{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:39:04Z","timestamp":1789623544110,"version":"build-2803163510"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82074158"],"award-info":[{"award-number":["82074158"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2019YFE0119300"],"award-info":[{"award-number":["2019YFE0119300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1007\/s10620-025-09133-5","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:14:00Z","timestamp":1751328840000},"page":"3815-3829","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Severe Acute Pancreatitis-Associated Lung Injury: A Comprehensive Quadruple Analysis of Animal Models"],"prefix":"10.1007","volume":"70","author":[{"given":"Xuanchi","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bowen","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyun","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aixia","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,1]]},"reference":[{"key":"9133_CR1","doi-asserted-by":"publisher","first-page":"8278","DOI":"10.1038\/s41467-024-52398-z","volume":"15","author":"X Chen","year":"2024","unstructured":"Chen X, Chen X, Yan D et al. GV-971 prevents severe acute pancreatitis by remodeling the microbiota-metabolic-immune axis. Nat Commun 2024;15:8278.","journal-title":"Nat Commun"},{"key":"9133_CR2","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1136\/gutjnl-2020-322163","volume":"70","author":"SG Barreto","year":"2021","unstructured":"Barreto SG, Habtezion A, Gukovskaya A et al. Critical thresholds: key to unlocking the door to the prevention and specific treatments for acute pancreatitis. Gut 2021;70:194\u2013203.","journal-title":"Gut"},{"key":"9133_CR3","doi-asserted-by":"publisher","first-page":"1077414","DOI":"10.3389\/fimmu.2022.1077414","volume":"13","author":"K Venkatesh","year":"2022","unstructured":"Venkatesh K, Glenn H, Delaney A et al. Fire in the belly: a scoping review of the immunopathological mechanisms of acute pancreatitis. Front Immunol 2022;13:1077414.","journal-title":"Front Immunol"},{"key":"9133_CR4","doi-asserted-by":"publisher","first-page":"468","DOI":"10.3892\/etm.2022.11395","volume":"24","author":"XX Hong","year":"2022","unstructured":"Hong XX, Wang HY, Yang JM et al. Systemic injury caused by taurocholate-induced severe acute pancreatitis in rats. Exp Ther Med 2022;24:468.","journal-title":"Exp Ther Med"},{"key":"9133_CR5","doi-asserted-by":"publisher","first-page":"e22174","DOI":"10.1096\/fj.202101371R","volume":"36","author":"M Jin","year":"2022","unstructured":"Jin M, Zhang H, Wu M et al. Colonic interleukin-22 protects intestinal mucosal barrier and microbiota abundance in severe acute pancreatitis. Faseb J 2022;36:e22174.","journal-title":"Faseb J"},{"key":"9133_CR6","doi-asserted-by":"publisher","first-page":"180","DOI":"10.4049\/jimmunol.2200484","volume":"210","author":"L Chen","year":"2023","unstructured":"Chen L, Zhang X, Liu Y et al. JMJD3 is required for acute pancreatitis and pancreatitis-associated lung injury. J Immunol 2023;210:180\u2013190.","journal-title":"J Immunol"},{"key":"9133_CR7","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.3748\/wjg.v27.i15.1643","volume":"27","author":"XY Liang","year":"2021","unstructured":"Liang XY, Jia TX, Zhang M. Intestinal bacterial overgrowth in the early stage of severe acute pancreatitis is associated with acute respiratory distress syndrome. World J Gastroenterol 2021;27:1643\u20131654.","journal-title":"World J Gastroenterol"},{"key":"9133_CR8","doi-asserted-by":"publisher","first-page":"110770","DOI":"10.1016\/j.biopha.2020.110770","volume":"132","author":"P Ge","year":"2020","unstructured":"Ge P, Luo Y, Okoye CS et al. Intestinal barrier damage, systemic inflammatory response syndrome, and acute lung injury: a troublesome trio for acute pancreatitis. Biomed Pharmacother 2020;132:110770.","journal-title":"Biomed Pharmacother"},{"key":"9133_CR9","doi-asserted-by":"publisher","first-page":"G343","DOI":"10.1152\/ajpgi.00372.2015","volume":"311","author":"X Zhan","year":"2016","unstructured":"Zhan X, Wang F, Bi Y et al. Animal models of gastrointestinal and liver diseases: animal models of acute and chronic pancreatitis. Am J Physiol Gastrointest Liver Physiol 2016;311:G343-55.