{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T20:02:20Z","timestamp":1785528140244,"version":"3.56.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T00:00:00Z","timestamp":1755129600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T00:00:00Z","timestamp":1755129600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1007\/s10620-025-09300-8","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T19:18:39Z","timestamp":1755199119000},"page":"85-94","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical Outcomes of Acute Pancreatitis in Patients with Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD): A Systematic Review and Meta-Analysis"],"prefix":"10.1007","volume":"71","author":[{"given":"Quanfeng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuwen","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,14]]},"reference":[{"key":"9300_CR1","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.1053\/j.gastro.2019.11.312","volume":"158","author":"M Eslam","year":"2020","unstructured":"Eslam M, Sanyal AJ, George J et al. Mafld: a consensus-driven proposed nomenclature for metabolic associated fatty liver disease. Gastroenterology 2020;158:1999\u20132014. https:\/\/doi.org\/10.1053\/j.gastro.2019.11.312.","journal-title":"Gastroenterology"},{"key":"9300_CR2","doi-asserted-by":"publisher","unstructured":"Younossi Zea Global epidemiology of nafld meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology 2019 https:\/\/doi.org\/10.1002\/hep.30254","DOI":"10.1002\/hep.30254"},{"key":"9300_CR3","doi-asserted-by":"publisher","first-page":"2698","DOI":"10.3390\/jcm9092698","volume":"9","author":"S V\u00e1ncsa","year":"2020","unstructured":"V\u00e1ncsa S, N\u00e9meth D, Hegyi P et al. P r G Fatty liver disease and non-alcoholic fatty liver disease worsen the outcome in acute pancreatitis: a systematic review and meta-analysis. Journal of Clinical Medicine 2020;9:2698. https:\/\/doi.org\/10.3390\/jcm9092698.","journal-title":"Journal of Clinical Medicine"},{"key":"9300_CR4","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1186\/s12916-020-01859-5","volume":"18","author":"G Ouyang","year":"2020","unstructured":"Ouyang G, Pan G, Liu Q. The global, regional, and national burden of pancreatitis in 195 countries and territories, 1990 2017: a systematic analysis for the global burden of disease study 2017. BMC Medicine 2020;18:388. https:\/\/doi.org\/10.1186\/s12916-020-01859-5.","journal-title":"BMC Medicine"},{"key":"9300_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.gtc.2018.09.004","volume":"48","author":"GIea Papachristou","year":"2019","unstructured":"Papachristou GIea. Acute pancreatitis: current perspectives on diagnosis and management. Gastroenterology Clinics of North America 2019;48:1\u201310. https:\/\/doi.org\/10.1016\/j.gtc.2018.09.004.","journal-title":"Gastroenterology Clinics of North America"},{"key":"9300_CR6","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1038\/s41574-021-00573-3","volume":"18","author":"R Wagner","year":"2022","unstructured":"Wagner R, Eckstein SS, Yamazaki H et al. Metabolic implications of pancreatic fat accumulation. Nature Reviews Endocrinology 2022;18:43\u201354. https:\/\/doi.org\/10.1038\/s41574-021-00573-3.","journal-title":"Nature Reviews Endocrinology"},{"key":"9300_CR7","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.aohep.2019.04.004","volume":"18","author":"Y Hou","year":"2019","unstructured":"Hou Y, Sun T-Y, Wang X-F, Wang W-D, Sun B. Fatty liver disease as a risk factor for complications in acute pancreatitis: a meta-analysis. Annals of Hepatology 2019;18:497\u2013503. https:\/\/doi.org\/10.1016\/j.aohep.2019.04.004.","journal-title":"Annals of Hepatology"},{"key":"9300_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2019\/9583790","volume":"2019","author":"D Wu","year":"2019","unstructured":"Wu D, Zhang M, Xu S et al. Nonalcoholic fatty