{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T03:20:46Z","timestamp":1787800846614,"version":"build-2784847793"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1007\/s10620-026-09958-8","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T20:01:24Z","timestamp":1778184084000},"page":"4474-4482","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Gastrointestinal Manifestations of Hypermobile Ehlers-Danlos Syndrome and Hypermobility Spectrum Disorders: A Mentored Review"],"prefix":"10.1007","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5997-6945","authenticated-orcid":false,"given":"Abdillahi","family":"Ahmed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bishal","family":"Paudel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,7]]},"reference":[{"key":"9958_CR1","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1002\/ajmg.c.31552","volume":"175","author":"F Malfait","year":"2017","unstructured":"Malfait F, Francomano C, Byers P et al. The 2017 international classification of the Ehlers-Danlos syndromes. Am J Med Genet C Semin Med Genet 2017;175:8\u201326. https:\/\/doi.org\/10.1002\/ajmg.c.31552.","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"9958_CR2","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1136\/ard.32.5.413","volume":"32","author":"P Beighton","year":"1973","unstructured":"Beighton P, Solomon L, Soskolne CL. Articular mobility in an African population. Ann Rheum Dis 1973;32:413\u2013418. https:\/\/doi.org\/10.1136\/ard.32.5.413.","journal-title":"Ann Rheum Dis"},{"key":"9958_CR3","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s12891-016-0905-2","volume":"17","author":"M Folci","year":"2016","unstructured":"Folci M, Capsoni F. Arthralgias, fatigue, paresthesias and visceral pain: can joint hypermobility solve the puzzle? A case report. BMC Musculoskelet Disord 2016;17:58. https:\/\/doi.org\/10.1186\/s12891-016-0905-2.","journal-title":"A case report. BMC Musculoskelet Disord"},{"key":"9958_CR4","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1111\/j.1742-1241.2003.tb10455.x","volume":"57","author":"AJ Hakim","year":"2003","unstructured":"Hakim AJ, Grahame R. A simple questionnaire to detect hypermobility: an adjunct to the assessment of patients with diffuse musculoskeletal pain. Int J Clin Pract 2003;57:163\u2013166.","journal-title":"Int J Clin Pract"},{"key":"9958_CR5","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1002\/ajmg.c.31539","volume":"175","author":"M Castori","year":"2017","unstructured":"Castori M, Tinkle B, Levy H et al. A framework for the classification of joint hypermobility and related conditions. Am J Med Genet C Semin Med Genet 2017;175:148\u2013157. https:\/\/doi.org\/10.1002\/ajmg.c.31539.","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"9958_CR6","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1002\/ajmg.a.61459","volume":"182","author":"L McGillis","year":"2020","unstructured":"McGillis L, Mittal N, Santa Mina D et al. Utilization of the 2017 diagnostic criteria for hEDS by the Toronto GoodHope Ehlers-Danlos syndrome clinic: A retrospective review. Am J Med Genet A 2020;182:484\u2013492. https:\/\/doi.org\/10.1002\/ajmg.a.61459.","journal-title":"Am J Med Genet A"},{"key":"9958_CR7","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-031365","volume":"9","author":"JC Demmler","year":"2019","unstructured":"Demmler JC, Atkinson MD, Reinhold EJ et al. Diagnosed prevalence of Ehlers-Danlos syndrome and hypermobility spectrum disorder in Wales, UK: a national electronic cohort study and case\u2013control comparison. BMJ Open 2019;9:e031365. https:\/\/doi.org\/10.1136\/bmjopen-2019-031365.","journal-title":"BMJ Open"},{"key":"9958_CR8","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1097\/MOP.0000000000000541","volume":"29","author":"M Castori","year":"2017","unstructured":"Castori M, Hakim A. Contemporary approach to joint hypermobility and related disorders. Curr Opin Pediatr 2017;29:640\u2013649. https:\/\/doi.org\/10.1097\/MOP.0000000000000541.","journal-title":"Curr Opin Pediatr"},{"key":"9958_CR9","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1002\/ajmg.c.31538","volume":"175","author":"B Tinkle","year":"2017","unstructured":"Tinkle B, Castori M, Berglund B et al. Hypermobile Ehlers-Danlos syndrome (a.k.a. Ehlers-Danlos syndrome Type III and Ehlers-Danlos syndrome hypermobility type): Clinical description and natural history. Am J Med Genet C Semin Med Genet 2017;175:48\u201369. https:\/\/doi.org\/10.1002\/ajmg.c.31538.","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"9958_CR10","doi-asserted-by":"publisher","first-page":"2076","DOI":"10.1111\/jgh.16341","volume":"38","author":"Y Zloof","year":"2023","unstructured":"Zloof Y, Peretz L, Braun M et al. Hypermobility spectrum disorders and irritable bowel syndrome: A nationwide study of 1.6 million adolescents. J Gastroenterol Hepatol 2023;38:2076\u20132082. https:\/\/doi.org\/10.1111\/jgh.16341.","journal-title":"J Gastroenterol Hepatol"},{"key":"9958_CR11","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.cgh.2020.02.034","volume":"19","author":"CY Lam","year":"2021","unstructured":"Lam CY, Palsson OS, Whitehead WE et al. Rome IV Functional Gastrointestinal Disorders and Health Impairment in Subjects With Hypermobility Spectrum Disorders or Hypermobile Ehlers-Danlos Syndrome. Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc 2021;19:277-287.e3. https:\/\/doi.org\/10.1016\/j.cgh.2020.02.034.","journal-title":"Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc"},{"key":"9958_CR12","doi-asserted-by":"publisher","first-page":"727","DOI":"10.14309\/ajg.0000000000002586","volume":"119","author":"R Topan","year":"2024","unstructured":"Topan R, Pandya S, Williams S et al. Comprehensive Assessment of Nutrition and Dietary Influences in Hypermobile Ehlers-Danlos Syndrome-A Cross-Sectional Study. Am J Gastroenterol 2024;119:727\u2013738.","journal-title":"Am J Gastroenterol"},{"key":"9958_CR13","doi-asserted-by":"publisher","DOI":"10.1111\/papr.13411","volume":"25","author":"MJ Desai","year":"2025","unstructured":"Desai MJ, Brestle M, Jonely H. Evidence for central sensitization as classified by the central sensitization inventory in patients with pain and hypermobility. Pain Pract 2025;25:e13411. https:\/\/doi.org\/10.1111\/papr.13411.","journal-title":"Pain Pract"},{"key":"9958_CR14","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13975","volume":"32","author":"FWD Tai","year":"2020","unstructured":"Tai FWD, Palsson OS, Lam CY et al. Functional gastrointestinal disorders are increased in joint hypermobility-related disorders with concomitant postural orthostatic tachycardia syndrome. Neurogastroenterol Motil 2020;32:e13975. https:\/\/doi.org\/10.1111\/nmo.13975.","journal-title":"Neurogastroenterol Motil"},{"key":"9958_CR15","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1111\/ene.15649","volume":"30","author":"D Igharo","year":"2023","unstructured":"Igharo D, Thiel JC, Rolke R et al. Skin biopsy reveals generalized small fibre neuropathy in hypermobile Ehlers-Danlos syndromes. Eur J Neurol 2023;30:719\u2013728. https:\/\/doi.org\/10.1111\/ene.15649.","journal-title":"Eur J Neurol"},{"key":"9958_CR16","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1002\/jpn3.12099","volume":"78","author":"S Nabar","year":"2024","unstructured":"Nabar S, Fernandez J, Prakash V, Safder S. Gastrointestinal manifestations seen in pediatric patients diagnosed with small fiber neuropathy. J Pediatr Gastroenterol Nutr 2024;78:583\u2013591. https:\/\/doi.org\/10.1002\/jpn3.12099.