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Patients with various ON etiologies, including glaucoma (n\u2009=\u200920), optic nerve compression by meningioma (n\u2009=\u200918), chiasm compression (n\u2009=\u20094), Leber hereditary optic neuropathy (LHON; n\u2009=\u20094), and autosomal dominant optic atrophy (ADOA; n\u2009=\u20093), were tested. Linear mixed-effects models and post hoc Tukey tests were used to analyze differences across subgroups of ON etiologies and a healthy control group (n\u2009=\u200940), regarding signal eccentricities and locations.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Pupillary escape was significantly higher in ON patients during central red stimulation (<jats:italic>p<\/jats:italic>\u2009=\u20090.0007). Glaucoma and meningioma groups showed reduced relMCA and prolonged latency for both stimuli compared to controls (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001 to <jats:italic>p<\/jats:italic>\u2009=\u20090.0058). RelMCA during blue stimulation was lower in glaucoma patients than in ADOA (<jats:italic>p<\/jats:italic>\u2009=\u20090.0183). LHON patients exhibited significantly prolonged PLR latency during blue stimulation compared to healthy (<jats:italic>p<\/jats:italic>\u2009=\u20090.0284).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>CPC effectively distinguished glaucoma and meningioma from healthy controls but was less reliable for differentiating ON subtypes. Our results indicate, that central pupillary escape is associated with inner retinal dysfunction.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s10633-025-10054-x","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T15:53:01Z","timestamp":1760543581000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Chromatic pupil campimetry as objective diagnostic tool for progressive optic neuropathies"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1394-4687","authenticated-orcid":false,"given":"M\u00e1rton Viktor","family":"Edelmayer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten","family":"Strasser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronja","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3624-8318","authenticated-orcid":false,"given":"Anton","family":"Sonntag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricarda","family":"Jendritza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Tonagel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Peters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Wilhelm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Wilhelm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina","family":"Kelbsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,15]]},"reference":[{"issue":"2","key":"10054_CR1","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/0002-9394(89)90006-8","volume":"108","author":"A Heijl","year":"1989","unstructured":"Heijl A, Lindgren A, Lindgren G (1989) Test-retest variability in glaucomatous visual fields. 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