{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T17:33:06Z","timestamp":1757611986723,"version":"3.44.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82303446"],"award-info":[{"award-number":["82303446"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Shenzhen High-level Hospital Construction Fund, and Peking University Shenzhen Hospital Scientific Research Fund","award":["KYQD2023303"],"award-info":[{"award-number":["KYQD2023303"]}]},{"DOI":"10.13039\/501100021171","name":"GuangDong Basic and Applied Basic Research Foundation","doi-asserted-by":"crossref","award":["2023A1515220200"],"award-info":[{"award-number":["2023A1515220200"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003785","name":"Medical Scientific Research Foundation of Guangdong Province of China","doi-asserted-by":"crossref","award":["A2024351"],"award-info":[{"award-number":["A2024351"]}],"id":[{"id":"10.13039\/501100003785","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Science and Technology Development Fund Project of Shenzhen","award":["JCYJ20240813115900001"],"award-info":[{"award-number":["JCYJ20240813115900001"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1007\/s10620-025-09083-y","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T12:50:10Z","timestamp":1748609410000},"page":"3021-3033","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cross-Trait Cross-Genome Cross-Organ Analysis of Gastrointestinal Disorders and Depression"],"prefix":"10.1007","volume":"70","author":[{"given":"Chengyi","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoqing","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0286-8754","authenticated-orcid":false,"given":"Erbao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangyang","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bowen","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miaomiao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanhuan","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,5,30]]},"reference":[{"key":"9083_CR1","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1038\/s41525-024-00440-w","volume":"9","author":"J Lee","year":"2024","unstructured":"Lee J, Oh SJ, Ha E et al. Gut microbial and human genetic signatures of inflammatory bowel disease increase risk of comorbid mental disorders. npj Genom Med. 2024;9:52. https:\/\/doi.org\/10.1038\/s41525-024-00440-w.","journal-title":"npj Genom Med."},{"key":"9083_CR2","doi-asserted-by":"publisher","first-page":"156788","DOI":"10.1016\/j.cyto.2024.156788","volume":"184","author":"Z Wang","year":"2024","unstructured":"Wang Z, Shu Q, Wu J et al. Evaluating the association between immunological proteins and common intestinal diseases using a bidirectional two-sample Mendelian randomization study. Cytokine. 2024;184:156788. https:\/\/doi.org\/10.1016\/j.cyto.2024.156788.","journal-title":"Cytokine."},{"key":"9083_CR3","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1186\/s12967-024-05758-8","volume":"22","author":"C Hu","year":"2024","unstructured":"Hu C, Ge M, Liu Y et al. From inflammation to depression: key biomarkers for IBD-related major depressive disorder. J Transl Med. 2024;22:997. https:\/\/doi.org\/10.1186\/s12967-024-05758-8.","journal-title":"J Transl Med."},{"key":"9083_CR4","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.gastrohep.2021.02.022","volume":"45","author":"E P\u00e9rez De Arce","year":"2022","unstructured":"P\u00e9rez De Arce E, Quera R, Beltr\u00e1n CJ, Madrid AM, Nos P. S\u00edndrome de intestino irritable en la enfermedad inflamatoria intestinal. \u00bfSinergia en las alteraciones del eje cerebro-intestino? Gastroenterolog\u00eda y Hepatolog\u00eda. 2022;45:66\u201376. https:\/\/doi.org\/10.1016\/j.gastrohep.2021.02.022.","journal-title":"Gastroenterolog\u00eda y Hepatolog\u00eda."