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"9958_CR17","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1111\/apt.17104","volume":"56","author":"A Choudhary","year":"2022","unstructured":"Choudhary A, Vollebregt PF, Aziz Q et al. Rectal hyposensitivity: a common pathophysiological finding in patients with constipation and associated hypermobile Ehlers-Danlos syndrome. Aliment Pharmacol Ther 2022;56:802\u2013813. https:\/\/doi.org\/10.1111\/apt.17104.","journal-title":"Aliment Pharmacol Ther"},{"key":"9958_CR18","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1053\/j.gastro.2005.11.014","volume":"130","author":"G Chiarioni","year":"2006","unstructured":"Chiarioni G, Whitehead WE, Pezza V et al. Biofeedback is superior to laxatives for normal transit constipation due to pelvic floor dyssynergia. Gastroenterology 2006;130:657\u2013664. https:\/\/doi.org\/10.1053\/j.gastro.2005.11.014.","journal-title":"Gastroenterology"},{"key":"9958_CR19","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.cgh.2006.12.023","volume":"5","author":"SSC Rao","year":"2007","unstructured":"Rao SSC, Seaton K, Miller M et al. Randomized controlled trial of biofeedback, sham feedback, and standard therapy for dyssynergic defecation. Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc 2007;5:331\u2013338. https:\/\/doi.org\/10.1016\/j.cgh.2006.12.023.","journal-title":"Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc"},{"key":"9958_CR20","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1053\/j.gastro.2005.05.015","volume":"129","author":"G Chiarioni","year":"2005","unstructured":"Chiarioni G, Salandini L, Whitehead WE. Biofeedback benefits only patients with outlet dysfunction, not patients with isolated slow transit constipation. Gastroenterology 2005;129:86\u201397. https:\/\/doi.org\/10.1053\/j.gastro.2005.05.015.","journal-title":"Gastroenterology"},{"key":"9958_CR21","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1007\/s10350-006-0814-9","volume":"50","author":"S Heymen","year":"2007","unstructured":"Heymen S, Scarlett Y, Jones K et al. Randomized, controlled trial shows biofeedback to be superior to alternative treatments for patients with pelvic floor dyssynergia-type constipation. Dis Colon Rectum 2007;50:428\u2013441. https:\/\/doi.org\/10.1007\/s10350-006-0814-9.","journal-title":"Dis Colon Rectum"},{"key":"9958_CR22","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1038\/s41395-018-0222-5","volume":"114","author":"AC Ford","year":"2019","unstructured":"Ford AC, Lacy BE, Harris LA et al. Effect of Antidepressants and Psychological Therapies in Irritable Bowel Syndrome: An Updated Systematic Review and Meta-Analysis. Am J Gastroenterol 2019;114:21\u201339. https:\/\/doi.org\/10.1038\/s41395-018-0222-5.","journal-title":"Am J Gastroenterol"},{"key":"9958_CR23","doi-asserted-by":"publisher","first-page":"1678","DOI":"10.1038\/ajg.2011.184","volume":"106","author":"SA Gaylord","year":"2011","unstructured":"Gaylord SA, Palsson OS, Garland EL et al. Mindfulness Training Reduces the Severity of Irritable Bowel Syndrome in Women: Results of a Randomized Controlled Trial. Am J Gastroenterol 2011;106:1678\u20131688. https:\/\/doi.org\/10.1038\/ajg.2011.184.","journal-title":"Am J Gastroenterol"},{"key":"9958_CR24","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1007\/s12529-012-9241-6","volume":"20","author":"KA Zernicke","year":"2013","unstructured":"Zernicke KA, Campbell