{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T04:05:58Z","timestamp":1783915558444,"version":"3.55.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T00:00:00Z","timestamp":1767398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T00:00:00Z","timestamp":1767398400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100010041","name":"Tianjin Municipal Science and Technology Committee","doi-asserted-by":"publisher","award":["21JCZDJC01070"],"award-info":[{"award-number":["21JCZDJC01070"]}],"id":[{"id":"10.13039\/501100010041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017964","name":"Tianjin Municipal Health Commission","doi-asserted-by":"publisher","award":["2021031"],"award-info":[{"award-number":["2021031"]}],"id":[{"id":"10.13039\/100017964","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017959","name":"Health Commission of Hebei Province","doi-asserted-by":"publisher","award":["T2025025"],"award-info":[{"award-number":["T2025025"]}],"id":[{"id":"10.13039\/100017959","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1007\/s10620-025-09641-4","type":"journal-article","created":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T07:43:19Z","timestamp":1767426199000},"page":"2313-2323","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Repression of Polycomb Group Factor 1 Inhibits EMT Progression in Colon Cancers Cells via Wnt\/\u03b2-Catenin and PI3K\/Akt\/mTOR Signaling Pathway"],"prefix":"10.1007","volume":"71","author":[{"given":"Peng","family":"An","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,3]]},"reference":[{"key":"9641_CR1","doi-asserted-by":"publisher","first-page":"1880","DOI":"10.1002\/cncr.33445","volume":"127","author":"JF Shi","year":"2021","unstructured":"Shi JF, Wang L, Ran JC, Wang H, Liu CC, Zhang HZ et al. Clinical characteristics, medical service utilization, and expenditure for colorectal cancer in China, 2005 to 2014: Overall design and results from a multicenter retrospective epidemiologic survey. Cancer. 2021;127:1880\u20131893.","journal-title":"Cancer."},{"key":"9641_CR2","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1038\/s41591-020-01195-4","volume":"27","author":"K Ganesh","year":"2021","unstructured":"Ganesh K, Massague J. Targeting metastatic cancer. Nature medicine. 2021;27:34\u201344.","journal-title":"Nature medicine."},{"key":"9641_CR3","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1159\/000147748","volume":"154","author":"ED Hay","year":"1995","unstructured":"Hay ED. An overview of epithelio-mesenchymal transformation. Acta Anat (Basel). 1995;154:8\u201320.","journal-title":"Acta Anat (Basel)."},{"key":"9641_CR4","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1242\/dev.116.4.1087","volume":"116","author":"CM Griffith","year":"1992","unstructured":"Griffith CM, Hay ED. Epithelial-mesenchymal transformation during palatal fusion: carboxyfluorescein traces cells at light and electron microscopic levels. Development. 1992;116:1087\u20131099.","journal-title":"Development."},{"key":"9641_CR5","doi-asserted-by":"publisher","first-page":"2787","DOI":"10.2147\/DDDT.S417077","volume":"17","author":"Q Du","year":"2023","unstructured":"Du Q, Lin Y, Ding C, Wu L, Xu Y, Feng Q. Pharmacological Activity of Matrine in Inhibiting Colon Cancer Cells VM Formation, Proliferation, and Invasion by Downregulating Claudin-9 Mediated EMT Process and MAPK Signaling Pathway. Drug design, development and therapy. 2023;17:2787\u20132804.","journal-title":"Drug design, development and therapy."},{"key":"9641_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2022.101937","volume":"79","author":"A Sun","year":"2022","unstructured":"Sun A, Li Y, Jiang X. CCL26 silence represses colon cancer by inhibiting the EMT signaling pathway. Tissue Cell. 2022;79:101937.","journal-title":"Tissue Cell."