{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T09:43:21Z","timestamp":1780393401001,"version":"3.54.1"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2016,5,14]],"date-time":"2016-05-14T00:00:00Z","timestamp":1463184000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2016,5,14]],"date-time":"2016-05-14T00:00:00Z","timestamp":1463184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Ensat cancer","award":["259735"],"award-info":[{"award-number":["259735"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Invest New Drugs"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1007\/s10637-016-0358-3","type":"journal-article","created":{"date-parts":[[2016,5,14]],"date-time":"2016-05-14T01:27:31Z","timestamp":1463189251000},"page":"531-540","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The aurora kinase inhibitor VX-680 shows anti-cancer effects in primary metastatic cells and the SW13 cell line"],"prefix":"10.1007","volume":"34","author":[{"given":"Raffaele","family":"Pezzani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Rubin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loris","family":"Bertazza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Redaelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susi","family":"Barollo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halenya","family":"Monticelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enke","family":"Baldini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Mian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Mucignat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Scaroni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Mantero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Ulisse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Iacobone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Boscaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,5,14]]},"reference":[{"key":"358_CR1","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1038\/nrm1245","volume":"4","author":"M Carmena","year":"2003","unstructured":"Carmena M, Earnshaw WC (2003) The cellular geography of aurora kinases. Nat Rev Mol Cell Biol 4:842\u2013854","journal-title":"Nat Rev Mol Cell Biol"},{"key":"358_CR2","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.1158\/1078-0432.CCR-07-2179","volume":"14","author":"O Gautschi","year":"2008","unstructured":"Gautschi O, Heighway J, Mack PC, Purnell PR, Lara PN Jr, Gandara DR (2008) Aurora kinases as anticancer drug targets. Clin Cancer Res 14:1639\u20131648","journal-title":"Clin Cancer Res"},{"key":"358_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1158\/1541-7786.MCR-06-0208","volume":"5","author":"J Fu","year":"2007","unstructured":"Fu J, Bian M, Jiang Q, Zhang C (2007) Roles of aurora kinases in mitosis and tumorigenesis. Mol Cancer Res 5:1\u201310","journal-title":"Mol Cancer Res"},{"key":"358_CR4","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1002\/pbc.24653","volume":"60","author":"KS Borges","year":"2013","unstructured":"Borges KS, Moreno DA, Martinelli CE Jr, Antonini SR, de Castro M, Tucci S Jr, Neder L, Ramalho LN, Seidinger AL, Cardinalli I, Mastellaro MJ, Yunes JA, Brandalise SR, Tone LG, Scrideli CA (2013) Spindle assembly checkpoint gene expression in childhood adrenocortical tumors (ACT): overexpression of aurora kinases a and B is associated with a poor prognosis. Pediatr Blood Cancer 60:1809\u20131816","journal-title":"Pediatr Blood Cancer"},{"key":"358_CR5","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.ejmech.2015.12.010","volume":"109","author":"JE Obreque-Balboa","year":"2016","unstructured":"Obreque-Balboa JE, Sun Q, Bernhardt G, Konig B, Buschauer A (2016) Flavonoid derivatives as selective ABCC1 modulators: synthesis and functional characterization. Eur J Med Chem 109:124\u2013133","journal-title":"Eur J Med Chem"},{"key":"358_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.drup.2014.11.002","volume":"18","author":"RJ Kathawala","year":"2015","unstructured":"Kathawala RJ, Gupta P, Ashby CR Jr, Chen ZS (2015) The modulation of ABC transporter-mediated multidrug resistance in cancer: a review of the past decade. Drug Resist Updat 18:1\u201317","journal-title":"Drug Resist Updat"},{"key":"358_CR7","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1007\/s12020-014-0374-z","volume":"47","author":"T Gagliano","year":"2014","unstructured":"Gagliano T, Gentilin E, Benfini K, Di Pasquale C, Tassinari M, Falletta S, Feo C, Tagliati F, Uberti ED, Zatelli MC (2014) Mitotane enhances doxorubicin