{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:49:38Z","timestamp":1791474578744,"version":"4.3.4"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2009,8,4]],"date-time":"2009-08-04T00:00:00Z","timestamp":1249344000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2009,8,4]],"date-time":"2009-08-04T00:00:00Z","timestamp":1249344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Invest New Drugs"],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1007\/s10637-009-9296-7","type":"journal-article","created":{"date-parts":[[2009,8,3]],"date-time":"2009-08-03T00:00:13Z","timestamp":1249257613000},"page":"677-683","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Phase II study of sunitinib malate in head and neck squamous cell carcinoma"],"prefix":"10.1007","volume":"28","author":[{"given":"Nicholas W.","family":"Choong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Kozloff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Taber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Shawn","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"James","family":"Wade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Percy","family":"Ivy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore G.","family":"Karrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Dekker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Everett E.","family":"Vokes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezra E. W.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,8,4]]},"reference":[{"key":"9296_CR1","doi-asserted-by":"publisher","first-page":"32","DOI":"10.3322\/CA.2007.0004","volume":"58","author":"N Choong","year":"2008","unstructured":"Choong N, Vokes E (2008) Expanding role of the medical oncologist in the management of head and neck cancer. CA Cancer J Clin 58:32\u201353","journal-title":"CA Cancer J Clin"},{"key":"9296_CR2","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1016\/S0959-8049(00)00054-X","volume":"36","author":"LP Kowalski","year":"2000","unstructured":"Kowalski LP, Carvalho AL (2000) Natural history of untreated head and neck cancer. Eur J Cancer 36:1032\u20137","journal-title":"Eur J Cancer"},{"key":"9296_CR3","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1200\/JCO.1992.10.8.1245","volume":"10","author":"AA Forastiere","year":"1992","unstructured":"Forastiere AA, Metch B, Schuller DE, Ensley JF, Hutchins LF, Triozzi P, Kish JA, McClure S, VonFeldt E, Williamson SK et al (1992) Randomized comparison of cisplatin plus fluorouracil and carboplatin plus fluorouracil versus methotrexate in advanced squamous-cell carcinoma of the head and neck: a Southwest Oncology Group study. J Clin Oncol 10:1245\u201351","journal-title":"J Clin Oncol"},{"key":"9296_CR4","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1056\/NEJMoa0802656","volume":"359","author":"JB Vermorken","year":"2008","unstructured":"Vermorken JB, Mesia R, Rivera F, Remenar E, Kawecki A, Rottey S, Erfan J, Zabolotnyy D, Kienzer HR, Cupissol D, Peyrade F, Benasso M, Vynnychenko I, De Raucourt D, Bokemeyer C, Schueler A, Amellal N, Hitt R (2008) Platinum-based chemotherapy plus cetuximab in head and neck cancer. N Engl J Med 359:1116\u201327","journal-title":"N Engl J Med"},{"key":"9296_CR5","first-page":"327","volume":"9","author":"DB Mendel","year":"2003","unstructured":"Mendel DB, Laird AD, Xin X, Louie SG, Christensen JG, Li G, Schreck RE, Abrams TJ, Ngai TJ, Lee LB, Murray LJ, Carver J, Chan E, Moss KG, Haznedar JO, Sukbuntherng J, Blake RA, Sun L, Tang C, Miller T, Shirazian S, McMahon G, Cherrington JM (2003) In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic\/pharmacodynamic relationship. Clin Cancer Res 9:327\u201337","journal-title":"Clin Cancer Res"},{"key":"9296_CR6","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1001\/archotol.129.8.882","volume":"129","author":"RV Lalla","year":"2003","unstructured":"Lalla RV, Boisoneau DS, Spiro JD, Kreutzer DL (2003) Expression of vascular endothelial growth factor receptors on tumor cells in head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg 129:882\u20138","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"9296_CR7","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1002\/1097-0142(20010801)92:3<556::AID-CNCR1355>3.0.CO;2-Q","volume":"92","author":"P O-charoenrat","year":"2001","unstructured":"O-charoenrat P, Rhys-Evans P, Eccles SA (2001) Expression of vascular endothelial growth factor family members in head and neck squamous cell carcinoma correlates with lymph node metastasis. Cancer 92:556\u201368","journal-title":"Cancer"},{"key":"9296_CR8","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1309\/BTLN5WTMJ3PCNRRC","volume":"124","author":"WM