},{"key":"9641_CR7","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1186\/s12915-022-01315-1","volume":"20","author":"A Lorzadeh","year":"2022","unstructured":"Lorzadeh A, Hammond C, Wang F, Knapp D, Wong JC, Zhu JYA et al. Polycomb contraction differentially regulates terminal human hematopoietic differentiation programs. BMC Biol. 2022;20:104.","journal-title":"BMC Biol."},{"key":"9641_CR8","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1002\/gcc.23036","volume":"61","author":"ALT Maciel","year":"2022","unstructured":"Maciel ALT, Wolch K, Emerenciano M, Mansur MB. CRLF2 overexpression defines an immature-like subgroup which is rescued through restoration of the PRC2 function in T-cell precursor acute lymphoblastic leukemia. Genes Chromosomes Cancer. 2022;61:437\u2013442.","journal-title":"Genes Chromosomes Cancer."},{"key":"9641_CR9","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1016\/j.stemcr.2022.04.010","volume":"17","author":"S Schouten","year":"2022","unstructured":"Schouten S, Bovee N, Liu Z, Marks H. PRC1 uncomplexed. Stem cell reports. 2022;17:1009\u20131011.","journal-title":"Stem cell reports."},{"key":"9641_CR10","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1002\/JLB.2RI0122-039R","volume":"111","author":"GA Melo","year":"2022","unstructured":"Melo GA, Caloba C, Brum G, Passos TO, Martinez GJ, Pereira RM. Epigenetic regulation of T cells by Polycomb group proteins. J Leukoc Biol. 2022;111:1253\u20131267.","journal-title":"J Leukoc Biol."},{"key":"9641_CR11","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1016\/j.tibs.2019.04.005","volume":"44","author":"HL Chan","year":"2019","unstructured":"Chan HL, Morey L. Emerging Roles for Polycomb-Group Proteins in Stem Cells and Cancer. Trends in biochemical sciences. 2019;44:688\u2013700.","journal-title":"Trends in biochemical sciences."},{"key":"9641_CR12","doi-asserted-by":"crossref","unstructured":"Lima de Oliveira J, More Milan T, Longo Bighetti-Trevisan R, Fernandes RR, Machado Leopoldino A, Oliveira de Almeida L. Epithelial-mesenchymal transition and cancer stem cells: A route to acquired cisplatin resistance through epigenetics in HNSCC. Oral Dis. 2022.","DOI":"10.1111\/ODI.14209\/v2\/response1"},{"key":"9641_CR13","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1111\/jcmm.17092","volume":"26","author":"W Yu","year":"2022","unstructured":"Yu W, Ma Y, Roy SK, Srivastava R, Shankar S, Srivastava RK. Ethanol exposure of human pancreatic normal ductal epithelial cells induces EMT phenotype and enhances pancreatic cancer development in KC (Pdx1-Cre and LSL-Kras(G12D) ) mice. Journal of cellular and molecular medicine. 2022;26:399\u2013409.","journal-title":"Journal of cellular and molecular medicine."},{"key":"9641_CR14","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1016\/j.stemcr.2022.02.020","volume":"17","author":"Y Zhu","year":"2022","unstructured":"Zhu Y, Dong L, Wang C, Hao K, Wang J, Zhao L et al. Functional redundancy among Polycomb complexes in maintaining the pluripotent state of embryonic stem cells. Stem cell reports. 2022;17:1198\u20131214.","journal-title":"Stem cell reports."},{"key":"9641_CR15","first-page":"550","volume":"30","author":"XD Wu","year":"2008","unstructured":"Wu XD, Zhang M, Gong YH, Qiang BQ, Yuan JG, Meng AM et al. Expression pattern of polycomb gene Nspc1 at the early developmental stage in zebrafish. Zhongguo yi xue ke xue yuan xue bao Acta Academiae Medicinae Sinicae. 2008;30:550\u2013553.","journal-title":"Zhongguo yi xue ke xue yuan xue bao Acta Academiae Medicinae Sinicae."