{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T03:20:13Z","timestamp":1787541613321,"version":"build-2736575974"},"reference-count":153,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1007\/s10620-026-09806-9","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T04:58:05Z","timestamp":1773896285000},"page":"3818-3831","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Beyond Supportive Care: Mitochondria as a Strategic Therapeutic Avenue in Acute Pancreatitis"],"prefix":"10.1007","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3503-8450","authenticated-orcid":false,"given":"Serge","family":"Chooklin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8979-721X","authenticated-orcid":false,"given":"Serhii","family":"Chuklin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,19]]},"reference":[{"key":"9806_CR1","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1001\/jama.2020.20317","volume":"325","author":"MA Mederos","year":"2021","unstructured":"Mederos MA, Reber HA, Girgis MD. Acute pancreatitis: a Review. JAMA 2021;325:382\u2013390. https:\/\/doi.org\/10.1001\/jama.2020.20317.","journal-title":"JAMA"},{"key":"9806_CR2","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1016\/S0140-6736(20)31310-6","volume":"396","author":"L Boxhoorn","year":"2020","unstructured":"Boxhoorn L, Voermans RP, Bouwense SA et al. Acute pancreatitis. Lancet 2020;396:726\u2013734. https:\/\/doi.org\/10.1016\/S0140-6736(20)31310-6.","journal-title":"Lancet"},{"key":"9806_CR3","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1007\/s12664-023-01506-w","volume":"43","author":"J Shah","year":"2024","unstructured":"Shah J, Viesca MFernandez Y, JagodzinskiArvanitakis RM. Infected pancreatic necrosis\u2014current trends in management. Indian J Gastroenterol 2024;43:578\u2013591. https:\/\/doi.org\/10.1007\/s12664-023-01506-w.","journal-title":"Indian J Gastroenterol"},{"key":"9806_CR4","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/s41392-024-02081-y","volume":"10","author":"M Li","year":"2025","unstructured":"Li M, Wu L, Si H et al. Engineered mitochondria in diseases: mechanisms, strategies, and applications. Signal Transduct Target Ther 2025;10:71. https:\/\/doi.org\/10.1038\/s41392-024-02081-y.","journal-title":"Signal Transduct Target Ther"},{"key":"9806_CR5","doi-asserted-by":"publisher","first-page":"167803","DOI":"10.1016\/j.bbadis.2025.167803","volume":"1871","author":"JP Moura","year":"2025","unstructured":"Moura JP, Oliveira PJ, Urbano AM. Mitochondria an overview of their origin, genome, architecture, and dynamics. Biochimica Biophysica Acta Mol Basis Dis 2025;1871:167803.","journal-title":"Biochimica Biophysica Acta Mol Basis Dis"},{"key":"9806_CR6","doi-asserted-by":"publisher","first-page":"9975","DOI":"10.3390\/ijms25189975","volume":"25","author":"Y Li","year":"2024","unstructured":"Li Y, Zhang H, Yu C et al. New insights into mitochondria in health and diseases. Int J Mol Sci 2024;25:9975. https:\/\/doi.org\/10.3390\/ijms25189975.","journal-title":"Int J Mol Sci"},{"key":"9806_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2024.111143","volume":"118","author":"M Xu","year":"2024","unstructured":"Xu M, Feng Y, Xiang X, Liu L, Tang G. MZB1 regulates cellular proliferation, mitochondrial dysfunction, and inflammation and targets the PI3K-Akt signaling pathway in acute pancreatitis. Cell Signal 2024;118:111143. https:\/\/doi.org\/10.1016\/j.cellsig.2024.111143.","journal-title":"Cell Signal"},{"key":"9806_CR8","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/s41420-024-01923-6","volume":"10","author":"W Liu","year":"2024","unstructured":"Liu W, Ren Y, Wang T et al. Blocking CIRP protects against acute pancreatitis by improving mitochondrial function and suppressing pyroptosis in acinar cells. Cell Death Discov 2024;10:156. https:\/\/doi.org\/10.1038\/s41420-024-01923-6.","journal-title":"Cell Death Discov"},{"key":"9806_CR9","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-024-02132-0","author":"D Zhang","year":"2024","unstructured":"Zhang D, Li J, Zhao L et al. Mitochondrial DNA leakage promotes persistent pancreatic acinar cell injury in acute pancreatitis via the cGAS-STING-NF-\u03baB pathway. Inflammation. 2024. https:\/\/doi.org\/10.1007\/s10753-024-02132-0.","journal-title":"Inflammation"},{"key":"9806_CR10","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1016\/j.pan.2022.07.011","volume":"22","author":"SJ Pandol","year":"2022","unstructured":"Pandol SJ, Gottlieb RA. Calcium, mitochondria and the initiation of acute pancreatitis. Pancreatology 2022;22:838\u2013845. https:\/\/doi.org\/10.1016\/j.pan.2022.07.011.","journal-title":"Pancreatology"},{"key":"9806_CR11","doi-asserted-by":"publisher","first-page":"1503087","DOI":"10.3389\/fimmu.2024.1503087","volume":"15","author":"F Chen","year":"2024","unstructured":"Chen F, Xu K, Han Y et al. Mitochondrial dysfunction in pancreatic acinar cells: mechanisms and therapeutic strategies in acute pancreatitis. Front Immunol 2024;15:1503087. https:\/\/doi.org\/10.3389\/fimmu.2024.1503087.","journal-title":"Front Immunol"},{"key":"9806_CR12","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.hbpd.2023.12.008","volume":"24","author":"X Chen","year":"2025","unstructured":"Chen X, Zhong R, Hu B. Mitochondrial dysfunction in the pathogenesis of acute pancreatitis. Hepatobiliary Pancreat Dis Int 2025;24:76\u201383. https:\/\/doi.org\/10.1016\/j.hbpd.2023.12.008.","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"9806_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116690","volume":"175","author":"Y Zhou","year":"2024","unstructured":"Zhou Y, Huang X, Jin Y et al. The role of mitochondrial damage-associated molecular patterns in acute pancreatitis. Biomed Pharmacother 2024;175:116690. https:\/\/doi.org\/10.1016\/j.biopha.2024.116690.","journal-title":"Biomed Pharmacother"},{"key":"9806_CR14","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s40779-024-00556-1","volume":"11","author":"WL Hong","year":"2024","unstructured":"Hong WL, Huang H, Zeng X, Duan CY. Targeting mitochondrial quality control: new therapeutic strategies for major diseases. Mil Med Res 2024;11:59. https:\/\/doi.org\/10.1186\/s40779-024-00556-1.","journal-title":"Mil Med Res"},{"key":"9806_CR15","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s43556-025-00284-5","volume":"6","author":"L Wang","year":"2025","unstructured":"Wang L, Zhou X, Lu T. Role of mitochondria in physiological activities, diseases, and therapy. Mol Biomed 2025;6:42. https:\/\/doi.org\/10.1186\/s43556-025-00284-5.","journal-title":"Mol Biomed"},{"key":"9806_CR16","first-page":"1793","volume":"87","author":"GF Soliman","year":"2019","unstructured":"Soliman GF, Ibrahim W, Abdallah H. Therapeutic Effect of L-Carnitine on Acute Pancreatitis Induced by L-Arginine in Rats: Possible Role of Beclin Gene and Inducible Nitric Oxide Synthase. Med J Cairo Univ 2019;87:1793\u20131803.","journal-title":"Med J Cairo Univ"},{"key":"9806_CR17","doi-asserted-by":"publisher","first-page":"241","DOI":"10.9738\/INTSURG-D-16-00058.1","volume":"101","author":"M Karakahya","year":"2016","unstructured":"Karakahya M, G\u00fcl M, I\u015f\u0131k S et al. The histopathologic effects of L-carnitine in Sodium Taurocholate Induced Severe Pancreatitis Model. Int Surg 2016;101:241\u2013248. https:\/\/doi.org\/10.9738\/INTSURG-D-16-00058.1.","journal-title":"Int Surg"},{"key":"9806_CR18","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.18203\/2319-2003.ijbcp20151367","volume":"4","author":"MIA Hasan","year":"2015","unstructured":"Hasan MIA, Bakr AG, Shalkami AS. Modulation of L-arginine induced acute pancreatitis by meloxicam and\/or L-carnitine in rats. Int J Basic Clin Pharmacol. 2015;4:1247\u20131253.","journal-title":"Int J Basic Clin Pharmacol."