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"9133_CR10","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.freeradbiomed.2021.07.009","volume":"173","author":"R Fan","year":"2021","unstructured":"Fan R, Sui J, Dong X et al. Wedelolactone alleviates acute pancreatitis and associated lung injury via GPX4 mediated suppression of pyroptosis and ferroptosis. Free Radic Biol Med 2021;173:29\u201340.","journal-title":"Free Radic Biol Med"},{"key":"9133_CR11","doi-asserted-by":"publisher","first-page":"806850","DOI":"10.3389\/fcell.2021.806850","volume":"9","author":"Z Liu","year":"2021","unstructured":"Liu Z, Qi M, Tian S et al. Ubiquitin-specific protease 25 aggravates acute pancreatitis and acute pancreatitis-related multiple organ injury by destroying tight junctions through activation of The STAT3 pathway. Front Cell Dev Biol 2021;9:806850.","journal-title":"Front Cell Dev Biol"},{"key":"9133_CR12","doi-asserted-by":"publisher","first-page":"411","DOI":"10.3109\/00365528009181493","volume":"15","author":"HJ Aho","year":"1980","unstructured":"Aho HJ, Koskensalo SM, Nevalainen TJ. Experimental pancreatitis in the rat: sodium taurocholate-induced acute haemorrhagic pancreatitis. Scand J Gastroenterol 1980;15:411\u20136.","journal-title":"Scand J Gastroenterol"},{"key":"9133_CR13","doi-asserted-by":"publisher","first-page":"106151","DOI":"10.1016\/j.intimp.2019.106151","volume":"80","author":"D Fang","year":"2020","unstructured":"Fang D, Lin Q, Wang C et al. Effects of sildenafil on inflammatory injury of the lung in sodium taurocholate-induced severe acute pancreatitis rats. Int Immunopharmacol 2020;80:106151.","journal-title":"Int Immunopharmacol"},{"key":"9133_CR14","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1165\/rcmb.2009-0210ST","volume":"44","author":"G Matute-Bello","year":"2011","unstructured":"Matute-Bello G, Downey G, Moore BB et al. An official American Thoracic Society workshop report: features and measurements of experimental acute lung injury in animals. Am J Respir Cell Mol Biol 2011;44:725\u201338.","journal-title":"Am J Respir Cell Mol Biol"},{"key":"9133_CR15","doi-asserted-by":"publisher","first-page":"2075","DOI":"10.3390\/diagnostics11112075","volume":"11","author":"A Bompoti","year":"2021","unstructured":"Bompoti A, Papazoglou AS, Moysidis DV et al. Volumetric imaging of lung tissue at micrometer resolution: clinical applications of micro-CT for the diagnosis of pulmonary diseases. Diagnostics (Basel) 2021;11:2075.","journal-title":"Diagnostics (Basel)"},{"key":"9133_CR16","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.ejmp.2021.07.005","volume":"88","author":"DP Clark","year":"2021","unstructured":"Clark DP, Badea CT. Advances in micro-CT imaging of small animals. Phys Med 2021;88:175\u2013192.","journal-title":"Phys Med"},{"key":"9133_CR17","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/j.ejmp.2014.05.011","volume":"30","author":"DP Clark","year":"2014","unstructured":"Clark DP, Badea CT. Micro-CT of rodents: state-of-the-art and future perspectives. Phys Med 2014;30:619\u2013634.","journal-title":"Phys Med"},{"key":"9133_CR18","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1165\/rcmb.2021-0531ST","volume":"66","author":"HS Kulkarni","year":"2022","unstructured":"Kulkarni HS, Lee JS, Bastarache JA et al. Update on the features and measurements of experimental acute lung injury in animals: an official American Thoracic Society workshop report. Am J Respir Cell Mol Biol 2022;66:e1\u2013e14.","journal-title":"Am J Respir Cell Mol Biol"},{"key":"9133_CR19","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.abb.2018.01.004","volume":"640","author":"Y