{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T12:02:24Z","timestamp":1789732944489,"version":"4.0.1"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Doc Ophthalmol"],"DOI":"10.1007\/s10633-026-10150-6","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T11:10:57Z","timestamp":1789729857000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tapetal-like reflex in RPGR-associated retinal dystrophies: two cases with distinct phenotypes"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5678-2159","authenticated-orcid":false,"given":"Patchrapa","family":"Wattanawinitchai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7321-307X","authenticated-orcid":false,"given":"Parith","family":"Wongkittichote","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5290-3605","authenticated-orcid":false,"given":"Boontip","family":"Tipsuriyaporn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6343-459X","authenticated-orcid":false,"given":"Tharikarn","family":"Sujirakul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,18]]},"reference":[{"issue":"1","key":"10150_CR1","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1167\/tvst.11.1.6","volume":"11","author":"S Tuupanen","year":"2022","unstructured":"Tuupanen S, Gall K, Sistonen J, Saarinen I, K\u00e4mpj\u00e4rvi K, Wells K et al (2022) Prevalence of RPGR-mediated retinal dystrophy in an unselected cohort of over 5000 patients. Transl Vis Sci Technol 11(1):6. https:\/\/doi.org\/10.1167\/tvst.11.1.6","journal-title":"Transl Vis Sci Technol"},{"key":"10150_CR2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21030835","author":"XT Nguyen","year":"2020","unstructured":"Nguyen XT, Talib M, van Schooneveld MJ, Brinks J, Ten Brink J, Florijn RJ et al (2020) RPGR-associated dystrophies: clinical, genetic, and histopathological features. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms21030835","journal-title":"Int J Mol Sci"},{"key":"10150_CR3","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.exer.2015.06.007","volume":"138","author":"RD Megaw","year":"2015","unstructured":"Megaw RD, Soares DC, Wright AF (2015) RPGR: its role in photoreceptor physiology, human disease, and future therapies. Exp Eye Res 138:32\u201341. https:\/\/doi.org\/10.1016\/j.exer.2015.06.007","journal-title":"Exp Eye Res"},{"issue":"49","key":"10150_CR4","doi-asserted-by":"publisher","first-page":"e2208707119","DOI":"10.1073\/pnas.2208707119","volume":"119","author":"J Cehajic-Kapetanovic","year":"2022","unstructured":"Cehajic-Kapetanovic J, Martinez-Fernandez de la Camara C, Birtel J, Rehman S, McClements ME, Charbel Issa P et al (2022) Impaired glutamylation of RPGR(ORF15) underlies the cone-dominated phenotype associated with truncating distal ORF15 variants. Proc Natl Acad Sci USA 119(49):e2208707119. https:\/\/doi.org\/10.1073\/pnas.2208707119","journal-title":"Proc Natl Acad Sci USA"},{"key":"10150_CR5","doi-asserted-by":"publisher","DOI":"10.1080\/13816810.2025.2524509","author":"SK Padhy","year":"2025","unstructured":"Padhy SK, Takkar B, Mukherjee S, Narayanan R (2025) Tapetal-like reflex in X-linked RPGR-associated retinopathy. Ophthalmic Genet. https:\/\/doi.org\/10.1080\/13816810.2025.2524509","journal-title":"Ophthalmic Genet"},{"issue":"12","key":"10150_CR6","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1167\/iovs.64.12.19","volume":"64","author":"MD Benson","year":"2023","unstructured":"Benson MD, Mukherjee S, Agather AR, Blain D, Cunningham D, Mays R et al (2023) RPGR: deep phenotyping and genetic characterization with findings specific to the 3\u2032-end of ORF15. Invest Ophthalmol Vis Sci 64(12):19. https:\/\/doi.org\/10.1167\/iovs.64.12.19","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"10","key":"10150_CR7","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1001\/archopht.125.10.1407","volume":"125","author":"ZB Jin","year":"2007","unstructured":"Jin ZB, Gu F, Ma X, Nao-i N (2007) Identification of a novel RPGR exon ORF15 mutation in a family with X-linked retinitis pigmentosa. Arch Ophthalmol 125(10):1407\u20131412. https:\/\/doi.org\/10.1001\/archopht.125.10.1407","journal-title":"Arch Ophthalmol"},{"key":"10150_CR8","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1038\/s41439-019-0065-7","volume":"6","author":"G Mawatari","year":"2019","unstructured":"Mawatari G, Fujinami K, Liu X, Yang L, Yokokawa YF, Komori S et al (2019) Clinical and genetic characteristics of 14 patients from 13 Japanese families with RPGR-associated retinal disorder: report of eight novel variants. Hum Genome Var 6:34. https:\/\/doi.org\/10.1038\/s41439-019-0065-7","journal-title":"Hum Genome Var"},{"key":"10150_CR9","doi-asserted-by":"publisher","first-page":"600210","DOI":"10.3389\/fgene.2021.600210","volume":"12","author":"J Yang","year":"2021","unstructured":"Yang J, Zhou L, Ouyang J, Xiao X, Sun W, Li S et al (2021) Genotype-phenotype analysis of RPGR variations: reporting of 62 Chinese families and a literature review. Front Genet 12:600210. https:\/\/doi.org\/10.3389\/fgene.2021.600210","journal-title":"Front Genet"},{"issue":"1","key":"10150_CR10","doi-asserted-by":"publisher","first-page":"100595","DOI":"10.1016\/j.xops.2024.100595","volume":"5","author":"RE