{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T08:58:16Z","timestamp":1772096296633,"version":"3.50.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s10620-025-09356-6","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T08:52:56Z","timestamp":1756803176000},"page":"636-642","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Correlation of Spleen Stiffness with Esophageo-gastric Variceal Bleeding in Patients with Non-cirrhotic Portal Hypertension"],"prefix":"10.1007","volume":"71","author":[{"given":"Ankur","family":"Jindal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitesh","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoj Kumar","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chitranshu","family":"Vashistha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guresh","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinod","family":"Arora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajan","family":"Vijayaraghavan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harsh Vardhan","family":"Tevethia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satender Pal","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiv Kumar","family":"Sarin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,9,2]]},"reference":[{"key":"9356_CR1","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.jhep.2005.10.013","volume":"44","author":"G D\u2019Amico","year":"2006","unstructured":"D\u2019Amico G, Garcia-Tsao G, Pagliaro L. Natural history and prognostic indicators of survival in cirrhosis: a systematic review of 118 studies. J Hepatol. 2006;44:217\u2013231.","journal-title":"J Hepatol."},{"key":"9356_CR2","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1055\/s-2002-23206","volume":"22","author":"SK Sarin","year":"2002","unstructured":"Sarin SK, Agarwal SR. Extrahepatic portal vein obstruction. Semin Liver Dis 2002;22:43\u201358.","journal-title":"Semin Liver Dis"},{"key":"9356_CR3","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1002\/hep.21731","volume":"45","author":"JK Lim","year":"2007","unstructured":"Lim JK, Groszmann RJ. Transient elastography for diagnosis of portal hypertension in liver cirrhosis: is there still a role for hepatic venous pressure gradient measurement? Hepatology 2007;45:1087\u20131090.","journal-title":"Hepatology"},{"key":"9356_CR4","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/S1590-8658(02)80246-8","volume":"34","author":"M Bolognesi","year":"2002","unstructured":"Bolognesi M, Merkel C, Sacerdoti D, Nava V, Gatta A. Role of spleen enlargement in cirrhosis with portal hypertension. Dig Liver Dis 2002;34:144\u2013150.","journal-title":"Dig Liver Dis"},{"key":"9356_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0165786","volume":"11","author":"X Ma","year":"2016","unstructured":"Ma X, Wang L, Wu H, Feng Y, Han X, Bu H et al. Spleen stiffness is superior to liver stiffness for predicting esophageal varices in chronic liver disease: a meta-analysis. PLOS ONE 2016;11:1\u201315.","journal-title":"PLOS ONE"},{"key":"9356_CR6","doi-asserted-by":"publisher","first-page":"e0165786","DOI":"10.1371\/journal.pone.0165786","volume":"11","author":"X Ma","year":"2016","unstructured":"Ma X, Wang L, Wu H, Feng Y, Han X, Bu H et al. Spleen stiffness is superior to liver stiffness for predicting esophageal varices in chronic liver disease: a meta-analysis. PLoS ONE 2016;11:e0165786.","journal-title":"PLoS ONE"},{"key":"9356_CR7","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.clinre.2017.11.002","volume":"42","author":"J Song","year":"2018","unstructured":"Song J, Huang J, Huang H, Liu S, Luo Y. Performance of spleen stiffness mea-surement in prediction of clinical significant portal hypertension: a meta-anal-ysis. Clin Res Hepatol Gastroenterol 2018;42:216\u2013226.","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"9356_CR8","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1016\/j.jhep.2018.10.018","volume":"70","author":"HY Kim","year":"2019","unstructured":"Kim HY, So YH, Kim W, Ahn DW, Jung YJ, Woo H et al. Non-invasive re-sponse prediction in prophylactic carvedilol therapy for cirrhotic patients with esophageal varices. J Hepatol 2019;70:412\u2013422.","journal-title":"J Hepatol"},{"key":"9356_CR9","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1007\/s12072-020-10062-w","volume":"14","author":"G Marasco","year":"2020","unstructured":"Marasco G, Dajti E, Ravaioli F, Alemanni LV, Capuano F, Gjini K et al. Spleen stiffness measurement for assessing the response to \u03b2-blockers therapy for high-risk esophageal varices patients. Hepatol Int 2020;14:850\u2013857.","journal-title":"Hepatol Int"},{"key":"9356_CR10","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1053\/j.gastro.2012.05.035","volume":"143","author":"A Colecchia","year":"2012","unstructured":"Colecchia A, Montrone L, Scaioli E, Bacchi-Reggiani ML, Colli A, Casazza G et al. Measurement of spleen stiffness to evaluate portal hypertension and the presence of esophageal varices in patients with HCV-related cirrhosis. Gastroenterology 2012;143:646\u2013654.","journal-title":"Gastroenterology"},{"key":"9356_CR11","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1016\/j.jhep.2014.02.024","volume":"60","author":"A Colecchia","year":"2014","unstructured":"Colecchia A, Colli A, Casazza G, Mandolesi D, Schiumerini R, Reggiani LB et al. Spleen stiffness measurement can predict clinical complications in compensated HCV-related cirrhosis: a prospective study. J Hepatol 