{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:26:19Z","timestamp":1791570379102,"version":"4.3.4"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1007\/s10620-025-09183-9","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T19:27:24Z","timestamp":1754508444000},"page":"129-137","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Work Impairment in Patients with Celiac Disease and Its Relationship with Persistence of Symptoms, Dietary Adherence, Quality of Life, and Psychological Morbidity"],"prefix":"10.1007","volume":"71","author":[{"given":"Michele","family":"Dota","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Rubbini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Massetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Scarcella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stiliano","family":"Maimaris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola Ilaria","family":"Bianchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria","family":"Maniero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Di Sabatino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Biagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana","family":"Zingone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Schiepatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,6]]},"reference":[{"key":"9183_CR1","doi-asserted-by":"publisher","first-page":"59","DOI":"10.14309\/ajg.0000000000002075","volume":"118","author":"A Rubio-Tapia","year":"2023","unstructured":"Rubio-Tapia A, Hill ID, Semrad C et al. American College of Gastroenterology Guidelines Update: diagnosis and management of celiac disease. Am J Gastroenterol 2023;118:59\u201376.","journal-title":"Am J Gastroenterol"},{"key":"9183_CR2","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1016\/j.dld.2022.06.023","volume":"54","author":"F Zingone","year":"2022","unstructured":"Zingone F, Maimaris S, Auricchio R et al. Guidelines of the Italian societies of gastroenterology on the diagnosis and management of coeliac disease and dermatitis herpetiformis. Dig Liver Dis. 2022;54:1304\u20131319.","journal-title":"Dig Liver Dis."},{"key":"9183_CR3","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1177\/2050640619844125","volume":"7","author":"A Al-Toma","year":"2019","unstructured":"Al-Toma A, Volta U, Auricchio R et al. European Society for the Study of Coeliac Disease (ESsCD) guideline for coeliac disease and other gluten-related disorders. United European Gastroenterol J. 2019;7:583\u2013613.","journal-title":"United European Gastroenterol J."},{"key":"9183_CR4","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1016\/j.cgh.2017.06.037","volume":"16","author":"P Singh","year":"2018","unstructured":"Singh P, Arora A, Strand TA et al. Global prevalence of celiac disease: systematic review and meta-analysis. Clin Gastroenterol Hepatol. 2018;16:823-836.e2.","journal-title":"Clin Gastroenterol Hepatol."},{"key":"9183_CR5","doi-asserted-by":"publisher","first-page":"e741","DOI":"10.1016\/j.cgh.2020.12.015","volume":"20","author":"A Schiepatti","year":"2022","unstructured":"Schiepatti A, Maimaris S, Nicolardi ML et al. Determinants and trends of adherence to a gluten-free diet in adult celiac patients on a long-term follow-up (2000\u20132020). Clin Gastroenterol Hepatol 2022;20:e741\u2013e749.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"9183_CR6","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1177\/2050640614560786","volume":"3","author":"F Zingone","year":"2015","unstructured":"Zingone F, Swift GL, Card TR et al. Psychological morbidity of celiac disease: a review of the literature. United European Gastroenterol J 2015;3:136\u2013145.","journal-title":"United European Gastroenterol J"},{"key":"9183_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2021.110537","volume":"147","author":"SP M\u00f6ller","year":"2021","unstructured":"M\u00f6ller SP, Hayes B, Wilding H et al. Systematic review: exploration of the impact of psychosocial factors on quality of life in adults living with coeliac disease. J Psychosom Res 2021;147:110537.","journal-title":"J Psychosom