{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T07:02:24Z","timestamp":1789628544923,"version":"build-2803163510"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1007\/s10620-026-10108-3","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T04:06:07Z","timestamp":1783569967000},"page":"5994-6008","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pediatric Hereditary Polyposis Syndromes: Diagnosis, Surveillance, and Management Across Evolving Guidelines"],"prefix":"10.1007","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0321-3989","authenticated-orcid":false,"given":"Hussein","family":"Khalifeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4988-819X","authenticated-orcid":false,"given":"Xiaoyi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3048-5662","authenticated-orcid":false,"given":"Brett J.","family":"Hoskins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,9]]},"reference":[{"key":"10108_CR1","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1097\/MOP.0000000000001044","volume":"33","author":"C Phen","year":"2021","unstructured":"Phen C, Rojas I. Paediatric polyposis syndromes: burden of disease and current concepts. Curr Opin Pediatr 2021;33:509\u2013514. https:\/\/doi.org\/10.1097\/MOP.0000000000001044.","journal-title":"Curr Opin Pediatr"},{"key":"10108_CR2","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/S2468-1253(23)00240-6","volume":"9","author":"L Valle","year":"2024","unstructured":"Valle L, Monahan KJ. Genetic predisposition to gastrointestinal polyposis: syndromes, tumour features, genetic testing, and clinical management. Lancet Gastroenterol Hepatol 2024;9:68\u201382. https:\/\/doi.org\/10.1016\/S2468-1253(23)00240-6.","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10108_CR3","doi-asserted-by":"publisher","first-page":"znae070","DOI":"10.1093\/bjs\/znae070","volume":"111","author":"G Zaffaroni","year":"2024","unstructured":"Zaffaroni G, Mannucci A, Koskenvuo L, de Lacy B, Maffioli A, Bisseling T, Half E, Cavestro GM, Valle L, Ryan N, Aretz S, Brown K, Buttitta F, Carneiro F, Claber O, Blanco-Colino R, Collard M, Crosbie E, Cunha M, Doulias T, Fleming C, Heinrich H, H\u00fcneburg R, Metras J, Nagtegaal I, Negoi I, Nielsen M, Pellino G, Ricciardiello L, Sagir A, S\u00e1nchez-Guill\u00e9n L, Sepp\u00e4l\u00e4 TT, Siersema P, Striebeck B, Sampson JR, Latchford A, Parc Y, Burn J, M\u00f6slein G. Br J Surg 2024;111:znae070. https:\/\/doi.org\/10.1093\/bjs\/znae070.","journal-title":"Br J Surg"},{"key":"10108_CR4","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1097\/MPG.0000000000002247","volume":"68","author":"W Hyer","year":"2019","unstructured":"Hyer W, Cohen S, Attard T, Vila-Miravet V, Pienar C, Auth M, Septer S, Hawkins J, Durno C, Latchford A. Management of Familial Adenomatous Polyposis in Children and Adolescents: Position Paper From the ESPGHAN Polyposis Working Group. J Pediatr Gastroenterol Nutr 2019;68:428\u2013441. https:\/\/doi.org\/10.1097\/MPG.0000000000002247.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10108_CR5","doi-asserted-by":"publisher","first-page":"638","DOI":"10.14309\/ajg.0000000000001140","volume":"116","author":"TM Attard","year":"2021","unstructured":"Attard TM, Burke CA, Hyer W, Durno C, Hurley KE, Lawson CE, Church J, Cohen S, Maddux MH. Pediatric Committee of the American College of Gastroenterology. ACG Clinical Report and Recommendations on Transition of Care in Children and Adolescents With Hereditary Polyposis Syndromes. Am J Gastroenterol 2021;116:638\u2013646.","journal-title":"Am J Gastroenterol"},{"key":"10108_CR6","doi-asserted-by":"publisher","first-page":"e2022057267L","DOI":"10.1542\/peds.2022-057267L","volume":"151","author":"MJ Meyers","year":"2023","unstructured":"Meyers MJ, Irwin CE. Health Care Transitions for Adolescents. Pediatrics 2023;151:e2022057267L. https:\/\/doi.org\/10.1542\/peds.2022-057267L.","journal-title":"Pediatrics"},{"key":"10108_CR7","doi-asserted-by":"publisher","first-page":"2063","DOI":"10.1053\/j.gastro.2022.02.021","volume":"162","author":"CR Boland","year":"2022","unstructured":"Boland CR, Idos GE, Durno C, Giardiello FM, Anderson JC, Burke CA, Dominitz JA, Gross S, Gupta S, Jacobson BC, Patel SG, Shaukat A, Syngal S, Robertson DJ. Diagnosis and Management of Cancer Risk in the Gastrointestinal Hamartomatous Polyposis Syndromes: Recommendations From the US Multi-Society Task Force on Colorectal Cancer. Gastroenterology 2022;162:2063\u20132085. https:\/\/doi.org\/10.1053\/j.gastro.2022.02.021.","journal-title":"Gastroenterology"},{"key":"10108_CR8","doi-asserted-by":"publisher","first-page":"4566","DOI":"10.1158\/1078-0432.CCR-24-0953","volume":"30","author":"SP MacFarland","year":"2024","unstructured":"MacFarland SP, Becktell K, Schneider KW, Kuiper RP, Lesmana H, Meade J, Nichols KE, Porter CC, Savage SA, Schultz KA, Scott H, States L, Tabori U, Tamura C, Tomlinson G, Zelley K, Durno C, Bauer A, Plon SE. Pediatric Cancer Screening in Hereditary Gastrointestinal Cancer Risk Syndromes: An Update from the AACR Childhood Cancer Predisposition Working Group. Clin Cancer Res 2024;30:4566\u20134571. https:\/\/doi.org\/10.1158\/1078-0432.CCR-24-0953.","journal-title":"Clin Cancer Res"},{"key":"10108_CR9","doi-asserted-by":"publisher","first-page":"e107","DOI":"10.1158\/1078-0432.CCR-17-0790","volume":"23","author":"MI Achatz","year":"2017","unstructured":"Achatz MI, Porter CC, Brugi\u00e8res L, Druker H, Frebourg T, Foulkes WD, Kratz CP, Kuiper RP, Hansford JR, Hernandez HS, Nathanson KL, Kohlmann WK, Doros L, Onel K, Schneider KW, Scollon SR, Tabori U, Tomlinson GE, Evans DGR, Plon SE. Cancer Screening Recommendations and Clinical Management of Inherited Gastrointestinal Cancer Syndromes in Childhood. Clin Cancer Res 2017;23:e107\u2013e114. https:\/\/doi.org\/10.1158\/1078-0432.CCR-17-0790.","journal-title":"Clin Cancer Res"},{"key":"10108_CR10","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1038\/s41436-020-0826-1","volume":"22","author":"R Blatter","year":"2020","unstructured":"Blatter R, Tschupp B, Aretz S, Bernstein I, Colas C, Evans DG, Genuardi M, Hes FJ, H\u00fcneburg R, J\u00e4rvinen H, Lalloo F, Moeslein G, Renkonen-Sinisalo L, Resta N, Spier I, Varvara D, Vasen H, Latchford AR, Heinimann K. Disease expression in juvenile polyposis syndrome: a retrospective survey on a cohort of 221 European patients and comparison with a literature-derived cohort of 473 SMAD4\/BMPR1A pathogenic variant carriers. Genet Med 2020;22:1524\u20131532. https:\/\/doi.org\/10.1038\/s41436-020-0826-1.","journal-title":"Genet Med"},{"key":"10108_CR11","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1158\/1940-6207.CAPR-25-0014","volume":"18","author":"JA Kurowski","year":"2025","unstructured":"Kurowski JA, Phen C, Liska D, Kay MH, DeRoss AL, Worley S, Burke CA, Attard TM. Current Practice of Hereditary Polyposis Syndromes in Children: A Survey of Providers Treating Pediatric Patients. Cancer Prev Res (Phila) 2025;18:603\u2013614. https:\/\/doi.org\/10.1158\/1940-6207.CAPR-25-0014.","journal-title":"Cancer Prev Res (Phila)"},{"key":"10108_CR12","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1158\/1940-6207.CAPR-25-0279","volume":"18","author":"L Ricciardiello","year":"2025","unstructured":"Ricciardiello L, You YN. Enhancing Standardization in the Pediatric Management of Hereditary Polyposis Syndromes. Cancer Prev Res (Phila) 2025;18:579\u2013581. https:\/\/doi.org\/10.1158\/1940-6207.CAPR-25-0279.","journal-title":"Cancer Prev Res (Phila)"},{"key":"10108_CR13","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1097\/MPG.0000000000002246","volume":"68","author":"S Cohen","year":"2019","unstructured":"Cohen S, Hyer W, Mas E, Auth M, Attard TM, Spalinger J, Latchford A, Durno C. Management of Juvenile Polyposis Syndrome in Children and Adolescents: A Position Paper From the ESPGHAN Polyposis Working Group. J Pediatr Gastroenterol Nutr 2019;68:453\u2013462. https:\/\/doi.org\/10.1097\/MPG.0000000000002246.