{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T12:15:22Z","timestamp":1793103322962,"version":"4.5.0"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1007\/s10620-025-09190-w","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T09:35:17Z","timestamp":1751362517000},"page":"3369-3382","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Identification and Confirmation of Shared Etiology and Hub Biomarkers in Nonalcoholic Steatohepatitis and Crohn's Disease"],"prefix":"10.1007","volume":"70","author":[{"given":"Donghui","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuxiu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,1]]},"reference":[{"key":"9190_CR1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11072004","author":"M Wlaz\u0142o","year":"2022","unstructured":"Wlaz\u0142o M, Kierku\u015b J. Dual Biologic Therapy for the Treatment of Pediatric Inflammatory Bowel Disease: A Review of the Literature. J Clin Med. 2022. https:\/\/doi.org\/10.3390\/jcm11072004.","journal-title":"J Clin Med."},{"key":"9190_CR2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/296470","volume":"2013","author":"L Ye","year":"2013","unstructured":"Ye L, Cao Q, Cheng J. Review of inflammatory bowel disease in China. ScientificWorldJournal. 2013;2013:296470.","journal-title":"ScientificWorldJournal."},{"key":"9190_CR3","doi-asserted-by":"publisher","first-page":"3012509","DOI":"10.1155\/2019\/3012509","volume":"2019","author":"DM Bunu","year":"2019","unstructured":"Bunu DM, Timofte CE, Ciocoiu M, Floria M, Tarniceriu CC, Barboi OB et al. Cardiovascular Manifestations of Inflammatory Bowel Disease: Pathogenesis, Diagnosis, and Preventive Strategies. Gastroenterol Res Pract. 2019;2019:3012509.","journal-title":"Gastroenterol Res Pract."},{"key":"9190_CR4","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1038\/nrgastro.2013.149","volume":"10","author":"A Wree","year":"2013","unstructured":"Wree A, Broderick L, Canbay A, Hoffman HM, Feldstein AE. From NAFLD to NASH to cirrhosis-new insights into disease mechanisms. Nat Rev Gastroenterol Hepatol. 2013;10:627\u2013636.","journal-title":"Nat Rev Gastroenterol Hepatol."},{"key":"9190_CR5","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1136\/bmj.285.6334.20","volume":"285","author":"AD Pearson","year":"1982","unstructured":"Pearson AD, Eastham EJ, Laker MF, Craft AW, Nelson R. Intestinal permeability in children with Crohn\u2019s disease and coeliac disease. Br Med J (Clin Res Ed). 1982;285:20\u201321.","journal-title":"Br Med J (Clin Res Ed)."},{"key":"9190_CR6","doi-asserted-by":"publisher","first-page":"1877","DOI":"10.1002\/hep.22848","volume":"49","author":"L Miele","year":"2009","unstructured":"Miele L, Valenza V, La Torre G, Montalto M, Cammarota G, Ricci R et al. Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease. Hepatology. 2009;49:1877\u20131887.","journal-title":"Hepatology."},{"key":"9190_CR7","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1002\/ibd.20933","volume":"15","author":"JP Gisbert","year":"2009","unstructured":"Gisbert JP, Bermejo F, P\u00e9rez-Calle JL, Taxonera C, Vera I, McNicholl AG et al. Fecal calprotectin and lactoferrin for the prediction of inflammatory bowel disease relapse. Inflamm Bowel Dis. 2009;15:1190\u20131198.","journal-title":"Inflamm Bowel Dis."},{"key":"9190_CR8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031131","volume":"7","author":"T Hisamatsu","year":"2012","unstructured":"Hisamatsu T, Okamoto S, Hashimoto M, Muramatsu T, Andou A, Uo M et al. Novel, objective, multivariate biomarkers composed of plasma amino acid profiles for the diagnosis and assessment of inflammatory bowel disease. PLoS One. 2012;7:e31131.","journal-title":"PLoS One."},{"key":"9190_CR9","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1002\/ibd.21035","volume":"16","author":"SK Hong","year":"2010","unstructured":"Hong SK, Maltz BE, Coburn LA, Slaughter JC, Chaturvedi R, Schwartz DA et al. Increased serum levels of L-arginine in ulcerative colitis and correlation with disease severity. Inflamm Bowel Dis. 2010;16:105\u2013111.","journal-title":"Inflamm Bowel Dis."