},{"key":"9641_CR16","doi-asserted-by":"publisher","first-page":"4152","DOI":"10.1182\/blood-2011-09-382390","volume":"119","author":"K Ross","year":"2012","unstructured":"Ross K, Sedello AK, Todd GP, Paszkowski-Rogacz M, Bird AW, Ding L et al. Polycomb group ring finger 1 cooperates with Runx1 in regulating differentiation and self-renewal of hematopoietic cells. Blood. 2012;119:4152\u20134161.","journal-title":"Blood."},{"key":"9641_CR17","doi-asserted-by":"publisher","first-page":"6158","DOI":"10.1093\/nar\/gkl834","volume":"34","author":"Y Gong","year":"2006","unstructured":"Gong Y, Yue J, Wu X, Wang X, Wen J, Lu L et al. NSPc1 is a cell growth regulator that acts as a transcriptional repressor of p21Waf1\/Cip1 via the RARE element. Nucleic acids research. 2006;34:6158\u20136169.","journal-title":"Nucleic acids research."},{"key":"9641_CR18","doi-asserted-by":"publisher","first-page":"4706","DOI":"10.1038\/onc.2017.34","volume":"36","author":"PS Hu","year":"2017","unstructured":"Hu PS, Xia QS, Wu F, Li DK, Qi YJ, Hu Y et al. NSPc1 promotes cancer stem cell self-renewal by repressing the synthesis of all-trans retinoic acid via targeting RDH16 in malignant glioma. Oncogene. 2017;36:4706\u20134718.","journal-title":"Oncogene."},{"key":"9641_CR19","doi-asserted-by":"publisher","first-page":"253","DOI":"10.2147\/OTT.S234517","volume":"13","author":"R Yan","year":"2020","unstructured":"Yan R, Cui F, Dong L, Liu Y, Chen X, Fan R. Repression of PCGF1 Decreases the Proliferation of Glioblastoma Cells in Association with Inactivation of c-Myc Signaling Pathway. OncoTargets and therapy. 2020;13:253\u2013261.","journal-title":"OncoTargets and therapy."},{"key":"9641_CR20","doi-asserted-by":"publisher","first-page":"W98","DOI":"10.1093\/nar\/gkx247","volume":"45","author":"Z Tang","year":"2017","unstructured":"Tang Z, Li C, Kang B, Gao G, Li C, Zhang Z. GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses. Nucleic acids research. 2017;45:W98\u2013W102.","journal-title":"Nucleic acids research."},{"key":"9641_CR21","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1007\/s10549-009-0674-9","volume":"123","author":"B Gyorffy","year":"2010","unstructured":"Gyorffy B, Lanczky A, Eklund AC, Denkert C, Budczies J, Li Q et al. An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients. Breast cancer research and treatment. 2010;123:725\u2013731.","journal-title":"Breast cancer research and treatment."},{"key":"9641_CR22","first-page":"1296","volume":"42","author":"Y Zeng","year":"2022","unstructured":"Zeng Y, Fan R. PCGF1 is highly expressed in rectal adenocarcinoma and silencing PCGF1 inhibits proliferation of rectal adenocarcinoma cells in vitro. Nan Fang Yi Ke Da Xue Xue Bao. 2022;42:1296\u20131302.","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao."},{"key":"9641_CR23","doi-asserted-by":"crossref","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: a cancer journal for clinicians. 2021;71(3):209\u201349.","DOI":"10.3322\/caac.21660"},{"key":"9641_CR24","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.2147\/OTT.S125724","volume":"10","author":"Y Wang","year":"2017","unstructured":"Wang Y, Sun J, Wei X, Luan L, Zeng X, Wang C et al. Decrease of miR-622 expression suppresses migration and invasion by targeting regulation of DYRK2 in colorectal cancer cells. OncoTargets and therapy. 2017;10:1091\u20131100.","journal-title":"OncoTargets and therapy."},{"key":"9641_CR25","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/s13045-017-0445-8","volume":"10","author":"M Sun","year":"2017","unstructured":"Sun M, Song H, Wang S, Zhang C, Zheng L, Chen F et al. Integrated analysis identifies microRNA-195 as a suppressor of Hippo-YAP pathway in colorectal cancer. Journal of hematology & oncology. 