TS, Blustein PK et al. Mindfulness-Based Stress Reduction for the Treatment of Irritable Bowel Syndrome Symptoms: A Randomized Wait-list Controlled Trial. Int J Behav Med 2013;20:385\u2013396. https:\/\/doi.org\/10.1007\/s12529-012-9241-6.","journal-title":"Int J Behav Med"},{"key":"9958_CR25","doi-asserted-by":"publisher","first-page":"30","DOI":"10.3390\/children3040030","volume":"3","author":"M Kanstrup","year":"2016","unstructured":"Kanstrup M, Wicksell R, Kemani M et al. A Clinical Pilot Study of Individual and Group Treatment for Adolescents with Chronic Pain and Their Parents: Effects of Acceptance and Commitment Therapy on Functioning. Children 2016;3:30. https:\/\/doi.org\/10.3390\/children3040030.","journal-title":"Children"},{"key":"9958_CR26","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1111\/apt.14503","volume":"47","author":"GS Sayuk","year":"2018","unstructured":"Sayuk GS, Kanuri N, Gyawali CP et al. Opioid medication use in patients with gastrointestinal diagnoses vs unexplained gastrointestinal symptoms in the US Veterans Health Administration. Aliment Pharmacol Ther 2018;47:784\u2013791. https:\/\/doi.org\/10.1111\/apt.14503.","journal-title":"Aliment Pharmacol Ther"},{"key":"9958_CR27","doi-asserted-by":"publisher","first-page":"727","DOI":"10.14309\/ajg.0000000000002586","volume":"119","author":"R Topan","year":"2024","unstructured":"Topan R, Pandya S, Williams S et al. Comprehensive Assessment of Nutrition and Dietary Influences in Hypermobile Ehlers-Danlos Syndrome\u2014A Cross-Sectional Study. Am J Gastroenterol 2024;119:727\u2013738.","journal-title":"Am J Gastroenterol"},{"key":"9958_CR28","doi-asserted-by":"publisher","first-page":"2314","DOI":"10.1002\/ajmg.a.34134","volume":"155A","author":"C Danese","year":"2011","unstructured":"Danese C, Castori M, Celletti C et al. Screening for celiac disease in the joint hypermobility syndrome\/Ehlers-Danlos syndrome hypermobility type. Am J Med Genet A 2011;155A:2314\u20132316. https:\/\/doi.org\/10.1002\/ajmg.a.34134.","journal-title":"Am J Med Genet A"},{"key":"9958_CR29","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1016\/j.dld.2016.05.019","volume":"48","author":"M Laszkowska","year":"2016","unstructured":"Laszkowska M, Roy A, Lebwohl B et al. Nationwide population-based cohort study of celiac disease and risk of Ehlers-Danlos syndrome and joint hypermobility syndrome. Dig Liver Dis Off J Ital Soc Gastroenterol Ital Assoc Study Liver 2016;48:1030\u20131034. https:\/\/doi.org\/10.1016\/j.dld.2016.05.019.","journal-title":"Dig Liver Dis Off J Ital Soc Gastroenterol Ital Assoc Study Liver"},{"key":"9958_CR30","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1002\/jpn3.12245","volume":"79","author":"V Sood","year":"2024","unstructured":"Sood V, Kaul A, El-Chammas KI et al. High prevalence of gastrointestinal disorders in a large cohort of patients with joint hypermobility. J Pediatr Gastroenterol Nutr 2024;79:42\u201347. https:\/\/doi.org\/10.1002\/jpn3.12245.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"9958_CR31","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1111\/apt.15231","volume":"49","author":"P Navarro","year":"2019","unstructured":"Navarro P, Arias \u00c1, Arias-Gonz\u00e1lez L et al. Systematic review with meta-analysis: the growing incidence and prevalence of eosinophilic oesophagitis in children and adults in population-based studies. Aliment Pharmacol Ther 2019;49:1116\u20131125. https:\/\/doi.org\/10.1111\/apt.15231.","journal-title":"Aliment Pharmacol Ther"},{"key":"9958_CR32","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1080\/09638288.2020.1761890","volume":"44","author":"J