Ongkeko","year":"2005","unstructured":"Ongkeko WM, Altuna X, Weisman RA, Wang-Rodriguez J (2005) Expression of protein tyrosine kinases in head and neck squamous cell carcinomas. Am J Clin Pathol 124:71\u20136","journal-title":"Am J Clin Pathol"},{"key":"9296_CR9","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/S1368-8375(03)00127-1","volume":"40","author":"S Shintani","year":"2004","unstructured":"Shintani S, Li C, Ishikawa T, Mihara M, Nakashiro K, Hamakawa H (2004) Expression of vascular endothelial growth factor A, B, C, and D in oral squamous cell carcinoma. Oral Oncol 40:13\u201320","journal-title":"Oral Oncol"},{"key":"9296_CR10","first-page":"389","volume":"14","author":"Y Tanigaki","year":"2004","unstructured":"Tanigaki Y, Nagashima Y, Kitamura Y, Matsuda H, Mikami Y, Tsukuda M (2004) The expression of vascular endothelial growth factor-A and -C, and receptors 1 and 3: correlation with lymph node metastasis and prognosis in tongue squamous cell carcinoma. Int J Mol Med 14:389\u201395","journal-title":"Int J Mol Med"},{"key":"9296_CR11","first-page":"775","volume":"5","author":"ER Sauter","year":"1999","unstructured":"Sauter ER, Nesbit M, Watson JC, Klein-Szanto A, Litwin S, Herlyn M (1999) Vascular endothelial growth factor is a marker of tumor invasion and metastasis in squamous cell carcinomas of the head and neck. Clin Cancer Res 5:775\u201382","journal-title":"Clin Cancer Res"},{"key":"9296_CR12","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1038\/modpathol.3800295","volume":"18","author":"PA Kyzas","year":"2005","unstructured":"Kyzas PA, Stefanou D, Batistatou A, Agnantis NJ (2005) Potential autocrine function of vascular endothelial growth factor in head and neck cancer via vascular endothelial growth factor receptor-2. Mod Pathol 18:485\u201394","journal-title":"Mod Pathol"},{"key":"9296_CR13","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1002\/hed.10235","volume":"25","author":"C Neuchrist","year":"2003","unstructured":"Neuchrist C, Erovic BM, Handisurya A, Fischer MB, Steiner GE, Hollemann D, Gedlicka C, Saaristo A, Burian M (2003) Vascular endothelial growth factor C and vascular endothelial growth factor receptor 3 expression in squamous cell carcinomas of the head and neck. Head Neck 25:464\u201374","journal-title":"Head Neck"},{"key":"9296_CR14","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1016\/j.oraloncology.2004.04.018","volume":"40","author":"PA Kyzas","year":"2004","unstructured":"Kyzas PA, Stefanou D, Agnantis NJ (2004) Immunohistochemical expression of vascular endothelial growth factor correlates with positive surgical margins and recurrence in T1 and T2 squamous cell carcinoma (SCC) of the lower lip. Oral Oncol 40:941\u20137","journal-title":"Oral Oncol"},{"key":"9296_CR15","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1002\/hed.10163","volume":"24","author":"TN Teknos","year":"2002","unstructured":"Teknos TN, Cox C, Yoo S, Chepeha DB, Wolf GT, Bradford CR, Carey TE, Fisher SG (2002) Elevated serum vascular endothelial growth factor and decreased survival in advanced laryngeal carcinoma. Head Neck 24:1004\u201311","journal-title":"Head Neck"},{"key":"9296_CR16","first-page":"103","volume":"62","author":"F Riedel","year":"2005","unstructured":"Riedel F, Gotte K, Hormann K, Grandis JR (2005) Antiangiogenic therapy of head and neck squamous cell carcinoma by vascular endothelial growth factor antisense therapy. Adv Otorhinolaryngol 62:103\u201320","journal-title":"Adv Otorhinolaryngol"},{"key":"9296_CR17","first-page":"577","volume":"23","author":"F Riedel","year":"2003","unstructured":"Riedel F, Gotte K, Li M, Hormann K, Grandis JR (2003) Abrogation of VEGF expression in human head and neck squamous cell carcinoma decreases angiogenic activity in vitro and in vivo. Int J Oncol 23:577\u201383","journal-title":"Int J Oncol"},{"key":"9296_CR18","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/S0002-9440(10)63905-3","volume":"162","author":"P Guo","year":"2003","unstructured":"Guo P, Hu B, Gu W, Xu L, Wang D, Huang HJ, Cavenee WK, Cheng SY (2003) Platelet-derived growth factor-B enhances glioma angiogenesis by stimulating vascular endothelial growth factor expression in tumor endothelia and by promoting pericyte recruitment. Am J Pathol 162:1083\u201393","journal-title":"Am J Pathol"},{"key":"9296_CR19","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1096\/fj.03-0271fje","volume":"18","author":"R Erber","year":"2004","unstructured":"Erber R, Thurnher A, Katsen AD, Groth G, Kerger H, Hammes HP, Menger MD, Ullrich A, Vajkoczy P (2004) Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms. FASEB