Res"},{"key":"9183_CR8","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/s40273-018-0707-5","volume":"37","author":"ES Mearns","year":"2019","unstructured":"Mearns ES, Taylor A, Boulanger T et al. Systematic literature review of the economic burden of celiac disease. Pharmacoeconomics 2019;37:45\u201361.","journal-title":"Pharmacoeconomics"},{"key":"9183_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/ecco-jcc\/jjad108","volume":"18","author":"H Gordon","year":"2024","unstructured":"Gordon H, Burisch J, Ellul P et al. ECCO guidelines on extraintestinal manifestations in inflammatory bowel disease. J Crohns Colitis 2024;18:1\u201337.","journal-title":"J Crohns Colitis"},{"key":"9183_CR10","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1053\/j.gastro.2016.02.014","volume":"150","author":"OS Palsson","year":"2016","unstructured":"Palsson OS, Whitehead WE, van Tilburg MA et al. Rome IV diagnostic questionnaires and tables for investigators and clinicians. Gastroenterology 2016;150:1481\u20131491.","journal-title":"Gastroenterology"},{"key":"9183_CR11","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/s10620-014-3368-z","volume":"60","author":"DN Floyd","year":"2015","unstructured":"Floyd DN, Langham S, S\u00e9verac HC et al. The economic and quality-of-life burden of Crohn\u2019s disease in Europe and the United States, 2000 to 2013: a systematic review. Dig Dis Sci 2015;60:299\u2013312. https:\/\/doi.org\/10.1007\/s10620-014-3368-z.","journal-title":"Dig Dis Sci"},{"key":"9183_CR12","doi-asserted-by":"publisher","first-page":"S34","DOI":"10.1093\/jcag\/gwy050","volume":"2","author":"ME Kuenzig","year":"2019","unstructured":"Kuenzig ME, Lee L, El-Matary W et al. The impact of inflammatory bowel disease in Canada 2018: indirect costs of IBD care. J Can Assoc Gastroenterol 2019;2:S34\u2013S41.","journal-title":"J Can Assoc Gastroenterol"},{"key":"9183_CR13","doi-asserted-by":"publisher","first-page":"1418","DOI":"10.1093\/ecco-jcc\/jjy123","volume":"12","author":"\u00c5H Everhov","year":"2018","unstructured":"Everhov \u00c5H, Khalili H, Askling J et al. sick leave and disability pension in prevalent patients with Crohn\u2019s disease. J Crohns Colitis. 2018;12:1418\u20131428.","journal-title":"J Crohns Colitis."},{"key":"9183_CR14","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1016\/j.dld.2019.01.024","volume":"51","author":"C Le Berre","year":"2019","unstructured":"Le Berre C, Peyrin-Biroulet L, Buisson A et al. Impact of inflammatory bowel diseases on working life: a French nationwide survey. Dig Liver Dis 2019;51:961\u2013966.","journal-title":"Dig Liver Dis"},{"key":"9183_CR15","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1093\/ibd\/izy382","volume":"25","author":"\u00c5H Everhov","year":"2019","unstructured":"Everhov \u00c5H, Khalili H, Askling J et al. Work loss before and after diagnosis of Crohn\u2019s disease. Inflamm Bowel Dis 2019;25:1237\u20131247.","journal-title":"Inflamm Bowel Dis"},{"key":"9183_CR16","doi-asserted-by":"publisher","first-page":"338","DOI":"10.5217\/ir.2017.15.3.338","volume":"15","author":"YS Kim","year":"2017","unstructured":"Kim YS, Jung SA, Lee KM et al. Impact of inflammatory bowel disease on daily life: an online survey by the Korean Association for the Study of Intestinal Diseases. Intest Res 2017;15:338\u2013344.","journal-title":"Intest Res"},{"key":"9183_CR17","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1007\/s10198-017-0896-4","volume":"19","author":"RSB Fr\u00f3es","year":"2018","unstructured":"Fr\u00f3es RSB, Carvalho ATP, Carneiro AJV et al. The socio-economic impact of work disability due to inflammatory bowel disease in Brazil. Eur J Health Econ 2018;19:463\u2013470.","journal-title":"Eur J Health Econ"},{"key":"9183_CR18","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.1097\/MIB.0000000000000399","volume":"21","author":"A Zand","year":"2015","unstructured":"Zand A, van Deen WK, Inserra EK et al. Presenteeism in inflammatory bowel diseases: a hidden problem with significant economic impact. Inflamm Bowel Dis 2015;21:1623\u20131630.","journal-title":"Inflamm Bowel