{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T17:34:45Z","timestamp":1762623285562},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2010,10,16]],"date-time":"2010-10-16T00:00:00Z","timestamp":1287187200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2010,10,16]],"date-time":"2010-10-16T00:00:00Z","timestamp":1287187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Invest New Drugs"],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1007\/s10637-010-9564-6","type":"journal-article","created":{"date-parts":[[2010,10,15]],"date-time":"2010-10-15T08:42:15Z","timestamp":1287132135000},"page":"417-422","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Anti-leukemic activity of Dasatinib in both p53wild-type and p53mutated B malignant cells"],"prefix":"10.1007","volume":"30","author":[{"given":"Raffaella","family":"Bosco","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Rabusin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Voltan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Celeghini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Corallini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvano","family":"Capitani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Secchiero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,10,16]]},"reference":[{"key":"9564_CR1","doi-asserted-by":"publisher","first-page":"2531","DOI":"10.1056\/NEJMoa055229","volume":"354","author":"M Talpaz","year":"2006","unstructured":"Talpaz M, Shah NP, Kantarjian H et al (2006) Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias. New Engl J Med 354:2531\u20132541","journal-title":"New Engl J Med"},{"key":"9564_CR2","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1111\/j.1365-2141.2008.07418.x","volume":"143","author":"L Amrein","year":"2008","unstructured":"Amrein L, Hernandez TA, Ferrario C et al (2008) Dasatinib sensitizes primary chronic lymphocytic leukaemia lymphocytes to chlorambucil and fludarabine in vitro. Br J Haematol 143:698\u2013706","journal-title":"Br J Haematol"},{"key":"9564_CR3","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1182\/blood-2007-11-123984","volume":"112","author":"A Veldurthy","year":"2008","unstructured":"Veldurthy A, Patz M, Hagist S et al (2008) The kinase inhibitor dasatinib induces apoptosis in chronic lymphocytic leukemia cells in vitro with preference for a subgroup of patients with unmutated IgVH genes. Blood 112:1443\u20131452","journal-title":"Blood"},{"key":"9564_CR4","doi-asserted-by":"publisher","first-page":"395","DOI":"10.2174\/138920007780655432","volume":"8","author":"P Secchiero","year":"2007","unstructured":"Secchiero P, Zerbinati C, di Iasio MG et al (2007) Synergistic cytotoxic activity of recombinant TRAIL plus the non-genotoxic activator of the p53 pathway nutlin-3 in acute myeloid leukemia cells. Curr Drug Metab 8:395\u2013403","journal-title":"Curr Drug Metab"},{"key":"9564_CR5","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1593\/neo.07523","volume":"9","author":"P Secchiero","year":"2007","unstructured":"Secchiero P, Zerbinati C, Melloni E et al (2007) The MDM-2 antagonist Nutlin-3 promotes maturation of acute myeloid leukemic blasts. Neoplasia 9:853\u2013861","journal-title":"Neoplasia"},{"key":"9564_CR6","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/j.leukres.2009.11.005","volume":"34","author":"S Tavolaro","year":"2010","unstructured":"Tavolaro S, Chiaretti S, Messina M et al (2010) Gene expression profile of protein kinases reveals a distinctive signature in chronic lymphocytic leukemia and in vitro experiments support a role of second generation protein kinase inhibitors. Leuk Res 34:733\u2013741","journal-title":"Leuk Res"},{"key":"9564_CR7","doi-asserted-by":"publisher","first-page":"3322","DOI":"10.1182\/blood-2008-04-154070","volume":"112","author":"T Zenz","year":"2008","unstructured":"Zenz T, Kr\u00f6ber A, Sherer K et al (2008) Monoallelic TP53 inactivation is associated with poor prognosis in chronic lymphocytic leukemia: results from a detailed genetic characterization with long-term follow-up. Blood 112:3322\u20133329","journal-title":"Blood"},{"key":"9564_CR8","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1099\/0022-1317-73-2-417","volume":"73","author":"G Zauli","year":"1992","unstructured":"Zauli G, Re MC, Furlini G, Giovannini M, La Placa M (1992) Human immunodeficiency virus type 1 envelope glycoprotein