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10108_CR14","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1097\/MPG.0000000000002248","volume":"68","author":"A Latchford","year":"2019","unstructured":"Latchford A, Cohen S, Auth M, Scaillon M, Viala J, Daniels R, Talbotec C, Attard T, Durno C, Hyer W. Management of Peutz-Jeghers Syndrome in Children and Adolescents: A Position Paper From the ESPGHAN Polyposis Working Group. J Pediatr Gastroenterol Nutr 2019;68:442\u2013452. https:\/\/doi.org\/10.1097\/MPG.0000000000002248.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10108_CR15","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1097\/DCR.0000000000003072","volume":"67","author":"VY Poylin","year":"2024","unstructured":"Poylin VY, Shaffer VO, Felder SI, Goldstein LE, Goldberg JE, Kalady MF, Lightner AL, Feingold DL, Paquette IM. Clinical Practice Guidelines Committee of the American Society of Colon and Rectal Surgeons. The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Management of Inherited Adenomatous Polyposis Syndromes. Dis Colon Rectum 2024;67:213\u2013227. https:\/\/doi.org\/10.1097\/DCR.0000000000003072.","journal-title":"Dis Colon Rectum"},{"key":"10108_CR16","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1016\/j.gie.2020.01.028","volume":"91","author":"J Yang","year":"2020","unstructured":"Yang J, Gurudu SR, Koptiuch C, Agrawal D, Buxbaum JL, Abbas Fehmi SM, Fishman DS, Khashab MA, Jamil LH, Jue TL, Law JK, Lee JK, Naveed M, Qumseya BJ, Sawhney MS, Thosani N, Wani SB, Samadder NJ. American Society for Gastrointestinal Endoscopy guideline on the role of endoscopy in familial adenomatous polyposis syndromes. Gastrointest Endosc 2020;91:963-982.e2. https:\/\/doi.org\/10.1016\/j.gie.2020.01.028.","journal-title":"Gastrointest Endosc"},{"key":"10108_CR17","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1002\/jpn3.12257","volume":"79","author":"S Cohen","year":"2024","unstructured":"Cohen S, Yerushalmy-Feler A, Rojas I, Phen C, Rudnick DA, Flahive CB, Erdman SH, Magen-Rimon R, Copova I, Attard T, Latchford A, Hyer W. Juvenile polyposis syndrome in children: The impact of SMAD4 and BMPR1A mutations on clinical phenotype and polyp burden. J Pediatr Gastroenterol Nutr 2024;79:161\u2013167. https:\/\/doi.org\/10.1002\/jpn3.12257.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10108_CR18","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1136\/gut.48.4.515","volume":"48","author":"W Friedl","year":"2001","unstructured":"Friedl W, Caspari R, Sengteller M, Uhlhaas S, Lamberti C, Jungck M, Kadmon M, Wolf M, Fahnenstich J, Gebert J, M\u00f6slein G, Mangold E, Propping P. Can APC mutation analysis contribute to therapeutic decisions in familial adenomatous polyposis? Experience from 680 FAP families. Gut 2001;48:515\u2013521. https:\/\/doi.org\/10.1136\/gut.48.4.515.","journal-title":"Gut"},{"key":"10108_CR19","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1080\/00365521.2019.1621930","volume":"54","author":"HFA Vasen","year":"2019","unstructured":"Vasen HFA, Ghorbanoghli Z, de Ruijter B, Trinidad R-A, Langers AMJ, Peeters KCMJ, Bonsing BA, Hardwick JCH. Optimizing the timing of colorectal surgery in patients with