J 18:338\u201340","journal-title":"FASEB J"},{"key":"9296_CR20","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1200\/JCO.2005.02.2194","volume":"24","author":"S Faivre","year":"2006","unstructured":"Faivre S, Delbaldo C, Vera K, Robert C, Lozahic S, Lassau N, Bello C, Deprimo S, Brega N, Massimini G, Armand JP, Scigalla P, Raymond E (2006) Safety, pharmacokinetic, and antitumor activity of SU11248, a novel oral multitarget tyrosine kinase inhibitor, in patients with cancer. J Clin Oncol 24:25\u201335","journal-title":"J Clin Oncol"},{"key":"9296_CR21","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1056\/NEJMoa065044","volume":"356","author":"RJ Motzer","year":"2007","unstructured":"Motzer RJ, Hutson TE, Tomczak P, Michaelson MD, Bukowski RM, Rixe O, Oudard S, Negrier S, Szczylik C, Kim ST, Chen I, Bycott PW, Baum CM, Figlin RA (2007) Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med 356:115\u201324","journal-title":"N Engl J Med"},{"key":"9296_CR22","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1200\/JCO.2008.16.2545","volume":"27","author":"SJ Crabb","year":"2009","unstructured":"Crabb SJ, Patsios D, Sauerbrei E, Ellis PM, Arnold A, Goss G, Leighl NB, Shepherd FA, Powers J, Seymour L, Laurie SA (2009) Tumor cavitation: impact on objective response evaluation in trials of angiogenesis inhibitors in non-small-cell lung cancer. J Clin Oncol 27:404\u201310","journal-title":"J Clin Oncol"},{"key":"9296_CR23","doi-asserted-by":"publisher","first-page":"3766","DOI":"10.1200\/JCO.2006.10.2871","volume":"25","author":"C Elser","year":"2007","unstructured":"Elser C, Siu LL, Winquist E, Agulnik M, Pond GR, Chin SF, Francis P, Cheiken R, Elting J, McNabola A, Wilkie D, Petrenciuc O, Chen EX (2007) Phase II trial of sorafenib in patients with recurrent or metastatic squamous cell carcinoma of the head and neck or nasopharyngeal carcinoma. J Clin Oncol 25:3766\u201373","journal-title":"J Clin Oncol"},{"key":"9296_CR24","doi-asserted-by":"crossref","unstructured":"Williamson, S., Moon, J., Huang, C., Guaglianone, P., Wolf, G. and Urba, S. (2007) A phase II trial of sorafenib in patients with recurrent and\/or metastatic head and neck squamous cell carcinoma (HNSCC): A Southwest Oncology Group (SWOG) trial. Proc Am Soc Clin Oncol 25:Abstract 6044","DOI":"10.1200\/jco.2007.25.18_suppl.6044"},{"key":"9296_CR25","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1007\/s10637-006-9011-x","volume":"25","author":"MG Fury","year":"2007","unstructured":"Fury MG, Zahalsky A, Wong R, Venkatraman E, Lis E, Hann L, Aliff T, Gerald W, Fleisher M, Pfister DG (2007) A Phase II study of SU5416 in patients with advanced or recurrent head and neck cancers. Invest New Drugs 25:165\u201372","journal-title":"Invest New Drugs"},{"key":"9296_CR26","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1038\/nrc2152","volume":"7","author":"HM Verheul","year":"2007","unstructured":"Verheul HM, Pinedo HM (2007) Possible molecular mechanisms involved in the toxicity of angiogenesis inhibition. Nat Rev Cancer 7:475\u201385","journal-title":"Nat Rev Cancer"},{"key":"9296_CR27","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/S1470-2045(09)70002-6","volume":"10","author":"EE Cohen","year":"2009","unstructured":"Cohen EE, Davis DW, Karrison TG, Seiwert TY, Wong SJ, Nattam S, Kozloff MF, Clark JI, Yan DH, Liu W, Pierce C, Dancey JE, Stenson K, Blair E, Dekker A, Vokes EE (2009) Erlotinib and bevacizumab in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck: a phase I\/II study. Lancet Oncol 10:247\u201357","journal-title":"Lancet Oncol"}],"container-title":["Investigational New Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10637-009-9296-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10637-009-9296-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10637-009-9296-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10637-009-9296-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,11]],"date-time":"2023-03-11T04:40:52Z","timestamp":1678509652000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10637-009-9296-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8,4]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["9296"],"URL":"https:\/\/doi.org\/10.1007\/s10637-009-9296-7","relation":{},"ISSN":["0167-6997","1573-0646"],"issn-type":[{"value":"0167-6997","type":"print"},{"value":"1573-0646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,8,4]]},"assertion":[{"value":"14 June 2009","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 July 2009","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 August 2009","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}