},{"key":"9190_CR10","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s11306-017-1311-y","volume":"14","author":"EA Scoville","year":"2018","unstructured":"Scoville EA, Allaman MM, Brown CT, Motley AK, Horst SN, Williams CS et al. Alterations in Lipid, Amino Acid, and Energy Metabolism Distinguish Crohn\u2019s Disease from Ulcerative Colitis and Control Subjects by Serum Metabolomic Profiling. Metabolomics. 2018;14:17.","journal-title":"Metabolomics."},{"key":"9190_CR11","doi-asserted-by":"publisher","first-page":"82","DOI":"10.14740\/gr1509","volume":"15","author":"A Abomhya","year":"2022","unstructured":"Abomhya A, Mahmoodurrahman M, Ayaz S, Hamad H, Khan F. Burden and Predictors of Non-Alcoholic Fatty Liver Disease in a Retrospective Cohort of Patients With Crohn\u2019s Disease. Gastroenterology Res. 2022;15:82\u201390.","journal-title":"Gastroenterology Res."},{"key":"9190_CR12","doi-asserted-by":"publisher","first-page":"2816","DOI":"10.1016\/j.cgh.2019.02.045","volume":"17","author":"S McHenry","year":"2019","unstructured":"McHenry S, Sharma Y, Tirath A, Tsai R, Mintz A, Fraum TJ et al. Crohn\u2019s Disease Is Associated With an Increased Prevalence of Nonalcoholic Fatty Liver Disease: A Cross-Sectional Study Using Magnetic Resonance Proton Density Fat Fraction Mapping. Clin Gastroenterol Hepatol. 2019;17:2816\u20132818.","journal-title":"Clin Gastroenterol Hepatol."},{"key":"9190_CR13","doi-asserted-by":"publisher","first-page":"1764","DOI":"10.1093\/ibd\/izz043","volume":"25","author":"ZY Zou","year":"2019","unstructured":"Zou ZY, Shen B, Fan JG. Systematic Review With Meta-analysis: Epidemiology of Nonalcoholic Fatty Liver Disease in Patients With Inflammatory Bowel Disease. Inflamm Bowel Dis. 2019;25:1764\u20131772.","journal-title":"Inflamm Bowel Dis."},{"key":"9190_CR14","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1093\/ibd\/izaa189","volume":"27","author":"A Lin","year":"2021","unstructured":"Lin A, Roth H, Anyane-Yeboa A, Rubin DT, Paul S. Prevalence of Nonalcoholic Fatty Liver Disease in Patients With Inflammatory Bowel Disease: A Systematic Review and Meta-analysis. Inflamm Bowel Dis. 2021;27:947\u2013955.","journal-title":"Inflamm Bowel Dis."},{"key":"9190_CR15","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20020395","author":"I Milosevic","year":"2019","unstructured":"Milosevic I, Vujovic A, Barac A, Djelic M, Korac M, Radovanovic Spurnic A et al. Gut-Liver Axis, Gut Microbiota, and Its Modulation in the Management of Liver Diseases: A Review of the Literature. Int J Mol Sci. 2019. https:\/\/doi.org\/10.3390\/ijms20020395.","journal-title":"Int J Mol Sci."},{"key":"9190_CR16","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1038\/s41575-018-0099-1","volume":"16","author":"JS Bajaj","year":"2019","unstructured":"Bajaj JS. Alcohol, liver disease and the gut microbiota. Nat Rev Gastroenterol Hepatol. 2019;16:235\u2013246.","journal-title":"Nat Rev Gastroenterol Hepatol."},{"key":"9190_CR17","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1038\/s41423-020-00592-6","volume":"18","author":"R Wang","year":"2021","unstructured":"Wang R, Tang R, Li B, Ma X, Schnabl B, Tilg H. Gut microbiome, liver immunology, and liver diseases. Cell Mol Immunol. 2021;18:4\u201317.","journal-title":"Cell Mol Immunol."},{"key":"9190_CR18","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11091775","author":"Y Qiu","year":"2022","unstructured":"Qiu Y, Nie X, Yang J, Wang L, Zhu C, Yang X et al. Effect of Resveratrol Supplementation on Intestinal Oxidative Stress, Immunity and Gut Microbiota in Weaned Piglets Challenged with Deoxynivalenol. Antioxidants (Basel). 2022. https:\/\/doi.org\/10.3390\/antiox11091775.","journal-title":"Antioxidants (Basel)."