{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:51:45Z","timestamp":1789865505292,"version":"4.0.1"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,5,16]],"date-time":"2018-05-16T00:00:00Z","timestamp":1526428800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2018,5,16]],"date-time":"2018-05-16T00:00:00Z","timestamp":1526428800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30EY019007"],"award-info":[{"award-number":["P30EY019007"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01EY018213"],"award-info":[{"award-number":["R01EY018213"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01EY024698"],"award-info":[{"award-number":["R01EY024698"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21AG050437"],"award-info":[{"award-number":["R21AG050437"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01EY024665"],"award-info":[{"award-number":["R01EY024665"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01Y025225"],"award-info":[{"award-number":["R01Y025225"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01EY024698"],"award-info":[{"award-number":["R01EY024698"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01EY026682"],"award-info":[{"award-number":["R01EY026682"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R21AG050437"],"award-info":[{"award-number":["R21AG050437"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["P30EY026877"],"award-info":[{"award-number":["P30EY026877"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["5P30CA013696"],"award-info":[{"award-number":["5P30CA013696"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Tistou and Charlotte Kerstan Foundation"},{"name":"Schneeweiss Stem Cell Fund"},{"name":"New York State","award":["C029572"],"award-info":[{"award-number":["C029572"]}]},{"name":"Gebroe Family Foundation"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Doc Ophthalmol"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1007\/s10633-018-9640-3","type":"journal-article","created":{"date-parts":[[2018,5,16]],"date-time":"2018-05-16T13:17:16Z","timestamp":1526476636000},"page":"15-23","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Deferoxamine-induced electronegative ERG responses"],"prefix":"10.1007","volume":"137","author":[{"given":"Ruben","family":"Jauregui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen Sophia","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander G.","family":"Bassuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinit B.","family":"Mahajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9082-2427","authenticated-orcid":false,"given":"Stephen H.","family":"Tsang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,5,16]]},"reference":[{"key":"9640_CR1","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1056\/NEJMct1004810","volume":"364","author":"GM Brittenham","year":"2011","unstructured":"Brittenham GM (2011) Iron-chelating therapy for transfusional iron overload. N Engl J Med 364:146\u2013156","journal-title":"N Engl J Med"},{"key":"9640_CR2","doi-asserted-by":"publisher","first-page":"159","DOI":"10.2147\/JBM.S61540","volume":"7","author":"K Bayanzay","year":"2016","unstructured":"Bayanzay K, Alzoebie L (2016) Reducing the iron burden and improving survival in transfusion-dependent thalassemia patients: Current perspectives. J Blood Med 7:159\u2013169","journal-title":"J Blood Med"},{"key":"9640_CR3","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1097\/ICB.0000000000000059","volume":"8","author":"R Gelman","year":"2014","unstructured":"Gelman R, Kiss S, Tsang SH (2014) Multimodal imaging in a case of deferoxamine-induced maculopathy. Retin Cases Brief Rep 8:306\u2013309","journal-title":"Retin Cases Brief Rep"},{"key":"9640_CR4","doi-asserted-by":"publisher","first-page":"249617","DOI":"10.1155\/2015\/249617","volume":"2015","author":"M Di Nicola","year":"2015","unstructured":"Di Nicola M, Barteselli G, Dell\u2019Arti L, Ratiglia R, Viola F (2015) Functional and structural abnormalities in deferoxamine retinopathy: a review of the literature. Biomed Res Int 2015:249617","journal-title":"Biomed Res Int"},{"key":"9640_CR5","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1016\/j.ophtha.2012.01.039","volume":"119","author":"F Viola","year":"2012","unstructured":"Viola F, Barteselli G, Dell\u2019arti L, Vezzola D, Villani E, Mapelli C, Zanaboni L, Cappellini MD, Ratiglia R (2012) Abnormal fundus autofluorescence results of patients in long-term treatment with deferoxamine. Ophthalmology 119:1693\u20131700","journal-title":"Ophthalmology"},{"key":"9640_CR6","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1097\/IAE.0000000000001315","volume":"37","author":"AA El-Shazly","year":"2017","unstructured":"El-Shazly AA, Ebeid WM, Elkitkat RS, Deghedy MR (2017) Electroretinographic and visual-evoked potential changes in relation to chelation modality in children with thalassemia. Retina 37:1168\u20131175","journal-title":"Retina"},{"key":"9640_CR7","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/S0161-6420(01)00947-2","volume":"109","author":"R Haimovici","year":"2002","unstructured":"Haimovici R, D\u2019Amico DJ, Gragoudas ES, Sokol S (2002) Deferoxamine retinopathy study G: the expanded clinical spectrum of deferoxamine retinopathy. Ophthalmology 109:164\u2013171","journal-title":"Ophthalmology"},{"key":"9640_CR8","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/1471-2415-14-88","volume":"14","author":"CH Wu","year":"2014","unstructured":"Wu CH, Yang CP, Lai CC, Wu WC, Chen YH (2014) Deferoxamine retinopathy: spectral domain-optical coherence tomography findings. BMC Ophthalmol 14:88","journal-title":"BMC Ophthalmol"},{"key":"9640_CR9","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.preteyeres.2014.09.001","volume":"45","author":"C Zeitz","year":"2015","unstructured":"Zeitz