{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T22:47:00Z","timestamp":1789080420629,"version":"build-2803163510"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2011,12,21]],"date-time":"2011-12-21T00:00:00Z","timestamp":1324425600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2011,12,21]],"date-time":"2011-12-21T00:00:00Z","timestamp":1324425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Invest New Drugs"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1007\/s10637-011-9778-2","type":"journal-article","created":{"date-parts":[[2011,12,20]],"date-time":"2011-12-20T06:51:34Z","timestamp":1324363894000},"page":"2132-2140","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Pretargeting of necrotic tumors with biotinylated hypericin using 123I-labeled avidin: evaluation of a two-step strategy"],"prefix":"10.1007","volume":"30","author":[{"given":"Thierry","family":"Marysael","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Bauwens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yicheng","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Bormans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jef","family":"Rozenski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"de Witte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,12,21]]},"reference":[{"issue":"12","key":"9778_CR1","doi-asserted-by":"publisher","first-page":"H18","DOI":"10.1002\/adma.201100140","volume":"23","author":"JA Barreto","year":"2011","unstructured":"Barreto JA, O'Malley W, Kubeil M, Graham B, Stephan H, Spiccia L (2011) Nanomaterials: applications in cancer imaging and therapy. Adv Mater 23(12):H18\u201340. doi:10.1002\/adma.201100140","journal-title":"Adv Mater"},{"issue":"5","key":"9778_CR2","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1158\/1078-0432.CCR-06-2436","volume":"13","author":"M Jain","year":"2007","unstructured":"Jain M, Venkatraman G, Batra SK (2007) Optimization of radioimmunotherapy of solid tumors: biological impediments and their modulation. Clin Cancer Res 13(5):1374\u201382. doi:1078-0432.CCR-06-2436","journal-title":"Clin Cancer Res"},{"key":"9778_CR3","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/S0065-230X(08)60971-9","volume":"21","author":"EH Cooper","year":"1975","unstructured":"Cooper EH, Bedford AJ, Kenny TE (1975) Cell death in normal and malignant tissues. Adv Cancer Res 21:59\u2013120","journal-title":"Adv Cancer Res"},{"issue":"20","key":"9778_CR4","first-page":"5842","volume":"48","author":"AL Epstein","year":"1988","unstructured":"Epstein AL, Chen FM, Taylor CR (1988) A novel method for the detection of necrotic lesions in human cancers. Cancer Res 48(20):5842\u20138","journal-title":"Cancer Res"},{"issue":"8","key":"9778_CR5","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1097\/01.rli.0000171811.48991.5a","volume":"40","author":"Y Ni","year":"2005","unstructured":"Ni Y, Bormans G, Chen F, Verbruggen A, Marchal G (2005) Necrosis avid contrast agents: functional similarity versus structural diversity. Invest Radiol 40(8):526\u201335","journal-title":"Invest Radiol"},{"key":"9778_CR6","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1148\/radiol.11102120","volume":"260","author":"J Li","year":"2011","unstructured":"Li J, Sun Z, Zhang J, Shao H, Miranda Cona M, Wang H et al (2011) A dual-targeting anticancer approach: soil and seed principle. Radiology 260:799\u2013807","journal-title":"Radiology"},{"issue":"9","key":"9778_CR7","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1097\/RLI.0b013e31821a2116","volume":"46","author":"H Wang","year":"2011","unstructured":"Wang H, Miranda Cona M, Chen F, Li J, Yu J, Feng Y Y et al (2011) Comparison between nonspecific and necrosis-avid gadolinium contrast agents in vascular disrupting agent-induced necrosis of rodent tumors at 3.0T. Invest Radiol 46(9):531\u20138. doi:10.1097\/RLI.0b013e31821a2116","journal-title":"Invest Radiol"},{"issue":"11","key":"9778_CR8","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1007\/s00432-011-1032-y","volume":"137","author":"T Marysael","year":"2011","unstructured":"Marysael T, Ni Y, Lerut E, de Witte P (2011) Influence of the vascular damaging agents DMXAA and ZD6126 on hypericin distribution and accumulation in RIF-1 tumors. J Cancer Res Clin Oncol 137(11):1619\u201327. doi:10.1007\/s00432-011-1032-y","journal-title":"J Cancer Res Clin Oncol"},{"issue":"1","key":"9778_CR9","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.acra.2007.08.008","volume":"15","author":"M Van de Putte","year":"2008","unstructured":"Van