2017;10:79.","journal-title":"Journal of hematology & oncology."},{"key":"9641_CR26","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.intimp.2018.10.035","volume":"65","author":"L Zhang","year":"2018","unstructured":"Zhang L, Chen C, Duanmu J, Wu Y, Tao J, Yang A et al. Cryptotanshinone inhibits the growth and invasion of colon cancer by suppressing inflammation and tumor angiogenesis through modulating MMP\/TIMP system, PI3K\/Akt\/mTOR signaling and HIF-1alpha nuclear translocation. Int Immunopharmacol. 2018;65:429\u2013437.","journal-title":"Int Immunopharmacol."},{"key":"9641_CR27","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1007\/s00280-017-3515-2","volume":"81","author":"HU Gali-Muhtasib","year":"2018","unstructured":"Gali-Muhtasib HU, Diab-Assaf M, Haddadin MJ. Retraction Note to: Quinoxaline 1,4-dioxides induce G(2)\/M cell cycle arrest and apoptosis in human colon cancer cells. Cancer chemotherapy and pharmacology. 2018;81:627.","journal-title":"Cancer chemotherapy and pharmacology."},{"key":"9641_CR28","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s13046-016-0487-8","volume":"36","author":"J Xu","year":"2017","unstructured":"Xu J, Liu D, Niu H, Zhu G, Xu Y, Ye D et al. Resveratrol reverses Doxorubicin resistance by inhibiting epithelial-mesenchymal transition (EMT) through modulating PTEN\/Akt signaling pathway in gastric cancer. Journal of experimental & clinical cancer research\u202f: CR. 2017;36:19.","journal-title":"Journal of experimental & clinical cancer research : CR."},{"key":"9641_CR29","doi-asserted-by":"publisher","first-page":"399","DOI":"10.3727\/096504018X15179675206495","volume":"27","author":"X Ning","year":"2019","unstructured":"Ning X, Wang C, Zhang M, Wang K. Ectopic Expression of miR-147 Inhibits Stem Cell Marker and Epithelial-Mesenchymal Transition (EMT)-Related Protein Expression in Colon Cancer Cells. Oncology research. 2019;27:399\u2013406.","journal-title":"Oncology research."},{"key":"9641_CR30","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1038\/nrm1835","volume":"7","author":"JP Thiery","year":"2006","unstructured":"Thiery JP, Sleeman JP. Complex networks orchestrate epithelial-mesenchymal transitions. Nature reviews Molecular cell biology. 2006;7:131\u2013142.","journal-title":"Nature reviews Molecular cell biology."},{"key":"9641_CR31","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/s41580-018-0080-4","volume":"20","author":"A Dongre","year":"2019","unstructured":"Dongre A, Weinberg RA. New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer. Nature reviews Molecular cell biology. 2019;20:69\u201384.","journal-title":"Nature reviews Molecular cell biology."},{"key":"9641_CR32","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/S0925-4773(01)00288-X","volume":"102","author":"M Nunes","year":"2001","unstructured":"Nunes M, Blanc I, Maes J, Fellous M, Robert B, McElreavey K. NSPc1, a novel mammalian Polycomb gene, is expressed in neural crest-derived structures of the peripheral nervous system. Mechanisms of development. 2001;102:219\u2013222.","journal-title":"Mechanisms of development."},{"key":"9641_CR33","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/j.bbrc.2013.09.095","volume":"440","author":"H Li","year":"2013","unstructured":"Li H, Fan R, Sun M, Jiang T, Gong Y. Nspc1 regulates the key pluripotent Oct4-Nanog-Sox2 axis in P19 embryonal carcinoma cells via directly activating Oct4. Biochemical and biophysical research communications. 2013;440:527\u2013532.","journal-title":"Biochemical and biophysical research communications."},{"key":"9641_CR34","doi-asserted-by":"crossref","unstructured":"Flavahan WA, Gaskell E, Bernstein BE. Epigenetic plasticity and the hallmarks of cancer. Science (New York, NY). 