Dis"},{"key":"9183_CR19","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1080\/13696998.2020.1789649","volume":"23","author":"AM Manceur","year":"2020","unstructured":"Manceur AM, Ding Z, Muser E et al. Burden of Crohn\u2019s disease in the United States: long-term healthcare and work-loss related costs. J Med Econ 2020;23:1092\u20131101.","journal-title":"J Med Econ"},{"key":"9183_CR20","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1111\/j.1365-2036.2006.03189.x","volume":"25","author":"RW Dubois","year":"2007","unstructured":"Dubois RW, Aguilar D, Fass R et al. Consequences of frequent nocturnal gastro-oesophageal reflux disease among employed adults: symptom severity, quality of life and work productivity. Aliment Pharmacol Ther 2007;25:487\u2013500.","journal-title":"Aliment Pharmacol Ther"},{"key":"9183_CR21","doi-asserted-by":"publisher","first-page":"1540","DOI":"10.1038\/s41395-018-0262-x","volume":"113","author":"\u00c5 Fr\u00e4ndemark","year":"2018","unstructured":"Fr\u00e4ndemark \u00c5, T\u00f6rnblom H, Jakobsson S, Simr\u00e9n M. Work productivity and activity impairment in irritable bowel syndrome (IBS): a multifaceted problem. Am J Gastroenterol 2018;113:1540\u20131549.","journal-title":"Am J Gastroenterol"},{"key":"9183_CR22","doi-asserted-by":"publisher","first-page":"102","DOI":"10.3390\/diseases3020102","volume":"3","author":"C Ciacci","year":"2015","unstructured":"Ciacci C, Zingone F. The perceived social burden in celiac disease. Diseases 2015;3:102\u2013110.","journal-title":"Diseases"},{"key":"9183_CR23","doi-asserted-by":"publisher","first-page":"3233","DOI":"10.3390\/nu13093233","volume":"13","author":"C Canova","year":"2021","unstructured":"Canova C, Rosato I, Marsilio I et al. Quality of life and psychological disorders in coeliac disease: a prospective multicentre study. Nutrients 2021;13:3233.","journal-title":"Nutrients"},{"key":"9183_CR24","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1016\/j.dld.2021.05.016","volume":"53","author":"F Zingone","year":"2021","unstructured":"Zingone F, Secchettin E, Marsilio I et al. Clinical features and psychological impact of celiac disease at diagnosis. Dig Liver Dis 2021;53:1565\u20131570.","journal-title":"Dig Liver Dis"},{"key":"9183_CR25","doi-asserted-by":"publisher","first-page":"2981","DOI":"10.3390\/nu12102981","volume":"12","author":"I Marsilio","year":"2020","unstructured":"Marsilio I, Canova C, D\u2019Odorico A et al. Quality-of-life evaluation in coeliac patients on a gluten-free diet. Nutrients 2020;12:2981.","journal-title":"Nutrients"},{"key":"9183_CR26","doi-asserted-by":"publisher","first-page":"2595","DOI":"10.3390\/nu16162595","volume":"16","author":"A Schiepatti","year":"2024","unstructured":"Schiepatti A, Maimaris S, Randazzo S et al. Resilience in adult coeliac patients on a gluten-free diet: a cross-sectional multicentre Italian study. Nutrients. 2024;16:2595.","journal-title":"Nutrients."},{"key":"9183_CR27","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1016\/j.cgh.2021.09.002","volume":"20","author":"SR Bozorg","year":"2022","unstructured":"Bozorg SR, S\u00f6derling J, Everhov \u00c5H et al. Work loss in patients with celiac disease: a population-based longitudinal study. Clin Gastroenterol Hepatol. 2022;20:1068-1076.e6.","journal-title":"Clin Gastroenterol Hepatol."},{"key":"9183_CR28","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1186\/1471-230X-12-125","volume":"12","author":"F Norstr\u00f6m","year":"2012","unstructured":"Norstr\u00f6m F, Sandstr\u00f6m O, Lindholm L et al. A gluten-free diet effectively reduces symptoms and health care consumption in a Swedish celiac disease population. BMC Gastroenterol 2012;12:125.","journal-title":"BMC Gastroenterol"},{"key":"9183_CR29","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1186\/1471-230X-12-136","volume":"12","author":"A Ukkola","year":"2012","unstructured":"Ukkola A, Kurppa K, Collin P et al. Use of health care services and pharmaceutical agents in coeliac disease: a prospective nationwide study. BMC Gastroenterol. 2012;12:136. https:\/\/doi.org\/10.1186\/1471-230X-12-136. (PMID: 23031447).","journal-title":"BMC Gastroenterol."