cytotoxic activity by inhibiting P-gp in human adrenocortical carcinoma cells. Endocrine 47:943\u2013951","journal-title":"Endocrine"},{"key":"358_CR8","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1038\/nrc2622","volume":"9","author":"DX Nguyen","year":"2009","unstructured":"Nguyen DX, Bos PD, Massague J (2009) Metastasis: from dissemination to organ-specific colonization. Nat Rev Cancer 9:274\u2013284","journal-title":"Nat Rev Cancer"},{"key":"358_CR9","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1016\/j.surg.2013.06.021","volume":"154","author":"P Moreno","year":"2013","unstructured":"Moreno P, de la Quintana BA, Musholt TJ, Paunovic I, Puccini M, Vidal O, Ortega J, Kraimps JL, Bollo Arocena E, Rodriguez JM, Gonzalez Lopez O, Del Pozo CD, Iacobone M, Veloso E, Del Pino JM, Garcia Sanz I, Scott-Coombes D, Villar-Del-Moral J, Rodriguez JI, Vazquez Echarri J, Gonzalez Sanchez C, Gutierrez Rodriguez MT, EscoreSsca I, Nuno Vazquez-Garza J, Tobalina Aguirrezabal E, Martin J, Candel Arenas MF, Lorenz K, Martos JM, Ramia JM (2013) Adrenalectomy for solid tumor metastases: results of a multicenter European study. Surgery 154:1215\u20131222 discussion 1222-1213","journal-title":"Surgery"},{"key":"358_CR10","unstructured":"http:\/\/endocrinediseases.org\/adrenal\/metastases.shtml"},{"key":"358_CR11","doi-asserted-by":"publisher","first-page":"45","DOI":"10.3389\/fcell.2015.00045","volume":"3","author":"R Libe","year":"2015","unstructured":"Libe R (2015) Adrenocortical carcinoma (ACC): diagnosis, prognosis, and treatment. Front Cell Dev Biol 3:45","journal-title":"Front Cell Dev Biol"},{"key":"358_CR12","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1016\/j.surg.2013.06.033","volume":"154","author":"BM Dy","year":"2013","unstructured":"Dy BM, Wise KB, Richards ML, Young WF Jr, Grant CS, Bible KC, Rosedahl J, Harmsen WS, Farley DR, Thompson GB (2013) Operative intervention for recurrent adrenocortical cancer. Surgery 154:1292\u20131299 discussion 1299","journal-title":"Surgery"},{"key":"358_CR13","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.surg.2011.09.030","volume":"152","author":"S Gaujoux","year":"2012","unstructured":"Gaujoux S, Brennan MF (2012) Recommendation for standardized surgical management of primary adrenocortical carcinoma. Surgery 152:123\u2013132","journal-title":"Surgery"},{"key":"358_CR14","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1530\/ERC-11-0337","volume":"19","author":"B Mariniello","year":"2012","unstructured":"Mariniello B, Rosato A, Zuccolotto G, Rubin B, Cicala MV, Finco I, Iacobone M, Frigo AC, Fassina A, Pezzani R, Mantero F (2012) Combination of sorafenib and everolimus impacts therapeutically on adrenocortical tumor models. Endocr Relat Cancer 19:527\u2013539","journal-title":"Endocr Relat Cancer"},{"key":"358_CR15","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.mce.2011.08.041","volume":"351","author":"T Wang","year":"2012","unstructured":"Wang T, Rainey WE (2012) Human adrenocortical carcinoma cell lines. Mol Cell Endocrinol 351:58\u201365","journal-title":"Mol Cell Endocrinol"},{"key":"358_CR16","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1111\/jcmm.12612","volume":"19","author":"L Bertazza","year":"2015","unstructured":"Bertazza L, Barollo S, Radu CM, Cavedon E, Simioni P, Faggian D, Plebani M, Pelizzo MR, Rubin B, Boscaro M, Pezzani R, Mian C (2015) Synergistic antitumour activity of RAF265 and ZSTK474 on human TT medullary thyroid cancer cells. J Cell Mol Med 19:2244\u20132252","journal-title":"J Cell Mol Med"},{"key":"358_CR17","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1007\/s10637-014-0108-3","volume":"32","author":"S Barollo","year":"2014","unstructured":"Barollo S, Bertazza L, Baldini E, Ulisse S, Cavedon E, Boscaro M, Pezzani R, Mian C (2014) The combination of RAF265, SB590885, ZSTK474 on thyroid cancer cell lines deeply impact on proliferation and MAPK and PI3K\/Akt signaling pathways. Investig New Drugs 32:626\u2013635","journal-title":"Investig New Drugs"},{"key":"358_CR18","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1507\/endocrj.EJ13-0225","volume":"61","author":"R Pezzani","year":"2014","unstructured":"Pezzani R, Rubin B, Redaelli M, Radu C, Barollo S, Cicala MV, Salva M, Mian C, Mucignat-Caretta C, Simioni P, Iacobone M, Mantero F (2014) The antiproliferative effects of ouabain and everolimus on adrenocortical tumor cells. Endocr J 61:41\u201353","journal-title":"Endocr J"},{"key":"358_CR19","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/j.ejmech.2015.04.039","volume":"96","author":"M