{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:04:06Z","timestamp":1787774646637,"version":"build-2784847793"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T00:00:00Z","timestamp":1761350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T00:00:00Z","timestamp":1761350400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease worldwide, affecting up to 38% of adults and nearly two-thirds of patients with type 2 diabetes, of whom one-third develop metabolic dysfunction-associated steatohepatitis (MASH). Although only a minority progress to cirrhosis or hepatocellular carcinoma, the absolute burden is substantial and continues to rise, particularly in Asia and Latin America. While population-level disparities are well documented, little is known about inequities within the scientific literature itself. We aimed to systematically map global MASLD\/MASH research to identify patterns in productivity, geographic distribution, authorship, and disparities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We analyzed publications from 1980 to 2024 in the Web of Science Core Collection (extraction May 15, 2025). After excluding meeting abstracts, 36,268 records were included. Using the\n                      <jats:italic>Bibliometrix<\/jats:italic>\n                      R package, we evaluated annual production, country and institutional contributions, authorship patterns, and journal sources. Disparity analyses focused on the 1000 most cited articles, assessing country contributions, first-author sex, and journal representation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Analysis of the 1000 most cited MASLD\/MASH publications revealed rapid growth since the early 2000s, peaking at over 60 papers annually between 2010 and 2020, with an apparent recent decline due to citation lag. The United States dominated both output and citations, far surpassing other countries. Hepatology, Journal of Hepatology, and Gastroenterology accounted for most influential publications. Leading contributors included two authors, with 50 articles each. Striking gender disparities emerged: only 3% of top 100 papers had female first authors. Overall, research remains concentrated geographically, institutionally, and by author, with persistent inequities in authorship representation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>MASLD\/MASH research is highly concentrated by geography, journals, and authorship, with pronounced gender disparities. Expanding inclusivity and fostering international collaborations are essential to advance this field.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10620-025-09498-7","type":"journal-article","created":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T11:09:12Z","timestamp":1761390552000},"page":"1269-1274","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Systematic Mapping of Worldwide Research on Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and Metabolic Dysfunction-Associated Steatohepatitis (MASH)"],"prefix":"10.1007","volume":"71","author":[{"given":"Melissa Lou","family":"Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renan","family":"Prado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,25]]},"reference":[{"key":"9498_CR1","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1056\/NEJMra2412865","volume":"393","author":"G Targher","year":"2025","unstructured":"Targher G, Valenti L, Byrne CD. Metabolic dysfunction-associated steatotic liver disease. N Engl J Med. 2025;393:683\u2013698.","journal-title":"N Engl J Med."},{"key":"9498_CR2","doi-asserted-by":"crossref","unstructured":"Unalp-Arida A, Ruhl CE. Prevalence of metabolic dysfunction\u2013associated steatotic liver disease and fibrosis defined by liver elastography in the United States using National Health and Nutrition Examination Survey 2017-March 2020 and August 2021\u2013August 2023 data. Hepatology. 2024.","DOI":"10.1097\/HEP.0000000000001211"},{"key":"9498_CR3","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.54707","volume":"8","author":"P Le","year":"2025","unstructured":"Le P, Tatar M, Dasarathy S et al. Estimated burden of metabolic dysfunction-associated steatotic liver disease in US adults, 2020 to 2050. JAMA Netw Open. 2025;8:e2454707.","journal-title":"JAMA Netw Open."},{"key":"9498_CR4","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1097\/HEP.0000000000000664","volume":"79","author":"CM Lee","year":"2024","unstructured":"Lee CM, Yoon EL, Kim M et al. Prevalence, distribution, and hepatic fibrosis burden of the different subtypes of steatotic liver disease in primary care settings. Hepatology. 2024;79:1393\u20131400.","journal-title":"Hepatology."},{"key":"9498_CR5","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1111\/nyas.15184","volume":"1538","author":"W Fan","year":"2024","unstructured":"Fan W, Bradford TM, T\u00f6r\u00f6k NJ. Metabolic dysfunction\u2014associated liver disease and diabetes: matrix remodeling, fibrosis, and therapeutic implications. Annals New York Acad Sci. 2024;1538:21\u201333.","journal-title":"Annals New York Acad Sci."},{"key":"9498_CR6","doi-asserted-by":"publisher","first-page":"11","DOI":"10.7326\/ANNALS-24-02933","volume":"178","author":"SMJ Ali","year":"2025","unstructured":"Ali SMJ, Lai M. Metabolic dysfunction\u2014associated steatotic liver disease. Ann Intern Med. 2025;178:11\u201316.","journal-title":"Ann Intern Med."},{"key":"9498_CR7","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1038\/s41572-025-00599-1","volume":"11","author":"DQ Huang","year":"2025","unstructured":"Huang DQ, Wong VWS, Rinella ME et al. Metabolic dysfunction-associated steatotic liver disease in adults. Nat Rev Dis Primers. 2025;11:14.","journal-title":"Nat Rev Dis Primers."},{"key":"9498_CR8","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1007\/s10620-024-08722-0","volume":"70","author":"KC Miller","year":"2025","unstructured":"Miller KC, Geyer B, Alexopoulos AS et al. Disparities in metabolic dysfunction-associated steatotic liver disease prevalence, diagnosis, treatment, and outcomes: a narrative review. Dig Dis Sci. 2025;70:154\u2013167. https:\/\/doi.org\/10.1007\/s10620-024-08722-0.","journal-title":"Dig Dis Sci."},{"key":"9498_CR9","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.cgh.2024.06.038","volume":"23","author":"K Tesfai","year":"2025","unstructured":"Tesfai K, Pace J, El-Newihi N et al. Disparities for hispanic adults with metabolic dysfunction-associated steatotic liver disease in the United States: a systematic review and meta-analysis. Clin Gastroenterol Hepatol. 2025;23:236\u2013249.","journal-title":"Clin Gastroenterol Hepatol."},{"key":"9498_CR10","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.2337\/dci24-0094","volume":"48","author":"K Cusi","year":"2025","unstructured":"Cusi K, Abdelmalek MF, Apovian CM et al. Metabolic dysfunction-associated steatotic liver disease (MASLD) in people with diabetes: the need for screening and early intervention. A consensus report of the American Diabetes Association. Diabetes Care. 2025;48:1057\u20131082.","journal-title":"Diabetes Care."},{"key":"9498_CR11","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000025291","volume":"100","author":"H Yang","year":"2021","unstructured":"Yang H, Wang D, Chen C et al. Global research status of gastroenterology and hepatology: a bibliometrics study. Medicine. 2021;100:e25291.","journal-title":"Medicine."},{"key":"9498_CR12","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1007\/s10620-021-07021-2","volume":"67","author":"S Bhatia","year":"2022","unstructured":"Bhatia S, Cotton CC, Kim E et al. Gender and nationality trends in manuscripts published in Prominent Gastroenterology Journals between 1997 and 2017. Dig Dis Sci. 2022;67:367\u2013376. https:\/\/doi.org\/10.1007\/s10620-021-07021-2.","journal-title":"Dig Dis Sci."}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-025-09498-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10620-025-09498-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-025-09498-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T08:42:32Z","timestamp":1777970552000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10620-025-09498-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,25]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["9498"],"URL":"https:\/\/doi.org\/10.1007\/s10620-025-09498-7","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-7492816\/v1","asserted-by":"object"}]},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,25]]},"assertion":[{"value":"30 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}