},{"key":"9083_CR5","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.jad.2024.10.013","volume":"369","author":"Q Luo","year":"2025","unstructured":"Luo Q, Zhou D, He J et al. Relationships between emotional states, bipolar disorder, and gastrointestinal disorders: A two-sample Mendelian randomization study. Journal of Affective Disorders. 2025;369:475\u2013482. https:\/\/doi.org\/10.1016\/j.jad.2024.10.013.","journal-title":"Journal of Affective Disorders."},{"key":"9083_CR6","doi-asserted-by":"publisher","first-page":"921546","DOI":"10.3389\/fimmu.2022.921546","volume":"13","author":"B Liu","year":"2022","unstructured":"Liu B, Ye D, Yang H et al. Two-Sample Mendelian Randomization Analysis Investigates Causal Associations Between Gut Microbial Genera and Inflammatory Bowel Disease, and Specificity Causal Associations in Ulcerative Colitis or Crohn\u2019s Disease. Front Immunol. 2022;13:921546. https:\/\/doi.org\/10.3389\/fimmu.2022.921546.","journal-title":"Front Immunol."},{"key":"9083_CR7","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/nrn3257","volume":"13","author":"R Schwarcz","year":"2012","unstructured":"Schwarcz R, Bruno JP, Muchowski PJ, Wu HQ. Kynurenines in the mammalian brain: when physiology meets pathology. Nat Rev Neurosci. 2012;13:465\u2013477. https:\/\/doi.org\/10.1038\/nrn3257.","journal-title":"Nat Rev Neurosci."},{"key":"9083_CR8","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1186\/s12863-024-01274-2","volume":"25","author":"W Liao","year":"2024","unstructured":"Liao W, Luo Q, Zhang L et al. Genetic overlap between inflammatory bowel disease and iridocyclitis: insights from a genome-wide association study in a European population. BMC Genom Data. 2024;25:92. https:\/\/doi.org\/10.1186\/s12863-024-01274-2.","journal-title":"BMC Genom Data."},{"key":"9083_CR9","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1002\/mds.30047","volume":"40","author":"YS Hwang","year":"2025","unstructured":"Hwang YS, Jo S, Lee SH et al. Identification of Novel Genetic Loci Affecting Age at Onset of Parkinson\u2019s Disease: A Genome-wide Association Study. Movement Disorders. 2025;40:77\u201386. https:\/\/doi.org\/10.1002\/mds.30047.","journal-title":"Movement Disorders."},{"key":"9083_CR10","doi-asserted-by":"publisher","first-page":"1396036","DOI":"10.3389\/fmed.2024.1396036","volume":"11","author":"Y Liu","year":"2024","unstructured":"Liu Y, Liu H, Bian Q. Causal effects of lipid-lowering drugs on skin diseases: a two-sample Mendelian randomization study. Front Med. 2024;11:1396036. https:\/\/doi.org\/10.3389\/fmed.2024.1396036.","journal-title":"Front Med."},{"key":"9083_CR11","doi-asserted-by":"publisher","first-page":"zsae209","DOI":"10.1093\/sleep\/zsae209","volume":"48","author":"N Jia","year":"2025","unstructured":"Jia N, Zhu Z, Liu Y et al. From single nucleotide variations to genes: identifying the genetic links between sleep and psychiatric disorders. SLEEP. 2025;48:zsae209. https:\/\/doi.org\/10.1093\/sleep\/zsae209.","journal-title":"SLEEP."},{"key":"9083_CR12","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1038\/s41586-022-05473-8","volume":"613","author":"MI Kurki","year":"2023","unstructured":"Kurki MI, Karjalainen J, Palta P et al. FinnGen provides genetic insights from a well-phenotyped isolated population. Nature. 2023;613:508\u2013518. https:\/\/doi.org\/10.1038\/s41586-022-05473-8.","journal-title":"Nature."},{"key":"9083_CR13","doi-asserted-by":"publisher","first-page":"D998","DOI":"10.1093\/nar\/gkae1070","volume":"53","author":"M Cerezo","year":"2025","unstructured":"Cerezo M, Sollis E, Ji Y et al. The NHGRI-EBI GWAS Catalog: standards for reusability, sustainability and diversity. Nucleic Acids Research. 