},{"key":"9190_CR19","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1002\/hep.26321","volume":"58","author":"P Hartmann","year":"2013","unstructured":"Hartmann P, Chen P, Wang HJ, Wang L, McCole DF, Brandl K et al. Deficiency of intestinal mucin-2 ameliorates experimental alcoholic liver disease in mice. Hepatology. 2013;58:108\u2013119.","journal-title":"Hepatology."},{"key":"9190_CR20","doi-asserted-by":"publisher","DOI":"10.3390\/nu11092146","author":"J Kim","year":"2019","unstructured":"Kim J, Moon Y. Worm-Based Alternate Assessment of Probiotic Intervention against Gut Barrier Infection. Nutrients. 2019. https:\/\/doi.org\/10.3390\/nu11092146.","journal-title":"Nutrients."},{"key":"9190_CR21","doi-asserted-by":"crossref","unstructured":"Harris MA, Clark J, Ireland A, Lomax J, Ashburner M, Foulger R, et al. The Gene Ontology (GO) database and informatics resource. Nucleic Acids Res. 2004;32(Database issue):D258\u201361.","DOI":"10.1093\/nar\/gkh036"},{"key":"9190_CR22","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1093\/nar\/27.1.29","volume":"27","author":"H Ogata","year":"1999","unstructured":"Ogata H, Goto S, Sato K, Fujibuchi W, Bono H, Kanehisa M. KEGG: Kyoto Encyclopedia of Genes and Genomes. Nucleic Acids Res. 1999;27:29\u201334.","journal-title":"Nucleic Acids Res."},{"key":"9190_CR23","doi-asserted-by":"crossref","unstructured":"Franceschini A, Szklarczyk D, Frankild S, Kuhn M, Simonovic M, Roth A, et al. STRING v9.1: protein-protein interaction networks, with increased coverage and integration. Nucleic Acids Res. 2013;41(Database issue):D808\u201315.","DOI":"10.1093\/nar\/gks1094"},{"key":"9190_CR24","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1093\/bioinformatics\/btq675","volume":"27","author":"ME Smoot","year":"2011","unstructured":"Smoot ME, Ono K, Ruscheinski J, Wang PL, Ideker T. Cytoscape 2.8: new features for data integration and network visualization. Bioinformatics. 2011;27:431\u2013432.","journal-title":"Bioinformatics."},{"key":"9190_CR25","doi-asserted-by":"crossref","unstructured":"Warde-Farley D, Donaldson SL, Comes O, Zuberi K, Badrawi R, Chao P, et al. The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function. Nucleic Acids Res. 2010; 38(Web Server issue):W214\u201320.","DOI":"10.1093\/nar\/gkq537"},{"key":"9190_CR26","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A. 2005;102:15545\u201315550.","journal-title":"Proc Natl Acad Sci U S A."},{"key":"9190_CR27","doi-asserted-by":"publisher","first-page":"D239","DOI":"10.1093\/nar\/gkx1141","volume":"46","author":"D Karagkouni","year":"2018","unstructured":"Karagkouni D, Paraskevopoulou MD, Chatzopoulos S, Vlachos IS, Tastsoglou S, Kanellos I et al. DIANA-TarBase v8: a decade-long collection of experimentally supported miRNA-gene interactions. Nucleic Acids Res. 2018;46:D239\u2013D245.","journal-title":"Nucleic Acids Res."},{"key":"9190_CR28","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1038\/nprot.2015.052","volume":"10","author":"J Xia","year":"2015","unstructured":"Xia J, Gill EE, Hancock RE. NetworkAnalyst for statistical, visual and network-based meta-analysis of gene expression data. Nat Protoc. 2015;10:823\u2013844.","journal-title":"Nat Protoc."},{"key":"9190_CR29","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1111\/iep.12008","volume":"94","author":"M Matsumoto","year":"2013","unstructured":"Matsumoto M, Hada N, Sakamaki Y, Uno A, Shiga T, Tanaka C et al. An improved mouse model that rapidly develops fibrosis in non-alcoholic steatohepatitis. Int J Exp Pathol. 2013;94:93\u2013103.","journal-title":"Int J Exp Pathol."},{"key":"9190_CR30","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.artmed.2017.02.001","volume":"76","author":"L Chen","year":"2017","unstructured":"Chen L, Zhang YH, Lu G, Huang T, Cai YD. Analysis of cancer-related lncRNAs using gene ontology and KEGG pathways. Artif Intell Med. 2017;76:27\u201336.","journal-title":"Artif Intell Med."