Leganger","year":"2022","unstructured":"Leganger J, Fonnes S, KulasS\u00f8borg ML et al. The most common comorbidities in patients with Ehlers-Danlos syndrome: a 15-year nationwide population-based cohort study. Disabil Rehabil 2022;44:189\u2013193. https:\/\/doi.org\/10.1080\/09638288.2020.1761890.","journal-title":"Disabil Rehabil"},{"key":"9958_CR33","doi-asserted-by":"publisher","first-page":"1053466","DOI":"10.3389\/fmed.2023.1053466","volume":"10","author":"BJ Doolan","year":"2023","unstructured":"Doolan BJ, Lavallee ME, Hausser I et al. Extracutaneous features and complications of the Ehlers-Danlos syndromes: A systematic review. Front Med 2023;10:1053466. https:\/\/doi.org\/10.3389\/fmed.2023.1053466.","journal-title":"Front Med"},{"key":"9958_CR34","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1002\/ajmg.a.33231","volume":"152A","author":"M Castori","year":"2010","unstructured":"Castori M, Camerota F, Celletti C et al. Natural history and manifestations of the hypermobility type Ehlers-Danlos syndrome: A pilot study on 21 patients. Am J Med Genet A 2010;152A:556\u2013564. https:\/\/doi.org\/10.1002\/ajmg.a.33231.","journal-title":"Am J Med Genet A"},{"key":"9958_CR35","first-page":"998","volume":"29","author":"M Castori","year":"2011","unstructured":"Castori M, Sperduti I, Celletti C et al. Symptom and joint mobility progression in the joint hypermobility syndrome (Ehlers-Danlos syndrome, hypermobility type). Clin Exp Rheumatol 2011;29:998\u20131005.","journal-title":"Clin Exp Rheumatol"},{"key":"9958_CR36","doi-asserted-by":"publisher","first-page":"1656","DOI":"10.14309\/01.ajg.0000714660.32906.3b","volume":"115","author":"W Takakura","year":"2020","unstructured":"Takakura W, Raphael Y, Sukov R, Rezaie A. S3153 Hypermobile Ehlers-Danlos Syndrome and Visceroptosis. Am J Gastroenterol 2020;115:1656\u20131657.","journal-title":"Am J Gastroenterol"},{"key":"9958_CR37","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1016\/j.ejmg.2012.06.012","volume":"55","author":"E Reinstein","year":"2012","unstructured":"Reinstein E, Pimentel M, Pariani M et al. Visceroptosis of the bowel in the hypermobility type of Ehlers-Danlos syndrome: presentation of a rare manifestation and review of the literature. Eur J Med Genet 2012;55:548\u2013551. https:\/\/doi.org\/10.1016\/j.ejmg.2012.06.012.","journal-title":"Eur J Med Genet"},{"key":"9958_CR38","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.1828","volume":"9","author":"S Kucera","year":"2017","unstructured":"Kucera S, Sullivan SN. Visceroptosis and the Ehlers-Danlos Syndrome. Cureus 2017;9:e1828. https:\/\/doi.org\/10.7759\/cureus.1828.","journal-title":"Visceroptosis and the Ehlers-Danlos Syndrome. Cureus"},{"key":"9958_CR39","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1002\/ajmg.a.35825","volume":"161","author":"C Dordoni","year":"2013","unstructured":"Dordoni C, Ritelli M, Venturini M et al. Recurring and Generalized Visceroptosis in Ehlers\u2013 D anlos Syndrome Hypermobility Type. Am J Med Genet A 2013;161:1143\u20131147. https:\/\/doi.org\/10.1002\/ajmg.a.35825.","journal-title":"Am J Med Genet A"},{"key":"9958_CR40","doi-asserted-by":"publisher","first-page":"00834","DOI":"10.14309\/ctg.0000000000000834","volume":"16","author":"Y Chan","year":"2025","unstructured":"Chan Y, Chang BW, Kamboj AK et al. Radiographic Identification of Visceroptosis in Patients With Hypermobile Ehlers-Danlos Syndrome With Functional Gastrointestinal Symptoms Compared With Healthy Subjects. Clin Transl Gastroenterol. 2025;16:00834.","journal-title":"Clin Transl Gastroenterol."