2014;60:1158\u20131164.","journal-title":"J Hepatol"},{"key":"9356_CR12","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.jhep.2018.04.023","volume":"69","author":"A Colecchia","year":"2018","unstructured":"Colecchia A, Ravaioli F, Marasco G, Colli A, Dajti E, Di Biase AR et al. A com-bined model based on spleen stiffness measurement and Baveno VI crite-ria to rule out high-risk varices in advanced chronic liver disease. J Hepatol 2018;69:308\u2013317.","journal-title":"J Hepatol"},{"key":"9356_CR13","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1111\/liv.14228","volume":"40","author":"H Stefanescu","year":"2020","unstructured":"Stefanescu H, Marasco G, Cal\u00e8s P, Fraquelli M, Rosselli M, Ganne-Carri\u00e8 N et al. A novel spleen-dedicated stiffness measurement by FibroScan\u00ae improves the screening of high-risk oesophageal varices. Liver Int 2020;40:175\u2013185.","journal-title":"Liver Int"},{"key":"9356_CR14","doi-asserted-by":"publisher","first-page":"e4","DOI":"10.1016\/j.cgh.2016.10.041","volume":"15","author":"Y Takuma","year":"2017","unstructured":"Takuma Y, Morimoto Y, Takabatake H, Toshikuni N, Tomokuni J, Sahara A et al. Measurement of spleen stiffness with acoustic radiation force impulse imaging predicts mortality and hepatic decompensation in patients with liver cirrhosis. Clin Gastroenterol Hepatol 2017;15:e4.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"9356_CR15","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1038\/ajg.2013.119","volume":"108","author":"P Sharma","year":"2013","unstructured":"Sharma P, Kirnake V, Tyagi P, Bansal N, Singla V, Kumar A et al. Spleen stiff-ness in patients with cirrhosis in predicting esophageal varices. Am J Gastroen-terol 2013;108:1101\u20131107.","journal-title":"Am J Gastroen-terol"},{"key":"9356_CR16","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1007\/s00535-012-0703-z","volume":"48","author":"Y Furuichi","year":"2013","unstructured":"Furuichi Y, Moriyasu F, Taira J, Sugimoto K, Sano T, Ichimura S et al. Noninvasive diagnostic method for idiopathic portal hypertension based on measurements of liver and spleen stiffness by ARFI elastography. J Gastroenterol. 2013;48:1061\u20131068.","journal-title":"J Gastroenterol."},{"key":"9356_CR17","doi-asserted-by":"crossref","unstructured":"Ahmad A.K., Atzori S., Taylor-Robinson S.D., Maurice J.B., Cooke G.S., Garvey L. Spleen stiffness measurements using point shear wave elastography detects noncirrhotic portal hypertension in human immunodeficiency virus. Medicine (Baltimore) 2019;98.","DOI":"10.1097\/MD.0000000000017961"},{"key":"9356_CR18","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.1080\/00365521.2021.1968485","volume":"56","author":"J Ferreira-Silva","year":"2021","unstructured":"Ferreira-Silva J, Gaspar R, Liberal R, Cardoso H, Macedo G. Transient splenic elastography predicts high-risk esophageal varices in patients with non-cirrhotic portal hypertension. Scand. J. Gastroenterol. 2021;56:1462\u20131466.","journal-title":"Scand. J. Gastroenterol."},{"key":"9356_CR19","doi-asserted-by":"publisher","first-page":"444","DOI":"10.3350\/cmh.2020.0022","volume":"26","author":"CR Lesmana","year":"2020","unstructured":"Lesmana CR, Raharjo M, Gani RA. Managing liver cirrhotic complications: Overview of esophageal and gastric varices. Clin Mol Hepatol. 2020;26:444\u2013460.","journal-title":"Clin Mol Hepatol."},{"key":"9356_CR20","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/j.cld.2006.08.021","volume":"10","author":"SK Sarin","year":"2006","unstructured":"Sarin SK, Kumar A. Non cirrhotic portal hypertension. Clin Liver Dis 2006;10:627\u2013651.","journal-title":"Clin Liver Dis"},{"key":"9356_CR21","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1111\/j.1478-3231.2006.01269.x","volume":"26","author":"SK Sarin","year":"2006","unstructured":"Sarin SK, Sollano JD, Chawla YK, Amarapurkar D, Hamid S, Hashizume M et al. Members of the APASL working party on portal hypertension. Consensus on extra-hepatic portal vein obstruction. Liver Int 2006;26:512\u2013519.","journal-title":"Liver Int"},{"key":"9356_CR22","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1136\/gut.28.3.260","volume":"28","author":"SK Sarin","year":"1987","unstructured":"Sarin SK, Sethi KK, Nanda R. Measurement and correlation of wedged hepatic, intrahepatic, intrasplenic and intravariceal pressures in patients with cirrhosis of liver and non-cirrhotic portal fibrosis. Gut 1987;28:260\u2013266.","journal-title":"Gut"},{"key":"9356_CR23","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1148\/radiol.12111046","volume":"263","author":"P Sharma","year":"2012","unstructured":"Sharma P, Mishra SR, Kumar M, Sharma BC, Sarin SK. Liver and spleen stiffness in patients with extrahepatic portal vein obstruction. Radiology 2012;263:893\u2013899.","journal-title":"Radiology"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-025-09356-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10620-025-09356-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-025-09356-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T08:01:45Z","timestamp":1772092905000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10620-025-09356-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,2]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["9356"],"URL":"https:\/\/doi.org\/10.1007\/s10620-025-09356-6","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,2]]},"assertion":[{"value":"20 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}