2025;53:D998\u2013D1005. https:\/\/doi.org\/10.1093\/nar\/gkae1070.","journal-title":"Nucleic Acids Research."},{"key":"9083_CR14","doi-asserted-by":"publisher","first-page":"281","DOI":"10.59249\/FBOT5313","volume":"97","author":"NS Ab Rajab","year":"2024","unstructured":"Ab Rajab NS, Yasin MAM, Ghazali WSW, Talib NA, Taib WRW, Sulong S. Schizophrenia and Rheumatoid Arthritis Genetic Scenery: PotentialNon-HLA Genes Involved in Both Diseases Relationship. Yale J Biol Med. 2024;97:281\u2013295. https:\/\/doi.org\/10.59249\/FBOT5313.","journal-title":"Yale J Biol Med."},{"key":"9083_CR15","doi-asserted-by":"publisher","first-page":"136961","DOI":"10.1016\/j.ijbiomac.2024.136961","volume":"282","author":"K Sun","year":"2024","unstructured":"Sun K, Wu F, Zheng J, Wang H, Li H, Xie Z. Essential blood molecular signature for progression of sepsis-induced acute lung injury: Integrated bioinformatic, single-cell RNA Seq and machine learning analysis. International Journal of Biological Macromolecules. 2024;282:136961. https:\/\/doi.org\/10.1016\/j.ijbiomac.2024.136961.","journal-title":"International Journal of Biological Macromolecules."},{"key":"9083_CR16","doi-asserted-by":"publisher","first-page":"1325538","DOI":"10.3389\/fendo.2023.1325538","volume":"14","author":"S Wang","year":"2024","unstructured":"Wang S, Wang K, Chen X, Lin S. The relationship between autoimmune thyroid disease, thyroid nodules and sleep traits: a Mendelian randomization study. Front Endocrinol. 2024;14:1325538. https:\/\/doi.org\/10.3389\/fendo.2023.1325538.","journal-title":"Front Endocrinol."},{"key":"9083_CR17","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1007\/s00403-024-03469-0","volume":"316","author":"Z Zhou","year":"2024","unstructured":"Zhou Z, Dan Zhan D, Li Fan L et al. Unraveling the genetic relationship between Alopecia areata and vitiligo. Arch Dermatol Res. 2024;316:712. https:\/\/doi.org\/10.1007\/s00403-024-03469-0.","journal-title":"Arch Dermatol Res."},{"key":"9083_CR18","doi-asserted-by":"publisher","first-page":"20243","DOI":"10.1038\/s41598-020-76791-y","volume":"10","author":"Y Shang","year":"2020","unstructured":"Shang Y, Li X, Liu W et al. Comprehensive genomic profile of Chinese lung cancer patients and mutation characteristics of individuals resistant to icotinib\/gefitinib. Sci Rep. 2020;10:20243. https:\/\/doi.org\/10.1038\/s41598-020-76791-y.","journal-title":"Sci Rep."},{"key":"9083_CR19","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1186\/s12967-024-05773-9","volume":"22","author":"G Shen","year":"2024","unstructured":"Shen G, Chen Y, Chen J et al. The causal effects of lifestyle, circulating, pigment, and metabolic factors on early age-related macular degeneration: a comprehensive Mendelian randomization study. J Transl Med. 2024;22:988. https:\/\/doi.org\/10.1186\/s12967-024-05773-9.","journal-title":"J Transl Med."},{"key":"9083_CR20","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1038\/s41431-022-01244-1","volume":"32","author":"TJ Mize","year":"2024","unstructured":"Mize TJ, Evans LM. Examination of a novel expression-based gene-SNP annotation strategy to identify tissue-specific contributions to heritability in multiple traits. Eur J Hum Genet. 2024;32:263\u2013269. https:\/\/doi.org\/10.1038\/s41431-022-01244-1.","journal-title":"Eur J Hum Genet."},{"key":"9083_CR21","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1097\/CEJ.0000000000000671","volume":"31","author":"J He","year":"2022","unstructured":"He J, Yu L, Qiao Z, Yu B, Liu Y, Ren H. Genetic polymorphisms of FCGR2A, ORAI1 and CD40 are associated with risk of lung cancer. European Journal of Cancer Prevention. 