MacLaren","year":"2025","unstructured":"MacLaren RE, Duncan JL, Fischer MD, Lam BL, Meunier I, Pennesi ME et al (2025) XOLARIS: a 24-month, prospective, natural history study of 201 participants with retinitis pigmentosa GTPase regulator-associated X-linked retinitis pigmentosa. Ophthalmol Sci 5(1):100595. https:\/\/doi.org\/10.1016\/j.xops.2024.100595","journal-title":"Ophthalmol Sci"},{"issue":"3","key":"10150_CR11","doi-asserted-by":"publisher","first-page":"e289","DOI":"10.1016\/j.jcjo.2023.11.016","volume":"59","author":"Y Zhai","year":"2024","unstructured":"Zhai Y, Wright T, Ballios BG (2024) X-linked cone dystrophy with an uncommon tapetal-like sheen caused by a novel RPGR variant. Can J Ophthalmol 59(3):e289\u2013e293. https:\/\/doi.org\/10.1016\/j.jcjo.2023.11.016","journal-title":"Can J Ophthalmol"},{"issue":"3","key":"10150_CR12","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1007\/s10633-022-09872-0","volume":"144","author":"AG Robson","year":"2022","unstructured":"Robson AG, Frishman LJ, Grigg J, Hamilton R, Jeffrey BG, Kondo M et al (2022) ISCEV standard for full-field clinical electroretinography (2022 update). Doc Ophthalmol 144(3):165\u2013177. https:\/\/doi.org\/10.1007\/s10633-022-09872-0","journal-title":"Doc Ophthalmol"},{"key":"10150_CR13","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.ajo.2020.08.004","volume":"221","author":"M Georgiou","year":"2021","unstructured":"Georgiou M, Grewal PS, Narayan A, Alser M, Ali N, Fujinami K et al (2021) Sector retinitis pigmentosa: extending the molecular genetics basis and elucidating the natural history. Am J Ophthalmol 221:299\u2013310. https:\/\/doi.org\/10.1016\/j.ajo.2020.08.004","journal-title":"Am J Ophthalmol"},{"issue":"10","key":"10150_CR14","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1167\/iovs.67.10.24","volume":"67","author":"MEA Abdalla Elsayed","year":"2026","unstructured":"Abdalla Elsayed MEA, Mahroo OA, Webster A, Tsang SH, Marques JP, Traboulsi E et al (2026) Defining a novel RPGR phenotype of sector retinitis pigmentosa with cone dystrophy. Invest Ophthalmol Vis Sci 67(10):24. https:\/\/doi.org\/10.1167\/iovs.67.10.24","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10150_CR15","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.exer.2013.05.003","volume":"113","author":"JH Acton","year":"2013","unstructured":"Acton JH, Greenberg JP, Greenstein VC, Marsiglia M, Tabacaru M, Theodore Smith R et al (2013) Evaluation of multimodal imaging in carriers of X-linked retinitis pigmentosa. Exp Eye Res 113:41\u201348. https:\/\/doi.org\/10.1016\/j.exer.2013.05.003","journal-title":"Exp Eye Res"},{"issue":"3","key":"10150_CR16","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1097\/IAE.0000000000001965","volume":"39","author":"A Kalitzeos","year":"2019","unstructured":"Kalitzeos A, Samra R, Kasilian M, Tee JJL, Strampe M, Langlo C et al (2019) Cellular imaging of the tapetal-like reflex in carriers of RPGR-associated retinopathy. Retina 39(3):570\u2013580. https:\/\/doi.org\/10.1097\/IAE.0000000000001965","journal-title":"Retina"}],"container-title":["Documenta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10633-026-10150-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10633-026-10150-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10633-026-10150-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T11:10:58Z","timestamp":1789729858000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10633-026-10150-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,18]]},"references-count":16,"alternative-id":["10150"],"URL":"https:\/\/doi.org\/10.1007\/s10633-026-10150-6","relation":{},"ISSN":["0012-4486","1573-2622"],"issn-type":[{"value":"0012-4486","type":"print"},{"value":"1573-2622","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,18]]},"assertion":[{"value":"19 June 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflicts of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was conducted in accordance with the principles of the 1964 Declaration of Helsinki and its subsequent amendments or comparable ethical standards. Written informed consent was obtained from the patients and\/or their legal guardians for participation and publication of clinical information and images.","order":2,"name":"Ethics","label":"Statement of human rights","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This article does not contain any studies with animals performed by any of the authors.","order":3,"name":"Ethics","label":"Statement on the welfare of animals","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study protocol was approved by the Ramathibodi Hospital Human Research Ethics Committee (COA. MURA 2025\/930) and complied with the 1964 Declaration of Helsinki and its later amendments. Each participating subject or their legal guardians provided written informed consent for the study and consent for publication, including the photographs.","order":4,"name":"Ethics","label":"Ethical Approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written informed consent was obtained from the patient and is available upon request.","order":5,"name":"Ethics","label":"Informed consent","group":{"name":"EthicsHeading","label":"Declarations"}}]}}