8951_CR27","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1007\/s10517-021-05273-6","volume":"171","author":"P Ergun","year":"2021","unstructured":"Ergun P, Capanoglu D, Kipcak S, Bor S. Response of Esophageal Epithelium to Acute and Chronic Stress in Rabbits. Bull Exp Biol Med 2021;171:582\u2013587. https:\/\/doi.org\/10.1007\/s10517-021-05273-6.","journal-title":"Bull Exp Biol Med"},{"key":"8951_CR28","doi-asserted-by":"publisher","unstructured":"Rinsma NF, Farre R, Troost FJ, et al. Exploration of the Esophageal Mucosal Barrier in Non-Erosive Reflux Disease. Int J Mol Sci 2017, 18, https:\/\/doi.org\/10.3390\/ijms18051091.","DOI":"10.3390\/ijms18051091"},{"key":"8951_CR29","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1007\/s10620-021-06980-w","volume":"67","author":"PR Mutha","year":"2022","unstructured":"Mutha PR, Fasullo M, Chu S, et al. Correlation of Probe-Based Confocal Laser Endomicroscopy (pCLE) and Mucosal Integrity Testing (MIT) with Epithelial Barrier Function and Presence of Gastroesophageal Reflux Disease (GERD). Dig Dis Sci 2022;67:1773\u20131782. https:\/\/doi.org\/10.1007\/s10620-021-06980-w.","journal-title":"Dig Dis Sci"},{"key":"8951_CR30","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1007\/s00535-016-1207-z","volume":"51","author":"T Oshima","year":"2016","unstructured":"Oshima T, Miwa H. Gastrointestinal mucosal barrier function and diseases. J Gastroenterol 2016;51:768\u2013778. https:\/\/doi.org\/10.1007\/s00535-016-1207-z.","journal-title":"J Gastroenterol"},{"key":"8951_CR31","doi-asserted-by":"publisher","first-page":"1924","DOI":"10.1053\/j.gastro.2021.08.047","volume":"161","author":"WT Kuo","year":"2021","unstructured":"Kuo WT, Zuo L, Odenwald MA, et al. The Tight Junction Protein ZO-1 Is Dispensable for Barrier Function but Critical for Effective Mucosal Repair. Gastroenterology 2021;161:1924\u20131939. https:\/\/doi.org\/10.1053\/j.gastro.2021.08.047.","journal-title":"Gastroenterology"},{"key":"8951_CR32","doi-asserted-by":"publisher","first-page":"3804","DOI":"10.7150\/ijbs.85765","volume":"19","author":"S Yu","year":"2023","unstructured":"Yu S, He J, Xie K. Zonula Occludens Proteins Signaling in Inflammation and Tumorigenesis. Int J Biol Sci 2023;19:3804\u20133815. https:\/\/doi.org\/10.7150\/ijbs.85765.","journal-title":"Int J Biol Sci"},{"key":"8951_CR33","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1111\/apt.14038","volume":"45","author":"L Mastracci","year":"2017","unstructured":"Mastracci L, Fiocca R, Engstr\u00f6m C, et al. The dynamics of the oesophageal squamous epithelium \u201cnormalisation\u201d process in patients with gastro-oesophageal reflux disease treated with long-term acid suppression or anti-reflux surgery. Aliment Pharmacol Ther 2017;45:1339\u20131349. https:\/\/doi.org\/10.1111\/apt.14038.","journal-title":"Aliment Pharmacol Ther"},{"key":"8951_CR34","doi-asserted-by":"publisher","unstructured":"Rodr\u00edguez de Santiago E, Alb\u00e9niz E, Estremera-Arevalo F, et al. Endoscopic anti-reflux therapy for gastroesophageal reflux disease. World J Gastroenterol 2021, 27, 6601\u20136614, https:\/\/doi.org\/10.3748\/wjg.v27.i39.6601.","DOI":"10.3748\/wjg.v27.i39.6601"},{"key":"8951_CR35","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/s1607-551x(09)70124-x","volume":"21","author":"CH Yi","year":"2005","unstructured":"Yi CH, Chen CL, Lin HH, Chen MC. Esophageal acid exposure in healthy adults in Taiwan: experience with pH step-up method by dual-channel pH-metry. Kaohsiung J Med Sci 2005;21:299\u2013303. https:\/\/doi.org\/10.1016\/s1607-551x(09)70124-x.","journal-title":"Kaohsiung J Med Sci"},{"key":"8951_CR36","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1038\/ajg.2011.102","volume":"106","author":"B Jovov","year":"2011","unstructured":"Jovov B, Que J, Tobey NA, et al. Role of E-cadherin in the pathogenesis of gastroesophageal reflux disease. Am J