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Sweerts: nothing to declare. The authors declare no competing interests. L. Vork: nothing to declare. Z. Mujagic: Research grants form MLDS, ZonMw, Niels Stensen Fellowship, Galapagos, TKI. Advisory board fees: Johnson & Johnson, Eli Lilly, Pfizer, Abbvie (paid to host institution). Speaker\u2019s fee: Galapagos, Eli Lilly, Takeda (paid to host institution). None related to the current study. J.M. Conchillo: nothing to declare. D. Keszthelyi: Research grants from MLDS, Rome Foundation, ZonMw, Rome Foundation, UEG, Horizon Europe, no conflict of interest regarding this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study protocol was approved by the MUMC\u2009+\u2009Committee of Ethics in July 2016, and all study procedures were executed in compliance with Good Clinical Practice Guidelines and according to the revised Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}