{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T20:32:50Z","timestamp":1778358770229,"version":"3.51.4"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Yunnan Provincial Department of Science and Technology Kunming Medical Joint Special Basic Research Program","award":["202101AY070001-111"],"award-info":[{"award-number":["202101AY070001-111"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1007\/s10620-025-09412-1","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T03:32:36Z","timestamp":1759721556000},"page":"991-1002","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Inhibition of PTP1B Through NADH Dehydrogenase Activity Reduces Acute Pancreatic Acinar Cell Pyroptosis by Inhibiting the ROS\/TXNIP\/NLRP3 Pathway"],"prefix":"10.1007","volume":"71","author":[{"given":"Jin","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongjie","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiying","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,10,6]]},"reference":[{"key":"9412_CR1","doi-asserted-by":"publisher","first-page":"2043","DOI":"10.1016\/j.ajpath.2016.04.012","volume":"186","author":"A Bettaieb","year":"2016","unstructured":"Bettaieb A, Koike S, Chahed S, Bachaalany S, Griffey S, Sastre J et al. Pancreatic protein tyrosine phosphatase 1B deficiency exacerbates acute pancreatitis in mice. Am J Pathol. 2016;186:2043\u20132054.","journal-title":"Am J Pathol."},{"key":"9412_CR2","doi-asserted-by":"publisher","first-page":"5479","DOI":"10.1128\/MCB.20.15.5479-5489.2000","volume":"20","author":"LD Klaman","year":"2000","unstructured":"Klaman LD, Boss O, Peroni OD, Kim JK, Martino JL, Zabolotny JM et al. Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice. Mol Cell Biol 2000;20:5479\u20135489.","journal-title":"Mol Cell Biol"},{"key":"9412_CR3","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.1126\/science.283.5407.1544","volume":"283","author":"M Elchebly","year":"1999","unstructured":"Elchebly M, Payette P, Michaliszyn E, Cromlish W, Collins S, Loy AL et al. Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science (New York, NY) 1999;283:1544\u20131548.","journal-title":"Science (New York, NY)"},{"key":"9412_CR4","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.bbadis.2013.11.003","volume":"1842","author":"V Garc\u00eda-Hern\u00e1ndez","year":"2014","unstructured":"Garc\u00eda-Hern\u00e1ndez V, Sarmiento N, S\u00e1nchez-Bernal C, Matell\u00e1n L, Calvo JJ, S\u00e1nchez-Yag\u00fce J. Modulation in the expression of SHP-1, SHP-2 and PTP1B due to the inhibition of MAPKs, cAMP and neutrophils early on in the development of cerulein-induced acute pancreatitis in rats. Biochim Biophys Acta 2014;1842:192\u2013201.","journal-title":"Biochim Biophys Acta"},{"key":"9412_CR5","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1478-811X-12-13","volume":"12","author":"A Bettaieb","year":"2014","unstructured":"Bettaieb A, Xi Y, Hosein E, Coggins N, Bachaalany S, Wiede F et al. Pancreatic T cell protein-tyrosine phosphatase deficiency ameliorates cerulein-induced acute pancreatitis. Cell Commun Signal 2014;12:13.","journal-title":"Cell Commun Signal"},{"key":"9412_CR6","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1016\/j.bbabio.2015.11.004","volume":"1857","author":"AD Vinogradov","year":"2016","unstructured":"Vinogradov AD, Grivennikova VG. Oxidation of NADH and ROS production by respiratory complex I. Biochim Biophys Acta 2016;1857:863\u2013871.","journal-title":"Biochim Biophys Acta"},{"key":"9412_CR7","doi-asserted-by":"publisher","first-page":"e62","DOI":"10.1097\/MPA.0000000000002225","volume":"52","author":"M Lin","year":"2023","unstructured":"Lin M, Jin Y, Wang F, Meng Y, Huang J, Qin X et al. MARCH9 mediates NOX2 ubiquitination to alleviate NLRP3 inflammasome-dependent pancreatic cell pyroptosis in acute pancreatitis. Pancreas 2023;52:e62\u2013e69.","journal-title":"Pancreas"},{"key":"9412_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.108885","volume":"108","author":"YT Huang","year":"2022","unstructured":"Huang YT, Liang QQ, Zhang HR, Chen SY, Xu LH, Zeng B et al. Baicalin inhibits necroptosis by decreasing oligomerization of phosphorylated MLKL and mitigates caerulein-induced acute pancreatitis in mice. Int Immunopharmacol 2022;108:108885.","journal-title":"Int Immunopharmacol"},{"key":"9412_CR9","first-page":"305","volume":"122","author":"W Halangk","year":"1997","unstructured":"Halangk W, Matthias R, Nedelev B, Schild L, Meyer F, Schulz HU et al. Modification of energy supply by pancreatic mitochondria in acute experimental pancreatitis. Zentralbl Chir 1997;122:305\u20138.","journal-title":"Zentralbl Chir"},{"key":"9412_CR10","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/j.devcel.2017.02.020","volume":"40","author":"EA