{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T21:24:15Z","timestamp":1788038655995,"version":"build-2784847793"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T00:00:00Z","timestamp":1772928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T00:00:00Z","timestamp":1772928000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1007\/s10620-026-09801-0","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T04:43:01Z","timestamp":1772944981000},"page":"3420-3434","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["WISP2 Overexpression Is Associated with Reduced Vasculogenic Mimicry and Epithelial\u2013Mesenchymal Transition in Gastric Cancer"],"prefix":"10.1007","volume":"71","author":[{"given":"Xinning","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yecheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longtao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengyi","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zenong","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoyu","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,8]]},"reference":[{"key":"9801_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2022.103841","volume":"181","author":"MJ L\u00f3pez","year":"2023","unstructured":"L\u00f3pez MJ, Carbajal J, Alfaro AL et al. Characteristics of gastric cancer around the world. Crit Rev Oncol Hematol. 2023;181:103841.","journal-title":"Crit Rev Oncol Hematol."},{"key":"9801_CR2","first-page":"394","volume":"68","author":"F Bray","year":"2018","unstructured":"Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68:394\u2013424.","journal-title":"CA Cancer J Clin."},{"key":"9801_CR3","doi-asserted-by":"publisher","first-page":"45","DOI":"10.2174\/0118744710284298240419115911","volume":"18","author":"AA Mart\u00ednez","year":"2025","unstructured":"Mart\u00ednez AA, Hernandez GS, Mora MM et al. Radiopharmaceuticals adverse events management. Curr Radiopharm. 2025;18:45\u201355.","journal-title":"Curr Radiopharm."},{"key":"9801_CR4","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s13045-023-01451-3","volume":"16","author":"WL Guan","year":"2023","unstructured":"Guan WL, He Y, Xu RH. Gastric cancer treatment: recent progress and future perspectives. J Hematol Oncol. 2023;16:57.","journal-title":"J Hematol Oncol."},{"key":"9801_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2024.134690","volume":"473","author":"Q Wang","year":"2024","unstructured":"Wang Q, Huang Y, Jiang M et al. The demethylase ALKBH5 mediates ZKSCAN3 expression through the m(6)A modification to activate VEGFA transcription and thus participates in MNNG-induced gastric cancer progression. J Hazard Mater. 2024;473:134690.","journal-title":"J Hazard Mater."},{"key":"9801_CR6","doi-asserted-by":"publisher","first-page":"e100622205820","DOI":"10.2174\/1570180819666220610102444","volume":"21","author":"D-Y Lu","year":"2024","unstructured":"Lu D-Y, Xu B, Lu T-R. Anticancer drug development: evaluative architecture. Lett Drug Des Discov 2024;21:e100622205820.","journal-title":"Lett Drug Des Discov"},{"key":"9801_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155962","volume":"134","author":"H Wang","year":"2024","unstructured":"Wang H, Ding Q, Zhou H et al. Dihydroartemisinin inhibited VM in gastric cancer through the FGF2\/FGFR1 signaling pathway. Phytomedicine. 2024;134:155962.","journal-title":"Phytomedicine."},{"key":"9801_CR8","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1038\/s41419-021-04456-3","volume":"12","author":"X Kang","year":"2021","unstructured":"Kang X, Xu E, Wang X et al. Correction to: tenascin-c knockdown suppresses VM of gastric cancer by inhibiting ERK-triggered EMT. Cell Death Dis. 2021;12:1154.","journal-title":"Cell Death Dis."},{"key":"9801_CR9","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s13045-020-00858-6","volume":"13","author":"Q Luo","year":"2020","unstructured":"Luo Q, Wang J, Zhao W et al. VM in carcinogenesis and clinical applications. J Hematol Oncol. 2020;13:19.","journal-title":"J Hematol Oncol."},{"key":"9801_CR10","doi-asserted-by":"publisher","first-page":"77","DOI":"10.3390\/ijms22010077","volume":"22","author":"Z Cao","year":"2020","unstructured":"Cao Z, Sun B, Zhao X et al. Correction: Cao, Z., et al. The expression and functional significance of Runx2 in hepatocellular carcinoma: its role in VM and EMT. Int J Mol Sci. 2017, 18, 500. Int J Mol Sci. 2020;22:77.","journal-title":"Int J Mol Sci."},{"key":"9801_CR11","doi-asserted-by":"publisher","first-page":"185","DOI":"10.2174\/1874471016666230214101830","volume":"16","author":"K Singh","year":"2023","unstructured":"Singh K, Alameri AA, Hamza AA et al. Cardiac injury following chemo\/radiation therapy: an updated review on mechanisms and therapeutic approaches. Curr Radiopharm. 