liver disease aggravated the severity of acute pancreatitis in patients. BioMed Research International 2019;2019:1\u20137. https:\/\/doi.org\/10.1155\/2019\/9583790.","journal-title":"BioMed Research International"},{"key":"9300_CR9","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.3969\/j.issn.1001-5256.2022.07.025","volume":"38","author":"M Zhang","year":"2022","unstructured":"Zhang M, Zhang L, Luo L, Chen Q. Influence of fatty liver on the severity of acute pancreatitis. Journal of Clinical Hepatology 2022;38:1595\u20131601. https:\/\/doi.org\/10.3969\/j.issn.1001-5256.2022.07.025.","journal-title":"Journal of Clinical Hepatology"},{"key":"9300_CR10","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1002\/ueg2.12389","volume":"11","author":"S V ncsa","year":"2023","unstructured":"V ncsa S, Sipos Z, V radi A et al. Metabolic-associated fatty liver disease is associated with acute pancreatitis with more severe course: Post hoc analysis of a prospectively collected international registry. United European Gastroenterology Journal 2023;11:371\u2013382. https:\/\/doi.org\/10.1002\/ueg2.12389.","journal-title":"United European Gastroenterology Journal"},{"key":"9300_CR11","doi-asserted-by":"publisher","first-page":"0142278","DOI":"10.1371\/journal.pone.0142278","volume":"10","author":"C Xu","year":"2015","unstructured":"Xu C, Qiao Z, Lu Y et al. Influence of fatty liver on the severity and clinical outcome in acute pancreatitis. PLoS ONE 2015;10:0142278. https:\/\/doi.org\/10.1371\/journal.pone.0142278.","journal-title":"PLoS ONE"},{"key":"9300_CR12","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.hpb.2017.02.186","volume":"19","author":"L Jin","year":"2017","unstructured":"Jin L et al. Impact of fatty liver disease on the severity of acute pancreatitis. HPB 2017;19:74. https:\/\/doi.org\/10.1016\/j.hpb.2017.02.186.","journal-title":"HPB"},{"key":"9300_CR13","doi-asserted-by":"publisher","first-page":"1000097","DOI":"10.1371\/journal.pmed.1000097","volume":"6","author":"D Moher","year":"2009","unstructured":"Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the prisma statement. PLOS Medicine 2009;6:1000097. https:\/\/doi.org\/10.1371\/journal.pmed.1000097.","journal-title":"PLOS Medicine"},{"key":"9300_CR14","doi-asserted-by":"publisher","first-page":"5928","DOI":"10.1136\/bmj.d5928","volume":"343","author":"JP Higgins","year":"2011","unstructured":"Higgins JP. The Cochrane collaboration s tool for assessing risk of bias in randomised trials. BMJ 2011;343:5928. https:\/\/doi.org\/10.1136\/bmj.d5928.","journal-title":"BMJ"},{"key":"9300_CR15","doi-asserted-by":"publisher","first-page":"94","DOI":"10.3969\/j.issn.1001-5256.2021.01.019","volume":"37","author":"P Mei","year":"2021","unstructured":"Mei P, Zhang Z, Tao J. Impact of nonalcoholic fatty liver disease on the severity of acute pancreatitis. Journal of Clinical Hepatology 2021;37:94\u201398. https:\/\/doi.org\/10.3969\/j.issn.1001-5256.2021.01.019.","journal-title":"Journal of Clinical Hepatology"},{"key":"9300_CR16","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1002\/ueg2.12389","volume":"11","author":"S V\u00e1ncsa","year":"2023","unstructured":"V\u00e1ncsa S, Sipos Z, V\u00e1radi A et al. Metabolic-associated fatty liver disease is associated with acute pancreatitis with more severe course: post hoc analysis of a prospectively collected international registry. United European Gastroenterology Journal 2023;11:371\u2013382. https:\/\/doi.org\/10.1002\/ueg2.12389.","journal-title":"United European Gastroenterology Journal"},{"key":"9300_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2017\/4532320","volume":"2017","author":"SB Yoon","year":"2017","unstructured":"Yoon SB, Choi J, Park JH et al. Impact of fatty liver on acute pancreatitis severity. Gastroenterology Research and Practice 2017;2017:1\u20137. https:\/\/doi.org\/10.1155\/2017\/4532320.","journal-title":"Gastroenterology