Bordt","year":"2017","unstructured":"Bordt EA, Clerc P, Roelofs BA, Saladino AJ, Tretter L, Adam-Vizi V et al. The putative Drp1 inhibitor mdivi-1 is a reversible mitochondrial complex I inhibitor that modulates reactive oxygen species. Dev Cell 2017;40:583\u201394.e6.","journal-title":"Dev Cell"},{"key":"9412_CR11","doi-asserted-by":"publisher","first-page":"4187398","DOI":"10.1155\/2021\/4187398","volume":"2021","author":"Q Zhu","year":"2021","unstructured":"Zhu Q, Hao L. CaMK II inhibition attenuates ROS dependent necroptosis in acinar cells and protects against acute pancreatitis in mice. Oxid Med Cell Longev 2021;2021:4187398.","journal-title":"Oxid Med Cell Longev"},{"key":"9412_CR12","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1097\/SHK.0000000000001992","volume":"58","author":"H Lv","year":"2022","unstructured":"Lv H, Liu X, Zhou H. USP25 upregulation boosts GSDMD -mediated pyroptosis of acinar cells in acute pancreatitis. Shock (Augusta, Ga) 2022;58:408\u2013416.","journal-title":"Shock (Augusta, Ga)"},{"key":"9412_CR13","first-page":"89","volume":"33","author":"T Lin","year":"2021","unstructured":"Lin T, Pan X, Wan Y, Wu Z, Lyu S, Wang Y et al. Mechanism of gasdermin D on intestinal injury in severe acute pancreatitis by mediating pyroptosis. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021;33:89\u201394.","journal-title":"Zhonghua Wei Zhong Bing Ji Jiu Yi Xue"},{"key":"9412_CR14","doi-asserted-by":"publisher","first-page":"2591","DOI":"10.3390\/nu14132591","volume":"14","author":"C Zhang","year":"2022","unstructured":"Zhang C, Niu H, Wan C, Yu X, Xin G, Zhu Y et al. Drug D, a diosgenin derive, inhibits L-arginine-induced acute pancreatitis through meditating GSDMD in the endoplasmic reticulum via the TXNIP\/HIF-1\u03b1 pathway. Nutrients 2022;14:2591.","journal-title":"Nutrients"},{"key":"9412_CR15","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1186\/s13287-020-02102-x","volume":"12","author":"L Bourebaba","year":"2021","unstructured":"Bourebaba L, Kornicka-Garbowska K, Al Naem M, R\u00f6cken M, \u0141yczko J, Marycz K. MSI-1436 improves EMS adipose derived progenitor stem cells in the course of adipogenic differentiation through modulation of ER stress, apoptosis, and oxidative stress. Stem Cell Res Therapy 2021;12:97.","journal-title":"Stem Cell Res Therapy"},{"key":"9412_CR16","doi-asserted-by":"crossref","unstructured":"Bhardwaj A, Antonelli M, Ueberheide B, Neel BG. Identification of a novel hypoxia-induced inflammatory cell death pathway. bioRxiv. 2023.","DOI":"10.1101\/2023.08.05.552118"},{"key":"9412_CR17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0278566","volume":"18","author":"L Bourebaba","year":"2023","unstructured":"Bourebaba L, Komakula SSB. The PTP1B selective inhibitor MSI-1436 mitigates Tunicamycin-induced ER stress in human hepatocarcinoma cell line through XBP1 splicing modulation. PLoS One 2023;18:e0278566.","journal-title":"PLoS One"},{"key":"9412_CR18","doi-asserted-by":"publisher","first-page":"14230","DOI":"10.1074\/jbc.M800061200","volume":"283","author":"JM Zabolotny","year":"2008","unstructured":"Zabolotny JM, Kim YB, Welsh LA, Kershaw EE, Neel BG, Kahn BB. Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo. J Biol Chem 2008;283:14230\u201314241.","journal-title":"J Biol Chem"},{"key":"9412_CR19","doi-asserted-by":"publisher","first-page":"467","DOI":"10.3892\/etm.2022.11394","volume":"24","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, Guan Q, Wang Z. PTP1B inhibition ameliorates inflammatory injury and dysfunction in ox-LDL-induced HUVECs by activating the AMPK\/SIRT1 signaling pathway via negative regulation of KLF2. Exp Ther Med 2022;24:467.","journal-title":"Exp Ther Med"},{"key":"9412_CR20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0070828","volume":"8","author":"J Zhang","year":"2013","unstructured":"Zhang J, Wang B, Zhang W, Wei Y, Bian Z, Zhang CY et al. Protein tyrosine phosphatase 1B deficiency ameliorates murine experimental colitis via the expansion of myeloid-derived suppressor cells. PLoS One 2013;8:e70828.","journal-title":"PLoS One"},{"key":"9412_CR21","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1038\/s41419-019-2073-4","volume":"10","author":"Q Xu","year":"2019","unstructured":"Xu Q, Wu N, Li X, Guo C, Li C, Jiang B et al. Inhibition of PTP1B blocks pancreatic cancer progression by targeting the PKM2\/AMPK\/mTOC1 pathway. Cell Death Dis. 2019;10:874.","journal-title":"Cell Death Dis."},{"key":"9412_CR22","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/s41420-024-01923-6","volume":"10","author":"W Liu","year":"2024","unstructured":"Liu W, Ren Y. Blocking CIRP protects against acute pancreatitis by improving mitochondrial function and suppressing pyroptosis in acinar cells. Cell Death Discov. 