},{"key":"9806_CR19","doi-asserted-by":"publisher","first-page":"794","DOI":"10.3748\/wjg.v27.i9.794","volume":"27","author":"SL McIlwrath","year":"2021","unstructured":"McIlwrath SL, Starr ME, High AE, Saito H, Westlund KN. Effect of acetyl-L-carnitine on hypersensitivity in acute recurrent caerulein-induced pancreatitis and microglial activation along the brain\u2019s pain circuitry. World J Gastroenterol 2021;27:794\u2013814. https:\/\/doi.org\/10.3748\/wjg.v27.i9.794.","journal-title":"World J Gastroenterol"},{"key":"9806_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2025.114620","volume":"155","author":"H Duan","year":"2025","unstructured":"Duan H, Zhang R, Asikaer A et al. Nicotinamide mononucleotide ameliorates hypertriglyceridemia pancreatitis via NAD+\/SIRT1-mediated TXNIP suppression and NOTCH pathway for accelerated repair-associated processes. Int Immunopharmacol 2025;155:114620. https:\/\/doi.org\/10.1016\/j.intimp.2025.114620.","journal-title":"Int Immunopharmacol"},{"key":"9806_CR21","doi-asserted-by":"publisher","first-page":"3006","DOI":"10.1038\/s41598-017-03418-0","volume":"7","author":"A Shen","year":"2017","unstructured":"Shen A, Kim HJ, Oh GS et al. NAD+ augmentation ameliorates acute pancreatitis through regulation of inflammasome signalling. Sci Rep 2017;7:3006. https:\/\/doi.org\/10.1038\/s41598-017-03418-0.","journal-title":"Sci Rep"},{"key":"9806_CR22","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1177\/0300060517747163","volume":"46","author":"WC Liao","year":"2018","unstructured":"Liao WC, Chen YH, Li HY et al. Diaphragmatic dysfunction in sepsis due to severe acute pancreatitis complicated by intra-abdominal hypertension. J Int Med Res 2018;46:1349\u20131357. https:\/\/doi.org\/10.1177\/0300060517747163.","journal-title":"J Int Med Res"},{"key":"9806_CR23","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5818479","author":"SA Mirmalek","year":"2016","unstructured":"Mirmalek SA, Gholamrezaei Boushehrinejad A, Yavari H et al. Antioxidant and anti-inflammatory effects of Coenzyme Q10 on L-arginine-induced acute pancreatitis in rat. Oxid Med Cell Longev. 2016. https:\/\/doi.org\/10.1155\/2016\/5818479.","journal-title":"Oxid Med Cell Longev"},{"key":"9806_CR24","doi-asserted-by":"publisher","first-page":"154","DOI":"10.21608\/jmh.2022.161806.1103","volume":"5","author":"RH Elsyade","year":"2021","unstructured":"Elsyade RH, Abdel Fattah MM, Khaled DM, Eldosoki DE. The beneficial effects of lipoic acid versus coenzyme Q10 on arginine-induced acute pancreatitis in albino rats: histological and immunohistochemical study. J Med Histology 2021;5:154\u2013170.","journal-title":"J Med Histology"},{"key":"9806_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106900","volume":"88","author":"JY Shin","year":"2020","unstructured":"Shin JY, Choi JW, Kim DG et al. Protective effects of coenzyme Q10 against acute pancreatitis. Int Immunopharmacol 2020;88:106900. https:\/\/doi.org\/10.1016\/j.intimp.2020.106900.","journal-title":"Int Immunopharmacol"},{"key":"9806_CR26","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1080\/10715762.2022.2163244","volume":"56","author":"Y Li","year":"2022","unstructured":"Li Y, Zhu Y, Li S et al. Deoxyarbutin attenuates severe acute pancreatitis via the HtrA2\/PGC-1\u03b1 pathway. Free Radic Res 2022;56:651\u2013665. https:\/\/doi.org\/10.1080\/10715762.2022.2163244.","journal-title":"Free Radic Res"},{"key":"9806_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2024.176646","volume":"975","author":"T Zhao","year":"2024","unstructured":"Zhao T, Fang R, Ding J et al. Melatonin ameliorates multiorgan injuries induced by severe acute pancreatitis in mice by regulating the Nrf2 signaling pathway. Eur J Pharmacol 2024;975:176646. https:\/\/doi.org\/10.1016\/j.ejphar.2024.176646.","journal-title":"Eur J Pharmacol"},{"key":"9806_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110833","volume":"124","author":"RS Alruhaimi","year":"2023","unstructured":"Alruhaimi RS, Hassanein EHM, Abd El-Aziz MK et al. The melatonin receptor agonist agomelatine protects against acute pancreatitis induced by cadmium by attenuating inflammation and oxidative stress and modulating Nrf2\/HO-1 pathway. Int Immunopharmacol 2023;124:110833. https:\/\/doi.org\/10.1016\/j.intimp.2023.110833.","journal-title":"Int Immunopharmacol"},{"key":"9806_CR29","first-page":"279","volume":"27","author":"D Ulu\u0131\u015f\u0131k","year":"2024","unstructured":"Ulu\u0131\u015f\u0131k D, Keskin E, \u00d6zayd\u0131n T, \u00d6znurlu Y. Ameliorative effects of melatonin on some cytokine levels, NF-\u03baB immunoreactivity, and apoptosis in rats with cerulein-induced acute pancreatitis. Iran J Basic Med Sci 2024;27:279\u2013285.","journal-title":"Iran J Basic Med Sci"},{"key":"9806_CR30","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1089\/ars.2019.7731","volume":"31","author":"Y Ren","year":"2019","unstructured":"Ren Y, Qiu M, Zhang J et al. Low serum irisin concentration is associated with poor outcomes in patients with acute pancreatitis, and irisin administration protects against experimental acute pancreatitis. Antioxid Redox Signal 2019;31:771\u2013785. https:\/\/doi.org\/10.1089\/ars.2019.7731.","journal-title":"Antioxid Redox Signal"},{"key":"9806_CR31","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/s00018-025-05845-z","volume":"82","author":"H Jiang","year":"2025","unstructured":"Jiang H, Liu J, Xu Z et al. Quercetin alleviates acute pancreatitis by modulating glycolysis and mitochondrial function via PFKFB3 inhibition. Cell Mol Life Sci 2025;82:311. https:\/\/doi.org\/10.1007\/s00018-025-05845-z.","journal-title":"Cell Mol Life Sci"},{"key":"9806_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2025.120526","volume":"354","author":"YF Miao","year":"2026","unstructured":"Miao YF, Bai D, Fan SH et al. Liquiritigenin alleviates inflammation and mitochondrial dysfunction in acute pancreatitis via ER\u03b2-VDAC1 signaling. J Ethnopharmacol 2026;354:120526. https:\/\/doi.org\/10.1016\/j.jep.2025.120526.","journal-title":"J Ethnopharmacol"},{"key":"9806_CR33","doi-asserted-by":"publisher","first-page":"5879","DOI":"10.1113\/JP278517","volume":"597","author":"E T\u00f3th","year":"2019","unstructured":"T\u00f3th E, Mal\u00e9th J, Z\u00e1vogy\u00e1n N et al. Novel mitochondrial transition pore inhibitor N-methyl-4-isoleucine cyclosporin is a new therapeutic option in acute pancreatitis. J Physiol 2019;597:5879\u20135898. https:\/\/doi.org\/10.1113\/JP278517.","journal-title":"J Physiol"},{"key":"9806_CR34","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202501155R","volume":"39","author":"N Mullappilly","year":"2025","unstructured":"Mullappilly N, Swain SM, Romac JM, Mikati H, Liddle RA. Phosphate improves mitochondrial function and reduces pancreatitis in hypertriglyceridemia. FASEB J 2025;39:e70983. https:\/\/doi.org\/10.1096\/fj.202501155R.","journal-title":"FASEB J"},{"key":"9806_CR35","doi-asserted-by":"publisher","first-page":"383","DOI":"10.5505\/tjtes.2011.99835","volume":"17","author":"NE Bulut","year":"2011","unstructured":"Bulut NE, \u00d6zkan E, Ekinci O et al. Beneficial effects of alpha lipoic acid on cerulein-induced experimental acute pancreatitis in rats. Ulus Travma Acil Cerrahi Derg 2011;17:383\u2013389.","journal-title":"Ulus Travma Acil Cerrahi Derg"},{"key":"9806_CR36","doi-asserted-by":"publisher","first-page":"4883","DOI":"10.3748\/wjg.v11.i31.4883","volume":"11","author":"SJ Park","year":"2005","unstructured":"Park SJ, Seo SW, Choi OS, Park CS. Alpha-lipoic acid protects against cholecystokinin-induced acute pancreatitis in rats. World J Gastroenterol 2005;11:4883\u20134885. https:\/\/doi.org\/10.3748\/wjg.v11.i31.4883.","journal-title":"World J Gastroenterol"},{"key":"9806_CR37","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.ejphar.2010.06.020","volume":"643","author":"AA Abdin","year":"2010","unstructured":"Abdin AA, El-Hamid MA, El-Seoud SH, Balaha MF. Effect of pentoxifylline and\/or alpha lipoic acid on experimentally induced acute pancreatitis. Eur J Pharmacol 2010;643:289\u2013296. https:\/\/doi.org\/10.1016\/j.ejphar.2010.06.020.","journal-title":"Eur J Pharmacol"},{"key":"9806_CR38","doi-asserted-by":"publisher","first-page":"264","DOI":"10.3892\/mmr.2022.12780","volume":"26","author":"Y Lee","year":"2022","unstructured":"Lee Y, Lim JW, Kim H. \u03b1-Lipoic acid inhibits cerulein\/resistin-induced expression of interleukin-6 by activating peroxisome proliferator-activated receptor-\u03b3 in pancreatic acinar cells. Mol Med Rep 2022;26:264. https:\/\/doi.org\/10.3892\/mmr.2022.12780.","journal-title":"Mol Med Rep"},{"key":"9806_CR39","first-page":"54","volume":"1","author":"H Fawzy","year":"2021","unstructured":"Fawzy H, Fikry E, Fawzy H, Mohammed A. Mito-TEMPO