{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T12:53:01Z","timestamp":1783428781623,"version":"3.54.6"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Invest New Drugs"],"published-print":{"date-parts":[[2008,8]]},"DOI":"10.1007\/s10637-008-9135-2","type":"journal-article","created":{"date-parts":[[2008,4,30]],"date-time":"2008-04-30T19:54:34Z","timestamp":1209585274000},"page":"347-354","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Phase I dose-escalation study of the thioxanthone SR271425 administered intravenously once every 3\u00a0weeks in patients with advanced malignancies"],"prefix":"10.1007","volume":"26","author":[{"given":"Priscila H.","family":"Goncalves","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francine","family":"High","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Juniewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gareth","family":"Shackleton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Boerner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia M.","family":"LoRusso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,5,1]]},"reference":[{"key":"9135_CR1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/978-1-4615-8152-9_5","volume-title":"Anticancer drugs development guide: preclinical screening, clinical trials and approval","author":"TH Corbett","year":"1997","unstructured":"Corbett TH, Valeriote FA, LoRusso P et al (1997) In vivo methods for screening and preclinical testing: use of rodent solid tumors for drug discovery. In: Teicher B (ed) Anticancer drugs development guide: preclinical screening, clinical trials and approval. Humana, Totowa, pp 75\u201399"},{"issue":"1","key":"9135_CR2","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1023\/A:1006267517726","volume":"17","author":"TH Corbett","year":"1999","unstructured":"Corbett TH, Panchapor C, Polin L et al (1999) Preclinical efficacy of thioxanthone SR271425 against transplanted solid tumors of mouse and human origin. Invest New Drugs 17(1):17\u201327","journal-title":"Invest New Drugs"},{"key":"9135_CR3","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1111\/j.1749-6632.1969.tb15867.x","volume":"160","author":"J Pellegrino","year":"1969","unstructured":"Pellegrino J, Katz N (1969) The pharmacological and chemotherapeutic properties of niridazole and other antischistomal compounds. Ann NY Acad Sci 160:429","journal-title":"Ann NY Acad Sci"},{"issue":"8","key":"9135_CR4","first-page":"1173","volume":"62","author":"SS Legha","year":"1978","unstructured":"Legha SS, Grose WE, Bodey GP (1978) Phase I study of hycanthone. Cancer Treat Rep 62(8):1173\u20131176","journal-title":"Cancer Treat Rep"},{"issue":"3","key":"9135_CR5","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1023\/A:1005875015011","volume":"15","author":"TH Corbett","year":"1997","unstructured":"Corbett TH, Valeriote FA, Demchik L et al (1997) Discovery of cryptophycin-1 and BCN-183577: examples of strategies and problems in the detection of antitumor activity in mice. Invest New drugs 15(3):207\u2013218","journal-title":"Invest New drugs"},{"issue":"3","key":"9135_CR6","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1007\/s002800050971","volume":"44","author":"JP Stevenson","year":"1999","unstructured":"Stevenson JP, DeMaria D, Reilly D et al (1999) Phase I\/pharmacokinetic trial of the novel thioxanthone SR233377 (WIN33377) on a 5-day schedule. Cancer Chemother Pharmacol 44(3):228\u2013234","journal-title":"Cancer Chemother Pharmacol"},{"issue":"8","key":"9135_CR7","first-page":"3088","volume":"6","author":"PM LoRusso","year":"2000","unstructured":"LoRusso PM, Foster BJ, Wozniak A et al (2000) Phase I pharmacokinetic study of the novel antitumor agent SR233377. Clin Cancer Res 6(8):3088\u20133094","journal-title":"Clin Cancer Res"},{"issue":"3","key":"9135_CR8","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1023\/A:1006152100299","volume":"16","author":"E Izbicka","year":"1998","unstructured":"Izbicka E, Lawrence R, Davidson K, Rake JB, Von Hoff DD (1998) Effects of SW 33377, SW 68210 and SW 71425 thioxanthones on in vitro colony formation of freshly explanted human tumor cells. Invest New Drugs 16(3):221\u2013225","journal-title":"Invest New Drugs"},{"issue":"11","key":"9135_CR9","first-page":"2047","volume":"3","author":"BJ Foster","year":"1997","unstructured":"Foster BJ, Wiegand RA, Pugh S, LoRusso PM, Rake J, Corbett TH (1997) Pharmacokinetic studies in mice of two new thioxanthenones (183577 and 232759) that showed preferential solid tumor activity. Clin Cancer Res 3(11):2047\u20132053","journal-title":"Clin Cancer Res"},{"key":"9135_CR10","volume-title":"Report on file: characterization of the interaction of SR271425 with topoisomerase I and II","author":"R Wadkins","year":"1999","unstructured":"Wadkins R (1999) Report on file: characterization of the interaction of SR271425 with topoisomerase I and II. CTRC Institute for Drug Development, San Antonio"},{"issue":"6","key":"9135_CR11","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1007\/s002800050844","volume":"42","author":"L Lun","year":"1998","unstructured":"Lun L, Sun PM, Trubey CM, Bachur NR (1998) Antihelicase action of CI-958, a new drug for prostate cancer. Cancer Chemother