2024;10:156.","journal-title":"Cell Death Discov."},{"key":"9412_CR23","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1038\/s41423-022-00905-x","volume":"19","author":"X Wei","year":"2022","unstructured":"Wei X, Xie F, Zhou X, Wu Y, Yan H, Liu T et al. Role of pyroptosis in inflammation and cancer. Cell Mol Immunol 2022;19:971\u2013992.","journal-title":"Cell Mol Immunol"},{"key":"9412_CR24","doi-asserted-by":"publisher","first-page":"8516","DOI":"10.1074\/jbc.M210432200","volume":"278","author":"N Li","year":"2003","unstructured":"Li N, Ragheb K, Lawler G, Sturgis J, Rajwa B, Melendez JA et al. Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production. J Biol Chem 2003;278:8516\u20138525.","journal-title":"J Biol Chem"},{"key":"9412_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1042\/BJ20081386","volume":"417","author":"MP Murphy","year":"2009","unstructured":"Murphy MP. How mitochondria produce reactive oxygen species. Biochem J 2009;417:1\u201313.","journal-title":"Biochem J"},{"key":"9412_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101450","volume":"32","author":"F Scial\u00f2","year":"2020","unstructured":"Scial\u00f2 F, Sriram A, Stefanatos R, Spriggs RV, Loh SHY, Martins LM et al. Mitochondrial complex I derived ROS regulate stress adaptation in Drosophila melanogaster. Redox Biol. 2020;32:101450.","journal-title":"Redox Biol."},{"key":"9412_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2023.166795","volume":"1869","author":"Q Yang","year":"2023","unstructured":"Yang Q, Zou Y, Wei X, Ye P, Wu Y, Ai H et al. PTP1B knockdown alleviates BMSCs senescence via activating AMPK-mediated mitophagy and promotes osteogenesis in senile osteoporosis. Biochim Biophys Acta Mol Basis Dis 2023;1869:166795.","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"9412_CR28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0139429","volume":"10","author":"J Fueller","year":"2015","unstructured":"Fueller J, Egorov MV, Walther KA, Sabet O, Mallah J, Grabenbauer M et al. Subcellular partitioning of protein tyrosine phosphatase 1B to the endoplasmic reticulum and mitochondria depends sensitively on the composition of its tail anchor. PLoS One 2015;10:e0139429.","journal-title":"PLoS One"},{"key":"9412_CR29","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1007\/s10495-022-01729-w","volume":"27","author":"A Al Mamun","year":"2022","unstructured":"Al Mamun A, Suchi SA, Aziz MA. Pyroptosis in acute pancreatitis and its therapeutic regulation. Apoptosis 2022;27:465\u2013481.","journal-title":"Apoptosis"},{"key":"9412_CR30","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1038\/s12276-023-01019-8","volume":"55","author":"EH Choi","year":"2023","unstructured":"Choi EH, Park SJ. TXNIP: A key protein in the cellular stress response pathway and a potential therapeutic target. Exp Mol Med 2023;55:1348\u201356.","journal-title":"Exp Mol Med"},{"key":"9412_CR31","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1080\/00952990.2023.2297349","volume":"50","author":"R Liu","year":"2024","unstructured":"Liu R, Zhao B, Zhao J, Zhang M. Ethanol causes non-communicable disease through activation of NLRP3 inflammasome: a review on mechanism of action and potential interventions. Am J Drug Alcohol Abuse 2024;50:139\u201349.","journal-title":"Am J Drug Alcohol Abuse"},{"key":"9412_CR32","doi-asserted-by":"publisher","first-page":"59","DOI":"10.15252\/emmm.201404082","volume":"7","author":"K Singh","year":"2015","unstructured":"Singh K, Maity P, Krug L, Meyer P, Treiber N, Lucas T et al. Superoxide anion radicals induce IGF-1 resistance through concomitant activation of PTP1B and PTEN. EMBO Mol Med 2015;7:59\u201377.","journal-title":"EMBO Mol Med"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-025-09412-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10620-025-09412-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-025-09412-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:10:53Z","timestamp":1773292253000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10620-025-09412-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,6]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["9412"],"URL":"https:\/\/doi.org\/10.1007\/s10620-025-09412-1","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,6]]},"assertion":[{"value":"22 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All authors have read and agreed to produce a version of the manuscript.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for participate"}},{"value":"All authors have read and agreed to produce a version of the manuscript.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}