2023;16:185\u2013203.","journal-title":"Curr Radiopharm."},{"key":"9801_CR12","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1111\/jcmm.12851","volume":"20","author":"Q Liu","year":"2016","unstructured":"Liu Q, Qiao L, Liang N et al. The relationship between VM and EMTs. J Cell Mol Med. 2016;20:1761\u20131769.","journal-title":"J Cell Mol Med."},{"key":"9801_CR13","doi-asserted-by":"publisher","first-page":"3768","DOI":"10.1111\/jcmm.13637","volume":"22","author":"H Wang","year":"2018","unstructured":"Wang H, Huang B, Li BM et al. ZEB1-mediated VM formation associates with EMT and cancer stem cell phenotypes in prostate cancer. J Cell Mol Med. 2018;22:3768\u20133781.","journal-title":"J Cell Mol Med."},{"key":"9801_CR14","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12600","volume":"52","author":"HF Wang","year":"2019","unstructured":"Wang HF, Wang SS, Zheng M et al. Hypoxia promotes VM formation by vascular endothelial growth factor A mediating EMT in salivary adenoid cystic carcinoma. Cell Prolif. 2019;52:e12600.","journal-title":"Cell Prolif."},{"key":"9801_CR15","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.yexmp.2015.08.009","volume":"99","author":"K Liu","year":"2015","unstructured":"Liu K, Sun B, Zhao X et al. Hypoxia induced EMT and VM formation by promoting Bcl-2\/Twist1 cooperation. Exp Mol Pathol. 2015;99:383\u2013391.","journal-title":"Exp Mol Pathol."},{"key":"9801_CR16","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1111\/cas.13949","volume":"110","author":"H Ou","year":"2019","unstructured":"Ou H, Chen Z, Xiang L et al. Frizzled 2-induced EMT correlates with VM, stemness, and Hippo signaling in hepatocellular carcinoma. Cancer Sci. 2019;110:1169\u20131182.","journal-title":"Cancer Sci."},{"key":"9801_CR17","doi-asserted-by":"publisher","first-page":"5611","DOI":"10.1158\/0008-5472.CAN-21-2939","volume":"81","author":"CE Barcus","year":"2021","unstructured":"Barcus CE, Longmore GD. Collagen linearization within tumors. Cancer Res. 2021;81:5611\u20135612.","journal-title":"Cancer Res."},{"key":"9801_CR18","doi-asserted-by":"publisher","first-page":"5666","DOI":"10.1158\/0008-5472.CAN-20-3982","volume":"81","author":"J Janjanam","year":"2021","unstructured":"Janjanam J, Pano G, Wang R et al. Matricellular protein WISP2 is an endogenous inhibitor of collagen linearization and cancer metastasis. Cancer Res. 2021;81:5666\u20135677.","journal-title":"Cancer Res."},{"key":"9801_CR19","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1186\/s13046-019-1108-0","volume":"38","author":"DM Chai","year":"2019","unstructured":"Chai DM, Qin YZ, Wu SW et al. WISP2 exhibits its potential antitumor activity via targeting ERK and E-cadherin pathways in esophageal cancer cells. J Exp Clin Cancer Res. 2019;38:102.","journal-title":"J Exp Clin Cancer Res."},{"key":"9801_CR20","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.3892\/ijmm.2015.2390","volume":"36","author":"J Li","year":"2015","unstructured":"Li J, Ye L, Owen S, Weeks HP, Zhang Z, Jiang WG. Emerging role of CCN family proteins in tumorigenesis and cancer metastasis (Review). Int J Mol Med. 2015;36:1451\u20131463.","journal-title":"Int J Mol Med."},{"key":"9801_CR21","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1038\/bjc.2015.285","volume":"113","author":"J Ji","year":"2015","unstructured":"Ji J, Jia S, Jia Y, Ji K, Hargest R, Jiang WG. WISP-2 in human gastric cancer and its potential metastatic suppressor role in gastric cancer cells mediated by JNK and PLC-\u03b3 pathways. Br J Cancer. 2015;113:921\u2013933.","journal-title":"Br J Cancer."},{"key":"9801_CR22","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.3390\/cancers14061487","volume":"14","author":"N Ferrand","year":"2022","unstructured":"Ferrand N, Fert A, Morichon R, Radosevic-Robin N, Zaoui M, Sabbah M. WISP2\/CCN5 suppresses VM through inhibition of YAP\/TAZ signaling in breast cancer cells. Cancers (Basel). 2022;14:1487.","journal-title":"Cancers (Basel)."},{"key":"9801_CR23","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.bbrc.2023.06.018","volume":"672","author":"D Zheng","year":"2023","unstructured":"Zheng D, Bashir M, Li Z. ER\u03b1 prevents tumorigenesis of both liver and breast cancer cells through CCN5. Biochem Biophys Res Commun. 2023;672:103\u2013112.","journal-title":"Biochem Biophys Res Commun."