Research and Practice"},{"key":"9300_CR18","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.ejim.2016.07.009","volume":"34","author":"I Mikolasevic","year":"2016","unstructured":"Mikolasevic I, Orlic L, Milic S et al. Metabolic syndrome and acute pancreatitis. European Journal of Internal Medicine 2016;34:79\u201383. https:\/\/doi.org\/10.1016\/j.ejim.2016.07.009.","journal-title":"European Journal of Internal Medicine"},{"key":"9300_CR19","doi-asserted-by":"publisher","first-page":"243","DOI":"10.4236\/ijcm.2018.94021","volume":"9","author":"J Jia","year":"2018","unstructured":"Jia J, Wu Q, Kou J, Yang M. Relationship between fatty liver and pancreatitis. Int. J. Clin. Med. 2018;9:243\u2013248. https:\/\/doi.org\/10.4236\/ijcm.2018.94021.","journal-title":"Int. J. Clin. Med."},{"key":"9300_CR20","doi-asserted-by":"publisher","first-page":"293","DOI":"10.4172\/2161-069X.1000293","volume":"5","author":"S Jasdanwala","year":"2015","unstructured":"Jasdanwala S, Babyatsky M. Nafld diagnosed with abdominal ultrasound is a marker of severity in acute pancreatitis. Journal of Gastrointestinal & Digestive System 2015;5:293. https:\/\/doi.org\/10.4172\/2161-069X.1000293.","journal-title":"Journal of Gastrointestinal & Digestive System"},{"key":"9300_CR21","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1136\/bmj.n71","volume":"2021","author":"MJ Page","year":"2020","unstructured":"Page MJ, McKenzie JE, Bossuyt PM et al. The prisma, statement: an updated guideline for reporting systematic reviews. BMJ 2020;2021:71. https:\/\/doi.org\/10.1136\/bmj.n71.","journal-title":"BMJ"},{"key":"9300_CR22","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.1053\/j.gastro.2019.11.312","volume":"158","author":"M Eslam","year":"2020","unstructured":"Eslam M, Sanyal AJ, George J. Mafld: a consensus-driven proposed nomenclature for metabolic associated fatty liver disease. Gastroenterology 2020;158:1999\u201320141. https:\/\/doi.org\/10.1053\/j.gastro.2019.11.312.","journal-title":"Gastroenterology"},{"key":"9300_CR23","unstructured":"Wells G, Shea B, O\u2019Connell D, Peterson J, Welch V, Losos M, Tugwell P The Newcastle Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp 2014"},{"issue":"1","key":"9300_CR24","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1186\/1471-2458-13-154","volume":"13","author":"R Herzog","year":"2013","unstructured":"Herzog R, \u00c1lvarez-Pasquin MJ, D\u00edaz C, Del Barrio JL, Estrada JM, Gil \u00c1. Are healthcare workers intentions to vaccinate related to their knowledge, beliefs and attitudes a systematic review. BMC Public Health 2013;13:154. https:\/\/doi.org\/10.1186\/1471-2458-13-154.","journal-title":"BMC Public Health"},{"key":"9300_CR25","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1186\/1471-2288-14-135","volume":"14","author":"X Wan","year":"2014","unstructured":"Wan X, Wang W, Liu J, Tong T. Estimating the sample mean and standard deviation from the sample size, median, range and\/or interquartile range. BMC Medical Research Methodology 2014;14:135\u2013143. https:\/\/doi.org\/10.1186\/1471-2288-14-135.","journal-title":"BMC Medical Research Methodology"},{"key":"9300_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2021.106059","volume":"95","author":"Y Ren","year":"2021","unstructured":"Ren Y, Jia Y, Yang M. Sample size calculations for randomized controlled trials with repeatedly measured continuous variables as primary outcomes need improvements: a cross-sectional study. International Journal of Surgery 2021;95:106059. https:\/\/doi.org\/10.1016\/j.ijsu.2021.106059.","journal-title":"International Journal of Surgery"},{"key":"9300_CR27","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1136\/jech-2013-203104","volume":"67","author":"JJ Barendregt","year":"2013","unstructured":"Barendregt JJ, Doi SA, Lee YL, Norman RE, Vos T. Meta-analysis of prevalence. Journal