{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T03:39:19Z","timestamp":1791171559952,"version":"4.1.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2010,6,22]],"date-time":"2010-06-22T00:00:00Z","timestamp":1277164800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2010,6,22]],"date-time":"2010-06-22T00:00:00Z","timestamp":1277164800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Invest New Drugs"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1007\/s10637-010-9466-7","type":"journal-article","created":{"date-parts":[[2010,6,21]],"date-time":"2010-06-21T06:26:54Z","timestamp":1277101614000},"page":"1213-1223","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Cytotoxicity in human cancer cells and mitochondrial dysfunction induced by a series of new copper(I) complexes containing tris(2-cyanoethyl)phosphines"],"prefix":"10.1007","volume":"29","author":[{"given":"Alessandro","family":"Zanella","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Gandin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Porchia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiorenzo","family":"Refosco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Tisato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Sorrentino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Scutari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Pia","family":"Rigobello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Marzano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,6,22]]},"reference":[{"key":"9466_CR1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.2174\/187152009787313837","volume":"9","author":"C Marzano","year":"2009","unstructured":"Marzano C, Pellei M, Tisato F, Santini C (2009) Copper complexes as anticancer agents. Anti-Cancer Agents Med Chem 9:185\u2013211","journal-title":"Anti-Cancer Agents Med Chem"},{"key":"9466_CR2","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.1021\/ja00960a067","volume":"88","author":"MR Taylor","year":"1966","unstructured":"Taylor MR, Gabe EJ, Glusker JP, Minkin JA, Patterson AL (1966) The crystal structures of compounds with antitumour activity. 2-keto-3-ethoxybutyraldehyde bis(thiosemicarbazone) and its cupric complex. J Am Chem Soc 88:1845\u20131846","journal-title":"J Am Chem Soc"},{"key":"9466_CR3","first-page":"1278","volume":"27","author":"JA Crim","year":"1967","unstructured":"Crim JA, Petering HG (1967) The antitumour activity of Cu(II)KTS, the copper (II) chelate of 3-ethoxy-2-oxobutyraldehyde bis(thiosemicarbazone). Cancer Res 27:1278\u20131285","journal-title":"Cancer Res"},{"key":"9466_CR4","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1007\/s00280-002-0480-0","volume":"50","author":"L Feun","year":"2002","unstructured":"Feun L, Modiano M, Lee K, Mao J, Marini A, Savaraj N, Plezia P, Almassian B, Colacino E, Fischer J, MacDonald S (2002) Phase I and pharmacokinetic study of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) using a single intravenous dose schedule. Cancer Chemother Pharmacol 50:223\u2013229","journal-title":"Cancer Chemother Pharmacol"},{"key":"9466_CR5","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1155\/MBD.1999.177","volume":"6","author":"A Murugkar","year":"1999","unstructured":"Murugkar A, Unnikrishnan B, Padhye S, Bhonde R, Teat S, Triantafillou E, Sinn E (1999) Hormone anchored metal complexes. 