familial adenomatous polyposis in clinical practice. Scand J Gastroenterol 2019;54:733\u2013739. https:\/\/doi.org\/10.1080\/00365521.2019.1621930.","journal-title":"Scand J Gastroenterol"},{"key":"10108_CR20","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.jpeds.2021.09.021","volume":"245","author":"CB Flahive","year":"2022","unstructured":"Flahive CB, Onwuka A, Bass LM, MacFarland SP, Minneci PC, Erdman SH. Characterizing Pediatric Familial Adenomatous Polyposis in Patients Undergoing Colectomy in the United States. J Pediatr 2022;245:117\u2013122. https:\/\/doi.org\/10.1016\/j.jpeds.2021.09.021.","journal-title":"J Pediatr"},{"key":"10108_CR21","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1001\/jama.2016.2522","volume":"315","author":"NJ Samadder","year":"2016","unstructured":"Samadder NJ, Neklason DW, Boucher KM, Byrne KR, Kanth P, Samowitz W, Jones D, Tavtigian SV, Done MW, Berry T, Jasperson K, Pappas L, Smith L, Sample D, Davis R, Topham MK, Lynch P, Strait E, McKinnon W, Burt RW, Kuwada SK. Effect of Sulindac and Erlotinib vs Placebo on Duodenal Neoplasia in Familial Adenomatous Polyposis: A Randomized Clinical Trial. JAMA 2016;315:1266\u20131275. https:\/\/doi.org\/10.1001\/jama.2016.2522.","journal-title":"JAMA"},{"key":"10108_CR22","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1001\/jamaoncol.2017.5431","volume":"4","author":"NJ Samadder","year":"2018","unstructured":"Samadder NJ, Kuwada SK, Boucher KM, Byrne K, Kanth P, Samowitz W, Jones D, Tavtigian SV, Westover M, Berry T, Jasperson K, Pappas L, Smith L, Sample D, Burt RW, Neklason DW. Association of Sulindac and Erlotinib vs Placebo With Colorectal Neoplasia in Familial Adenomatous Polyposis: Secondary Analysis of a Randomized Clinical Trial. JAMA Oncol 2018;4:671\u2013677. https:\/\/doi.org\/10.1001\/jamaoncol.2017.5431.","journal-title":"JAMA Oncol"},{"key":"10108_CR23","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1056\/NEJMoa1916063","volume":"383","author":"CA Burke","year":"2020","unstructured":"Burke CA, Dekker E, Lynch P, Samadder NJ, Balaguer F, H\u00fcneburg R, Burn J, Castells A, Gallinger S, Lim R, Stoffel EM, Gupta S, Henderson A, Kallenberg FG, Kanth P, Roos VH, Ginsberg GG, Sinicrope FA, Strassburg CP, Van Cutsem E, Church J, Lalloo F, Willingham FF, Wise PE, Grady WM, Ford M, Weiss JM, Gryfe R, Rustgi AK, Syngal S, Cohen A. Eflornithine plus Sulindac for Prevention of Progression in Familial Adenomatous Polyposis. N Engl J Med 2020;383:1028\u20131039. https:\/\/doi.org\/10.1056\/NEJMoa1916063.","journal-title":"N Engl J Med"},{"key":"10108_CR24","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1056\/NEJMoa050405","volume":"352","author":"SD Solomon","year":"2005","unstructured":"Solomon SD, McMurray JJV, Pfeffer MA, Wittes J, Fowler R, Finn P, Anderson WF, Zauber A, Hawk E, Bertagnolli M. Adenoma Prevention with Celecoxib (APC) Study Investigators. Cardiovascular risk associated with celecoxib in a clinical trial for colorectal adenoma prevention. N Engl J Med 2005;352:1071\u20131080. https:\/\/doi.org\/10.1056\/NEJMoa050405.","journal-title":"N Engl J Med"},{"key":"10108_CR25","unstructured":"Larsen Haidle J, MacFarland SP, Howe JR. Juvenile Polyposis Syndrome. In: Adam MP, Bick S, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews\u00ae, Seattle (WA): University of Washington, Seattle; 1993."