de Putte M, Wang H, Chen F, de Witte PA, Ni Y (2008) Hypericin as a marker for determination of tissue viability after intratumoral ethanol injection in a murine liver tumor model. Acad Radiol 15(1):107\u201313","journal-title":"Acad Radiol"},{"issue":"4","key":"9778_CR10","first-page":"927","volume":"19","author":"M Van de Putte","year":"2008","unstructured":"Van de Putte M, Wang H, Chen F, De Witte PA, Ni Y (2008) Hypericin as a marker for determination of tissue viability after radiofrequency ablation in a murine liver tumor model. Oncol Rep 19(4):927\u201332","journal-title":"Oncol Rep"},{"issue":"6","key":"9778_CR11","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1038\/nrc1628","volume":"5","author":"GM Tozer","year":"2005","unstructured":"Tozer GM, Kanthou C, Baguley BC (2005) Disrupting tumour blood vessels. Nat Rev Cancer 5(6):423\u201335. doi:10.1038\/nrc1628","journal-title":"Nat Rev Cancer"},{"issue":"1\u20132","key":"9778_CR12","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1002\/jlcr.1468","volume":"51","author":"H Fonge","year":"2008","unstructured":"Fonge H, Jin LX, Wang HJ, Bormans G, Ni YC, Verbruggen A (2008) Synthesis and preliminary biological evaluation of a Tc-99m-labeled hypericin derivative as a necrosis avid imaging agent. J Label Compd Radiopharm 51(1\u20132):33\u201340. doi:10.1002\/jlcr.1468","journal-title":"J Label Compd Radiopharm"},{"issue":"3","key":"9778_CR13","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1042\/bj2420923","volume":"242","author":"G Gitlin","year":"1987","unstructured":"Gitlin G, Bayer EA, Wilchek M (1987) Studies on the biotin-binding site of avidin. Lysine residues involved in the active site. Biochem J 242(3):923\u20136","journal-title":"Biochem J"},{"issue":"Pt 1","key":"9778_CR14","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1042\/bj3160193","volume":"316","author":"E Morag","year":"1996","unstructured":"Morag E, Bayer EA, Wilchek M (1996) Reversibility of biotin-binding by selective modification of tyrosine in avidin. Biochem J 316(Pt 1):193\u20139","journal-title":"Biochem J"},{"issue":"1","key":"9778_CR15","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1080\/00304940009356746","volume":"32","author":"E Gruszecka-Kowalik","year":"2000","unstructured":"Gruszecka-Kowalik E, Zalkow LH (2000) An improved synthesis of hypericin and related compounds. Org Prep Proced Int 32(1):57\u201361","journal-title":"Org Prep Proced Int"},{"issue":"2","key":"9778_CR16","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/0003-2697(86)90092-8","volume":"153","author":"DM Mock","year":"1986","unstructured":"Mock DM, DuBois DB (1986) A sequential, solid-phase assay for biotin in physiologic fluids that correlates with expected biotin status. Anal Biochem 153(2):272\u20138","journal-title":"Anal Biochem"},{"issue":"4","key":"9778_CR17","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1038\/sj.bjc.6601606","volume":"90","author":"LM Ching","year":"2004","unstructured":"Ching LM, Zwain S, Baguley BC (2004) Relationship between tumour endothelial cell apoptosis and tumour blood flow shutdown following treatment with the antivascular agent DMXAA in mice. Br J Cancer 90(4):906\u201310. doi:10.1038\/sj.bjc.6601606","journal-title":"Br J Cancer"},{"issue":"23","key":"9778_CR18","doi-asserted-by":"publisher","first-page":"6347","DOI":"10.1016\/j.bmc.2005.09.003","volume":"13","author":"I Crnolatac","year":"2005","unstructured":"Crnolatac I, Huygens A, van Aerschot A, Busson R, Rozenski J, de Witte PA (2005) Synthesis, in vitro cellular uptake and photo-induced antiproliferative effects of lipophilic hypericin acid derivatives. Bioorg Med Chem 13(23):6347\u201353. doi:10.1016\/j.bmc.2005.09.003","journal-title":"Bioorg Med Chem"},{"issue":"2","key":"9778_CR19","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S0021-9258(18)65575-9","volume":"208","author":"DB Melville","year":"1954","unstructured":"Melville DB (1954) Biotin sulfoxide. J Biol Chem 208(2):495\u2013501","journal-title":"J Biol Chem"},{"issue":"4","key":"9778_CR20","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1093\/jn\/125.4.941","volume":"125","author":"DM Mock","year":"1995","unstructured":"Mock DM, Lankford GL, Mock NI (1995) Biotin accounts for only half of the total avidin-binding substances in human serum. J Nutr 125(4):941\u20136","journal-title":"J Nutr"},{"key":"9778_CR21","doi-asserted-by":"publisher","unstructured":"Van de Putte M, Marysael T, Fonge H, Roskams T, Miranda Cona M, Li J et al (2011) Radiolabeled iodohypericin as tumor necrosis avid tracer: diagnostic and therapeutic potential. Int J Cancer. doi:10.1002\/ijc.26492","DOI":"10.1002\/ijc.26492"},{"issue":"5","key":"9778_CR22","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1089\/cbr.2010.0797","volume":"25","author":"F Petronzelli","year":"2010","unstructured":"Petronzelli F, Pelliccia A, Anastasi AM, Lindstedt R, Manganello S, Ferrari LE et al (2010) Therapeutic use of avidin is not hampered by antiavidin antibodies in humans. Cancer Biother Radiopharm 25(5):563\u201370. doi:10.1089\/cbr.2010.0797","journal-title":"Cancer Biother Radiopharm"},{"issue":"5","key":"9778_CR23","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1007\/s00259-005-0013-2","volume":"33","author":"Y Ni","year":"2006","unstructured":"Ni Y, Huyghe D, Verbeke K, de Witte PA, Nuyts J, Mortelmans L et al (2006) First preclinical evaluation of mono-[123I]iodohypericin as a necrosis-avid tracer agent. Eur J Nucl Med Mol Imaging 33(5):595\u2013601. doi:10.1007\/s00259-005-0013-2","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"2","key":"9778_CR24","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1093\/eurheartj\/ehm588","volume":"29","author":"H Fonge","year":"2008","unstructured":"Fonge H, Vunckx K, Wang H, Feng Y, Mortelmans L, Nuyts J et al (2008) Non-invasive detection and quantification of acute myocardial infarction in rabbits using mono-[123I]iodohypericin microSPECT. Eur Heart J 29(2):260\u20139. doi:10.1093\/eurheartj\/ehm588","journal-title":"Eur Heart J"},{"issue":"5","key":"9778_CR25","doi-asserted-by":"publisher","first-page":"792","DOI":"10.2967\/jnumed.110.086116","volume":"52","author":"S Song","year":"2011","unstructured":"Song S, Xiong C, Zhou M, Lu W, Huang Q, Ku G et al (2011) Small-animal PET of tumor damage induced by photothermal ablation with 64Cu-bis-DOTA-hypericin. J Nucl Med 52(5):792\u20139","journal-title":"J Nucl Med"},{"issue":"4","key":"9778_CR26","first-page":"921","volume":"19","author":"M Van de Putte","year":"2008","unstructured":"Van de Putte M, Ni Y, De Witte PA (2008) Exploration of the mechanism underlying the tumor necrosis avidity of hypericin. Oncol Rep 19(4):921\u20136","journal-title":"Oncol Rep"},{"issue":"2","key":"9778_CR27","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1111\/j.1432-1033.1990.tb15493.x","volume":"189","author":"B Schechter","year":"1990","unstructured":"Schechter B, Silberman R, Arnon R, Wilchek M (1990) Tissue distribution of avidin and streptavidin injected to mice\u2014effect of avidin carbohydrate, streptavidin truncation and exogenous biotin. Eur J Biochem 189(2):327\u201331","journal-title":"Eur J Biochem"},{"issue":"40","key":"9778_CR28","doi-asserted-by":"crossref","first-page":"6288","DOI":"10.3748\/wjg.v11.i40.6288","volume":"11","author":"GP Li","year":"2005","unstructured":"Li GP, Zhang H, Zhu CM, Zhang J, Jiang XF (2005) Avidin-biotin system pretargeting radioimmunoimaging and radioimmunotherapy and its application in mouse model of human colon carcinoma. World J Gastroenterol 11(40):6288\u201394","journal-title":"World J Gastroenterol"},{"issue":"16","key":"9778_CR29","first-page":"4578","volume":"49","author":"FM Chen","year":"1989","unstructured":"Chen FM, Taylor CR, Epstein AL (1989) Tumor necrosis treatment of Me-180 human cervical-carcinoma model with I-131-labeled Tnt-1 monoclonal-antibody. Cancer Res 49(16):4578\u201385","journal-title":"Cancer Res"}],"container-title":["Investigational New Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10637-011-9778-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10637-011-9778-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10637-011-9778-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10637-011-9778-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,16]],"date-time":"2025-03-16T04:38:01Z","timestamp":1742099881000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10637-011-9778-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,21]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["9778"],"URL":"https:\/\/doi.org\/10.1007\/s10637-011-9778-2","relation":{},"ISSN":["0167-6997","1573-0646"],"issn-type":[{"value":"0167-6997","type":"print"},{"value":"1573-0646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,21]]},"assertion":[{"value":"30 September 2011","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 November 2011","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 December 2011","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}