2017;357(6348).","DOI":"10.1126\/science.aal2380"},{"key":"9641_CR35","doi-asserted-by":"publisher","first-page":"3373","DOI":"10.1042\/BCJ20210084","volume":"478","author":"JF Chen","year":"2021","unstructured":"Chen JF, Yan Q. The roles of epigenetics in cancer progression and metastasis. Biochem J. 2021;478:3373\u20133393.","journal-title":"Biochem J."},{"key":"9641_CR36","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1186\/s13046-019-1392-8","volume":"38","author":"J Wang","year":"2019","unstructured":"Wang J, Xing Y, Wang Y, He Y, Wang L, Peng S et al. A novel BMI-1 inhibitor QW24 for the treatment of stem-like colorectal cancer. Journal of experimental & clinical cancer research\u202f: CR. 2019;38:422.","journal-title":"Journal of experimental & clinical cancer research : CR."},{"key":"9641_CR37","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1016\/j.apsb.2020.11.018","volume":"11","author":"Z Xu","year":"2021","unstructured":"Xu Z, Zhou Z, Zhang J, Xuan F, Fan M, Zhou D et al. Targeting BMI-1-mediated epithelial-mesenchymal transition to inhibit colorectal cancer liver metastasis. Acta pharmaceutica Sinica B. 2021;11:1274\u20131285.","journal-title":"Acta pharmaceutica Sinica B."},{"key":"9641_CR38","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1053\/j.gastro.2017.07.044","volume":"153","author":"X Liu","year":"2017","unstructured":"Liu X, Wei W, Li X, Shen P, Ju D, Wang Z et al. BMI1 and MEL18 Promote Colitis-Associated Cancer in Mice via REG3B and STAT3. Gastroenterology. 2017;153:1607\u20131620.","journal-title":"Gastroenterology."},{"key":"9641_CR39","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.canlet.2008.12.015","volume":"277","author":"P Zhang","year":"2009","unstructured":"Zhang P, Zhang Y, Mao L, Zhang Z, Chen W. Side population in oral squamous cell carcinoma possesses tumor stem cell phenotypes. Cancer letters. 2009;277:227\u2013234.","journal-title":"Cancer letters."},{"key":"9641_CR40","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.581636","volume":"8","author":"X Li","year":"2020","unstructured":"Li X, Ji G, Zhou J, Du J, Li X, Shi W et al. Pcgf1 Regulates Early Neural Tube Development Through Histone Methylation in Zebrafish. Front Cell Dev Biol. 2020;8:581636.","journal-title":"Front Cell Dev Biol."},{"key":"9641_CR41","doi-asserted-by":"publisher","first-page":"18388","DOI":"10.1038\/srep18388","volume":"5","author":"G Oliviero","year":"2015","unstructured":"Oliviero G, Munawar N, Watson A, Streubel G, Manning G, Bardwell V et al. The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis. Scientific reports. 2015;5:18388.","journal-title":"Scientific reports."},{"key":"9641_CR42","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0158700","volume":"11","author":"B Dupret","year":"2016","unstructured":"Dupret B, Volkel P, Le Bourhis X, Angrand PO. The Polycomb Group Protein Pcgf1 Is Dispensable in Zebrafish but Involved in Early Growth and Aging. PloS one. 2016;11:e0158700.","journal-title":"PloS one."},{"key":"9641_CR43","doi-asserted-by":"publisher","first-page":"46276","DOI":"10.1038\/srep46276","volume":"7","author":"Y Yan","year":"2017","unstructured":"Yan Y, Zhao W, Huang Y, Tong H, Xia Y, Jiang Q et al. Loss of Polycomb Group Protein Pcgf1 Severely Compromises Proper Differentiation of Embryonic Stem Cells. Scientific reports. 2017;7:46276.","journal-title":"Scientific reports."},{"key":"9641_CR44","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1038\/onc.2009.433","volume":"29","author":"Y Ye","year":"2010","unstructured":"Ye Y, Xiao Y, Wang W, Yearsley K, Gao JX, Shetuni B et al. ERalpha signaling through slug regulates E-cadherin and EMT. Oncogene. 