1. Synthesis, structure, spectroscopy and in vitro antitumour activity of testosterone acetate thiosemicarbazone and its metal complexes. Met-Based Drugs 6:177\u2013182","journal-title":"Met-Based Drugs"},{"key":"9466_CR6","first-page":"5486","volume":"46","author":"SJ Berners-Price","year":"1986","unstructured":"Berners-Price SJ, Mirabelli CK, Johnson RK, Mattern MR, McCabe FL, Faucette LF, Sung CM, Mong SM, Sadler PJ, Crooke ST (1986) In vivo antitumour activity and in vitro cytotoxic properties of bis[1, 2-bis(diphenylphosphino)ethane]gold(I) chloride. Cancer Res 46:5486\u20135493","journal-title":"Cancer Res"},{"key":"9466_CR7","doi-asserted-by":"publisher","first-page":"2467","DOI":"10.1021\/cr980421n","volume":"9","author":"ER Jamieson","year":"1999","unstructured":"Jamieson ER, Lippard SJ (1999) Structure, recognition, and processing of cisplatin-DNA adducts. Chem Rev 9:2467\u20132498","journal-title":"Chem Rev"},{"key":"9466_CR8","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1002\/med.10038","volume":"23","author":"YP Ho","year":"2003","unstructured":"Ho YP, Au-Yeung SCF, To KKW (2003) Platinum-based anticancer agents: innovative design strategies and biological perspectives. Med Res Review 23:633\u2013655","journal-title":"Med Res Review"},{"key":"9466_CR9","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/S1367-5931(03)00081-4","volume":"7","author":"CX Zhang","year":"2003","unstructured":"Zhang CX, Lippard SJ (2003) New metal complexes as potential therapeutics. Curr Opin Chem Biol 7:481\u2013489","journal-title":"Curr Opin Chem Biol"},{"key":"9466_CR10","first-page":"5054","volume":"46","author":"RM Snyder","year":"1986","unstructured":"Snyder RM, Mirabelli CK, Johnson RK, Sung CM, Faucette LF, McCabe FL, Zimmerman JP, Whitman M, Hempel JC, Crooke ST (1986) Modulation of the antitumour and biochemical properties of bis(diphenylphosphine)ethane with metals. Cancer Res 46:5054\u20135060","journal-title":"Cancer Res"},{"key":"9466_CR11","doi-asserted-by":"publisher","first-page":"3383","DOI":"10.1021\/ic00267a034","volume":"26","author":"SJ Berners-Price","year":"1987","unstructured":"Berners-Price SJ, Johnson RK, Mirabelli CK, Faucette LF, McCabe FL, Sadler PJ (1987) Copper(I) complexes with bidentate tertiary phosphine ligands: solution chemistry and antitumour activity. Inorg Chem 26:3383\u20133387","journal-title":"Inorg Chem"},{"key":"9466_CR12","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/3-540-50130-4_2","volume":"70","author":"SJ Berners-Price","year":"1988","unstructured":"Berners-Price SJ, Sadler PJ (1988) Phosphines and metal phosphine complexes: relationship of chemistry to anticancer and other biological activity. Struct Bonding 70:27\u201310","journal-title":"Struct Bonding"},{"key":"9466_CR13","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1021\/jm701146c","volume":"51","author":"C Marzano","year":"2008","unstructured":"Marzano C, Gandin V, Pellei M, Colavito D, Papini G, Gioia Lobbia G, Del Giudice E, Porchia M, Tisato F, Santini C (2008) In Vitro antitumour activity of the water soluble copper(I) complexes bearing the tris(hydroxymethyl) phosphine Ligand. J Med Chem 51:798\u2013808","journal-title":"J Med Chem"},{"key":"9466_CR14","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.1016\/j.jinorgbio.2009.09.005","volume":"103","author":"M Porchia","year":"2009","unstructured":"Porchia M, Benetollo F, Refosco F, Tisato F, Marzano C, Gandin V (2009) Synthesis and structural characterization of copper(I) complexes bearing N-methyl-1, 3, 5-triaza-7-phosphaadamantane (mPTA). Cytotoxic activity evaluation of a series of water soluble Cu(I) derivatives containing PTA, PTAH and mPTA ligands. J Inorg Biochem 103:1644\u20131651","journal-title":"J Inorg Biochem"},{"key":"9466_CR15","doi-asserted-by":"publisher","first-page":"7317","DOI":"10.1021\/jm0601248","volume":"49","author":"C Marzano","year":"2006","unstructured":"Marzano C, Pellei M, Colavito D, Alidori S, Lobbia GG, Gandin V, Tisato F, Santini C (2006) Synthesis, characterization, and in vitro antitumour properties of tris(hydroxymethyl)phosphine Copper(I) complexes containing the new bis(1, 2, 4-triazol-1-yl)acetate