improved L-arginine-induced acute pancreatitis in rats via TLR-4\/NF-\u03baB\/NLRP3 inflammasome downregulation and antioxidant properties. Azhar Int J Pharm Med Sci 2021;1:54\u201365.","journal-title":"Azhar Int J Pharm Med Sci"},{"key":"9806_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115576","volume":"167","author":"X Wang","year":"2023","unstructured":"Wang X, Guo Y, Cui T et al. Telomerase reverse transcriptase restores pancreatic microcirculation profiles and attenuates endothelial dysfunction by inhibiting mitochondrial superoxide production: a potential target for acute pancreatitis therapy. Biomed Pharmacother 2023;167:115576. https:\/\/doi.org\/10.1016\/j.biopha.2023.115576.","journal-title":"Biomed Pharmacother"},{"key":"9806_CR41","doi-asserted-by":"publisher","first-page":"5658","DOI":"10.1039\/d1fo01154e","volume":"12","author":"ZL Luo","year":"2021","unstructured":"Luo ZL, Sun HY, Wu XB, Cheng L, Ren JD. Epigallocatechin-3-gallate attenuates acute pancreatitis\u2013induced lung injury by targeting mitochondrial reactive oxygen species\u2013triggered NLRP3 inflammasome activation. Food Funct 2021;12:5658\u20135667. https:\/\/doi.org\/10.1039\/d1fo01154e.","journal-title":"Food Funct"},{"key":"9806_CR42","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102423","volume":"56","author":"S Rius-P\u00e9rez","year":"2022","unstructured":"Rius-P\u00e9rez S, P\u00e9rez S, Toledano MB, Sastre J. p53 drives necroptosis via downregulation of sulfiredoxin and peroxiredoxin 3. Redox Biol 2022;56:102423. https:\/\/doi.org\/10.1016\/j.redox.2022.102423.","journal-title":"Redox Biol"},{"key":"9806_CR43","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/901780","volume":"2015","author":"W Huang","year":"2015","unstructured":"Huang W, Cash N, Wen L et al. Effects of the mitochondria-targeted antioxidant mitoquinone in murine acute pancreatitis. Mediators Inflamm 2015;2015:901780. https:\/\/doi.org\/10.1155\/2015\/901780.","journal-title":"Mediators Inflamm"},{"key":"9806_CR44","doi-asserted-by":"publisher","first-page":"1700","DOI":"10.3390\/ijms20071700","volume":"20","author":"JA Armstrong","year":"2019","unstructured":"Armstrong JA, Cash NJ, Morton JC, Tepikin AV, Sutton R, Criddle DN. Mitochondrial targeting of antioxidants alters pancreatic acinar cell bioenergetics and determines cell fate. Int J Mol Sci 2019;20:1700. https:\/\/doi.org\/10.3390\/ijms20071700.","journal-title":"Int J Mol Sci"},{"key":"9806_CR45","doi-asserted-by":"publisher","first-page":"4650489","DOI":"10.1155\/2016\/4650489","volume":"2016","author":"M Weniger","year":"2016","unstructured":"Weniger M, Reinelt L, Neumann J et al. The analgesic effect of the mitochondria-targeted antioxidant SkQ1 in pancreatic inflammation. Oxid Med Cell Longev 2016;2016:4650489. https:\/\/doi.org\/10.1155\/2016\/4650489.","journal-title":"Oxid Med Cell Longev"},{"key":"9806_CR46","doi-asserted-by":"publisher","first-page":"519","DOI":"10.3390\/antiox11030519","volume":"11","author":"J Lee","year":"2022","unstructured":"Lee J, Lim JW, Kim H. Lycopene inhibits IL-6 expression by upregulating NQO1 and HO-1 via activation of Nrf2 in ethanol\/lipopolysaccharide-stimulated pancreatic acinar cells. Antioxidants (Basel) 2022;11:519. https:\/\/doi.org\/10.3390\/antiox11030519.","journal-title":"Antioxidants (Basel)"},{"key":"9806_CR47","doi-asserted-by":"publisher","first-page":"2101","DOI":"10.3390\/ijms22042101","volume":"22","author":"J Lee","year":"2021","unstructured":"Lee J, Lim JW, Kim H. Lycopene inhibits oxidative stress\u2013mediated inflammatory responses in ethanol\/palmitoleic acid\u2013stimulated pancreatic acinar AR42J cells. Int J Mol Sci 2021;22:2101. https:\/\/doi.org\/10.3390\/ijms22042101.","journal-title":"Int J Mol Sci"},{"key":"9806_CR48","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1007\/s00210-016-1250-6","volume":"389","author":"H Ateyya","year":"2016","unstructured":"Ateyya H, Wagih HM, El-Sherbeeny NA. Effect of tiron on remote organ injury in rats with severe acute pancreatitis induced by L-arginine. Naunyn Schmiedebergs Arch Pharmacol 2016;389:873\u2013885. https:\/\/doi.org\/10.1007\/s00210-016-1250-6.","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"9806_CR49","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.bbrc.2010.02.005","volume":"393","author":"H Chen","year":"2010","unstructured":"Chen H, Sun YP, Li Y et al. Hydrogen-rich saline ameliorates the severity of L-arginine\u2013induced acute pancreatitis in rats. Biochem Biophys Res Commun 2010;393:308\u2013313. https:\/\/doi.org\/10.1016\/j.bbrc.2010.02.005.","journal-title":"Biochem Biophys Res Commun"},{"key":"9806_CR50","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/731932","volume":"2013","author":"DQ Zhang","year":"2013","unstructured":"Zhang DQ, Feng H, Chen WC. Effects of hydrogen-rich saline on taurocholate-induced acute pancreatitis in rat. Evid Based Complement Alternat Med 2013;2013:731932. https:\/\/doi.org\/10.1155\/2013\/731932.","journal-title":"Evid Based Complement Alternat Med"},{"key":"9806_CR51","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/930894","volume":"2014","author":"JD Ren","year":"2014","unstructured":"Ren JD, Ma J, Hou J et al. Hydrogen-rich saline inhibits NLRP3 inflammasome activation and attenuates experimental acute pancreatitis in mice. Mediators Inflamm 2014;2014:930894. https:\/\/doi.org\/10.1155\/2014\/930894.","journal-title":"Mediators Inflamm"},{"key":"9806_CR52","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/685043","volume":"2015","author":"Q Shi","year":"2015","unstructured":"Shi Q, Liao KS, Zhao KL et al. Hydrogen-rich saline attenuates acute renal injury in sodium taurocholate\u2013induced severe acute pancreatitis by inhibiting ROS and NF-\u03baB pathway. Mediators Inflamm 2015;2015:685043. https:\/\/doi.org\/10.1155\/2015\/685043.","journal-title":"Mediators Inflamm"},{"key":"9806_CR53","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.1097\/MPA.0000000000000678","volume":"45","author":"Q Shi","year":"2016","unstructured":"Shi Q, Chen C, Deng WH et al. Hydrogen-rich saline attenuates acute hepatic injury in acute necrotizing pancreatitis by inhibiting inflammation and apoptosis, involving JNK and p38 mitogen-activated protein kinase\u2013dependent reactive oxygen species. Pancreas 2016;45:1424\u20131431. https:\/\/doi.org\/10.1097\/MPA.0000000000000678.","journal-title":"Pancreas"},{"key":"9806_CR54","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1097\/TA.0b013e31824a7913","volume":"72","author":"J Ren","year":"2012","unstructured":"Ren J, Luo Z, Tian F et al. Hydrogen-rich saline reduces the oxidative stress and relieves the severity of trauma-induced acute pancreatitis in rats. J Trauma Acute Care Surg 2012;72:1555\u20131561. https:\/\/doi.org\/10.1097\/TA.0b013e31824a7913.","journal-title":"J Trauma Acute Care Surg"},{"key":"9806_CR55","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118641","volume":"264","author":"Y Li","year":"2021","unstructured":"Li Y, Li G, Suo L, Zhang J. Recent advances in studies of molecular hydrogen in the treatment of pancreatitis. Life Sci 2021;264:118641. https:\/\/doi.org\/10.1016\/j.lfs.2020.118641.","journal-title":"Life Sci"},{"key":"9806_CR56","doi-asserted-by":"publisher","first-page":"7864150","DOI":"10.1155\/2016\/7864150","volume":"2016","author":"Z Dong","year":"2016","unstructured":"Dong Z, Shang H, Chen YQ, Pan LL, Bhatia M, Sun J. Sulforaphane protects pancreatic acinar cell injury by modulating Nrf2-mediated oxidative stress and NLRP3 inflammatory pathway. Oxid Med Cell Longev 2016;2016:7864150. https:\/\/doi.org\/10.1155\/2016\/7864150.","journal-title":"Oxid Med Cell Longev"},{"key":"9806_CR57","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.1093\/jpp\/rgac065","volume":"74","author":"P Zhang","year":"2022","unstructured":"Zhang P, Yin X, Wang X, Wang J, Na G, \u041aopo\u0442\u043ao\u0432a \u0418. Paeonol protects against acute pancreatitis by Nrf2 and NF-\u03baB pathways in mice. J Pharm Pharmacol 2022;74:1618\u20131628. https:\/\/doi.org\/10.1093\/jpp\/rgac065.","journal-title":"J Pharm Pharmacol"},{"key":"9806_CR58","doi-asserted-by":"publisher","first-page":"2477","DOI":"10.1007\/s10620-024-08398-6","volume":"69","author":"Q