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A separate set of age-matched mice (\n                      <jats:italic>n<\/jats:italic>\n                      =9) underwent RBF and ffERG measurements before and after steady light stimulation (SLS) at 1 cd\/m\n                      <jats:sup>2<\/jats:sup>\n                      under similar conditions. The changes in RBF (arterial and venous flow) as well as the amplitudes and implicit times of the a-wave, b-wave, oscillatory potentials (OPs), and photopic negative response (PhNR) were analyzed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      FLS significantly increased both arterial (\n                      <jats:italic>p<\/jats:italic>\n                      =0.003) and venous (\n                      <jats:italic>p<\/jats:italic>\n                      =0.018) blood flow as well as b-wave amplitudes (\n                      <jats:italic>p<\/jats:italic>\n                      =0.017) compared to SLS, which did not have any significant changes in either RBF or ERG. However, no significant differences were found in other ffERG responses (amplitudes and implicit times of a-wave, OPs, and PhNR, as well as b-wave implicit time) between the two groups after light stimulation. An increase in b-wave amplitude was positively associated with an increase in both arterial (r=0.655,\n                      <jats:italic>p<\/jats:italic>\n                      =0.040) and venous blood flow (r=0.638,\n                      <jats:italic>p<\/jats:italic>\n                      =0.047) in the FLS group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results suggest that transient FLS not only increases RBF but also enhances electro-retinal responses of the middle retinal layer, as shown by ffERG, thus demonstrating its substantial effects on both the vascular and neuronal components of retinal neurovascular coupling in mice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10633-025-10049-8","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T07:39:14Z","timestamp":1758785954000},"page":"205-218","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of flickering light stimulation on retinal blood flow and full-field electroretinogram in mice"],"prefix":"10.1007","volume":"151","author":[{"given":"Milan","family":"Rai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamunadevi","family":"Lakshmanan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai Yip","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8516-4711","authenticated-orcid":false,"given":"Henry Ho-lung","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,25]]},"reference":[{"key":"10049_CR1","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.preteyeres.2004.07.002","volume":"24","author":"CE Riva","year":"2005","unstructured":"Riva CE, Logean E, Falsini B (2005) Visually evoked hemodynamical response and assessment of neurovascular coupling in the optic nerve and retina. 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