C, Robson AG, Audo I (2015) Congenital stationary night blindness: an analysis and update of genotype-phenotype correlations and pathogenic mechanisms. Prog Retin Eye Res 45:58\u2013110","journal-title":"Prog Retin Eye Res"},{"key":"9640_CR10","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.survophthal.2007.10.010","volume":"53","author":"I Audo","year":"2008","unstructured":"Audo I, Robson AG, Holder GE, Moore AT (2008) The negative erg: clinical phenotypes and disease mechanisms of inner retinal dysfunction. Surv Ophthalmol 53:16\u201340","journal-title":"Surv Ophthalmol"},{"key":"9640_CR11","doi-asserted-by":"publisher","first-page":"4648","DOI":"10.1167\/iovs.13-12111","volume":"54","author":"A Raghuram","year":"2013","unstructured":"Raghuram A, Hansen RM, Moskowitz A, Fulton AB (2013) Photoreceptor and postreceptor responses in congenital stationary night blindness. Invest Ophthalmol Vis Sci 54:4648\u20134658","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"9640_CR12","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s10633-007-9084-7","volume":"116","author":"I Tsui","year":"2008","unstructured":"Tsui I, Casper D, Chou CL, Tsang SH (2008) Electronegative electroretinogram associated with topiramate toxicity and vitelliform maculopathy. Doc Ophthalmol 116:57\u201360","journal-title":"Doc Ophthalmol"},{"key":"9640_CR13","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1001\/jamaophthalmol.2014.3616","volume":"133","author":"RF Spaide","year":"2015","unstructured":"Spaide RF, Klancnik JM Jr, Cooney MJ (2015) Retinal vascular layers imaged by fluorescein angiography and optical coherence tomography angiography. JAMA Ophthalmol 133:45\u201350","journal-title":"JAMA Ophthalmol"},{"key":"9640_CR14","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1186\/s12886-016-0285-2","volume":"16","author":"A Liaska","year":"2016","unstructured":"Liaska A, Petrou P, Georgakopoulos CD, Diamanti R, Papaconstantinou D, Kanakis MG, Georgalas I (2016) Beta-thalassemia and ocular implications: a systematic review. BMC Ophthalmol 16:102","journal-title":"BMC Ophthalmol"},{"key":"9640_CR15","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1097\/01.ICB.0000279640.76453.eb","volume":"1","author":"S Reddy","year":"2007","unstructured":"Reddy S, Iturralde D, Meyerle C, Gross NE, Yannuzzi LA (2007) Fundus autofluorescence in retinopathy caused by deferoxamine toxicity. Retin Cases Brief Rep 1:120\u2013122","journal-title":"Retin Cases Brief Rep"},{"key":"9640_CR16","doi-asserted-by":"publisher","first-page":"e0177059","DOI":"10.1371\/journal.pone.0177059","volume":"12","author":"MR Munk","year":"2017","unstructured":"Munk MR, Giannakaki-Zimmermann H, Berger L, Huf W, Ebneter A, Wolf S, Zinkernagel MS (2017) Oct-angiography: a qualitative and quantitative comparison of 4 oct-a devices. PLoS ONE 12:e0177059","journal-title":"PLoS ONE"},{"key":"9640_CR17","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1007\/s12098-017-2339-8","volume":"84","author":"RH Merchant","year":"2017","unstructured":"Merchant RH, Punde H, Thacker N, Bhatt D (2017) Ophthalmic evaluation in beta-thalassemia. Indian J Pediatr 84:509\u2013514","journal-title":"Indian J Pediatr"},{"key":"9640_CR18","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1016\/j.bbagen.2010.03.011","volume":"1800","author":"W Wang","year":"2010","unstructured":"Wang W, Knovich MA, Coffman LG, Torti FM, Torti SV (2010) Serum ferritin: past, present and future. Biochim Biophys Acta 1800:760\u2013769","journal-title":"Biochim Biophys Acta"},{"key":"9640_CR19","doi-asserted-by":"publisher","first-page":"122","DOI":"10.3109\/15569521003745685","volume":"29","author":"A Klettner","year":"2010","unstructured":"Klettner A, Koinzer S, Waetzig V, Herdegen T, Roider J (2010) Deferoxamine mesylate is toxic for retinal pigment epithelium cells in vitro, and its toxicity is mediated by p38. Cutan Ocul Toxicol 29:122\u2013129","journal-title":"Cutan Ocul Toxicol"},{"key":"9640_CR20","doi-asserted-by":"publisher","first-page":"e14319","DOI":"10.7554\/eLife.14319","volume":"5","author":"T Kurihara","year":"2016","unstructured":"Kurihara T, Westenskow PD, Gantner ML, Usui Y, Schultz A, Bravo S, Aguilar E, Wittgrove C, Friedlander M, Paris LP, Chew E, Siuzdak G, Friedlander M (2016) Hypoxia-induced metabolic stress in retinal pigment epithelial cells is sufficient to induce photoreceptor degeneration. Elife 5:e14319. \n                    https:\/\/doi.org\/10.7554\/eLife.14319","journal-title":"Elife"}],"container-title":["Documenta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10633-018-9640-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10633-018-9640-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10633-018-9640-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T17:06:40Z","timestamp":1589648800000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10633-018-9640-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,16]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["9640"],"URL":"https:\/\/doi.org\/10.1007\/s10633-018-9640-3","relation":{},"ISSN":["0012-4486","1573-2622"],"issn-type":[{"value":"0012-4486","type":"print"},{"value":"1573-2622","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,16]]},"assertion":[{"value":"30 January 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 May 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 May 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"The patient has given informed consent for submission of this case report to the journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statement of human rights"}},{"value":"This article does not contain any studies with animals performed by any of the authors.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statement on the welfare of animals"}}]}}