},{"key":"9801_CR24","doi-asserted-by":"publisher","first-page":"14160","DOI":"10.1039\/C8RA10468A","volume":"9","author":"C Liu","year":"2019","unstructured":"Liu C, Ji L, Song X. Long non coding RNA UCA1 contributes to the autophagy and survival of colorectal cancer cells via sponging miR-185-5p to up-regulate the WISP2\/\u03b2-catenin pathway. RSC Adv. 2019;9:14160\u201314166.","journal-title":"RSC Adv."},{"key":"9801_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2023.102971","volume":"299","author":"H Zhang","year":"2023","unstructured":"Zhang H, Song W, Ma X, Yu M, Chen L, Tao Y. Acetylation stabilizes the signaling protein WISP2 by preventing its degradation to suppress the progression of acute myeloid leukemia. J Biol Chem. 2023;299:102971.","journal-title":"J Biol Chem."},{"key":"9801_CR26","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.21873\/anticanres.11424","volume":"37","author":"K Spiliopoulos","year":"2017","unstructured":"Spiliopoulos K, Peschos D, Batistatou A et al. Immunohistochemical study of VM and angiogenesis in melanocytic tumors of the eye and the periocular area. Anticancer Res. 2017;37:1113\u20131120.","journal-title":"Anticancer Res."},{"key":"9801_CR27","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1111\/jop.13516","volume":"53","author":"DA de Santana","year":"2024","unstructured":"de Santana DA, Braga PR, Camillo-Coutinho CM et al. E-CADERIN, N-CADERIN, SLUG, SNAIL, and TWIST contribute to EMT in salivary gland tumors. J Oral Pathol Med. 2024;53:193\u2013200.","journal-title":"J Oral Pathol Med."},{"key":"9801_CR28","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1186\/s12967-023-04120-8","volume":"21","author":"Z Li","year":"2023","unstructured":"Li Z, Yang Z, Liu W et al. Disheveled3 enhanced EMT and cancer stem-like cells properties via Wnt\/\u03b2-catenin\/c-Myc\/SOX2 pathway in colorectal cancer. J Transl Med. 2023;21:302.","journal-title":"J Transl Med."},{"key":"9801_CR29","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.joca.2015.07.019","volume":"24","author":"HG Xu","year":"2016","unstructured":"Xu HG, Zheng Q, Song JX et al. Intermittent cyclic mechanical tension promotes endplate cartilage degeneration via canonical Wnt signaling pathway and E-cadherin\/\u03b2-catenin complex cross-talk. Osteoarthr Cartil. 2016;24:158\u2013168.","journal-title":"Osteoarthr Cartil."},{"key":"9801_CR30","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1186\/s12943-022-01616-7","volume":"21","author":"H Zhao","year":"2022","unstructured":"Zhao H, Ming T, Tang S et al. Wnt signaling in colorectal cancer: pathogenic role and therapeutic target. Mol Cancer. 2022;21:144.","journal-title":"Mol Cancer."},{"key":"9801_CR31","doi-asserted-by":"publisher","first-page":"3571","DOI":"10.7150\/thno.25194","volume":"8","author":"J Song","year":"2018","unstructured":"Song J, Xie C, Jiang L et al. Transcription factor AP-4 promotes tumorigenic capability and activates the Wnt\/\u03b2-catenin pathway in hepatocellular carcinoma. Theranostics. 2018;8:3571\u20133583.","journal-title":"Theranostics."},{"key":"9801_CR32","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1186\/s12931-017-0650-6","volume":"18","author":"J Rapp","year":"2017","unstructured":"Rapp J, Jaromi L, Kvell K, Miskei G, Pongracz JE. WNT signalling\u2014lung cancer is no exception. Respir Res. 2017;18:167.","journal-title":"Respir Res."}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-026-09801-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10620-026-09801-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-026-09801-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T03:01:28Z","timestamp":1787540488000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10620-026-09801-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,8]]},"references-count":32,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["9801"],"URL":"https:\/\/doi.org\/10.1007\/s10620-026-09801-0","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,8]]},"assertion":[{"value":"19 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Ethics Committee of the First Affiliated Hospital of Bengbu Medical University. All procedures involving human participants were conducted in accordance with the Declaration of Helsinki. Animal experiments were approved by the Animal Ethics Committee of Bengbu Medical University and were performed in compliance with institutional guidelines for the care and use of laboratory animals.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written informed consent was obtained from all patients prior to sample collection.","order":3,"name":"Ethics","label":"Informed consent","group":{"name":"EthicsHeading","label":"Declarations"}}]}}