},{"key":"9190_CR31","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/j.bpg.2014.07.008","volume":"28","author":"P Dietrich","year":"2014","unstructured":"Dietrich P, Hellerbrand C. Non-alcoholic fatty liver disease, obesity and the metabolic syndrome. Best Pract Res Clin Gastroenterol. 2014;28:637\u2013653.","journal-title":"Best Pract Res Clin Gastroenterol."},{"key":"9190_CR32","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1002\/hep.24376","volume":"54","author":"AJ Sanyal","year":"2011","unstructured":"Sanyal AJ, Brunt EM, Kleiner DE, Kowdley KV, Chalasani N, Lavine JE et al. Endpoints and clinical trial design for nonalcoholic steatohepatitis. Hepatology. 2011;54:344\u2013353.","journal-title":"Hepatology."},{"key":"9190_CR33","doi-asserted-by":"publisher","first-page":"5216","DOI":"10.1080\/21655979.2022.2037374","volume":"13","author":"G Jiang","year":"2022","unstructured":"Jiang G, Sun C, Wang X, Mei J, Li C, Zhan H et al. Hepatoprotective mechanism of Silybum marianum on nonalcoholic fatty liver disease based on network pharmacology and experimental verification. Bioengineered. 2022;13:5216\u20135235.","journal-title":"Bioengineered."},{"key":"9190_CR34","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1002\/hep.29367","volume":"67","author":"N Chalasani","year":"2018","unstructured":"Chalasani N, Younossi Z, Lavine JE, Charlton M, Cusi K, Rinella M et al. The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases. Hepatology. 2018;67:328\u2013357.","journal-title":"Hepatology."},{"key":"9190_CR35","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.891410","volume":"13","author":"L Chen","year":"2022","unstructured":"Chen L, Fan Z, Sun X, Qiu W, Chen Y, Zhou J et al. Mendelian Randomization Rules Out Causation Between Inflammatory Bowel Disease and Non-Alcoholic Fatty Liver Disease. Front Pharmacol. 2022;13:891410.","journal-title":"Front Pharmacol."},{"key":"9190_CR36","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1055\/s-2006-926502","volume":"44","author":"A Canbay","year":"2006","unstructured":"Canbay A, Bechmann LP, Best J, Jochum C, Treichel U, Gerken G. Crohn\u2019s disease-induced non-alcoholic fatty liver disease (NAFLD) sensitizes for severe acute hepatitis B infection and liver failure. Z Gastroenterol. 2006;44:245\u2013248.","journal-title":"Z Gastroenterol."},{"key":"9190_CR37","doi-asserted-by":"publisher","first-page":"3083","DOI":"10.1038\/ncomms4083","volume":"5","author":"A Mardinoglu","year":"2014","unstructured":"Mardinoglu A, Agren R, Kampf C, Asplund A, Uhlen M, Nielsen J. Genome-scale metabolic modelling of hepatocytes reveals serine deficiency in patients with non-alcoholic fatty liver disease. Nat Commun. 2014;5:3083.","journal-title":"Nat Commun."},{"key":"9190_CR38","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1007\/s00125-005-0066-6","volume":"49","author":"EB Marliss","year":"2006","unstructured":"Marliss EB, Chevalier S, Gougeon R, Morais JA, Lamarche M, Adegoke OA et al. Elevations of plasma methylarginines in obesity and ageing are related to insulin sensitivity and rates of protein turnover. Diabetologia. 2006;49:351\u2013359.","journal-title":"Diabetologia."},{"key":"9190_CR39","doi-asserted-by":"publisher","first-page":"56","DOI":"10.2337\/db07-0887","volume":"57","author":"S Pereira","year":"2008","unstructured":"Pereira S, Marliss EB, Morais JA, Chevalier S, Gougeon R. Insulin resistance of protein metabolism in type 2 diabetes. Diabetes. 2008;57:56\u201363.","journal-title":"Diabetes."},{"key":"9190_CR40","doi-asserted-by":"publisher","first-page":"128","DOI":"10.2337\/dc07-1268","volume":"31","author":"R Gougeon","year":"2008","unstructured":"Gougeon R, Morais JA, Chevalier S, Pereira S, Lamarche M, Marliss EB. Determinants of whole-body protein metabolism in subjects with and without type 2 diabetes. Diabetes Care. 2008;31:128\u2013133.","journal-title":"Diabetes Care."