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We employed spectral analysis of electroretinographic (ERG) responses to assess retinal changes\u00a0in mTBI as a function of the degree of photalgia.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The design was a case\u2013control study of the changes in the ERG waveform as a function of level of light sensitivity in individuals who had suffered incidents of mild traumatic brain injury. The mTBI participants were categorized into non-, mild-, and severe-photalgic groups based on their spectral nociophysical settings. Light-adapted ERG responses were recorded from each eye for 200\u00a0ms on\u2013off stimulation of three spectral colors (R:red, G:green, and B:blue) and their sum (W:white) at the highest pain-free intensity level for each participant. The requirement of controls\u00a0for testing hypersensitive individuals at lower light levels was addressed by recording a full light intensity series in the control group.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Both the b-wave and the photopic negative response (PhNR) were significantly reduced in the non-photalgic mTBI group relative to controls. In the photalgic groups, the main b-wave peak shifted to the timing of the rod b-wave, with reduced amplitude at the timing of the cone response.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>These results suggest the interpretation that the primary etiology of the painful light sensitivity in mTBI is release of the rod pathway from cone-mediated inhibition at high light levels, causing overactivation of the rod pathway.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10633-022-09871-1","type":"journal-article","created":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T18:03:18Z","timestamp":1650477798000},"page":"179-190","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Brain trauma impacts retinal processing: photoreceptor pathway interactions in traumatic light sensitivity"],"prefix":"10.1007","volume":"144","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1512-4626","authenticated-orcid":false,"given":"Christopher W.","family":"Tyler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lora T.","family":"Likova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,4,20]]},"reference":[{"key":"9871_CR1","first-page":"1124","volume":"40","author":"S Viswanathan","year":"1999","unstructured":"Viswanathan S, Frishman LJ, Robson JG, Harwerth RS, Smith E (1999) The photopic negative response of the macaque electroretinogram: reduction by experimental glaucoma. 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