},{"key":"9958_CR41","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1002\/ajmg.c.31949","volume":"187","author":"W Sandmann","year":"2021","unstructured":"Sandmann W, Scholbach T, Verginis K. Surgical treatment of abdominal compression syndromes: The significance of hypermobility-related disorders. Am J Med Genet C Semin Med Genet 2021;187:570\u2013578. https:\/\/doi.org\/10.1002\/ajmg.c.31949.","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"9958_CR42","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.64182","volume":"197","author":"A Milunsky","year":"2025","unstructured":"Milunsky A, Milunsky JM, Hsu R. Abdominal Compression Syndromes in the Hypermobile Ehlers-Danlos Syndrome. Am J Med Genet A 2025;197:e64182. https:\/\/doi.org\/10.1002\/ajmg.a.64182.","journal-title":"Am J Med Genet A"},{"key":"9958_CR43","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s00192-009-0976-9","volume":"21","author":"BT Haylen","year":"2010","unstructured":"Haylen BT, de Ridder D, Freeman RM et al. An International Urogynecological Association (IUGA)\/International Continence Society (ICS) joint report on the terminology for female pelvic floor dysfunction. Int Urogynecology J 2010;21:5\u201326. https:\/\/doi.org\/10.1007\/s00192-009-0976-9.","journal-title":"Int Urogynecology J"},{"key":"9958_CR44","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1067\/mob.2000.105410","volume":"182","author":"ME Carley","year":"2000","unstructured":"Carley ME, Schaffer J. Urinary incontinence and pelvic organ prolapse in women with Marfan or Ehlers-Danlos syndrome. Am J Obstet Gynecol 2000;182:1021\u20131023. https:\/\/doi.org\/10.1067\/mob.2000.105410.","journal-title":"Am J Obstet Gynecol"},{"key":"9958_CR45","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1007\/s00192-022-05273-8","volume":"34","author":"O Kciuk","year":"2023","unstructured":"Kciuk O, Li Q, Huszti E, McDermott CD. Pelvic floor symptoms in cisgender women with Ehlers-Danlos syndrome: an international survey study. Int Urogynecology J 2023;34:473\u2013483. https:\/\/doi.org\/10.1007\/s00192-022-05273-8.","journal-title":"Int Urogynecology J"},{"key":"9958_CR46","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1007\/s00192-015-2896-1","volume":"27","author":"N Veit-Rubin","year":"2016","unstructured":"Veit-Rubin N, Cartwright R, Singh AU et al. Association between joint hypermobility and pelvic organ prolapse in women: a systematic review and meta-analysis. Int Urogynecology J 2016;27:1469\u20131478. https:\/\/doi.org\/10.1007\/s00192-015-2896-1.","journal-title":"Int Urogynecology J"},{"key":"9958_CR47","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1053\/j.gastro.2025.08.004","volume":"169","author":"K Staller","year":"2025","unstructured":"Staller K, Parkman HP, Greer KB et al. AGA Clinical Practice Guideline on Management of Gastroparesis. Gastroenterology 2025;169:828\u2013861. https:\/\/doi.org\/10.1053\/j.gastro.2025.08.004.","journal-title":"Gastroenterology"},{"key":"9958_CR48","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.7881","author":"M Alomari","year":"2020","unstructured":"Alomari M, Hitawala A, Chadalavada P et al. Prevalence and Predictors of Gastrointestinal Dysmotility in Patients with Hypermobile Ehlers-Danlos Syndrome: A Tertiary Care Center Experience. Cureus. 2020. https:\/\/doi.org\/10.7759\/cureus.7881.","journal-title":"Cureus"},{"key":"9958_CR49","doi-asserted-by":"publisher","first-page":"2239","DOI":"10.1016\/j.cgh.2022.07.011","volume":"21","author":"S Dilmaghani","year":"2023","unstructured":"Dilmaghani S, Zheng T, Camilleri M. Epidemiology and Healthcare Utilization in Patients With Gastroparesis: A Systematic Review. Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc 2023;21:2239-2251.e2. https:\/\/doi.org\/10.1016\/j.cgh.2022.07.011.","journal-title":"Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc"},{"key":"9958_CR50","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1111\/apt.18471","volume":"61","author":"KWE Sweerts","year":"2025","unstructured":"Sweerts KWE, Mujagic Z, Keszthelyi D, Conchillo JM. Analysis of Antroduodenal Motility in Patients With Hypermobility Spectrum Disorders\/Hypermobile Ehlers-Danlos Syndrome. Aliment Pharmacol Ther 2025;61:702\u2013705. https:\/\/doi.org\/10.1111\/apt.18471.","journal-title":"Aliment Pharmacol Ther"},{"key":"9958_CR51","doi-asserted-by":"publisher","first-page":"e41","DOI":"10.1016\/j.hrthm.2015.03.029","volume":"12","author":"RS Sheldon","year":"2015","unstructured":"Sheldon RS, Grubb BP, Olshansky B et al. 2015 heart rhythm society expert consensus statement on the diagnosis and treatment of postural tachycardia syndrome, inappropriate sinus tachycardia, and vasovagal syncope. Heart Rhythm 2015;12:e41-63. https:\/\/doi.org\/10.1016\/j.hrthm.2015.03.029.","journal-title":"Heart Rhythm"},{"key":"9958_CR52","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2020.102637","volume":"224","author":"AJ Miller","year":"2020","unstructured":"Miller AJ, Stiles LE, Sheehan T et al. Prevalence of hypermobile Ehlers-Danlos syndrome in postural orthostatic tachycardia syndrome. Auton Neurosci Basic Clin 2020;224:102637. https:\/\/doi.org\/10.1016\/j.autneu.2020.102637.","journal-title":"Auton Neurosci Basic Clin"},{"key":"9958_CR53","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2024.103163","volume":"253","author":"JP Moak","year":"2024","unstructured":"Moak JP, Ramwell CB, Gordish-Dressman H et al. Small fiber neuropathy in children, adolescents, and young adults with chronic orthostatic intolerance and postural orthostatic tachycardia syndrome: A retrospective study. Auton Neurosci 2024;253:103163. https:\/\/doi.org\/10.1016\/j.autneu.2024.103163.","journal-title":"Auton Neurosci"},{"key":"9958_CR54","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.semarthrit.2013.12.006","volume":"44","author":"I De Wandele","year":"2014","unstructured":"De Wandele I, Rombaut L, Leybaert L et al. Dysautonomia and its underlying mechanisms in the hypermobility type of Ehlers-Danlos syndrome. Semin Arthritis Rheum 2014;44:93\u2013100. https:\/\/doi.org\/10.1016\/j.semarthrit.2013.12.006.","journal-title":"Semin Arthritis Rheum"},{"key":"9958_CR55","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1056\/NEJM200010053431404","volume":"343","author":"G Jacob","year":"2000","unstructured":"Jacob G, Costa F, Shannon JR et al. The Neuropathic Postural Tachycardia Syndrome. N Engl J Med 2000;343:1008\u20131014. https:\/\/doi.org\/10.1056\/NEJM200010053431404.","journal-title":"N Engl J Med"},{"key":"9958_CR56","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1212\/WNL.43.1_Part_1.132","volume":"43","author":"R Schondorf","year":"1993","unstructured":"Schondorf R, Low PA. Idiopathic postural orthostatic tachycardia syndrome: An attenuated form of acute pandysautonomia? Neurology 1993;43:132\u2013132. https:\/\/doi.org\/10.1212\/WNL.43.1_Part_1.132.","journal-title":"Neurology"},{"key":"9958_CR57","doi-asserted-by":"publisher","first-page":"308","DOI":"10.4065\/82.3.308","volume":"82","author":"MJ Thieben","year":"2007","unstructured":"Thieben MJ, Sandroni P, Sletten DM et al. Postural Orthostatic Tachycardia Syndrome: The Mayo Clinic Experience. Mayo Clin Proc 2007;82:308\u2013313. https:\/\/doi.org\/10.4065\/82.3.308.","journal-title":"Mayo Clin Proc"},{"key":"9958_CR58","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2025.07.001","author":"CS Kwok","year":"2025","unstructured":"Kwok