Ligand. J Med Chem 49:7317\u20137324","journal-title":"J Med Chem"},{"key":"9466_CR16","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.jinorgbio.2005.11.014","volume":"100","author":"C Marzano","year":"2006","unstructured":"Marzano C, Pellei M, Alidori S, Brossa A, Lobbia GG, Tisato F, Santini C (2006) New copper(I) phosphane complexes of dihydrobis(3-nitro-1, 2, 4-triazolyl)borate ligand showing cytotoxic activity. J Inorg Biochem 100:299\u2013304","journal-title":"J Inorg Biochem"},{"key":"9466_CR17","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1021\/ja01514a022","volume":"81","author":"M Rauhut","year":"1959","unstructured":"Rauhut M, Hechenbleikner I, Currier HA, Schaefer FC, Wystrach VP (1959) The cyanoethylation of phosphine and phenylphosphine. J Am Chem Soc 81:1103\u20131107","journal-title":"J Am Chem Soc"},{"key":"9466_CR18","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1021\/i360020a011","volume":"5","author":"WJ Vullo","year":"1966","unstructured":"Vullo WJ (1966) Hydroxymethyl replacement reactions of tetrakis(hydroxymethyl) phosphonium chloride. Ind Eng Chem Prod Res Dev 5:346\u2013349","journal-title":"Ind Eng Chem Prod Res Dev"},{"key":"9466_CR19","first-page":"125","volume":"2651","author":"C Chylewski","year":"1977","unstructured":"Chylewski C, Jan G, Kurzen R, Meier M, Schellemberg M (1977) Chem Abs 2651:125\u2013353","journal-title":"Chem Abs"},{"key":"9466_CR20","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1021\/ac60164a027","volume":"32","author":"CA Streuli","year":"1960","unstructured":"Streuli CA (1960) Determination of basicity of substituted phosphines by nonaqueous titrimetry. Anal Chem 32:985\u2013987","journal-title":"Anal Chem"},{"key":"9466_CR21","unstructured":"Kosolapoff GM, Maier L (1972) In: Organic phosphorus compounds, Vol. 1. Wiley-Interscience, New York"},{"key":"9466_CR22","doi-asserted-by":"crossref","unstructured":"Blake AJ, McQuillan GP (1984) Structures, vibrational spectra, and ligand behaviour of tris(2-cyanoethyl)phosphine and its oxide, sulphide, and selenide. J Chem Soc Dalton Trans 1849\u20131855","DOI":"10.1039\/dt9840001849"},{"key":"9466_CR23","doi-asserted-by":"publisher","first-page":"2212","DOI":"10.1021\/om00042a040","volume":"11","author":"MR Mason","year":"1992","unstructured":"Mason MR, Verkade JG (1992) Fluoride-induced reduction of palladium(II) and platinum(II) phosphine complexes. Organometallics 11:2212\u20132220","journal-title":"Organometallics"},{"key":"9466_CR24","doi-asserted-by":"publisher","first-page":"2696","DOI":"10.1021\/ic00263a028","volume":"26","author":"MAS Aquino","year":"1987","unstructured":"Aquino MAS, Macartney DH (1987) Axial-ligand substitution reactions of dirhodium(II) tetraacetate with phosphines and phosphites in acetonitrile. Inorg Chem 26:2696\u20132699","journal-title":"Inorg Chem"},{"key":"9466_CR25","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/S0022-328X(97)00541-X","volume":"550","author":"A Guy Orpen","year":"1998","unstructured":"Guy Orpen A, Pringle PG, Smith MB, Worboys K (1998) Synthesis and properties of new tris(cyanoethyl)phosphine complexes of platinum (0, II), palladium (0, II), iridium (I) and rhodium (I). Conformational analysis of tris(cyanoethyl)phosphine ligands. J Organomet Chem 550:255\u2013266","journal-title":"J Organomet Chem"},{"key":"9466_CR26","doi-asserted-by":"crossref","unstructured":"Liu CW, Pan H, Fackler Jr GP, Wu G, Wasylishen RE, Shang M (1995) Studies of [Ag(PPh3)2]NO3, [Ag{P(CH2CH2CN)3}2]NO3 and [Ag{P(C6H4Me\u2013m)3}2]NO3 by X-ray diffraction and solid-state nuclear magnetic resonance. J Chem Soc Dalton Trans 3691\u20133697","DOI":"10.1039\/DT9950003691"},{"key":"9466_CR27","doi-asserted-by":"publisher","first-page":"2502","DOI":"10.1021\/ic00063a050","volume":"32","author":"NI