Redaelli","year":"2015","unstructured":"Redaelli M, Mucignat-Caretta C, Isse AA, Gennaro A, Pezzani R, Pasquale R, Pavan V, Crisma M, Ribaudo G, Zagotto G (2015) New naphthoquinone derivatives against glioma cells. Eur J Med Chem 96:458\u2013466","journal-title":"Eur J Med Chem"},{"key":"358_CR20","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1089\/thy.2013.0403","volume":"24","author":"S Barollo","year":"2014","unstructured":"Barollo S, Pezzani R, Cristiani A, Redaelli M, Zambonin L, Rubin B, Bertazza L, Zane M, Mucignat-Caretta C, Bulfone A, Pennelli G, Casal Ide E, Pelizzo MR, Mantero F, Moro S, Mian C (2014) Prevalence, tumorigenic role, and biochemical implications of rare BRAF alterations. Thyroid 24:809\u2013819","journal-title":"Thyroid"},{"key":"358_CR21","doi-asserted-by":"publisher","first-page":"526","DOI":"10.3109\/07357907.2015.1080832","volume":"33","author":"B Rubin","year":"2015","unstructured":"Rubin B, Monticelli H, Redaelli M, Mucignat C, Barollo S, Bertazza L, Mian C, Betterle C, Iacobone M, Fassina A, Boscaro M, Pezzani R, Mantero F (2015) Mitogen-activated protein kinase pathway: genetic analysis of 95 adrenocortical tumors. Cancer Investig 33:526\u2013531","journal-title":"Cancer Investig"},{"key":"358_CR22","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1002\/ijc.21344","volume":"118","author":"T Hienonen","year":"2006","unstructured":"Hienonen T, Salovaara R, Mecklin JP, Jarvinen H, Karhu A, Aaltonen LA (2006) Preferential amplification of AURKA 91\u00a0a (Ile31) in familial colorectal cancers. Int J Cancer 118:505\u2013508","journal-title":"Int J Cancer"},{"key":"358_CR23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030734","volume":"7","author":"TW Failes","year":"2012","unstructured":"Failes TW, Mitic G, Abdel-Halim H, Po\u2019uha ST, Liu M, Hibbs DE, Kavallaris M (2012) Evolution of resistance to aurora kinase B inhibitors in leukaemia cells. PLoS One 7:e30734","journal-title":"PLoS One"},{"key":"358_CR24","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1055\/s-0033-1351299","volume":"121","author":"S Barollo","year":"2013","unstructured":"Barollo S, Pezzani R, Cristiani A, Bertazza L, Rubin B, Bulfone A, Pelizzo MR, Torresan F, Mantero F, Pennelli G, Moro S, Mian C (2013) Functional significance of the novel H-RAS gene mutation M72I in a patient with medullary thyroid cancer. Exp Clin Endocrinol Diabetes 121:546\u2013550","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"358_CR25","doi-asserted-by":"publisher","first-page":"50","DOI":"10.3389\/fcell.2015.00050","volume":"3","author":"SM Quartuccio","year":"2015","unstructured":"Quartuccio SM, Schindler K (2015) Functions of aurora kinase C in meiosis and cancer. Front Cell Dev Biol 3:50","journal-title":"Front Cell Dev Biol"},{"key":"358_CR26","doi-asserted-by":"publisher","first-page":"241","DOI":"10.3727\/096504013X13589503482978","volume":"20","author":"A Zekri","year":"2012","unstructured":"Zekri A, Lesan V, Ghaffari SH, Tabrizi MH, Modarressi MH (2012) Gene amplification and overexpression of aurora-C in breast and prostate cancer cell lines. Oncol Res 20:241\u2013250","journal-title":"Oncol Res"},{"key":"358_CR27","doi-asserted-by":"publisher","first-page":"1930","DOI":"10.1093\/carcin\/bgn176","volume":"29","author":"XB Wan","year":"2008","unstructured":"Wan XB, Long ZJ, Yan M, Xu J, Xia LP, Liu L, Zhao Y, Huang XF, Wang XR, Zhu XF, Hong MH, Liu Q (2008) Inhibition of aurora-a suppresses epithelial-mesenchymal transition and invasion by downregulating MAPK in nasopharyngeal carcinoma cells. Carcinogenesis 29:1930\u20131937","journal-title":"Carcinogenesis"},{"key":"358_CR28","doi-asserted-by":"publisher","first-page":"2854","DOI":"10.1182\/blood-2007-07-099325","volume":"111","author":"XF Huang","year":"2008","unstructured":"Huang XF, Luo SK, Xu J, Li J, Xu DR, Wang LH, Yan M, Wang XR, Wan XB, Zheng FM, Zeng YX, Liu Q (2008) Aurora kinase inhibitory VX-680 increases Bax\/Bcl-2 ratio and induces apoptosis in aurora-A-high acute myeloid leukemia. Blood 111:2854\u20132865","journal-title":"Blood"},{"key":"358_CR29","unstructured":"Leong L, Madame Curie Bioscience Database, Landes Bioscience, Austin (TX)"},{"key":"358_CR30","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2014.60","volume":"4","author":"JF Seymour","year":"2014","unstructured":"Seymour JF, Kim DW, Rubin E, Haregewoin A, Clark J, Watson P, Hughes T, Dufva I, Jimenez JL, Mahon FX, Rousselot P, Cortes J, Martinelli G, Papayannidis C, Nagler A, Giles FJ (2014) A phase 