},{"key":"9190_CR41","doi-asserted-by":"publisher","first-page":"2725","DOI":"10.1210\/jc.2009-1235","volume":"94","author":"SC Kalhan","year":"2009","unstructured":"Kalhan SC. Fatty acids, insulin resistance, and protein metabolism. J Clin Endocrinol Metab. 2009;94:2725\u20132727.","journal-title":"J Clin Endocrinol Metab."},{"key":"9190_CR42","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1002\/ptr.7383","volume":"36","author":"J Mao","year":"2022","unstructured":"Mao J, Zhan H, Meng F, Wang G, Huang D, Liao Z et al. Costunolide protects against alcohol-induced liver injury by regulating gut microbiota, oxidative stress and attenuating inflammation in vivo and in vitro. Phytotherapy Research. 2022;36:1268\u20131283.","journal-title":"Phytotherapy Research."},{"key":"9190_CR43","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1038\/s41586-019-1237-9","volume":"569","author":"J Lloyd-Price","year":"2019","unstructured":"Lloyd-Price J, Arze C, Ananthakrishnan AN, Schirmer M, Avila-Pacheco J, Poon TW et al. Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases. Nature. 2019;569:655\u2013662.","journal-title":"Nature."},{"key":"9190_CR44","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1021\/pr060470d","volume":"6","author":"JR Marchesi","year":"2007","unstructured":"Marchesi JR, Holmes E, Khan F, Kochhar S, Scanlan P, Shanahan F et al. Rapid and noninvasive metabonomic characterization of inflammatory bowel disease. J Proteome Res. 2007;6:546\u2013551.","journal-title":"J Proteome Res."},{"key":"9190_CR45","first-page":"122","volume":"11","author":"JT Bjerrum","year":"2015","unstructured":"Bjerrum JT, Wang Y, Hao F, Coskun M, Ludwig C, G\u00fcnther U et al. Metabonomics of human fecal extracts characterize ulcerative colitis. Crohn\u2019s disease and healthy individuals. Metabolomics. 2015;11:122\u2013133.","journal-title":"Crohn's disease and healthy individuals. Metabolomics."},{"key":"9190_CR46","doi-asserted-by":"publisher","first-page":"1798","DOI":"10.3389\/fmicb.2018.01798","volume":"9","author":"N Li","year":"2018","unstructured":"Li N, Huang S, Jiang L, Wang W, Li T, Zuo B et al. Differences in the Gut Microbiota Establishment and Metabolome Characteristics Between Low- and Normal-Birth-Weight Piglets During Early-Life. Front Microbiol. 2018;9:1798.","journal-title":"Front Microbiol."},{"key":"9190_CR47","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1016\/j.devcel.2006.03.015","volume":"10","author":"S Benhamouche","year":"2006","unstructured":"Benhamouche S, Decaens T, Godard C, Chambrey R, Rickman DS, Moinard C et al. Apc tumor suppressor gene is the \u201czonation-keeper\u201d of mouse liver. Dev Cell. 2006;10:759\u2013770.","journal-title":"Dev Cell."},{"key":"9190_CR48","doi-asserted-by":"publisher","first-page":"26358","DOI":"10.1074\/jbc.M110.147439","volume":"285","author":"I Ishii","year":"2010","unstructured":"Ishii I, Akahoshi N, Yamada H, Nakano S, Izumi T, Suematsu M. Cystathionine gamma-Lyase-deficient mice require dietary cysteine to protect against acute lethal myopathy and oxidative injury. J Biol Chem. 2010;285:26358\u201326368.","journal-title":"J Biol Chem."},{"key":"9190_CR49","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/B978-0-12-800174-5.00013-2","volume":"95","author":"M Xue","year":"2014","unstructured":"Xue M, Jackson CJ. Activated protein C and its potential applications in prevention of islet \u03b2-cell damage and diabetes. Vitam Horm. 2014;95:323\u2013363.","journal-title":"Vitam Horm."},{"key":"9190_CR50","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1677\/JOE-07-0242","volume":"194","author":"UM Fi\u00faza","year":"2007","unstructured":"Fi\u00faza UM, Arias AM. Cell and molecular biology of Notch. J Endocrinol. 2007;194:459\u2013474.","journal-title":"J Endocrinol."},{"key":"9190_CR51","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017415","volume":"6","author":"L Zhu","year":"2011","unstructured":"Zhu L, Wang L, Wang X, Luo X, Yang L, Zhang R et al. Hepatic deletion of Smad7 in mouse leads to spontaneous liver dysfunction and aggravates alcoholic liver injury. PLoS One. 2011;6:e17415.","journal-title":"PLoS One."