Khan","year":"1993","unstructured":"Khan NI, King C, Fackler GP Jr, Winpenny REP (1993) Syntheses and characterization of gold(I) and platinum(II) complexes containing tris(2-cyanoethyl)phosphine. X-ray crystal structures of [(CEP)2Au]Cl, cis-(CEP)(Et2S)PtCl2, and trans-(CEP)2PtCl2. Inorg Chem 32:2502\u20132505","journal-title":"Inorg Chem"},{"key":"9466_CR28","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1007\/s10870-007-9198-5","volume":"37","author":"S Al-Fayez","year":"2007","unstructured":"Al-Fayez S, Abdel-Rahman LH, Shemsi AM, Seddigi ZS, Fettouhi M (2007) Synthesis and Crystal Structures of Bromo(1, 10-phenanthroline-N, N)tris(2-cyanoethyl)phosphinocopper(I) and Bromo(2, 2\u00a2-bipyridine-N, N\u00a2)tris(2-cyanoethyl)phosphinocopper(I). J Chem Crystallogr 37:517\u2013521","journal-title":"J Chem Crystallogr"},{"key":"9466_CR29","doi-asserted-by":"publisher","first-page":"10861","DOI":"10.1039\/b912281h","volume":"28","author":"RJ Bowen","year":"2009","unstructured":"Bowen RJ, Navarro M, Shearwood AM, Healy PC, Skelton BW, Filipovska A, Berners-Price SJ (2009) 1: 2 Adducts of copper(I) halides with 1, 2-bis(di-2-pyridylphosphino)ethane: solid state and solution structural studies and antitumour activity. Dalton Trans 28:10861\u201310870","journal-title":"Dalton Trans"},{"key":"9466_CR30","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1002\/med.20174","volume":"30","author":"F Tisato","year":"2010","unstructured":"Tisato F, Marzano C, Porchia M, Pellei M, Santini C (2010) Copper in diseases and treatments, and copper-based anticancer strategies. Med Res Rev 30:708\u2013749","journal-title":"Med Res Rev"},{"key":"9466_CR31","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1007\/s002800000166","volume":"46","author":"MJ McKeage","year":"2000","unstructured":"McKeage MJ, Berners-Price SJ, Galettis P, Bowen RJ, Brouwer W, Ding L, Zhuang L, Baguley BC (2000) Role of lipophilicity in determining cellular uptake and antitumour activity of gold phosphine complexes. Cancer Chemoter Pharmacol 46:343\u2013350","journal-title":"Cancer Chemoter Pharmacol"},{"key":"9466_CR32","doi-asserted-by":"crossref","unstructured":"Braumann T (1986) Determination of hydrophobic parameters by reversed-phase liquid chromatography: theory, experimental techniques, and application in studies on quantitative structure-activity relationships 373:191\u2013225","DOI":"10.1016\/S0021-9673(00)80213-7"},{"key":"9466_CR33","first-page":"589","volume":"48","author":"MC Alley","year":"1988","unstructured":"Alley MC, Scudiero DA, Monks A, Hursey ML, Czerwinski MJ, Fine DL, Abbott BJ, Mayo JG, Shoemaker RH, Boyd MR (1988) Feasibility of drug screening with panels of human tumour cell lines using a microculture tetrazolium assay. Cancer Res 48:589\u2013601","journal-title":"Cancer Res"},{"key":"9466_CR34","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"OH Lowry","year":"1951","unstructured":"Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265\u2013275","journal-title":"J Biol Chem"},{"key":"9466_CR35","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1042\/bj0670558","volume":"67","author":"DK Myers","year":"1957","unstructured":"Myers DK, Slater EC (1957) The enzymatic hydrolysis of adenosine triphosphate by rat liver mitochondria. I. Activities at different pH values. Biochem J 67:558\u2013572","journal-title":"Biochem J"},{"key":"9466_CR36","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/0076-6879(67)10010-4","volume":"10","author":"RW Estabrook","year":"1967","unstructured":"Estabrook RW (1967) Mitochondrial respiratory control and the polarographic measurement of ADP: O ratios. Methods Enzymol 10:41\u201347","journal-title":"Methods