Gastroenterol 2011;106:1039\u20131047. https:\/\/doi.org\/10.1038\/ajg.2011.102.","journal-title":"Am J Gastroenterol"},{"key":"8951_CR37","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1159\/000508661","volume":"102","author":"K Norita","year":"2021","unstructured":"Norita K, Asanuma K, Koike T, et al. Impaired Mucosal Integrity in Proximal Esophagus Is Involved in Development of Proton Pump Inhibitor-Refractory Nonerosive Reflux Disease. Digestion 2021;102:404\u2013414. https:\/\/doi.org\/10.1159\/000508661.","journal-title":"Digestion"},{"key":"8951_CR38","doi-asserted-by":"publisher","unstructured":"Ergun P, Kipcak S, Gorgulu V, et al. Investigation of tight junction molecules according to PPI responses in patients with gastroesophageal reflux disease. Neurogastroenterology and Motility 2023, 35, https:\/\/doi.org\/10.1111\/nmo.14637.","DOI":"10.1111\/nmo.14637"},{"key":"8951_CR39","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1186\/1471-230X-12-128","volume":"12","author":"K Monkemuller","year":"2012","unstructured":"Monkemuller K, Wex T, Kuester D, et al. Role of tight junction proteins in gastroesophageal reflux disease. BMC Gastroenterol 2012;12:128. https:\/\/doi.org\/10.1186\/1471-230X-12-128.","journal-title":"BMC Gastroenterol"},{"key":"8951_CR40","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1007\/s00535-005-1628-6","volume":"40","author":"D Asaoka","year":"2005","unstructured":"Asaoka D, Miwa H, Hirai S, et al. Altered localization and expression of tight-junction proteins in a rat model with chronic acid reflux esophagitis. J Gastroenterol 2005;40:781\u2013790. https:\/\/doi.org\/10.1007\/s00535-005-1628-6.","journal-title":"J Gastroenterol"},{"key":"8951_CR41","doi-asserted-by":"publisher","first-page":"2226","DOI":"10.1007\/s10620-023-07901-9","volume":"68","author":"SJ Layne","year":"2023","unstructured":"Layne SJ, Lorsch ZS, Patel A. Novel Diagnostic Techniques in the Evaluation of Gastroesophageal Reflux Disease (GERD). Dig Dis Sci 2023;68:2226\u20132236. https:\/\/doi.org\/10.1007\/s10620-023-07901-9.","journal-title":"Dig Dis Sci"},{"key":"8951_CR42","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1111\/j.1572-0241.2007.01688.x","volume":"103","author":"H van Malenstein","year":"2008","unstructured":"van Malenstein H, Farr\u00e9 R, Sifrim D. Esophageal dilated intercellular spaces (DIS) and nonerosive reflux disease. Am J Gastroenterol 2008;103:1021\u20131028. https:\/\/doi.org\/10.1111\/j.1572-0241.2007.01688.x.","journal-title":"Am J Gastroenterol"},{"key":"8951_CR43","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1186\/s12967-024-05878-1","volume":"22","author":"S Chen","year":"2024","unstructured":"Chen S, Jiang D, Zhuang Q, et al. Esophageal microbial dysbiosis impairs mucosal barrier integrity via toll-like receptor 2 pathway in patients with gastroesophageal reflux symptoms. J Transl Med 2024;22:1145. https:\/\/doi.org\/10.1186\/s12967-024-05878-1.","journal-title":"J Transl Med"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-025-08951-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10620-025-08951-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-025-08951-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T06:46:54Z","timestamp":1755672414000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10620-025-08951-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,16]]},"references-count":43,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["8951"],"URL":"https:\/\/doi.org\/10.1007\/s10620-025-08951-x","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,16]]},"assertion":[{"value":"16 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was conducted in accordance with the Declaration of Helsinki and approved by the Ege University Clinical Research Ethics Committee, Izmir, Turkiye (18-2.1\/36, 20\/02\/2018).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}