2022;31:7\u201313. https:\/\/doi.org\/10.1097\/CEJ.0000000000000671.","journal-title":"European Journal of Cancer Prevention."},{"key":"9083_CR22","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1002\/tox.24433","volume":"40","author":"X Zhang","year":"2025","unstructured":"Zhang X, Dong M, Zheng G et al. MCM4 Promotes the Progression of Malignant Melanoma by Activating the PI3K\/AKT Pathway. Environmental Toxicology. 2025;40:306\u2013317. https:\/\/doi.org\/10.1002\/tox.24433.","journal-title":"Environmental Toxicology."},{"key":"9083_CR23","doi-asserted-by":"publisher","first-page":"111172","DOI":"10.1016\/j.pnpbp.2024.111172","volume":"136","author":"Q Song","year":"2025","unstructured":"Song Q, Zhang C, Wang W, Wang C, Yi C. Exploring the genetic landscape of the brain-heart axis: A comprehensive analysis of pleiotropic effects between heart disease and psychiatric disorders. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2025;136:111172. https:\/\/doi.org\/10.1016\/j.pnpbp.2024.111172.","journal-title":"Progress in Neuro-Psychopharmacology and Biological Psychiatry."},{"key":"9083_CR24","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1186\/s13148-024-01772-1","volume":"16","author":"XX Dong","year":"2024","unstructured":"Dong XX, Chen DL, Chen HM et al. DNA methylation biomarkers and myopia: a multi-omics study integrating GWAS, mQTL and eQTL data. Clin Epigenet. 2024;16:157. https:\/\/doi.org\/10.1186\/s13148-024-01772-1.","journal-title":"Clin Epigenet."},{"key":"9083_CR25","doi-asserted-by":"publisher","unstructured":"Zouridis S, Ashraf MF, Tempera P, et al. A Comparison of the Effects of COVID-19 on Irritable Bowel Syndrome and Inflammatory Bowel Disease Patients While Working at Home and in the Office: A Retrospective Study. Cureus. Published online January 2, 2023. https:\/\/doi.org\/10.7759\/cureus.33266","DOI":"10.7759\/cureus.33266"},{"key":"9083_CR26","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.1038\/ajg.2012.260","volume":"107","author":"SJ Halpin","year":"2012","unstructured":"Halpin SJ, Ford AC. Prevalence of Symptoms Meeting Criteria for Irritable Bowel Syndrome in Inflammatory Bowel Disease: Systematic Review and Meta-Analysis. American Journal of Gastroenterology. 2012;107:1474\u20131482. https:\/\/doi.org\/10.1038\/ajg.2012.260.","journal-title":"American Journal of Gastroenterology."},{"key":"9083_CR27","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1038\/ajg.2012.263","volume":"107","author":"EMM Quigley","year":"2012","unstructured":"Quigley EMM, Bernstein CN. Editorial: \u201cIrritable Bowel Symptoms\u201d in Inflammatory Bowel Disease: Diagnostic Uncertainty Meets Pathological Reality. American Journal of Gastroenterology. 2012;107:1483\u20131485. https:\/\/doi.org\/10.1038\/ajg.2012.263.","journal-title":"American Journal of Gastroenterology."},{"key":"9083_CR28","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.mehy.2017.10.020","volume":"110","author":"A Szilagyi","year":"2018","unstructured":"Szilagyi A, Xue X. Comparison of geographic distributions of Irritable Bowel Syndrome with Inflammatory Bowel Disease fail to support common evolutionary roots. Medical Hypotheses. 2018;110:31\u201337. https:\/\/doi.org\/10.1016\/j.mehy.2017.10.020.","journal-title":"Medical Hypotheses."},{"key":"9083_CR29","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1080\/1744666X.2021.1939012","volume":"17","author":"P Wu","year":"2021","unstructured":"Wu P, Zhang Y, Nie G et al. Association between genetic variants in ZNF365 and inflammatory bowel disease risk in Caucasians: a meta-analysis and trial sequential analysis. Expert Review of Clinical Immunology. 