Enzymol"},{"key":"9466_CR37","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1152\/physrev.1962.42.3.467","volume":"42","author":"AL Lehninger","year":"1962","unstructured":"Lehninger AL (1962) Water uptake and extrusion by mitochondria in relation to oxidative phosphorylation. Physiol Rev 42:467\u2013517","journal-title":"Physiol Rev"},{"key":"9466_CR38","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/0005-2728(86)90112-X","volume":"850","author":"RK Emaus","year":"1986","unstructured":"Emaus RK, Grunwald R, Lemasters JL (1986) Rhodamine 123 as a probe of transmembrane potential in isolated rat-liver mitochondria: spectral and metabolic properties. Biochim Biophys Acta 850:436\u2013448","journal-title":"Biochim Biophys Acta"},{"key":"9466_CR39","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1016\/j.freeradbiomed.2006.12.021","volume":"42","author":"C Marzano","year":"2007","unstructured":"Marzano C, Gandin V, Folda A, Scutari G, Bindoli A, Rigobello MP (2007) Inhibition of thioredoxin reductase by auranofin induces apoptosis in cisplatin-resistant human ovarian cancer cells. Free Radic Biol Med 42:872\u2013881","journal-title":"Free Radic Biol Med"},{"key":"9466_CR40","unstructured":"Gandin V, Pellei M, et al. manuscript in preparation."},{"key":"9466_CR41","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1002\/aoc.535","volume":"17","author":"M Bragadin","year":"2003","unstructured":"Bragadin M, Manente S, Marton D, Cima F, Rigobello MP, Bindoli A (2003) The interaction of zinc pyrithione with mitochondria from rat liver and a study of the mechanism of inhibition of ATP synthesis. Appl Organomet Chem 17:869\u2013874","journal-title":"Appl Organomet Chem"},{"key":"9466_CR42","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1021\/jm049430g","volume":"48","author":"NJ Sanghamitra","year":"2005","unstructured":"Sanghamitra NJ, Phatak P, Das S, Samuelson AG, Somasundaram K (2005) Mechanism of cytotoxicity of copper(I) complexes of 1, 2-bis(diphenylphosphino)ethane. J Med Chem 48:977\u2013985","journal-title":"J Med Chem"},{"key":"9466_CR43","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.bbabio.2006.04.029","volume":"1757","author":"DB Zorov","year":"2006","unstructured":"Zorov DB, Juhaszova M, Sollott SJ (2006) Mitochondrial ROS-induced ROS release: an update and review. Biochim Biophys Acta 1757:509\u2013517","journal-title":"Biochim Biophys Acta"},{"key":"9466_CR44","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1016\/S0891-5849(02)01111-5","volume":"33","author":"R Radi","year":"2002","unstructured":"Radi R, Cassina A, Hodara R, Quijano C, Castro L (2002) Peroxynitrite reactions and formation in mitochondria. Free Radic Biol Med 33:1451\u20131464","journal-title":"Free Radic Biol Med"}],"container-title":["Investigational New Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10637-010-9466-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10637-010-9466-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10637-010-9466-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10637-010-9466-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T18:11:58Z","timestamp":1711563118000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10637-010-9466-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,22]]},"references-count":44,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["9466"],"URL":"https:\/\/doi.org\/10.1007\/s10637-010-9466-7","relation":{},"ISSN":["0167-6997","1573-0646"],"issn-type":[{"value":"0167-6997","type":"print"},{"value":"1573-0646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6,22]]},"assertion":[{"value":"7 April 2010","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 May 2010","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2010","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}