of Epidemiology and Community Health 2013;67:974\u2013978. https:\/\/doi.org\/10.1136\/jech-2013-203104.","journal-title":"Journal of Epidemiology and Community Health"},{"key":"9300_CR28","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","volume":"327","author":"JP Higgins","year":"2003","unstructured":"Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ 2003;327:557\u2013560. https:\/\/doi.org\/10.1136\/bmj.327.7414.557.","journal-title":"BMJ"},{"key":"9300_CR29","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","volume":"315","author":"M Egger","year":"1997","unstructured":"Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997;315:629\u2013634. https:\/\/doi.org\/10.1136\/bmj.315.7109.629.","journal-title":"BMJ"},{"key":"9300_CR30","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1111\/j.0006-341X.2000.00455.x","volume":"56","author":"S Duval","year":"2000","unstructured":"Duval S, Tweedie R. Trim and fill: a simple funnel-plot based method of testing and adjusting for publication bias in meta-analysis. Biometrics 2000;56:455\u2013463. https:\/\/doi.org\/10.1111\/j.0006-341X.2000.00455.x.","journal-title":"Biometrics"},{"key":"9300_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2021.106059","volume":"95","author":"Q Bao","year":"2021","unstructured":"Bao Q, Ba T. Commentary on fatty liver disease is associated with the severity of acute pancreatitis: A systematic review and meta-analysis [int. j. surg. 65 (2019) 147 153]. International Journal of Surgery 2021;95:106059. https:\/\/doi.org\/10.1016\/j.ijsu.2021.106059.","journal-title":"International Journal of Surgery"},{"key":"9300_CR32","doi-asserted-by":"publisher","first-page":"7660","DOI":"10.3748\/wjg.v22.i34.7660","volume":"22","author":"R Catanzaro","year":"2016","unstructured":"Catanzaro R. Fatty liver and acute pancreatitis: synergic or coincidental association? World Journal of Gastroenterology 2016;22:7660\u20137670. https:\/\/doi.org\/10.3748\/wjg.v22.i34.7660.","journal-title":"World Journal of Gastroenterology"},{"key":"9300_CR33","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.livres.2021.06.003","volume":"5","author":"Y Liu","year":"2021","unstructured":"Liu Y, Wang X, Fan J-G. Targeting bile acid signaling for the treatment of metabolic diseases. Liver Research 2021;5:180\u2013188. https:\/\/doi.org\/10.1016\/j.livres.2021.06.003.","journal-title":"Liver Research"},{"key":"9300_CR34","doi-asserted-by":"publisher","first-page":"5870","DOI":"10.3390\/molecules28155870","volume":"28","author":"X Gou","year":"2023","unstructured":"Gou X, Qin L, Wu D. Research progress of takeda g protein-coupled receptor 5 in metabolic syndrome. Molecules 2023;28:5870. https:\/\/doi.org\/10.3390\/molecules28155870.","journal-title":"Molecules"},{"key":"9300_CR35","doi-asserted-by":"publisher","unstructured":"Regn r S, nnerhag K, Sternby H, Regn r S, nnerhag K. Metabolic-associated fatty liver disease is associated with acute pancreatitis severity: post hoc analysis of a prospectively collected international registry. United European Gastroenterol J 2023;11:371\u2013380. https:\/\/doi.org\/10.1002\/ueg2.12389.","DOI":"10.1002\/ueg2.12389"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-025-09300-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10620-025-09300-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-025-09300-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T20:06:40Z","timestamp":1771272400000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10620-025-09300-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,14]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["9300"],"URL":"https:\/\/doi.org\/10.1007\/s10620-025-09300-8","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,14]]},"assertion":[{"value":"15 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no Conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}