gp120-mediated killing of human haematopoietic progenitors (CD34+ cells). J Gen Virol 73:417\u2013421","journal-title":"J Gen Virol"},{"key":"9564_CR9","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1007\/s00018-004-4197-6","volume":"61","author":"P Secchiero","year":"2004","unstructured":"Secchiero P, Zerbinati C, Rimondi E et al (2004) TRAIL promotes the survival, migration and proliferation of vascular smooth muscle cells. Cell Mol Life Sci 61:1965\u20131974","journal-title":"Cell Mol Life Sci"},{"key":"9564_CR10","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1046\/j.1471-4159.2003.01805.x","volume":"86","author":"D Milani","year":"2003","unstructured":"Milani D, Zauli G, Rimondi E et al (2003) Tumour necrosis factor-related apoptosis-inducing ligand sequentially activates pro-survival and pro-apoptotic pathways in SK-N-MC neuronal cells. J Neurochem 86:126\u2013135","journal-title":"J Neurochem"},{"key":"9564_CR11","doi-asserted-by":"publisher","first-page":"22961","DOI":"10.1074\/jbc.271.38.22961","volume":"271","author":"D Milani","year":"1996","unstructured":"Milani D, Mazzoni M, Borgatti P, Zauli G, Cantley L, Capitani S (1996) Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells. J Biol Chem 271:22961\u201322964","journal-title":"J Biol Chem"},{"key":"9564_CR12","doi-asserted-by":"publisher","first-page":"6232","DOI":"10.1158\/1078-0432.CCR-09-0224","volume":"15","author":"GD Demetri","year":"2009","unstructured":"Demetri GD, Lo Russo P, MacPherson IRJ (2009) Phase I dose-escalation and pharmacokinetic study of dasatinib in patients with advanced solid tumors. Clin Cancer Res 15:6232\u20136240","journal-title":"Clin Cancer Res"},{"key":"9564_CR13","doi-asserted-by":"crossref","first-page":"6051","DOI":"10.4049\/jimmunol.181.9.6051","volume":"181","author":"A Sainz-Perez","year":"2008","unstructured":"Sainz-Perez A, Gary-Gouy H, Gaudin F et al (2008) IL-24 induces apoptosis of chronic lymphocytic leukemia B cells engaged into the cell cycle through dephosphorylation of STAT3 and stabilization of p53 expression. J Immunol 181:6051\u20136060","journal-title":"J Immunol"},{"key":"9564_CR14","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1158\/1078-0432.CCR-08-1511","volume":"15","author":"AK Ghosh","year":"2009","unstructured":"Ghosh AK, Kay NE, Secreto CR, Shanafelt TD (2009) Curcumin inhibits prosurvival pathways in chronic lymphocytic leukemia B cells and may overcome their stromal protection in combination with EGCG. Clin Cancer Res 15:1250\u20131258","journal-title":"Clin Cancer Res"},{"key":"9564_CR15","doi-asserted-by":"publisher","first-page":"2418","DOI":"10.1182\/blood-2004-04-1294","volume":"104","author":"P Mirandola","year":"2004","unstructured":"Mirandola P, Ponti C, Gobbi G et al (2004) Activated human NK and CD8+ T cells express both TNF-related apoptosis inducing ligand (TRAIL) and TRAIL receptors, but are resistant to TRAIL-mediated cytotoxicity. Blood 104:2418\u20132424","journal-title":"Blood"},{"key":"9564_CR16","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1182\/blood-2007-04-083600","volume":"111","author":"JC Cheng","year":"2008","unstructured":"Cheng JC, Kinjo K, Judelson DR et al (2008) CREB is a critical regulator of normal hematopoiesis and leukemogenesis. Blood 111:1182\u20131192","journal-title":"Blood"}],"container-title":["Investigational New Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10637-010-9564-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10637-010-9564-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10637-010-9564-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10637-010-9564-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,11]],"date-time":"2023-03-11T05:10:21Z","timestamp":1678511421000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10637-010-9564-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10,16]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["9564"],"URL":"https:\/\/doi.org\/10.1007\/s10637-010-9564-6","relation":{},"ISSN":["0167-6997","1573-0646"],"issn-type":[{"value":"0167-6997","type":"print"},{"value":"1573-0646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10,16]]},"assertion":[{"value":"24 September 2010","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 October 2010","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 October 2010","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}