},{"key":"10108_CR26","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1002\/bjs.9693","volume":"102","author":"E Aytac","year":"2015","unstructured":"Aytac E, Sulu B, Heald B, O\u2019Malley M, LaGuardia L, Remzi FH, Kalady MF, Burke CA, Church JM. Genotype-defined cancer risk in juvenile polyposis syndrome. Br J Surg 2015;102:114\u2013118. https:\/\/doi.org\/10.1002\/bjs.9693.","journal-title":"Br J Surg"},{"key":"10108_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2022.101799","volume":"58\u201359","author":"A Dal Buono","year":"2022","unstructured":"Dal Buono A, Gaiani F, Poliani L, Laghi L. Juvenile polyposis syndrome: An overview. Best Pract Res Clin Gastroenterol 2022;58\u201359:101799. https:\/\/doi.org\/10.1016\/j.bpg.2022.101799.","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"10108_CR28","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1097\/MEG.0000000000002702","volume":"36","author":"S Cohen","year":"2024","unstructured":"Cohen S, Hyer W, Attard T. Endoscopy in pediatric polyposis syndromes: why, when and how. Eur J Gastroenterol Hepatol 2024;36:255\u2013263. https:\/\/doi.org\/10.1097\/MEG.0000000000002702.","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10108_CR29","doi-asserted-by":"publisher","first-page":"1562075","DOI":"10.3389\/fped.2025.1562075","volume":"13","author":"BJ Hoskins","year":"2025","unstructured":"Hoskins BJ. Deep enteroscopy in children: techniques, applications, and future directions. Front Pediatr 2025;13:1562075. https:\/\/doi.org\/10.3389\/fped.2025.1562075.","journal-title":"Front Pediatr"},{"key":"10108_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.vgie.2025.09.006","author":"JM Grabau","year":"2025","unstructured":"Grabau JM, Bhatti U, Hoskins BJ. Ischemic Polypectomy for Small Bowel Polyps in Pediatric Peutz-Jeghers Syndrome. VideoGIE. 2025. https:\/\/doi.org\/10.1016\/j.vgie.2025.09.006.","journal-title":"VideoGIE"},{"key":"10108_CR31","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.1053\/j.gastro.2017.02.011","volume":"152","author":"C Durno","year":"2017","unstructured":"Durno C, Boland CR, Cohen S, Dominitz JA, Giardiello FM, Johnson DA, Kaltenbach T, Levin TR, Lieberman D, Robertson DJ, Rex DK. Recommendations on Surveillance and Management of Biallelic Mismatch Repair Deficiency (BMMRD) Syndrome: A Consensus Statement by the US Multi-Society Task Force on Colorectal Cancer. Gastroenterology 2017;152:1605\u20131614. https:\/\/doi.org\/10.1053\/j.gastro.2017.02.011.","journal-title":"Gastroenterology"},{"key":"10108_CR32","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.1038\/s41431-024-01708-6","volume":"32","author":"C Colas","year":"2024","unstructured":"Colas C, Guerrini-Rousseau L, Suerink M, Gallon R, Kratz CP, Ayuso \u00c9, ERN GENTURIS CMMRD Guideline Group, Brugi\u00e8res L, Wimmer K. ERN GENTURIS guidelines on constitutional mismatch repair deficiency diagnosis, genetic counselling, surveillance, quality of life, and clinical management. Eur J Hum Genet 2024;32:1526\u20131541. https:\/\/doi.org\/10.1038\/s41431-024-01708-6.","journal-title":"Eur J Hum Genet"},{"key":"10108_CR33","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1053\/j.gastro.2014.04.001","volume":"147","author":"FM Giardiello","year":"2014","unstructured":"Giardiello FM, Allen JI, Axilbund JE, Boland CR, Burke CA, Burt RW, Church JM, Dominitz JA, Johnson DA, Kaltenbach T, Levin TR, Lieberman DA, Robertson DJ, Syngal S, Rex DK. US Multi-Society Task Force on Colorectal Cancer. Guidelines on genetic evaluation and management of Lynch syndrome: a consensus statement by the US Multi-Society Task Force on colorectal cancer. Gastroenterology 2014;147:502\u2013526. https:\/\/doi.org\/10.1053\/j.gastro.2014.04.001.","journal-title":"Gastroenterology"},{"key":"10108_CR34","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1002\/jgc4.1546","volume":"31","author":"S Holter","year":"2022","unstructured":"Holter S, Hall MJ, Hampel H, Jasperson K, Kupfer SS, Larsen Haidle J, Mork ME, Palaniapppan S, Senter L, Stoffel EM, Weissman SM, Yurgelun MB. Risk assessment