Pharmacol 42(6):447\u2013453","journal-title":"Cancer Chemother Pharmacol"},{"issue":"1","key":"9135_CR12","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/0166-6851(90)90133-7","volume":"43","author":"S Archer","year":"1990","unstructured":"Archer S, el-Hamouly W, Seyed-Mozaffari A, Butler RH, Pica-Mattoccia L, Cioli D (1990) Mode of action of the schistosomicide hycanthone: site of DNA alkylation. Mol Biochem Parasitol 43(1):89\u201395","journal-title":"Mol Biochem Parasitol"},{"issue":"1","key":"9135_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1254\/jjp.83.1","volume":"83","author":"J Tamargo","year":"2000","unstructured":"Tamargo J (2000) Drug-induced torsade de pointes: from molecular biology to bedside. Jpn J Pharmacol 83(1):1\u201319","journal-title":"Jpn J Pharmacol"},{"key":"9135_CR14","volume-title":"Cellular electrophysiological studies of SR233377 in rabbit Purkinje and ventricular fibers. Sanofi Research, Montpellier RS0008951030\/01","author":"P Gautier","year":"1995","unstructured":"Gautier P (1995) Cellular electrophysiological studies of SR233377 in rabbit Purkinje and ventricular fibers. Sanofi Research, Montpellier RS0008951030\/01. Sanofi, Malvern"},{"key":"9135_CR15","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1200\/JCO.2005.03.037","volume":"23","author":"SLE Wadler","year":"2005","unstructured":"Wadler SLE, Pilat MJ et al (2005) A phase I trial of SR271425 given as a one hour infusion every 3 weeks to patients with advanced solid tumors. Proc Am Soc Clin Oncol 23:142","journal-title":"Proc Am Soc Clin Oncol"},{"key":"9135_CR16","first-page":"220","volume":"23","author":"FSC De Braud","year":"2005","unstructured":"De Braud FSC, Gallerani E et al (2005) Phase I dose escalation study of SR271425 administered as 24-hour intravenous infusion in patients with refractory solid tumors. Proc Am Soc Clin Oncol 23:220","journal-title":"Proc Am Soc Clin Oncol"},{"key":"9135_CR17","first-page":"215","volume":"23","author":"ELA Calvo","year":"2005","unstructured":"Calvo ELA, Tolcher AW et al (2005) A phase I dose-escalation study of weekly multiple dose intravenously administered SR271425 in patients with refractory solid tumors. Proc Am Soc Clin Oncol 23:215","journal-title":"Proc Am Soc Clin Oncol"},{"key":"9135_CR18","first-page":"224","volume":"23","author":"P Fumoleau","year":"2005","unstructured":"Fumoleau P, Campone M, Isambert N et al (2005) A phase I dose escalation study of SR271425 administered intravenously in split doses (d1\u2013d2\u2013d3) in patients with refractory solid tumors.. Proc Am Soc Clin Oncol 23:224","journal-title":"Proc Am Soc Clin Oncol"},{"issue":"2","key":"9135_CR19","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1097\/01.coc.0000255604.32888.b5","volume":"30","author":"JC Soria","year":"2007","unstructured":"Soria JC, Dieras V, Girre V, Yovine A, Mialaret K, Armand JP (2007) QTc monitoring during a phase I study: experience with SR271425. Am J Clin Oncol 30(2):106\u2013112","journal-title":"Am J Clin Oncol"},{"issue":"3","key":"9135_CR20","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1200\/JCO.2000.18.3.684","volume":"18","author":"EA Eisenhauer","year":"2000","unstructured":"Eisenhauer EA, O\u2019Dwyer PJ, Christian M, Humphrey JS (2000) Phase I clinical trial design in cancer drug development. J Clin Oncol 18(3):684\u2013692","journal-title":"J Clin Oncol"},{"issue":"6","key":"9135_CR21","doi-asserted-by":"publisher","first-page":"23B","DOI":"10.1016\/0002-9149(93)90036-C","volume":"72","author":"AJ Moss","year":"1993","unstructured":"Moss AJ (1993) Measurement of the QT interval and the risk associated with QTc interval prolongation: a review. Am J Cardiol 72(6):23B\u201325B","journal-title":"Am J Cardiol"},{"issue":"17","key":"9135_CR22","doi-asserted-by":"publisher","first-page":"5967","DOI":"10.1158\/1078-0432.CCR-04-0534","volume":"10","author":"M Varterasian","year":"2004","unstructured":"Varterasian M, Fingert H, Agin M, Meyer M (2004) Consideration of QT\/QTc interval data in a phase I study in patients with advanced cancer. Clin Cancer Res 10(17):5967\u20135968 author reply 8\u20139","journal-title":"Clin Cancer Res"}],"container-title":["Investigational New Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10637-008-9135-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10637-008-9135-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10637-008-9135-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10637-008-9135-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,11]],"date-time":"2023-03-11T18:31:11Z","timestamp":1678559471000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10637-008-9135-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5,1]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["9135"],"URL":"https:\/\/doi.org\/10.1007\/s10637-008-9135-2","relation":{},"ISSN":["0167-6997","1573-0646"],"issn-type":[{"value":"0167-6997","type":"print"},{"value":"1573-0646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,5,1]]},"assertion":[{"value":"23 January 2008","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 April 2008","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 May 2008","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}