},{"key":"9190_CR52","doi-asserted-by":"publisher","first-page":"7883","DOI":"10.3390\/ijms15057883","volume":"15","author":"G Chen","year":"2014","unstructured":"Chen G, Zhang Z, Cheng Y, Xiao W, Qiu Y, Yu M et al. The canonical Notch signaling was involved in the regulation of intestinal epithelial cells apoptosis after intestinal ischemia\/reperfusion injury. Int J Mol Sci. 2014;15:7883\u20137896.","journal-title":"Int J Mol Sci."},{"key":"9190_CR53","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1038\/nrg1990","volume":"8","author":"K Chen","year":"2007","unstructured":"Chen K, Rajewsky N. The evolution of gene regulation by transcription factors and microRNAs. Nat Rev Genet. 2007;8:93\u2013103.","journal-title":"Nat Rev Genet."},{"key":"9190_CR54","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1161\/ATVBAHA.118.312233","volume":"39","author":"J Fernandez Esmerats","year":"2019","unstructured":"Fernandez Esmerats J, Villa-Roel N, Kumar S, Gu L, Salim MT, Ohh M et al. Disturbed Flow Increases UBE2C (Ubiquitin E2 Ligase C) via Loss of miR-483-3p, Inducing Aortic Valve Calcification by the pVHL (von Hippel-Lindau Protein) and HIF-1\u03b1 (Hypoxia-Inducible Factor-1\u03b1) Pathway in Endothelial Cells. Arterioscler Thromb Vasc Biol. 2019;39:467\u2013481.","journal-title":"Arterioscler Thromb Vasc Biol."},{"key":"9190_CR55","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1038\/nrm2890","volume":"11","author":"EN Olson","year":"2010","unstructured":"Olson EN, Nordheim A. Linking actin dynamics and gene transcription to drive cellular motile functions. Nat Rev Mol Cell Biol. 2010;11:353\u2013365.","journal-title":"Nat Rev Mol Cell Biol."},{"key":"9190_CR56","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101302","volume":"26","author":"M Kong","year":"2019","unstructured":"Kong M, Chen X, Lv F, Ren H, Fan Z, Qin H et al. Serum response factor (SRF) promotes ROS generation and hepatic stellate cell activation by epigenetically stimulating NCF1\/2 transcription. Redox Biol. 2019;26:101302.","journal-title":"Redox Biol."},{"key":"9190_CR57","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1053\/j.gastro.2016.09.047","volume":"152","author":"F Rieder","year":"2017","unstructured":"Rieder F, Fiocchi C, Rogler G. Mechanisms, Management, and Treatment of Fibrosis in Patients With Inflammatory Bowel Diseases. Gastroenterology. 2017;152:340\u201350.e6.","journal-title":"Gastroenterology."},{"key":"9190_CR58","doi-asserted-by":"crossref","unstructured":"Assump\u00e7\u00e3o A, Fu G, Singh DK, Lu Z, Kuehnl AM, Welch R, et al. A lineage-specific requirement for YY1 Polycomb Group protein function in early T cell development. Development. 2021; 148","DOI":"10.1242\/dev.197319"},{"key":"9190_CR59","doi-asserted-by":"publisher","first-page":"20059","DOI":"10.1038\/srep20059","volume":"6","author":"N Mu","year":"2016","unstructured":"Mu N, Gu J, Huang T, Zhang C, Shu Z, Li M et al. A novel NF-\u03baB\/YY1\/microRNA-10a regulatory circuit in fibroblast-like synoviocytes regulates inflammation in rheumatoid arthritis. Sci Rep. 2016;6:20059.","journal-title":"Sci Rep."}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-025-09190-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10620-025-09190-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-025-09190-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T07:03:44Z","timestamp":1760598224000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10620-025-09190-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,1]]},"references-count":59,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["9190"],"URL":"https:\/\/doi.org\/10.1007\/s10620-025-09190-w","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,1]]},"assertion":[{"value":"13 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}