Aratani","year":"2018","unstructured":"Aratani Y. Myeloperoxidase: Its role for host defense, inflammation, and neutrophil function. Arch Biochem Biophys 2018;640:47\u201352.","journal-title":"Arch Biochem Biophys"},{"key":"9133_CR20","doi-asserted-by":"publisher","first-page":"614591","DOI":"10.3389\/fphys.2020.614591","volume":"11","author":"X Yang","year":"2020","unstructured":"Yang X, Yao L, Fu X et al. Experimental acute pancreatitis models: history, current status, and role in translational research. Front Physiol 2020;11:614591.","journal-title":"Front Physiol"},{"key":"9133_CR21","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1016\/j.rmed.2012.06.003","volume":"106","author":"H Akbarshahi","year":"2012","unstructured":"Akbarshahi H, Rosendahl AH, Westergren-Thorsson G et al. Acute lung injury in acute pancreatitis\u2013awaiting the big leap. Respir Med 2012;106:1199\u2013210.","journal-title":"Respir Med"},{"key":"9133_CR22","doi-asserted-by":"publisher","first-page":"1590","DOI":"10.1136\/gut.2007.124230","volume":"56","author":"JM Laukkarinen","year":"2007","unstructured":"Laukkarinen JM, Van Acker GJ, Weiss ER et al. A mouse model of acute biliary pancreatitis induced by retrograde pancreatic duct infusion of Na-taurocholate. Gut 2007;56:1590\u20138.","journal-title":"Gut"},{"key":"9133_CR23","doi-asserted-by":"publisher","first-page":"l6227","DOI":"10.1136\/bmj.l6227","volume":"367","author":"OJ Hines","year":"2019","unstructured":"Hines OJ, Pandol SJ. Management of severe acute. BMJ 2019;367:l6227.","journal-title":"BMJ"},{"key":"9133_CR24","doi-asserted-by":"publisher","first-page":"13356","DOI":"10.1038\/s41598-021-92653-7","volume":"11","author":"SA Abd El-Baset","year":"2021","unstructured":"Abd El-Baset SA, Abd El-Haleem MR, Abdul-Maksoud RS et al. Mesna ameliorates acute lung injury induced by intestinal ischemia-reperfusion in rats. Sci Rep 2021;11:13356.","journal-title":"Sci Rep"},{"key":"9133_CR25","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1097\/00000658-199201000-00007","volume":"215","author":"J Schmidt","year":"1992","unstructured":"Schmidt J, Rattner DW, Lewandrowski K et al. A better model of acute pancreatitis for evaluating therapy. Ann Surg 1992;215:44\u201356.","journal-title":"Ann Surg"},{"key":"9133_CR26","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1136\/gut.43.2.232","volume":"43","author":"MO Osman","year":"1998","unstructured":"Osman MO, Kristensen JU, Jacobsen NO et al. A monoclonal anti-interleukin 8 antibody (WS-4) inhibits cytokine response and acute lung injury in experimental severe acute necrotising pancreatitis in rabbits. Gut 1998;43:232\u20139.","journal-title":"Gut"},{"key":"9133_CR27","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.arcmed.2008.11.004","volume":"40","author":"C Chen","year":"2009","unstructured":"Chen C, Xu S, Wang WX et al. Rosiglitazone attenuates the severity of sodium taurocholate-induced acute pancreatitis and pancreatitis-associated lung injury. Arch Med Res 2009;40:79\u201388.","journal-title":"Arch Med Res"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-025-09133-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10620-025-09133-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-025-09133-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T04:53:49Z","timestamp":1763441629000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10620-025-09133-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,1]]},"references-count":27,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["9133"],"URL":"https:\/\/doi.org\/10.1007\/s10620-025-09133-5","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,1]]},"assertion":[{"value":"13 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All animal experiments were approved by the Committee for Research and Animal Ethics of Dalian Medical University.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}