2010;29:1451\u20131462.","journal-title":"Oncogene."},{"key":"9641_CR45","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1083\/jcb.201305050","volume":"203","author":"CD Rogers","year":"2013","unstructured":"Rogers CD, Saxena A, Bronner ME. Sip1 mediates an E-cadherin-to-N-cadherin switch during cranial neural crest EMT. The Journal of cell biology. 2013;203:835\u2013847.","journal-title":"The Journal of cell biology."},{"key":"9641_CR46","doi-asserted-by":"crossref","unstructured":"Miricescu D, Totan A, Stanescu S, II, Badoiu SC, Stefani C, Greabu M. PI3K\/AKT\/mTOR Signaling Pathway in Breast Cancer: From Molecular Landscape to Clinical Aspects. International journal of molecular sciences. 2020;22(1).","DOI":"10.3390\/ijms22010173"},{"key":"9641_CR47","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118513","volume":"262","author":"S Fattahi","year":"2020","unstructured":"Fattahi S, Amjadi-Moheb F, Tabaripour R, Ashrafi GH, Akhavan-Niaki H. PI3K\/AKT\/mTOR signaling in gastric cancer: Epigenetics and beyond. Life sciences. 2020;262:118513.","journal-title":"Life sciences."},{"key":"9641_CR48","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.semcancer.2019.05.012","volume":"59","author":"MK Ediriweera","year":"2019","unstructured":"Ediriweera MK, Tennekoon KH, Samarakoon SR. Role of the PI3K\/AKT\/mTOR signaling pathway in ovarian cancer: Biological and therapeutic significance. Semin Cancer Biol. 2019;59:147\u2013160.","journal-title":"Semin Cancer Biol."},{"key":"9641_CR49","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1186\/s12935-024-03324-2","volume":"24","author":"J Yu","year":"2024","unstructured":"Yu J, Sun J, Tang J, Xu J, Qian G, Zhou J. C6orf15 promotes liver metastasis via WNT\/beta-catenin signalling in colorectal cancer. Cancer cell international. 2024;24:146.","journal-title":"Cancer cell international."},{"key":"9641_CR50","doi-asserted-by":"crossref","unstructured":"Novellasdemunt L, Antas P, Li VS. Targeting Wnt signaling in colorectal cancer. A Review in the Theme: Cell Signaling: Proteins, Pathways and Mechanisms. Am J Physiol Cell Physiol. 2015;309(8):C511\u201321.","DOI":"10.1152\/ajpcell.00117.2015"},{"key":"9641_CR51","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1007\/s12015-007-0001-y","volume":"3","author":"P Neth","year":"2007","unstructured":"Neth P, Ries C, Karow M, Egea V, Ilmer M, Jochum M. The Wnt signal transduction pathway in stem cells and cancer cells: influence on cellular invasion. Stem Cell Rev. 2007;3:18\u201329.","journal-title":"Stem Cell Rev."}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-025-09641-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10620-025-09641-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-025-09641-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T04:01:16Z","timestamp":1783915276000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10620-025-09641-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,3]]},"references-count":51,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["9641"],"URL":"https:\/\/doi.org\/10.1007\/s10620-025-09641-4","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,3]]},"assertion":[{"value":"8 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All procedures were carried out in accordance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals (NIH Publication No. 8023, revised 1978). All experimental protocols were approved by the Ethics Committee of Tianjin Xiqing hospital (license number: Yijian-2021\u201313). Prior to the experiment, all participants provided written informed consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}