Cui","year":"2024","unstructured":"Cui Q, Wang W, Shi J et al. Glycyrrhizin ameliorates cardiac injury in rats with severe acute pancreatitis by inhibiting ferroptosis via the Keap1\/Nrf2\/HO-1 pathway. Dig Dis Sci 2024;69:2477\u20132487. https:\/\/doi.org\/10.1007\/s10620-024-08398-6.","journal-title":"Dig Dis Sci"},{"key":"9806_CR59","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s12876-025-03660-1","volume":"25","author":"G Shen","year":"2025","unstructured":"Shen G, Wen H, Li H et al. Emodin protects against severe acute pancreatitis\u2013associated acute lung injury by activating Nrf2\/HO-1\/GPX4 signal and inhibiting ferroptosis in vivo and in vitro. BMC Gastroenterol 2025;25:57. https:\/\/doi.org\/10.1186\/s12876-025-03660-1.","journal-title":"BMC Gastroenterol"},{"key":"9806_CR60","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2025.107620","volume":"212","author":"J Yao","year":"2025","unstructured":"Yao J, Jiang Y, Zhang P et al. Genetic and pharmacological targeting of HINT2 promotes OXPHOS to alleviate inflammatory responses and cell necrosis in acute pancreatitis. Pharmacol Res 2025;212:107620. https:\/\/doi.org\/10.1016\/j.phrs.2025.107620.","journal-title":"Pharmacol Res"},{"key":"9806_CR61","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1007\/s10787-020-00767-7","volume":"29","author":"B Sheng","year":"2021","unstructured":"Sheng B, Zhao L, Zang X et al. Quercetin inhibits caerulein-induced acute pancreatitis through regulating miR-216b by targeting MAP2K6 and NEAT1. Inflammopharmacology 2021;29:549\u2013559. https:\/\/doi.org\/10.1007\/s10787-020-00767-7.","journal-title":"Inflammopharmacology"},{"key":"9806_CR62","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1016\/j.pan.2018.08.001","volume":"18","author":"Z Junyuan","year":"2018","unstructured":"Junyuan Z, Hui X, Chunlan H et al. Quercetin protects against intestinal barrier disruption and inflammation in acute necrotizing pancreatitis through TLR4\/MyD88\/p38 MAPK and ERS inhibition. Pancreatology 2018;18:742\u2013752. https:\/\/doi.org\/10.1016\/j.pan.2018.08.001.","journal-title":"Pancreatology"},{"key":"9806_CR63","doi-asserted-by":"publisher","first-page":"3784","DOI":"10.3390\/ijms25073784","volume":"25","author":"X Li","year":"2024","unstructured":"Li X, Wang T, Zhou Q et al. Isorhamnetin alleviates mitochondrial injury in severe acute pancreatitis via modulation of KDM5B\/HtrA2 signaling pathway. Int J Mol Sci 2024;25:3784. https:\/\/doi.org\/10.3390\/ijms25073784.","journal-title":"Int J Mol Sci"},{"key":"9806_CR64","doi-asserted-by":"publisher","first-page":"781","DOI":"10.3390\/antiox9090781","volume":"9","author":"R Fusco","year":"2020","unstructured":"Fusco R, Cordaro M, Siracusa R et al. Biochemical evaluation of the antioxidant effects of hydroxytyrosol on pancreatitis-associated gut injury. Antioxidants (Basel) 2020;9:781. https:\/\/doi.org\/10.3390\/antiox9090781.","journal-title":"Antioxidants (Basel)"},{"key":"9806_CR65","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2019.e02222","volume":"5","author":"P Siriviriyakul","year":"2019","unstructured":"Siriviriyakul P, Chingchit T, Klaikeaw N, Chayanupatkul M, Werawatganon D. Effects of curcumin on oxidative stress, inflammation and apoptosis in L-arginine-induced acute pancreatitis in mice. Heliyon 2019;5:e02222. https:\/\/doi.org\/10.1016\/j.heliyon.2019.e02222.","journal-title":"Heliyon"},{"key":"9806_CR66","doi-asserted-by":"publisher","first-page":"3027","DOI":"10.3892\/mmr.2019.10547","volume":"20","author":"Y Wang","year":"2019","unstructured":"Wang Y, Bu C, Wu K, Wang R, Wang J. Curcumin protects the pancreas from acute pancreatitis via the mitogen-activated protein kinase signaling pathway. Mol Med Rep 2019;20:3027\u20133034. https:\/\/doi.org\/10.3892\/mmr.2019.10547.","journal-title":"Mol Med Rep"},{"key":"9806_CR67","doi-asserted-by":"publisher","first-page":"2869","DOI":"10.1016\/j.xphs.2018.07.009","volume":"107","author":"P Anchi","year":"2018","unstructured":"Anchi P, Khurana A, Swain D, Samanthula G, Godugu C. Sustained-release curcumin microparticles for effective prophylactic treatment of exocrine dysfunction of pancreas: a preclinical study on cerulein-induced acute pancreatitis. J Pharm Sci 2018;107:2869\u20132882. https:\/\/doi.org\/10.1016\/j.xphs.2018.07.009.","journal-title":"J Pharm Sci"},{"key":"9806_CR68","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.3892\/etm.2017.4647","volume":"14","author":"S Zhu","year":"2017","unstructured":"Zhu S, Zhang C, Weng Q, Ye B. Curcumin protects against acute renal injury by suppressing JAK2\/STAT3 pathway in severe acute pancreatitis in rats. Exp Ther Med 2017;14:1669\u20131674. https:\/\/doi.org\/10.3892\/etm.2017.4647.","journal-title":"Exp Ther Med"},{"key":"9806_CR69","doi-asserted-by":"publisher","first-page":"2280","DOI":"10.12659\/MSM.909557","volume":"24","author":"S Yu","year":"2018","unstructured":"Yu S, Wang M, Guo X, Qin R. Curcumin attenuates inflammation in a severe acute pancreatitis animal model by regulating TRAF1\/ASK1 signaling. Med Sci Monit 2018;24:2280\u20132286.","journal-title":"Med Sci Monit"},{"key":"9806_CR70","doi-asserted-by":"publisher","first-page":"5279","DOI":"10.1002\/ptr.7958","volume":"37","author":"M Chegini","year":"2023","unstructured":"Chegini M, Sadeghi A, Zaeri F, Zamani M, Hekmatdoost A. Nano-curcumin supplementation in patients with mild and moderate acute pancreatitis: A randomized, placebo-controlled trial. Phytother Res 2023;37:5279\u20135288. https:\/\/doi.org\/10.1002\/ptr.7958.","journal-title":"Phytother Res"},{"key":"9806_CR71","doi-asserted-by":"publisher","first-page":"2349","DOI":"10.1111\/jcmm.12928","volume":"20","author":"L Ji","year":"2016","unstructured":"Ji L, Li L, Qu F et al. Hydrogen sulphide exacerbates acute pancreatitis by over-activating autophagy via AMPK\/mTOR pathway. J Cell Mol Med 2016;20:2349\u20132361. https:\/\/doi.org\/10.1111\/jcmm.12928.","journal-title":"J Cell Mol Med"},{"key":"9806_CR72","doi-asserted-by":"publisher","first-page":"158","DOI":"10.5152\/UCD.2017.3653","volume":"33","author":"K Sa\u011flam","year":"2017","unstructured":"Sa\u011flam K, Alhan E, T\u00fcrky\u0131lmaz S, Vanizor BK, Er\u00e7in C. The anti-inflammatory effect of hydrogen sulphide on acute necrotizing pancreatitis in rats. Turk J Surg 2017;33:158\u2013163. https:\/\/doi.org\/10.5152\/UCD.2017.3653.","journal-title":"Turk J Surg"},{"key":"9806_CR73","doi-asserted-by":"publisher","first-page":"4555","DOI":"10.3748\/wjg.v21.i15.4555","volume":"21","author":"CY Rao","year":"2015","unstructured":"Rao CY, Fu LY, Hu CL et al. H2S mitigates severe acute pancreatitis through the PI3K\/AKT-NF-\u03baB pathway in vivo. World J Gastroenterol 2015;21:4555\u20134563. https:\/\/doi.org\/10.3748\/wjg.v21.i15.4555.","journal-title":"World J Gastroenterol"},{"key":"9806_CR74","doi-asserted-by":"publisher","first-page":"625","DOI":"10.3892\/ijmm.2015.2070","volume":"35","author":"L Qiu","year":"2015","unstructured":"Qiu L, Yin G, Cheng L et al. Astragaloside IV ameliorates acute pancreatitis in rats by inhibiting the activation of nuclear factor-\u03baB. Int J Mol Med 2015;35:625\u2013636. https:\/\/doi.org\/10.3892\/ijmm.2015.2070.","journal-title":"Int J Mol Med"},{"key":"9806_CR75","doi-asserted-by":"publisher","first-page":"7936316","DOI":"10.1155\/2021\/7936316","volume":"2021","author":"J Yuan","year":"2021","unstructured":"Yuan J, Wei Z, Xin G et al. Vitamin B12 attenuates acute pancreatitis by suppressing oxidative stress and improving mitochondria dysfunction via CBS\/SIRT1 pathway. Oxid Med Cell Longev 2021;2021:7936316. https:\/\/doi.org\/10.1155\/2021\/7936316.","journal-title":"Oxid Med Cell Longev"},{"key":"9806_CR76","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.109974","volume":"117","author":"QQ Liang","year":"2023","unstructured":"Liang QQ, Shi ZJ, Yuan T et al. Celastrol inhibits necroptosis by attenuating the RIPK1\/RIPK3\/MLKL pathway and confers protection against acute pancreatitis in mice. Int Immunopharmacol 2023;117:109974. https:\/\/doi.org\/10.1016\/j.intimp.2023.109974.","journal-title":"Int Immunopharmacol"},{"key":"9806_CR77","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.1021\/acs.molpharmaceut.7b00028","volume":"14","author":"S Luo","year":"2017","unstructured":"Luo