CS, Lee S, Hall M et al. The evidence for treatments for postural orthostatic tachycardia syndrome: a systematic review of randomized trials. Trends Cardiovasc Med. 2025. https:\/\/doi.org\/10.1016\/j.tcm.2025.07.001.","journal-title":"Trends Cardiovasc Med"},{"key":"9958_CR59","doi-asserted-by":"publisher","first-page":"2298","DOI":"10.14309\/ajg.0000000000002910","volume":"119","author":"PJ Pasricha","year":"2024","unstructured":"Pasricha PJ, McKnight M, Villatoro L et al. Joint Hypermobility, Autonomic Dysfunction, Gastrointestinal Dysfunction, and Autoimmune Markers: Clinical Associations and Response to Intravenous Immunoglobulin Therapy. Am J Gastroenterol 2024;119:2298\u20132306.","journal-title":"Am J Gastroenterol"},{"key":"9958_CR60","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1159\/000096442","volume":"142","author":"K Sonneck","year":"2007","unstructured":"Sonneck K, Florian S, M\u00fcllauer L et al. Diagnostic and subdiagnostic accumulation of mast cells in the bone marrow of patients with anaphylaxis: Monoclonal mast cell activation syndrome. Int Arch Allergy Immunol 2007;142:158\u2013164. https:\/\/doi.org\/10.1159\/000096442.","journal-title":"Int Arch Allergy Immunol"},{"key":"9958_CR61","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.anai.2023.09.015","volume":"132","author":"DBK Golden","year":"2024","unstructured":"Golden DBK, Wang J, Waserman S et al. Anaphylaxis: A 2023 practice parameter update. Ann Allergy Asthma Immunol Off Publ Am Coll Allergy Asthma Immunol 2024;132:124\u2013176. https:\/\/doi.org\/10.1016\/j.anai.2023.09.015.","journal-title":"Ann Allergy Asthma Immunol Off Publ Am Coll Allergy Asthma Immunol"},{"key":"9958_CR62","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1046\/j.1365-2567.2002.01375.x","volume":"105","author":"HRP Miller","year":"2002","unstructured":"Miller HRP, Pemberton AD. Tissue-specific expression of mast cell granule serine proteinases and their role in inflammation in the lung and gut. Immunology 2002;105:375\u2013390. https:\/\/doi.org\/10.1046\/j.1365-2567.2002.01375.x.","journal-title":"Immunology"},{"key":"9958_CR63","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0161347","volume":"11","author":"N Chiarelli","year":"2016","unstructured":"Chiarelli N, Carini G, Zoppi N et al. Transcriptome-Wide Expression Profiling in Skin Fibroblasts of Patients with Joint Hypermobility Syndrome\/Ehlers-Danlos Syndrome Hypermobility Type. PloS One 2016;11:e0161347. https:\/\/doi.org\/10.1371\/journal.pone.0161347.","journal-title":"PloS One"},{"key":"9958_CR64","doi-asserted-by":"publisher","first-page":"5636","DOI":"10.3390\/jcm14165636","volume":"14","author":"V Daylor","year":"2025","unstructured":"Daylor V, Griggs M, Weintraub A et al. Defining the chronic complexities of hEDS and HSD: a global survey of diagnostic challenges, life-long comorbidities, and Unmet Needs. J Clin Med 2025;14:5636. https:\/\/doi.org\/10.3390\/jcm14165636.","journal-title":"J Clin Med"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-026-09958-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10620-026-09958-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-026-09958-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T03:15:23Z","timestamp":1787800523000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10620-026-09958-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,7]]},"references-count":64,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["9958"],"URL":"https:\/\/doi.org\/10.1007\/s10620-026-09958-8","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,7]]},"assertion":[{"value":"18 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}