and genetic counseling for Lynch syndrome - Practice resource of the National Society of Genetic Counselors and the Collaborative Group of the Americas on Inherited Gastrointestinal Cancer. J Genet Couns 2022;31:568\u2013583. https:\/\/doi.org\/10.1002\/jgc4.1546.","journal-title":"J Genet Couns"},{"key":"10108_CR35","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/s10689-021-00256-y","volume":"21","author":"C Palles","year":"2022","unstructured":"Palles C, Martin L, Domingo E, Chegwidden L, McGuire J, Cuthill V, Heitzer E, Kerr R, CORGI Consortium, Kerr D, Kearsey S, Clark SK, Tomlinson I, Latchford A. The clinical features of polymerase proof-reading associated polyposis (PPAP) and recommendations for patient management. Fam Cancer 2022;21:197\u2013209. https:\/\/doi.org\/10.1007\/s10689-021-00256-y.","journal-title":"Fam Cancer"},{"key":"10108_CR36","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1002\/gcc.23112","volume":"62","author":"J Leclerc","year":"2023","unstructured":"Leclerc J, Beaumont M, Vibert R, Pinson S, Vermaut C, Flament C, Lovecchio T, Delattre L, Demay C, Coulet F, Guillerm E, Hamzaoui N, Benusiglio PR, Brahimi A, Cornelis F, Delhomelle H, Fert-Ferrer S, Fournier BPJ, Hovnanian A, Legrand C, Lortholary A, Malka D, Petit F, Saurin J-C, Lejeune S, Colas C, Buisine M-P. AXIN2 germline testing in a French cohort validates pathogenic variants as a rare cause of predisposition to colorectal polyposis and cancer. Genes Chromosomes Cancer 2023;62:210\u2013222. https:\/\/doi.org\/10.1002\/gcc.23112.","journal-title":"Genes Chromosomes Cancer"},{"key":"10108_CR37","doi-asserted-by":"publisher","first-page":"1876","DOI":"10.1053\/j.gastro.2017.02.014","volume":"152","author":"S Lieberman","year":"2017","unstructured":"Lieberman S, Walsh T, Schechter M, Adar T, Goldin E, Beeri R, Sharon N, Baris H, Ben Avi L, Half E, Lerer I, Shirts BH, Pritchard CC, Tomlinson I, King M-C, Levy-Lahad E, Peretz T, Goldberg Y. Features of Patients With Hereditary Mixed Polyposis Syndrome Caused by Duplication of GREM1 and Implications for Screening and Surveillance. Gastroenterology 2017;152:1876-1880.e1. https:\/\/doi.org\/10.1053\/j.gastro.2017.02.014.","journal-title":"Gastroenterology"},{"key":"10108_CR38","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1158\/1078-0432.CCR-24-3819","volume":"31","author":"A Dhawan","year":"2025","unstructured":"Dhawan A, Baitamouni S, Liu D, Yehia L, Anthony K, McCarther A, Tischkowitz M, MacFarland SP, Ngeow J, Hoogerbrugge N, Eng C. Cancer and Overgrowth Manifestations of PTEN Hamartoma Tumor Syndrome: Management Recommendations from the International PHTS Consensus Guidelines Working Group. Clin Cancer Res 2025;31:1754\u20131765. https:\/\/doi.org\/10.1158\/1078-0432.CCR-24-3819.","journal-title":"Clin Cancer Res"},{"key":"10108_CR39","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1158\/1078-0432.CCR-24-1947","volume":"31","author":"KAP Schultz","year":"2025","unstructured":"Schultz KAP, MacFarland SP, Perrino MR, Mitchell SG, Kamihara J, Nelson AT, Mallinger PHR, Brzezinski JJ, Maxwell KN, Woodward ER, Gallinger B, Kim SY, Greer M-LC, Schneider KW, Scollon SR, Das A, Wasserman JD, Eng C, Malkin D, Foulkes WD, Michaeli O, Bauer AJ, Stewart DR. Update on Pediatric Surveillance Recommendations for PTEN Hamartoma Tumor Syndrome, DICER1-Related Tumor Predisposition, and Tuberous Sclerosis Complex. Clin Cancer Res 2025;31:234\u2013244. https:\/\/doi.org\/10.1158\/1078-0432.CCR-24-1947.","journal-title":"Clin Cancer Res"},{"key":"10108_CR40","unstructured":"Yehia L, Eng C. PTEN Hamartoma Tumor Syndrome. In: Adam MP, Bick S, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews\u00ae, Seattle (WA): University of Washington, Seattle; 1993."