S, Li P, Li S et al. N,N-Dimethyl tertiary amino group mediated dual pancreas- and lung-targeting therapy against acute pancreatitis. Mol Pharm 2017;14:1771\u20131781. https:\/\/doi.org\/10.1021\/acs.molpharmaceut.7b00028.","journal-title":"Mol Pharm"},{"key":"9806_CR78","doi-asserted-by":"publisher","first-page":"8032","DOI":"10.1074\/jbc.RA118.003200","volume":"293","author":"JA Armstrong","year":"2018","unstructured":"Armstrong JA, Cash NJ, Ouyang Y et al. Oxidative stress alters mitochondrial bioenergetics and modifies pancreatic cell death independently of cyclophilin D, resulting in an apoptosis-to-necrosis shift. J Biol Chem 2018;293:8032\u20138047. https:\/\/doi.org\/10.1074\/jbc.RA118.003200.","journal-title":"J Biol Chem"},{"key":"9806_CR79","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1111\/bph.14169","volume":"175","author":"Y Shen","year":"2018","unstructured":"Shen Y, Wen L, Zhang R et al. Dihydrodiosgenin protects against experimental acute pancreatitis and associated lung injury through mitochondrial protection and PI3K\u03b3\/Akt inhibition. Br J Pharmacol 2018;175:1621\u20131636. https:\/\/doi.org\/10.1111\/bph.14169.","journal-title":"Br J Pharmacol"},{"key":"9806_CR80","doi-asserted-by":"publisher","first-page":"2591","DOI":"10.3390\/nu14132591","volume":"14","author":"C Zhang","year":"2022","unstructured":"Zhang C, Niu H, Wan C et al. Drug D, a diosgenin derive, inhibits L-arginine-induced acute pancreatitis through meditating GSDMD in the endoplasmic reticulum via the TXNIP\/HIF-1\u03b1 pathway. Nutrients 2022;14:2591. https:\/\/doi.org\/10.3390\/nu14132591.","journal-title":"Nutrients"},{"key":"9806_CR81","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1097\/MPA.0000000000000953","volume":"47","author":"MA Javed","year":"2018","unstructured":"Javed MA, Wen L, Awais M et al. TRO40303 ameliorates alcohol-induced pancreatitis through reduction of fatty acid ethyl ester-induced mitochondrial injury and necrotic cell death. Pancreas 2018;47:18\u201324. https:\/\/doi.org\/10.1097\/MPA.0000000000000953.","journal-title":"Pancreas"},{"key":"9806_CR82","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.bbrc.2022.10.044","volume":"635","author":"X Yu","year":"2022","unstructured":"Yu X, Dai C, Zhao X et al. Ruthenium red attenuates acute pancreatitis by inhibiting MCU and improving mitochondrial function. Biochem Biophys Res Commun 2022;635:236\u2013243. https:\/\/doi.org\/10.1016\/j.bbrc.2022.10.044.","journal-title":"Biochem Biophys Res Commun"},{"key":"9806_CR83","doi-asserted-by":"publisher","first-page":"147","DOI":"10.3892\/etm.2024.12435","volume":"27","author":"Y Lei","year":"2024","unstructured":"Lei Y, Yang HY, Meng N et al. Mitochondrial calcium uniporter promotes mitophagy by regulating the PINK1\/Parkin pathway in caerulein-treated pancreatic ductal epithelial cells in vitro. Exp Ther Med 2024;27:147. https:\/\/doi.org\/10.3892\/etm.2024.12435.","journal-title":"Exp Ther Med"},{"key":"9806_CR84","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1038\/s41401-021-00744-y","volume":"43","author":"ZN Ren","year":"2022","unstructured":"Ren ZN, Yang J, Zhang MY et al. A novel resveratrol analog upregulates sirtuin 1 and inhibits inflammatory cell infiltration in acute pancreatitis. Acta Pharmacol Sin 2022;43:1264\u20131273. https:\/\/doi.org\/10.1038\/s41401-021-00744-y.","journal-title":"Acta Pharmacol Sin"},{"key":"9806_CR85","doi-asserted-by":"publisher","first-page":"26216","DOI":"10.1038\/s41598-024-76825-9","volume":"14","author":"SK Wu","year":"2024","unstructured":"Wu SK, Wang L, Wang F, Zhang J. Resveratrol improved mitochondrial biogenesis by activating SIRT1\/PGC-1\u03b1 signal pathway in SAP. Sci Rep 2024;14:26216. https:\/\/doi.org\/10.1038\/s41598-024-76825-9.","journal-title":"Sci Rep"},{"key":"9806_CR86","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/j.pan.2016.06.002","volume":"16","author":"M Liu","year":"2016","unstructured":"Liu M, Shi L, Zou X et al. Caspase inhibitor zVAD-fmk protects against acute pancreatitis-associated lung injury via inhibiting inflammation and apoptosis. Pancreatology 2016;16:733\u2013738. https:\/\/doi.org\/10.1016\/j.pan.2016.06.002.","journal-title":"Pancreatology"},{"key":"9806_CR87","doi-asserted-by":"publisher","first-page":"3370","DOI":"10.1074\/jbc.M511276200","volume":"281","author":"OA Mareninova","year":"2006","unstructured":"Mareninova OA, Sung KF, Hong P et al. Cell death in pancreatitis: caspases protect from necrotizing pancreatitis. J Biol Chem 2006;281:3370\u20133381. https:\/\/doi.org\/10.1074\/jbc.M511276200.","journal-title":"J Biol Chem"},{"key":"9806_CR88","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.clinre.2014.06.003","volume":"39","author":"A Tanoglu","year":"2015","unstructured":"Tanoglu A, Yazgan Y, Kaplan M et al. Trimetazidine significantly reduces cerulein-induced pancreatic apoptosis. Clin Res Hepatol Gastroenterol 2015;39:145\u2013150. https:\/\/doi.org\/10.1016\/j.clinre.2014.06.003.","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"9806_CR89","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1503\/cjs.032811","volume":"56","author":"A Yenicerioglu","year":"2013","unstructured":"Yenicerioglu A, Cetinkaya Z, Girgin M et al. Effects of trimetazidine in acute pancreatitis induced by L-arginine. Can J Surg 2013;56:175\u2013179. https:\/\/doi.org\/10.1503\/cjs.032811.","journal-title":"Can J Surg"},{"key":"9806_CR90","doi-asserted-by":"publisher","first-page":"549","DOI":"10.5152\/tjg.2020.18666","volume":"31","author":"H Erg\u00fcc\u00fck","year":"2020","unstructured":"Erg\u00fcc\u00fck H, Isik S, Iflazoglu N, Kayaalp C, Sarac M, Gursul S. The effect of trimet(h)azidine on mortality in an experimental acute pancreatitis model. Turk J Gastroenterol 2020;31:549\u2013557. https:\/\/doi.org\/10.5152\/tjg.2020.18666.","journal-title":"Turk J Gastroenterol"},{"key":"9806_CR91","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1007\/s10753-020-01228-7","volume":"43","author":"Q Mei","year":"2020","unstructured":"Mei Q, Zeng Y, Huang C et al. Rapamycin alleviates hypertriglyceridemia-related acute pancreatitis via restoring autophagy flux and inhibiting endoplasmic reticulum stress. Inflammation 2020;43:1510\u20131523. https:\/\/doi.org\/10.1007\/s10753-020-01228-7.","journal-title":"Inflammation"},{"key":"9806_CR92","doi-asserted-by":"publisher","DOI":"10.3389\/fgstr.2022.977169","volume":"1","author":"MK Sharma","year":"2022","unstructured":"Sharma MK, Priyam K, Kumar P, Garg PK, Roy TS, Jacob TG. Effect of calorie-restriction and rapamycin on autophagy and the severity of caerulein-induced experimental acute pancreatitis in mice. Front Gastroenterol 2022;1:977169. https:\/\/doi.org\/10.3389\/fgstr.2022.977169.","journal-title":"Front Gastroenterol"},{"key":"9806_CR93","doi-asserted-by":"publisher","first-page":"2639","DOI":"10.1007\/s10620-018-5053-0","volume":"63","author":"J Wan","year":"2018","unstructured":"Wan J, Chen J, Wu D et al. Regulation of autophagy affects the prognosis of mice with severe acute pancreatitis. Dig Dis Sci 2018;63:2639\u20132650. https:\/\/doi.org\/10.1007\/s10620-018-5053-0.","journal-title":"Dig Dis Sci"},{"key":"9806_CR94","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116125","volume":"171","author":"X Chen","year":"2024","unstructured":"Chen X, Hu K, Shi HZ et al. Syk\/BLNK\/NF-\u03baB signaling promotes pancreatic injury induced by tacrolimus and potential protective effect from rapamycin. Biomed Pharmacother 2024;171:116125. https:\/\/doi.org\/10.1016\/j.biopha.2024.116125.","journal-title":"Biomed Pharmacother"},{"key":"9806_CR95","doi-asserted-by":"publisher","first-page":"13885","DOI":"10.1021\/acsnano.4c03044","volume":"18","author":"H Kang","year":"2024","unstructured":"Kang H, Hu Q, Yang Y et al. Urolithin A\u2019s role in alleviating severe acute pancreatitis via endoplasmic reticulum-mitochondrial calcium channel modulation. ACS Nano 2024;18:13885\u201313898. https:\/\/doi.org\/10.1021\/acsnano.4c03044.","journal-title":"ACS Nano"},{"key":"9806_CR96","doi-asserted-by":"publisher","first-page":"2549","DOI":"10.3390\/nu14122549","volume":"14","author":"K Li","year":"2022","unstructured":"Li K, Xiao Y, Bian J et al. Ameliorative effects of gut microbial metabolite