2021;17:915\u2013921. https:\/\/doi.org\/10.1080\/1744666X.2021.1939012.","journal-title":"Expert Review of Clinical Immunology."},{"key":"9083_CR30","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1038\/ajg.2008.112","volume":"104","author":"RK Weersma","year":"2009","unstructured":"Weersma RK, Stokkers PCF, Cleynen I et al. Confirmation of Multiple Crohn\u2019s Disease Susceptibility Loci in a Large Dutch-Belgian Cohort. Am J Gastroenterol. 2009;104:630\u2013638. https:\/\/doi.org\/10.1038\/ajg.2008.112.","journal-title":"Am J Gastroenterol."},{"key":"9083_CR31","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1111\/j.1469-1809.2010.00606.x","volume":"74","author":"JJ Lee","year":"2010","unstructured":"Lee JJ, Essers JB, Kugathasan S et al. Association of Linear Growth Impairment in Pediatric Crohn\u2019s Disease and a Known Height Locus: A Pilot Study. Annals of Human Genetics. 2010;74:489\u2013497. https:\/\/doi.org\/10.1111\/j.1469-1809.2010.00606.x.","journal-title":"Annals of Human Genetics."},{"key":"9083_CR32","doi-asserted-by":"publisher","first-page":"894","DOI":"10.3389\/fimmu.2018.00894","volume":"9","author":"C Engman","year":"2018","unstructured":"Engman C, Garciafigueroa Y, Phillips BE, Trucco M, Giannoukakis N. Co-Stimulation-Impaired Bone Marrow-Derived Dendritic Cells Prevent Dextran Sodium Sulfate-Induced Colitis in Mice. Front Immunol. 2018;9:894. https:\/\/doi.org\/10.3389\/fimmu.2018.00894.","journal-title":"Front Immunol."},{"key":"9083_CR33","doi-asserted-by":"publisher","first-page":"1379335","DOI":"10.3389\/fmed.2024.1379335","volume":"11","author":"J Devereaux","year":"2024","unstructured":"Devereaux J, Robinson AM, Stavely R et al. Alterations in tryptophan metabolism and de novo NAD+ biosynthesis within the microbiota-gut-brain axis in chronic intestinal inflammation. Front Med. 2024;11:1379335. https:\/\/doi.org\/10.3389\/fmed.2024.1379335.","journal-title":"Front Med."},{"key":"9083_CR34","doi-asserted-by":"publisher","first-page":"1516","DOI":"10.1002\/ijc.31417","volume":"143","author":"X Liu","year":"2018","unstructured":"Liu X, Zhou W, Zhang X, Ding Y, Du Q, Hu R. 1-L-MT, an IDO inhibitor, prevented colitis-associated cancer by inducing CDC20 inhibition-mediated mitotic death of colon cancer cells. Intl Journal of Cancer. 2018;143:1516\u20131529. https:\/\/doi.org\/10.1002\/ijc.31417.","journal-title":"Intl Journal of Cancer."},{"key":"9083_CR35","doi-asserted-by":"publisher","unstructured":"Correction: Durable Therapeutic Efficacy Utilizing Combinatorial Blockade against IDO, CTLA-4, and PD-L1 in Mice with Brain Tumors. Clinical Cancer Research. 2015;21:662\u2013662. https:\/\/doi.org\/10.1158\/1078-0432.CCR-14-3211","DOI":"10.1158\/1078-0432.CCR-14-3211"},{"key":"9083_CR36","doi-asserted-by":"publisher","unstructured":"The NIDDK IBD Genetics Consortium, McGovern DPB, Gardet A, et al. Genome-wide association identifies multiple ulcerative colitis susceptibility loci. Nat Genet. 2010;42:332\u2013337. https:\/\/doi.org\/10.1038\/ng.549","DOI":"10.1038\/ng.549"},{"key":"9083_CR37","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.3389\/fonc.2020.01302","volume":"10","author":"F Li","year":"2020","unstructured":"Li F, Teng H, Liu M et al. Prognostic Value of Immune-Related Genes in the Tumor Microenvironment of Bladder Cancer. Front Oncol. 2020;10:1302. https:\/\/doi.org\/10.3389\/fonc.2020.01302.","journal-title":"Front Oncol."