},{"key":"10108_CR41","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.1038\/s41436-021-01207-9","volume":"23","author":"R Mao","year":"2021","unstructured":"Mao R, Krautscheid P, Graham RP, Ganguly A, Shankar S, Ferber M, Hegde M, ACMG Laboratory Quality Assurance Committee. Genetic testing for inherited colorectal cancer and polyposis, 2021 revision: a technical standard of the American College of Medical Genetics and Genomics (ACMG). Genet Med 2021;23:1807\u20131817. https:\/\/doi.org\/10.1038\/s41436-021-01207-9.","journal-title":"Genet Med"},{"key":"10108_CR42","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1007\/s10689-020-00170-9","volume":"19","author":"B Heald","year":"2020","unstructured":"Heald B, Hampel H, Church J, Dudley B, Hall MJ, Mork ME, Singh A, Stoffel E, Stoll J, You YN, Yurgelun MB, Kupfer SS, Collaborative Group of the Americas on Inherited Gastrointestinal Cancer. Collaborative Group of the Americas on Inherited Gastrointestinal Cancer Position statement on multigene panel testing for patients with colorectal cancer and\/or polyposis. Fam Cancer 2020;19:223\u2013239. https:\/\/doi.org\/10.1007\/s10689-020-00170-9.","journal-title":"Fam Cancer"},{"key":"10108_CR43","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1097\/MPG.0000000000001189","volume":"63","author":"H Pall","year":"2016","unstructured":"Pall H, Lerner D, Khlevner J, Reynolds C, Kurowski J, Troendle D, Utterson E, Evans PM, Brill H, Wilsey M, Fishman DS. Developing the Pediatric Gastrointestinal Endoscopy Unit: A Clinical Report by the Endoscopy and Procedures Committee. J Pediatr Gastroenterol Nutr 2016;63:295\u2013306. https:\/\/doi.org\/10.1097\/MPG.0000000000001189.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10108_CR44","doi-asserted-by":"publisher","DOI":"10.1002\/jpn3.70194","author":"BJ Hoskins","year":"2025","unstructured":"Hoskins BJ, Grabau JM, Rex DK. Pediatric endoscopic mucosal resection: A 10-year single-center experience. J Pediatr Gastroenterol Nutr. 2025. https:\/\/doi.org\/10.1002\/jpn3.70194.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10108_CR45","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1158\/1940-6207.CAPR-22-0500","volume":"16","author":"KJ Monahan","year":"2023","unstructured":"Monahan KJ, Swinyard O, Latchford A. Biology of Precancers and Opportunities for Cancer Interception: Lesson from Colorectal Cancer Susceptibility Syndromes. Cancer Prev Res (Phila) 2023;16:421\u2013427. https:\/\/doi.org\/10.1158\/1940-6207.CAPR-22-0500.","journal-title":"Cancer Prev Res (Phila)"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-026-10108-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10620-026-10108-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10620-026-10108-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T06:08:07Z","timestamp":1789625287000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10620-026-10108-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,9]]},"references-count":45,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["10108"],"URL":"https:\/\/doi.org\/10.1007\/s10620-026-10108-3","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,9]]},"assertion":[{"value":"21 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Brett J. Hoskins is a consultant for Medtronic plc, Mirum Pharmaceuticals, Inc., and 3-D Matrix, Ltd. Xiaoyi Zhang reports institutional research support from AbbVie, including partial salary support, for participation as a site principal investigator in clinical trials, outside the submitted work. Hussein Khalifeh declares no conflicts of interest. No funds, grants, or other support were received.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}