{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T03:20:44Z","timestamp":1787541644678,"version":"build-2736575974"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001782","name":"University of Melbourne","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001782","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Differentiating bacterial enterocolitis from acute severe ulcerative colitis (ASUC) is a common diagnostic problem. Monocytes play a role in the pathogenesis of ulcerative colitis and show variation in size, which is measurable as monocyte distribution width (MDW). We aimed to assess whether MDW can differentiate bacterial enterocolitis from ASUC and predict therapeutic response in ASUC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cohort study comprising three patient groups: ASUC, bacterial enterocolitis, and controls at a tertiary Australian center. MDW, routine biomarkers and clinical outcomes were recorded. Primary outcomes included the difference in MDW between patient groups and the performance of MDW in distinguishing ASUC from bacterial enterocolitis. Secondary outcomes included the prediction of treatment response in ASUC and the performance in identifying biochemical remission post-ASUC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      176 patients were identified (53 ASUC, 70 bacterial enterocolitis and 53 controls). At presentation, patients with bacterial enterocolitis had the highest MDW (median 23.6, IQR 20.7\u201325.8) compared to ASUC (19.0, IQR 17.9\u201321.2;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) and controls (16.8, IQR 15.9\u201318.0;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). MDW discriminated bacterial enterocolitis from ASUC (Area under the curve [AUC]: 0.78, 95% CI: 0.70\u20130.87,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). In ASUC, MDW correlated with CRP and fecal calprotectin. MDW on the day of infliximab administration predicted infliximab response (AUC: 0.80, 95% CI: 0.61\u20131.0,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.002). Three months post-ASUC, MDW identified biochemical remission (fecal calprotectin\u2009&lt;\u2009100\u00a0\u00b5g\/g; AUC 0.80, 95% CI: 0.64\u20130.95,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MDW is a novel biomarker that may help distinguish ASUC from bacterial enterocolitis. In patients with ASUC, MDW may predict inpatient infliximab response and identify biochemical remission at 3\u00a0months. Validation is required to confirm its utility.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10620-026-09786-w","type":"journal-article","created":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T18:17:48Z","timestamp":1772475468000},"page":"3291-3301","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Monocyte Distribution Width Differentiates Bacterial Enterocolitis from Acute Severe Ulcerative Colitis in the Emergency Department"],"prefix":"10.1007","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4095-1153","authenticated-orcid":false,"given":"Christopher F. 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Z.","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4983-6103","authenticated-orcid":false,"given":"Danny","family":"Con","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Wiid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Hogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5206-0097","authenticated-orcid":false,"given":"Matthew C.","family":"Choy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1176-5442","authenticated-orcid":false,"given":"Kumar","family":"Visvanathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3399-7236","authenticated-orcid":false,"given":"Peter","family":"De Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"9786_CR1","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/s2468-1253(23)00313-8","volume":"9","author":"P Rivi\u00e8re","year":"2024","unstructured":"Rivi\u00e8re P, Li Wai Suen C, Chaparro M, De Cruz P, Spinelli A, Laharie D. 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Li Wai Suen has received educational support from Pfizer and has received research funding from the Robert C Bulley Charitable Foundation and the St Vincent\u2019s Hospital Melbourne Research Endowment Fund. Christopher F.D. Li Wai Suen is supported by an Australian National Health and Medical Research Council (NHMRC) Postgraduate scholarship and by the Commonwealth through an Australian Government Research Training Program Scholarship [\n                      \n                      ].  Shipraa Kaul: none to declare. Ethan XZ Tan: none to declare. Danny Con has received educational support from Viatris and is supported by a NHMRC Postgraduate scholarship.  Michalle Taylor: none to declare. Joanne Wiid: none to declare. Chris Hogan: none to declare. Matthew C. Choy has received research funding from Janssen and Gandel Philanthropy. K. Visvanathan has received research funding from Gilead Sciences and Abbvie and has received speaker fees from Gilead.  Peter De Cruz has served as a consultant, an advisory board member, or a speaker for AbbVie, Baxter, Ferring, Janssen, Celltrion, Pfizer, Emerge Health, Shire and Takeda. Peter De Cruz is supported by a NHMRC Emerging Leader 2 Fellowship and has received research support from AbbVie, Ferring, Shire, Janssen, Pfizer and Takeda.","order":1,"name":"Ethics","label":"Conflict of interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study complied with the Declaration of Helsinki and was approved by the Institutional Research Ethics Committee (HREC\/88449).","order":2,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Need for informed consent was waived due to the low-risk, retrospective design using de-identified data.","order":3,"name":"Ethics","label":"Patient consent statement","group":{"name":"EthicsHeading","label":"Declarations"}}]}}