},{"key":"9083_CR38","doi-asserted-by":"publisher","first-page":"100365","DOI":"10.1016\/j.bpsgos.2024.100365","volume":"4","author":"Q Wang","year":"2024","unstructured":"Wang Q, Wang H, Dwivedi Y. Integrated Long Noncoding RNA and Messenger RNA Expression Analysis Identifies Molecules Specifically Associated With Resiliency and Susceptibility to Depression and Antidepressant Response. Biological Psychiatry Global Open Science. 2024;4:100365. https:\/\/doi.org\/10.1016\/j.bpsgos.2024.100365.","journal-title":"Biological Psychiatry Global Open Science."},{"key":"9083_CR39","doi-asserted-by":"publisher","unstructured":"Dai J, Lin XT, Shen LL, et al. Immune indicators and depression in adolescents: Associations with monocytes, lymphocytes, and direct bilirubin. World J Psychiatry. 2025;15. https:\/\/doi.org\/10.5498\/wjp.v15.i2.101818","DOI":"10.5498\/wjp.v15.i2.101818"},{"key":"9083_CR40","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1186\/s12974-022-02431-z","volume":"19","author":"NL Cluny","year":"2022","unstructured":"Cluny NL, Nyuyki KD, Almishri W et al. Recruitment of \u03b14\u03b27 monocytes and neutrophils to the brain in experimental colitis is associated with elevated cytokines and anxiety-like behavior. J Neuroinflammation. 2022;19:73. https:\/\/doi.org\/10.1186\/s12974-022-02431-z.","journal-title":"J Neuroinflammation."},{"key":"9083_CR41","doi-asserted-by":"publisher","first-page":"1419346","DOI":"10.3389\/fendo.2024.1419346","volume":"15","author":"B Cui","year":"2024","unstructured":"Cui B, Chen A, Xu C, Mao C, Chen Y. Causal relationship between antihypertensive drugs and Hashimoto\u2019s thyroiditis: a drug-target Mendelian randomization study. Front Endocrinol. 2024;15:1419346. https:\/\/doi.org\/10.3389\/fendo.2024.1419346.","journal-title":"Front Endocrinol."},{"key":"9083_CR42","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1146\/annurev-pharmtox-010814-124915","volume":"55","author":"ER Gross","year":"2015","unstructured":"Gross ER, Zambelli VO, Small BA, Ferreira JCB, Chen CH, Mochly-Rosen D. A Personalized Medicine Approach for Asian Americans with the Aldehyde Dehydrogenase 2*2 Variant. Annu Rev Pharmacol Toxicol. 2015;55:107\u2013127. https:\/\/doi.org\/10.1146\/annurev-pharmtox-010814-124915.","journal-title":"Annu Rev Pharmacol Toxicol."},{"key":"9083_CR43","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1093\/alcalc\/agz011","volume":"54","author":"MJ Zaso","year":"2019","unstructured":"Zaso MJ, Goodhines PA, Wall TL, Park A. Meta-Analysis on Associations of Alcohol Metabolism Genes With Alcohol Use Disorder in East Asians. Alcohol and Alcoholism. 2019;54:216\u2013224. https:\/\/doi.org\/10.1093\/alcalc\/agz011.","journal-title":"Alcohol and Alcoholism."}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-025-09083-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10620-025-09083-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-025-09083-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T05:17:34Z","timestamp":1756963054000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10620-025-09083-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,30]]},"references-count":43,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["9083"],"URL":"https:\/\/doi.org\/10.1007\/s10620-025-09083-y","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"type":"print","value":"0163-2116"},{"type":"electronic","value":"1573-2568"}],"subject":[],"published":{"date-parts":[[2025,5,30]]},"assertion":[{"value":"18 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008 (5). Informed consent was obtained from all patients for being included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent in studies with human subjects"}},{"value":"This article does not contain any studies with human or animal subjects.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Animal studies"}}]}}