2 study of MK-0457 in patients with BCR-ABL T315I mutant chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia. Blood Cancer J 4:e238","journal-title":"Blood Cancer J"},{"key":"358_CR31","first-page":"237","volume":"114","author":"H Wagnerova","year":"2013","unstructured":"Wagnerova H, Lazurova I, Felsoci M (2013) Adrenal metastases. Bratisl Lek Listy 114:237\u2013240","journal-title":"Bratisl Lek Listy"},{"key":"358_CR32","doi-asserted-by":"publisher","first-page":"2607","DOI":"10.1038\/bjc.2013.643","volume":"109","author":"E Tavanti","year":"2013","unstructured":"Tavanti E, Sero V, Vella S, Fanelli M, Michelacci F, Landuzzi L, Magagnoli G, Versteeg R, Picci P, Hattinger CM, Serra M (2013) Preclinical validation of aurora kinase-targeting drugs in osteosarcoma. Br J Cancer 109:2607\u20132618","journal-title":"Br J Cancer"},{"key":"358_CR33","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1186\/1471-2407-11-411","volume":"11","author":"E Baldini","year":"2011","unstructured":"Baldini E, Arlot-Bonnemains Y, Sorrenti S, Mian C, Pelizzo MR, De Antoni E, Palermo S, Morrone S, Barollo S, Nesca A, Moretti CG, D\u2019Armiento M, Ulisse S (2011) Aurora kinases are expressed in medullary thyroid carcinoma (MTC) and their inhibition suppresses in vitro growth and tumorigenicity of the MTC-derived cell line TT. BMC Cancer 11:411","journal-title":"BMC Cancer"},{"key":"358_CR34","doi-asserted-by":"publisher","first-page":"2218","DOI":"10.1091\/mbc.E08-08-0885","volume":"20","author":"JS Nair","year":"2009","unstructured":"Nair JS, Ho AL, Tse AN, Coward J, Cheema H, Ambrosini G, Keen N, Schwartz GK (2009) Aurora B kinase regulates the postmitotic endoreduplication checkpoint via phosphorylation of the retinoblastoma protein at serine 780. Mol Biol Cell 20:2218\u20132228","journal-title":"Mol Biol Cell"},{"key":"358_CR35","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1038\/nrc1502","volume":"4","author":"N Keen","year":"2004","unstructured":"Keen N, Taylor S (2004) Aurora-kinase inhibitors as anticancer agents. Nat Rev Cancer 4:927\u2013936","journal-title":"Nat Rev Cancer"},{"key":"358_CR36","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1016\/j.surg.2009.09.028","volume":"146","author":"A Samadi","year":"2009","unstructured":"Samadi A, Loo P, Mukerji R, O\u2019Donnell G, Tong X, Timmermann BN, Cohen MS (2009) A novel HSP90 modulator with selective activity against thyroid cancers in vitro. Surgery 146:1196\u20131207","journal-title":"Surgery"},{"key":"358_CR37","doi-asserted-by":"publisher","first-page":"7668","DOI":"10.1158\/0008-5472.CAN-05-3353","volume":"66","author":"F Gizatullin","year":"2006","unstructured":"Gizatullin F, Yao Y, Kung V, Harding MW, Loda M, Shapiro GI (2006) The aurora kinase inhibitor VX-680 induces endoreduplication and apoptosis preferentially in cells with compromised p53-dependent postmitotic checkpoint function. Cancer Res 66:7668\u20137677","journal-title":"Cancer Res"},{"key":"358_CR38","doi-asserted-by":"publisher","first-page":"2304","DOI":"10.1002\/ijc.22154","volume":"119","author":"H Yang","year":"2006","unstructured":"Yang H, He L, Kruk P, Nicosia SV, Cheng JQ (2006) Aurora-a induces cell survival and chemoresistance by activation of Akt through a p53-dependent manner in ovarian cancer cells. Int J Cancer 119:2304\u20132312","journal-title":"Int J Cancer"}],"container-title":["Investigational New Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10637-016-0358-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10637-016-0358-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10637-016-0358-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10637-016-0358-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,11]],"date-time":"2023-03-11T04:56:52Z","timestamp":1678510612000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10637-016-0358-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,14]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["358"],"URL":"https:\/\/doi.org\/10.1007\/s10637-016-0358-3","relation":{},"ISSN":["0167-6997","1573-0646"],"issn-type":[{"value":"0167-6997","type":"print"},{"value":"1573-0646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,14]]},"assertion":[{"value":"16 March 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 May 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 May 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All authors have read the journal\u2019s policy on conflicts of interest and have none to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosure"}}]}}