urolithin A on pancreatic diseases. Nutrients 2022;14:2549. https:\/\/doi.org\/10.3390\/nu14122549.","journal-title":"Nutrients"},{"key":"9806_CR97","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.459","volume":"4","author":"Y Yang","year":"2020","unstructured":"Yang Y, Hu Q, Kang H et al. Wan M (2023) Urolithin A protects severe acute pancreatitis-associated acute cardiac injury by regulating mitochondrial fatty acid oxidative metabolism in cardiomyocytes. MedComm 2020;4:e459. https:\/\/doi.org\/10.1002\/mco2.459.","journal-title":"MedComm"},{"key":"9806_CR98","doi-asserted-by":"publisher","first-page":"2583","DOI":"10.1007\/s11030-023-10698-4","volume":"28","author":"Y Shen","year":"2024","unstructured":"Shen Y, Duan H, Yuan L et al. Computational biology-based study of the molecular mechanism of spermidine amelioration of acute pancreatitis. Mol Divers 2024;28:2583\u20132601. https:\/\/doi.org\/10.1007\/s11030-023-10698-4.","journal-title":"Mol Divers"},{"key":"9806_CR99","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1053\/j.gastro.2017.10.012","volume":"154","author":"G Biczo","year":"2018","unstructured":"Biczo G, Vegh ET, Shalbueva N et al. Mitochondrial dysfunction, through impaired autophagy, leads to endoplasmic reticulum stress, deregulated lipid metabolism, and pancreatitis in animal models. Gastroenterology 2018;154:689\u2013703. https:\/\/doi.org\/10.1053\/j.gastro.2017.10.012.","journal-title":"Gastroenterology"},{"key":"9806_CR100","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.18512","volume":"28","author":"DB Hamo-Giladi","year":"2024","unstructured":"Hamo-Giladi DB, Fokra A, Sabo E et al. Involvement of heparanase in the pathogenesis of acute pancreatitis: implication of novel therapeutic approaches. J Cell Mol Med 2024;28:e18512. https:\/\/doi.org\/10.1111\/jcmm.18512.","journal-title":"J Cell Mol Med"},{"key":"9806_CR101","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2025.151916","volume":"768","author":"P Han","year":"2025","unstructured":"Han P, Ma X, Ge Y, Ren H, Wu Y. Selenium corrects dysregulated mitophagy and lipophagy in obesity-related acute pancreatitis through the GPX1-Mfn2-PLIN2 axis. Biochem Biophys Res Commun 2025;768:151916. https:\/\/doi.org\/10.1016\/j.bbrc.2025.151916.","journal-title":"Biochem Biophys Res Commun"},{"key":"9806_CR102","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1038\/s41420-023-01655-z","volume":"9","author":"K Wang","year":"2023","unstructured":"Wang K, Zhao A, Tayier D et al. Activation of AMPK ameliorates acute severe pancreatitis by suppressing pancreatic acinar cell necroptosis in obese mice models. Cell Death Discov 2023;9:363. https:\/\/doi.org\/10.1038\/s41420-023-01655-z.","journal-title":"Cell Death Discov"},{"key":"9806_CR103","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119435","volume":"277","author":"XD Wang","year":"2021","unstructured":"Wang XD, Yu WL, Sun Y. Activation of AMPK restored impaired autophagy and inhibited inflammation reaction by up-regulating SIRT1 in acute pancreatitis. Life Sci 2021;277:119435. https:\/\/doi.org\/10.1016\/j.lfs.2021.119435.","journal-title":"Life Sci"},{"key":"9806_CR104","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.724514","volume":"12","author":"L Kong","year":"2021","unstructured":"Kong L, Zhang H, Lu C et al. AICAR, an AMP-activated protein kinase activator, ameliorates acute pancreatitis-associated liver injury partially through Nrf2-mediated antioxidant effects and inhibition of NLRP3 inflammasome activation. Front Pharmacol 2021;12:724514. https:\/\/doi.org\/10.3389\/fphar.2021.724514.","journal-title":"Front Pharmacol"},{"key":"9806_CR105","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1002\/tox.24468","volume":"40","author":"SP Bansod","year":"2025","unstructured":"Bansod SP, Saifi MA, Chilvery S, Doijad N, Godugu C. Berberine attenuates cerulein-induced acute pancreatitis by modulating Nrf2\/NOX2 signaling pathway via AMPK activation. Environ Toxicol 2025;40:764\u2013773. https:\/\/doi.org\/10.1002\/tox.24468.","journal-title":"Environ Toxicol"},{"key":"9806_CR106","doi-asserted-by":"publisher","first-page":"101","DOI":"10.14715\/cmb\/2021.67.2.15","volume":"67","author":"P Sun","year":"2021","unstructured":"Sun P, Nie M. Effect and mechanism of Angelic Shaoyaosan mediated AMPK\/SIRT1 positive feedback loop to promote autophagy and regulate the systemic inflammatory response in acute pancreatitis. Cell Mol Biol Noisy-le-grand. 2021;67:101\u2013108.","journal-title":"Cell Mol Biol Noisy-le-grand."},{"key":"9806_CR107","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1186\/s12967-024-05764-w","volume":"22","author":"B Wen","year":"2024","unstructured":"Wen B, Huang Y, Deng G, Yan Q, Jia L. Gut microbiota analysis and LC-MS-based metabolomics to investigate AMPK\/NF-\u03baB regulated by Clostridium butyricum in the treatment of acute pancreatitis. J Transl Med 2024;22:1072. https:\/\/doi.org\/10.1186\/s12967-024-05764-w.","journal-title":"J Transl Med"},{"key":"9806_CR108","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1007\/s00203-024-04001-8","volume":"206","author":"G Deng","year":"2024","unstructured":"Deng G, Wen B, Jia L, Liu J, Yan Q. Clostridium butyricum upregulates GPR109A\/AMPK\/PGC-1\u03b1 and ameliorates acute pancreatitis-associated intestinal barrier injury in mice. Arch Microbiol 2024;206:265. https:\/\/doi.org\/10.1007\/s00203-024-04001-8.","journal-title":"Arch Microbiol"},{"key":"9806_CR109","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117645","volume":"251","author":"J Yang","year":"2020","unstructured":"Yang J, Zhou Y, Shi J. Cordycepin protects against acute pancreatitis by modulating NF-\u03baB and NLRP3 inflammasome activation via AMPK. Life Sci 2020;251:117645. https:\/\/doi.org\/10.1016\/j.lfs.2020.117645.","journal-title":"Life Sci"},{"key":"9806_CR110","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1007\/s11418-021-01597-9","volume":"76","author":"L Zhu","year":"2022","unstructured":"Zhu L, He C. Crocetin alleviates the caerulein-induced apoptosis and inflammation in AR42J cells by activating SIRT1 via NF-\u03baB. J Nat Med 2022;76:410\u2013418. https:\/\/doi.org\/10.1007\/s11418-021-01597-9.","journal-title":"J Nat Med"},{"key":"9806_CR111","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.jphs.2024.08.007","volume":"156","author":"Z Zhang","year":"2024","unstructured":"Zhang Z, Luo Y, Zhuang X, Gao H, Yang Q, Chen H. Emodin alleviates lung injury via the miR-217-5p\/Sirt1 axis in rats with severe acute pancreatitis. J Pharmacol Sci 2024;156:188\u2013197. https:\/\/doi.org\/10.1016\/j.jphs.2024.08.007.","journal-title":"J Pharmacol Sci"},{"key":"9806_CR112","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116854","volume":"176","author":"BM Ali","year":"2024","unstructured":"Ali BM, Al-Mokaddem AK, Selim HMRM et al. Pinocembrin\u2019s protective effect against acute pancreatitis in a rat model: the correlation between TLR4\/NF-\u03baB\/NLRP3 and miR-34a-5p\/SIRT1\/Nrf2\/HO-1 pathways. Biomed Pharmacother 2024;176:116854. https:\/\/doi.org\/10.1016\/j.biopha.2024.116854.","journal-title":"Biomed Pharmacother"},{"key":"9806_CR113","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.107246","volume":"90","author":"S Bansod","year":"2021","unstructured":"Bansod S, Godugu C. Nimbolide ameliorates pancreatic inflammation and apoptosis by modulating NF-\u03baB\/SIRT1 and apoptosis signaling in acute pancreatitis model. Int Immunopharmacol 2021;90:107246. https:\/\/doi.org\/10.1016\/j.intimp.2020.107246.","journal-title":"Int Immunopharmacol"},{"key":"9806_CR114","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2024.117136","volume":"492","author":"D Li","year":"2024","unstructured":"Li D, Li C, Jiang S et al. Lonicerin protects pancreatic acinar cells from caerulein-induced apoptosis, inflammation, and ferroptosis by activating the SIRT1\/GPX4 signaling pathway. Toxicol Appl Pharmacol 2024;492:117136. https:\/\/doi.org\/10.1016\/j.taap.2024.117136.","journal-title":"Toxicol Appl Pharmacol"},{"key":"9806_CR115","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1053\/j.gastro.2019.09.034","volume":"158","author":"M Sendler","year":"2020","unstructured":"Sendler M, van den Brandt C, Glaubitz J et al. NLRP3 inflammasome regulates development of systemic inflammatory response and compensatory anti-inflammatory response syndromes in mice with acute pancreatitis. Gastroenterology 2020;158:253-269.e14. https:\/\/doi.org\/10.1053\/j.gastro.2019.09.034.","journal-title":"Gastroenterology"},{"key":"9806_CR116","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.freeradbiomed.2021.02.019","volume":"166","author":"J Zhang","year":"2021","unstructured":"Zhang J, Huang W, He Q et al. PINK1\/PARK2 dependent mitophagy effectively suppresses NLRP3 inflammasome to alleviate acute pancreatitis. Free Radic Biol Med 2021;166:147\u2013164. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2021.02.019.","journal-title":"Free Radic Biol Med"},{"key":"9806_CR117","doi-asserted-by":"publisher","DOI":"10.1590\/acb370706","volume":"37","author":"Y Shen","year":"2022","unstructured":"Shen Y, Yang H, Wu D, Yang H, Hong D. NLRP3 inflammasome inhibitor MCC950 can reduce the damage of pancreatic and intestinal barrier function in mice with acute pancreatitis. Acta Cir Bras 2022;37:e370706. https:\/\/doi.org\/10.1590\/acb370706.","journal-title":"Acta Cir Bras"},{"key":"9806_CR118","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/j.hbpd.2023.11.006","volume":"23","author":"Q Huang","year":"2024","unstructured":"Huang Q, Liu JW, Dong HB et al. Mesenteric adipose tissue B lymphocytes promote intestinal injury in severe acute pancreatitis by mediating enteric pyroptosis. Hepatobiliary Pancreat Dis Int 2024;23:300\u2013309. https:\/\/doi.org\/10.1016\/j.hbpd.2023.11.006.","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"9806_CR119","doi-asserted-by":"publisher","first-page":"1294951","DOI":"10.1155\/2018\/1294951","volume":"2018","author":"Q Fu","year":"2018","unstructured":"Fu Q, Zhai Z, Wang Y et al. NLRP3 deficiency alleviates severe acute pancreatitis and pancreatitis-associated lung injury in a mouse model. Biomed Res Int 2018;2018:1294951. https:\/\/doi.org\/10.1155\/2018\/1294951.","journal-title":"Biomed Res Int"},{"key":"9806_CR120","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1097\/MPA.0000000000001971","volume":"51","author":"L Gao","year":"2022","unstructured":"Gao L, Chong E, Pendharkar S et al. The effects of NLRP3 inflammasome inhibition in experimental acute pancreatitis: a systematic review and meta-analysis. Pancreas 2022;51:13\u201324. https:\/\/doi.org\/10.1097\/MPA.0000000000001971.","journal-title":"Pancreas"},{"key":"9806_CR121","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2021.112634","volume":"404","author":"CX Li","year":"2021","unstructured":"Li CX, Cui LH, Zhang LQ et al. Role of NLR family pyrin domain-containing 3 inflammasome in the activation of pancreatic stellate cells. Exp Cell Res 2021;404:112634. https:\/\/doi.org\/10.1016\/j.yexcr.2021.112634.","journal-title":"Exp Cell Res"},{"key":"9806_CR122","first-page":"0551","volume":"7","author":"J Yang","year":"2024","unstructured":"Yang J, Jiao C, Liu N et al. Polydatin-mediated inhibition of HSP90\u03b1 disrupts NLRP3 complexes and alleviates acute pancreatitis. Res (Wash D C) 2024;7:0551.","journal-title":"Res (Wash D C)"},{"key":"9806_CR123","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.trsl.2014.06.012","volume":"164","author":"JM York","year":"2014","unstructured":"York JM, Castellanos KJ, Cabay RJ, Fantuzzi G. Inhibition of the NLRP3 inflammasome reduces the severity of experimentally induced acute pancreatitis in obese mice. Transl Res 2014;164:259\u2013269. https:\/\/doi.org\/10.1016\/j.trsl.2014.06.012.","journal-title":"Transl Res"},{"key":"9806_CR124","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202207691","volume":"10","author":"Z Hu","year":"2023","unstructured":"Hu Z, Wang D, Gong J et al. MSCs deliver hypoxia-treated mitochondria reprogramming acinar metabolism to alleviate severe acute pancreatitis injury. Adv Sci (Weinh) 2023;10:e2207691. https:\/\/doi.org\/10.1002\/advs.202207691.","journal-title":"Adv Sci (Weinh)"},{"key":"9806_CR125","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1016\/j.jconrel.2022.11.029","volume":"352","author":"S Li","year":"2022","unstructured":"Li S, Li H, Zhangdi H et al. Hair follicle\u2013MSC-derived small extracellular vesicles as a novel remedy for acute pancreatitis. J Control Release 2022;352:1104\u20131115. https:\/\/doi.org\/10.1016\/j.jconrel.2022.11.029.","journal-title":"J Control Release"},{"key":"9806_CR126","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119189","volume":"272","author":"S Ren","year":"2021","unstructured":"Ren S, Pan L, Yang L et al. miR-29a-3p transferred by mesenchymal stem cell\u2013derived extracellular vesicles protects against myocardial injury after severe acute pancreatitis. Life Sci 2021;272:119189. https:\/\/doi.org\/10.1016\/j.lfs.2021.119189.","journal-title":"Life Sci"},{"key":"9806_CR127","first-page":"375","volume":"12","author":"T Mahmoudi","year":"2022","unstructured":"Mahmoudi T, Jalili A, Abdolmohammadi K et al. Human bone marrow mesenchymal stromal cells attenuate tissue injury and reduce inflammation in experimental acute pancreatitis. Adv Pharm Bull 2022;12:375\u2013382.","journal-title":"Adv Pharm Bull"},{"key":"9806_CR128","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2022.100226","volume":"14","author":"H Liu","year":"2022","unstructured":"Liu H, Liu S, Song X et al. Nanoparticle-encapsulated CQ\/TAM combination harmonizes with MSCs in arresting progression of severity in AP mice through iNOS (IDO) signaling. Mater Today Bio 2022;14:100226. https:\/\/doi.org\/10.1016\/j.mtbio.2022.100226.","journal-title":"Mater Today Bio"},{"key":"9806_CR129","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1097\/MPA.0000000000000541","volume":"45","author":"K Kawakubo","year":"2016","unstructured":"Kawakubo K, Ohnishi S, Fujita H et al. Effect of fetal membrane\u2013derived mesenchymal stem cell transplantation in rats with acute and chronic pancreatitis. Pancreas 2016;45:707\u2013713. https:\/\/doi.org\/10.1097\/MPA.0000000000000541.","journal-title":"Pancreas"},{"key":"9806_CR130","doi-asserted-by":"publisher","first-page":"7174319","DOI":"10.1155\/2016\/7174319","volume":"2016","author":"H Zhao","year":"2016","unstructured":"Zhao H, He Z, Huang D et al. Infusion of bone marrow mesenchymal stem cells attenuates experimental severe acute pancreatitis in rats. Stem Cells Int 2016;2016:7174319. https:\/\/doi.org\/10.1155\/2016\/7174319.","journal-title":"Stem Cells Int"},{"key":"9806_CR131","doi-asserted-by":"publisher","first-page":"7521","DOI":"10.1021\/acsami.4c21010","volume":"17","author":"E Wen","year":"2025","unstructured":"Wen E, Tian Y, Fang M et al. The P2X7-mediated mitochondrial ROS as an emerging core target of tuftsin nanoparticles in severe acute pancreatitis therapy via regulating mitophagy. ACS Appl Mater Interfaces 2025;17:7521\u20137538. https:\/\/doi.org\/10.1021\/acsami.4c21010.","journal-title":"ACS Appl Mater Interfaces"},{"key":"9806_CR132","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.nano.2019.02.018","volume":"18","author":"A Khurana","year":"2019","unstructured":"Khurana A, Anchi P, Allawadhi P et al. Yttrium oxide nanoparticles reduce the severity of acute pancreatitis caused by cerulein hyperstimulation. Nanomedicine 2019;18:54\u201365. https:\/\/doi.org\/10.1016\/j.nano.2019.02.018.","journal-title":"Nanomedicine"},{"key":"9806_CR133","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2025.04.006","author":"J Wu","year":"2025","unstructured":"Wu J, Huang H, Xu W et al. Inflammation-driven biomimetic nano-polyphenol drug delivery system alleviates severe acute pancreatitis by inhibiting macrophage PANoptosis and pancreatic enzymes oversecretion. J Adv Res. 2025. https:\/\/doi.org\/10.1016\/j.jare.2025.04.006.","journal-title":"J Adv Res"},{"key":"9806_CR134","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1186\/s12951-024-02439-y","volume":"22","author":"E Wen","year":"2024","unstructured":"Wen E, Cao Y, He S et al. The mitochondria-targeted kaempferol nanoparticle ameliorates severe acute pancreatitis. J Nanobiotechnology 2024;22:148. https:\/\/doi.org\/10.1186\/s12951-024-02439-y.","journal-title":"J Nanobiotechnology"},{"key":"9806_CR135","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1002\/jbm.a.37679","volume":"112","author":"W