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In certain groups of patients or study participants, stable central fixation of the stimulus is not guaranteed. The present study aimed at assessing the effects of misfixation on the ssPERG response to checkerboard reversal stimuli.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Using two check sizes (0.8\u00b0 and 15\u00b0), we compared ssPERG responses for several amounts of fixation deviation, ranging from 0\u00b0 to 19\u00b0 horizontally and from 0\u00b0 to 14\u00b0 diagonally. The stimulus area extended to 15\u00b0 eccentricity, stimulus reversal rate was 15\/s.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Up to around 7\u00b0 eccentricity, there was no sizable effect of fixation deviation under most conditions. Effects were somewhat larger for nasal than for temporal deviation, in particular for small checks. Diagonal deviation was associated with a response to luminance onset\/offset at 7.5\u00a0Hz (subharmonic of the reversal rate), most prominently when the interior of a large check was fixated.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Generally, moderate inaccuracies of fixation do not have a sizable effect on ssPERG amplitude. However, with large checks, the luminance response has to be considered.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10633-024-09967-w","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T07:02:32Z","timestamp":1709103752000},"page":"87-95","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of eccentric fixation on the steady-state pattern electroretinogram"],"prefix":"10.1007","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9862-9656","authenticated-orcid":false,"given":"Evelyn B. 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N. Friedel has no conflict of interest; Julia Haldina has no conflict of interest; Ludger Tebartz van Elst involved in advisory boards, lectures, or travel grants within the last three years: Roche, Eli Lilly, Janssen-Cilag, Novartis, Shire, UCB, GSK, Servier, Janssen and Cyberonics, and Kathrin Nickel have no conflict of interest; Michael Bach has no conflict of interest; Sven P. Heinrich has no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study protocol was approved by the local Ethics Committee of the University of Freiburg (Approval ID: 314\/18).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All participants provided written informed consent to participate in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"All procedures performed in the scope of the study were in agreement with the local ethical standards, as well as in accordance with the tenets of the Declaration of Helsinki.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statement of human rights"}},{"value":"No animal experiments were conducted for the study.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statement on the welfare of animal rights"}}]}}