},{"key":"9183_CR30","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1093\/eurpub\/ckr140","volume":"22","author":"A d\u2019Errico","year":"2012","unstructured":"d\u2019Errico A, Costa G. Socio-demographic and work-related risk factors for medium- and long-term sickness absence among Italian workers. Eur J Public Health. 2012;22:683\u2013688.","journal-title":"Eur J Public Health."},{"key":"9183_CR31","doi-asserted-by":"publisher","first-page":"353","DOI":"10.2165\/00019053-199304050-00006","volume":"4","author":"MC Reilly","year":"1993","unstructured":"Reilly MC, Zbrozek AS, Dukes EM. The validity and reproducibility of a work productivity and activity impairment instrument. PharmacoEconomics 1993;4:353\u2013365.","journal-title":"PharmacoEconomics"},{"key":"9183_CR32","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1111\/j.1365-2036.2009.04220.x","volume":"31","author":"SD Dorn","year":"2010","unstructured":"Dorn SD, Hernandez L, Minaya MT et al. The development and validation of a new coeliac disease quality of life survey (CD-QOL). Aliment Pharmacol Ther 2010;31:666\u2013675.","journal-title":"Aliment Pharmacol Ther"},{"key":"9183_CR33","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.dld.2012.10.018","volume":"45","author":"F Zingone","year":"2013","unstructured":"Zingone F, Iavarone A, Tortora R et al. The Italian translation of the celiac disease-specific quality of life scale in celiac patients on gluten free diet. Dig Liver Dis 2013;45:115\u2013118.","journal-title":"Dig Liver Dis"},{"key":"9183_CR34","volume-title":"Manual for the State-Trait Anxiety Inventory","author":"CD Spielberger","year":"1983","unstructured":"Spielberger CD, Gorsuch RL, Lushene R et al. Manual for the State-Trait Anxiety Inventory. Palo Alto: Consulting Psychologists Press; 1983."},{"key":"9183_CR35","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1001\/archpsyc.1961.01710120031004","volume":"4","author":"AT Beck","year":"1961","unstructured":"Beck AT, Ward CH, Mendelson M et al. An inventory for measuring depression. Arch Gen Psychiatry 1961;4:561\u2013571.","journal-title":"Arch Gen Psychiatry"},{"key":"9183_CR36","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1017\/S0007114509301579","volume":"102","author":"F Biagi","year":"2009","unstructured":"Biagi F, Andrealli A, Bianchi PI et al. A gluten-free diet score to evaluate dietary compliance in patients with coeliac disease. Br J Nutr 2009;102:882\u2013887.","journal-title":"Br J Nutr"},{"key":"9183_CR37","doi-asserted-by":"publisher","first-page":"3374","DOI":"10.1007\/s10620-022-07727-x","volume":"68","author":"A Schiepatti","year":"2023","unstructured":"Schiepatti A, Maimaris S, Lusetti F et al. High prevalence of functional gastrointestinal disorders in celiac patients with persistent symptoms on a gluten-free diet: a 20-year follow-up study. Dig Dis Sci 2023;68:3374\u20133382. https:\/\/doi.org\/10.1007\/s10620-022-07727-x.","journal-title":"Dig Dis Sci"},{"key":"9183_CR38","doi-asserted-by":"publisher","first-page":"216","DOI":"10.3390\/nu12010216","volume":"12","author":"HA Penny","year":"2020","unstructured":"Penny HA, Baggus EMR, Rej A et al. Non-responsive coeliac disease: a comprehensive review from the NHS England National Centre for Refractory Coeliac Disease. Nutrients 2020;12:216.","journal-title":"Nutrients"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-025-09183-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10620-025-09183-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-025-09183-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T20:04:28Z","timestamp":1771272268000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10620-025-09183-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,6]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["9183"],"URL":"https:\/\/doi.org\/10.1007\/s10620-025-09183-9","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,6]]},"assertion":[{"value":"24 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"FZ has served as a consultant for Takeda and Tillotts Pharma. AS has served as a consultant for Tillotts Pharma. No other COI to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}