Jin","year":"2024","unstructured":"Jin W, Xie X, Shen S et al. Ultrasmall polyvinylpyrrolidone-modified iridium nanoparticles with antioxidant and anti-inflammatory activity for acute pancreatitis alleviation. J Biomed Mater Res A 2024;112:988\u20131003. https:\/\/doi.org\/10.1002\/jbm.a.37679.","journal-title":"J Biomed Mater Res A"},{"key":"9806_CR136","doi-asserted-by":"publisher","first-page":"8644","DOI":"10.1021\/acs.nanolett.5c01495","volume":"25","author":"L Wang","year":"2025","unstructured":"Wang L, Gao Z, Tian M et al. A nanosystem alleviates severe acute pancreatitis via reactive oxygen species scavenging and enhancing mitochondrial autophagy. Nano Lett 2025;25:8644\u20138654. https:\/\/doi.org\/10.1021\/acs.nanolett.5c01495.","journal-title":"Nano Lett"},{"key":"9806_CR137","doi-asserted-by":"publisher","first-page":"1805","DOI":"10.2217\/nnm-2018-0318","volume":"14","author":"A Khurana","year":"2019","unstructured":"Khurana A, Anchi P, Allawadhi P et al. Superoxide dismutase mimetic nanoceria restrains cerulein-induced acute pancreatitis. Nanomedicine (Lond) 2019;14:1805\u20131825. https:\/\/doi.org\/10.2217\/nnm-2018-0318.","journal-title":"Nanomedicine (Lond)"},{"key":"9806_CR138","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adj1896","author":"Q Zhang","year":"2025","unstructured":"Zhang Q, Shen Y, Zhang C et al. Immunoengineered mitochondria for efficient therapy of acute organ injuries via modulation of inflammation and cell repair. Sci Adv. 2025. https:\/\/doi.org\/10.1126\/sciadv.adj1896.","journal-title":"Sci Adv"},{"key":"9806_CR139","doi-asserted-by":"publisher","first-page":"11778","DOI":"10.1021\/acsnano.4c00218","volume":"18","author":"Y Wang","year":"2024","unstructured":"Wang Y, Wang X, Zhang X et al. Inflammation and acinar cell dual-targeting nanomedicines for synergistic treatment of acute pancreatitis via Ca2+ homeostasis regulation and pancreas autodigestion inhibition. ACS Nano 2024;18:11778\u201311803. https:\/\/doi.org\/10.1021\/acsnano.4c00218.","journal-title":"ACS Nano"},{"key":"9806_CR140","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202413925","volume":"12","author":"D Wang","year":"2025","unstructured":"Wang D, Wang S, Liu J et al. Nanomedicine penetrating blood\u2013pancreas barrier for effective treatment of acute pancreatitis. Adv Sci (Weinh) 2025;12:e2413925. https:\/\/doi.org\/10.1002\/advs.202413925.","journal-title":"Adv Sci (Weinh)"},{"key":"9806_CR141","doi-asserted-by":"publisher","DOI":"10.1093\/rb\/rbaf012","author":"X Lu","year":"2025","unstructured":"Lu X, Gao Z, Yu Y et al. Natural product\u2013based nano-antioxidant for the treatment of acute pancreatitis. Regen Biomater. 2025. https:\/\/doi.org\/10.1093\/rb\/rbaf012.","journal-title":"Regen Biomater"},{"key":"9806_CR142","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1038\/s41419-025-08081-2","volume":"16","author":"Y Wu","year":"2025","unstructured":"Wu Y, Yao X, Yu Q et al. Ubiquitin-specific protease 7 regulates macrophage polarization via pyruvate kinase M2-mediated metabolic reprogramming in severe acute pancreatitis. Cell Death Dis 2025;16:764.","journal-title":"Cell Death Dis"},{"key":"9806_CR143","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1097\/JP9.0000000000000168","volume":"7","author":"S Zaman","year":"2024","unstructured":"Zaman S, Gorelick F. Acute pancreatitis: pathogenesis and emerging therapies. J Pancreatol 2024;7:10\u201320. https:\/\/doi.org\/10.1097\/JP9.0000000000000168.","journal-title":"J Pancreatol"},{"key":"9806_CR144","doi-asserted-by":"publisher","first-page":"944","DOI":"10.3390\/ijms26030944","volume":"26","author":"C Tung","year":"2025","unstructured":"Tung C, Varzideh F, Farroni E et al. Elamipretide: a review of its structure, mechanism of action, and therapeutic potential. Int J Mol Sci 2025;26:944. https:\/\/doi.org\/10.3390\/ijms26030944.","journal-title":"Int J Mol Sci"},{"key":"9806_CR145","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.169481","volume":"9","author":"T Zhang","year":"2024","unstructured":"Zhang T, Chen S, Li L et al. PFKFB3 controls acinar IP3R-mediated Ca2+ overload to regulate acute pancreatitis severity. JCI Insight 2024;9:e169481. https:\/\/doi.org\/10.1172\/jci.insight.169481.","journal-title":"JCI Insight"},{"key":"9806_CR146","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1186\/s10020-024-00903-x","volume":"30","author":"L Zhu","year":"2024","unstructured":"Zhu L, Xu Y, Lei J. Molecular mechanism and potential role of mitophagy in acute pancreatitis. Mol Med 2024;30:136. https:\/\/doi.org\/10.1186\/s10020-024-00903-x.","journal-title":"Mol Med"},{"key":"9806_CR147","doi-asserted-by":"publisher","first-page":"1444657","DOI":"10.3389\/fphar.2024.1444657","volume":"15","author":"WG Zhang","year":"2024","unstructured":"Zhang WG, Wu QZ, Shao BZ. The role of autophagy in pancreatic diseases. Front Pharmacol 2024;15:1444657.","journal-title":"Front Pharmacol"},{"key":"9806_CR148","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1038\/s41420-023-01550-7","volume":"9","author":"T Liu","year":"2023","unstructured":"Liu T, Wang Q, Du Z et al. The trigger for pancreatic disease: NLRP3 inflammasome. Cell Death Discov 2023;9:246. https:\/\/doi.org\/10.1038\/s41420-023-01550-7.","journal-title":"Cell Death Discov"},{"key":"9806_CR149","doi-asserted-by":"publisher","first-page":"945","DOI":"10.3390\/biology13110945","volume":"13","author":"K Papantoniou","year":"2024","unstructured":"Papantoniou K, Aggeletopoulou I, Michailides C, Pastras P, Triantos C. Understanding the role of NLRP3 inflammasome in acute pancreatitis. Biology (Basel) 2024;13:945. https:\/\/doi.org\/10.3390\/biology13110945.","journal-title":"Biology (Basel)"},{"key":"9806_CR150","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.70098","volume":"14","author":"L Luo","year":"2024","unstructured":"Luo L, Zhuang X, Fu L et al. The interplay between macrophage glycolytic reprogramming and NLRP3 inflammasome activation in acute lung injury\/ARDS. Clin Transl Med 2024;14:e70098. https:\/\/doi.org\/10.1002\/ctm2.70098.","journal-title":"Clin Transl Med"},{"key":"9806_CR151","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1136\/gut.2006.115873","volume":"56","author":"AK Siriwardena","year":"2007","unstructured":"Siriwardena AK, Mason JM, Balachandra S et al. Randomised, double blind, placebo controlled trial of intravenous antioxidant (n-acetylcysteine, selenium, vitamin C) therapy in severe acute pancreatitis. Gut 2007;56:1439\u20131444. https:\/\/doi.org\/10.1136\/gut.2006.115873.","journal-title":"Gut"},{"key":"9806_CR152","doi-asserted-by":"publisher","first-page":"174","DOI":"10.4103\/1319-3767.80379","volume":"17","author":"D Bansal","year":"2011","unstructured":"Bansal D, Bhalla A, Bhasin DK et al. Safety and efficacy of vitamin-based antioxidant therapy in patients with severe acute pancreatitis: a randomized controlled trial. Saudi J Gastroenterol 2011;17:174\u2013179. https:\/\/doi.org\/10.4103\/1319-3767.80379.","journal-title":"Saudi J Gastroenterol"},{"key":"9806_CR153","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s13613-025-01437-z","volume":"15","author":"B Zhao","year":"2025","unstructured":"Zhao B, Sun W, Wang Y et al. High-dose intravenous vitamin C reduce C-reactive protein levels, fluid retention, and APACHE II scores in patients with moderately severe acute pancreatitis: a prospective, randomized, double-blinded, placebo-controlled study. Ann Intensive Care 2025;15:30. https:\/\/doi.org\/10.1186\/s13613-025-01437-z.","journal-title":"Ann Intensive Care"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-026-09806-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10620-026-09806-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-026-09806-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T03:00:18Z","timestamp":1787540418000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10620-026-09806-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,19]]},"references-count":153,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["9806"],"URL":"https:\/\/doi.org\/10.1007\/s10620-026-09806-9","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,19]]},"assertion":[{"value":"28 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}